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108 products
Vetaminex - 60 Twist-Off Capsules - Vitamin and Mineral Complex for Dogs and Cats
123,50 lei
Unit price perVetaminex - 60 Twist-Off Capsules - Vitamin and Mineral Complex for Dogs and Cats
123,50 lei
Unit price perVetAminex is a supplement containing vitamins and minerals for dogs and cats.
Properties:
VetAminex contains a balanced and carefully selected dose of vitamins and minerals. It is recommended for balancing the nutritional intake of dogs and cats going through periods of increased nutritional needs. It is especially recommended for:
Pregnant or lactating female dogs and cats
Kittens and puppies during growth
Animals fed home-cooked food with low vitamin and nutrient content
Elderly cats and dogs
Animals recovering from conditions that led to decreased appetite/food intake
Animals suffering from digestive tract disorders, particularly malabsorption
Animals that, due to their lifestyle, require an increased intake of nutritional substances.
Ingredients:
Tricalcium Phosphate
Magnesium Oxide
Soybean Oil.
Additives:
- Vitamin
- Zinc
- Vitamin E
- Iron
- Magnesium
- Copper
- Folic Acid
- Biotin
- Vitamin B1
- Vitamin B2
- Vitamin B6
- Vitamin B12
- Vitamin A
- Vitamin D3
Dosage:
- Cats – 1 capsule/day.
- Puppies up to 5 kg BW – 1 capsule/day.
- Dogs – 1 capsule/10 kg BW/day.
Important: Consult your veterinarian for diagnosis, medication prescription, or diet based on your dog's (cat's) specific needs. This product is dispensed only with a prescription.
VetoMune is a nutritional supplement for dogs and cats that supports the improvement of non-specific immunity at both humoral and cellular levels.
It is indicated for growing puppies, older dogs, dogs with a high risk of infections or viral and bacterial diseases, as well as for pregnant bitches to stimulate maternal immunity, which will then be transferred to the offspring.
Properties: Beta-1,3/1,6-glucan present in the product's composition is one of the most well-known substances with immunostimulatory properties. It has the ability to directly stimulate the antimicrobial mechanism in the body or can support and strengthen the effect of preventive vaccines. Oral administration of beta-glucan increases both mucosal and serum titers of specific IgG and IgA antibodies. Currently, the substance is widely used in the production of immunostimulating supplements for dogs and cats.
HMB (beta-hydroxy-methylbutyrate acid), in addition to its well-known anti-catabolic action, is also used to enhance the metabolic and phagocytic activity of immune cells by increasing the number of antibody-producing cells, which will lead to the stimulation of the immune system.
Composition: Saccharomyces cerevisiae R6446 (YSC 1111) max 100 cfu/g as a source of beta-glucan 80 mg.
Nutritional additives: HMB 40 mg, food additives and flavourings.
The complete formula to combat dry, itchy skin.
Contains pure honey, salmon oil, flaxseed oil, sunflower oil, coconut oil, turmeric, curcumin.
The oils soften and moisturize the skin and coat, while reducing dermal inflammation.
Oncovet I is a food supplement in tablet form, for dogs and cats of all ages. The product is indicated for oncological conditions in pets with nutritional deficiencies that are difficult to compensate. In these cases, the normal functions of the body are severely compromised, requiring an antioxidant and nutritional adjuvant for the elimination of tumor cells.
It is also beneficial during chemotherapy and radiotherapy, as well as before and after surgical operations. Thanks to the included amino acids (L-glutamine), the formula alleviates the side effects of these treatments, strengthens the immune system and reduces the risk of recurrence.
Silymarin, pomegranate extract, green tea and grape seeds have a strong antioxidant and immunomodulatory effect, fighting against free radicals and protecting cells from further damage. It is recommended to combine with Oncovet II.
Composition: Glutamic acid, silymarin, pomegranate, green tea, turmeric, grape seeds, L-selenomethionine, excipients.
Administer 1 tablet/10 kg body weight, twice a day.
Urinovet Dog Canine 400mg - Normal functioning of the urinary system in dogs
117,61 lei
Unit price perUrinovet Dog Canine 400mg - Normal functioning of the urinary system in dogs
117,61 lei
Unit price perUrinovet Dog Canine 400mg - 30 Tablets is indicated for the support of the normal functioning of the urinary system in dogs.
Recommendations:
- for patients suffering from or prone to acute urinary tract conditions or infections
- for patients undergoing treatment for urolithiasis regardless of the type of calculus (urates, struvites, oxalates) and after surgical removal of calculi.
- for the protection of patients who have undergone catheterization procedures.
Properties:
Cranberry extract (vaccinum macrocarpon) contains proanthocyanidin (PAC A2, PAC B2, 3-PAC trimers), which interacts with the receptor surface of pathogenic bacteria and deactivates the adhesins and fimbriae on it. The lack of fimbrial adhesion prevents bacteria from attaching to the epithelial cells of the urinary tract. This anti-adhesion property of cranberry prevents a concentration of bacteria that could lead to chronic urinary infections in the bladder (e.g., Escherichia Colli).
Parsley extract (petroselinum savitum) has diuretic properties (increases urine volume) and facilitates the removal of pathogenic bacteria from the urinary tract. It also reduces the pumping activity of sodium and potassium (Na+K/K+ATP) in the kidneys, which reduces both the reuptake of sodium ion (Na+) and the extraction of potassium ions. These aspects are notable in the osmotic flow of water into the renal tubules and the increase in diuresis and urine volume.
Glucosamine, a precursor of glycosaminoglycans - components of the extracellular matrix that cover the mucous membrane of the lower urinary tract. Glucosamine decreases the permeability of the bladder wall to bacteria and toxins.
This combination of ingredients represents the most effective method to support the normal functioning of the urinary system.
Important: Consult your veterinarian to establish a diagnosis, prescribe medication, or diet based on the specific needs of your dog (cat). This product is dispensed by prescription only.
Carminal Pets Dog and Cat Supplement, for treating digestive system disorders and restoring the gastrointestinal mucosa.
The supplement helps reduce stomach acidity, bloating, and intestinal gas, acting throughout the entire length of the intestinal tract.
Carminal Pets has an antispasmodic effect, calms intestinal pain, and stops diarrhea and vomiting.
The blend of natural ingredients helps combat the symptoms of peptic ulcers, minimizes gastroesophageal reflux, and eliminates abdominal bloating.
Fennel extract is a powerful digestive stimulant.
No side effects have been reported!
Ingredients: Aloe Vera, glutamine, B vitamin group, glycyrrhizic acid, L-carnosine, zinc, fennel.
Nutritional additives: glutamine 0.3 g, folic acid 0.6 mg, pyridoxal 6 mg, riboflavin 0.45 mg, zinc sulfate 120 mg, lactic extract 0.3 g, liver flavor 0.3 g, sodium benzoate 0.3 g, potassium sorbate 0.3 g, and water up to 150 ml.
Analytical constituents: protein 1.09 g, carbohydrates 1.7 g, fats 0.0 g. Energy value 16 kcal (68 kJ).
Apply to the daily food portion.
1 ml/ per 5 kg animal weight/ every 12 hours.
The correct dosage and administration period depend on the individual needs of the animal and will be determined by a veterinarian.
Supports the health of the digestive tract and immune system, while restoring the optimal balance of the intestinal flora.
Contains HealthFactor11, a patented blend of 11 active ingredients (2 prebiotics + 8 probiotics + pumpkin), 8 Probiotics (Bacillus coagulans, Lactobacillus reuteri, Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus brevis, Lactobacillus casei, Lactobacillus plantarum, Streptococcus thermophilus).
Target species: dogs
Administration:
Dogs 11.5 kg BW - 1 tab/ day
Dogs 12-34 kg BW - 2 tabs/ day
Over 34 kg BW - 3 tabs/ day
Nutritional support for dogs and cats with anemia due to iron deficiency or other nutritional deficiencies.
It is indicated in convalescence, inappetence, recovery situations, and for blood donor animals.
It is a nutritional support for pregnant or lactating females.
Formula based on Iron, Copper, VIT B2, B6, B9, B12 and K3 which are essential for erythrocyte synthesis; Vit A, D3, E, B1, B3, B5, choline and minerals (K, Mn, Se, Zn) for appetite stimulation and metabolism, antioxidant action.
Administration:
For convalescence: 1 ml/kg body weight
For anemia: 4 ml/kg body weight
Connecten, Supplements for joint and cartilage protection and regeneration for dogs, 100 tablets
150,00 lei
Unit price perConnecten, Supplements for joint and cartilage protection and regeneration for dogs, 100 tablets
150,00 lei
Unit price perConnecten is a supplement for the protection and regeneration of joints and cartilage for dogs of all ages (tendons, ligaments, connective tissue, and soft tissue).
Connecten is an ideal complementary food recommended as an addition to regular food, designed to harness the effects of Glucosamine, Chondroitin, and MSM in maintaining joint and connective tissue health in dogs of all ages and sizes, especially large breed dogs.
Connecten helps with:
- formation and regeneration of articular cartilage
- promotes dog mobility and activity
- protects cartilage
- improves cartilage elasticity
- lubricates joints
- acts as an anti-inflammatory (reduces pain and swelling)
- helps strengthen connective tissue in joints.
It can be used preventively, but is also highly recommended for:
- joint pain
- inflammation, acute and chronic weakness
- degeneration of tendons and connective tissue
- joint stiffness (spondylosis and arthritis)
Analytical constituents: crude fiber - 17%, crude ash - 14.5%, protein - 2%, crude fat 1.5%, sodium 0.11%.
Composition: glucosamine sulfate - 35%, chondroitin sulfate - 10%, methylsulfonylmethane (MSM) - 5%, hyaluronic acid - 0.5%, microcrystalline cellulose, brewer's yeast, silicon dioxide, magnesium stearate.
Nutritional additives per tablet (1 g):
| Vitamin E 3a700, dl-alpha-tocopheryl acetate | 10 mg |
| Methionine 3c301 | 10 mg |
| Zinc 3b607 (Zn) | 5 mg |
| Vitamin C 3a300, ascorbic acid | 50 mg |
| Manganese 3b506 (Mn) | 2.5 mg |
| Copper 3b413 (Cu) | 0.4 mg |
Warning: Consult your veterinarian before using this product if your dog has health problems such as fish meat or fish-derived product allergies, diabetes, urinary tract disorders, blood clotting disorders, or if they are undergoing anticoagulant treatment, etc.
Consult your veterinarian before using the product in pregnant females, in the last period of gestation or during lactation.
Instructions for use:
For best results, administer for 4-6 weeks and extend if necessary.
Usual, recommended daily dose:
1/2 tablet per 10 kg body weight, twice a day, during meals.
Intensive-therapeutic, recommended daily dose (first 2 weeks):
1 tablet per 10 kg body weight, twice a day, during meals.
1 tablet = 1,000 mg
This product is not intended for human consumption.
Store in a dry place, away from direct sunlight.
Keep out of reach of children.
Vitamin and mineral supplement for adult dogs, growing puppies, and lactating bitches.
Properties:
- Vitamins A, D3, calcium, phosphorus, iodine, magnesium, and manganese play an important role in protein synthesis and bone mineralization.
- B vitamins, vitamin PP, and lysine are involved in energy metabolism and in the synthesis of amino acids or proteins.
- Arginine and choline support liver activity during periods of overload and during recovery after intense activity.
- Vitamin A, biotin, zinc, linoleic acid are essential for skin and coat.
Indications: PET-PHOS Ca/P=1.3 is a nutritional supplement for growing puppies, lactating females, and adult dogs (for maintenance, convalescence, or debilitation).
The phosphorus-calcium ratio of 1:3 ensures normal mineral balance for growing puppies as well as for adults.
Administration and dosage: Administer as is or mixed with food.
- For adult dogs: 1 tablet per 10 kg in courses of 7-14 days, which can be repeated monthly.
- Growing puppies: 2 tablets per 5 kg daily.
- Pregnant bitches: 1 tablet per 7 kg daily (2 tablets for those fed homemade food).
- Lactating bitches: 2 tablets per 5 kg daily.
VetAminex contains a balanced and carefully selected dose of vitamins and minerals for dogs and cats
It is recommended for balancing the nutritional intake of dogs and cats going through periods of increased nutritional needs.
Target species: dogs, cats
Administration method:
Cats and dogs under 5 kg body weight: 1 capsule/ day
Dogs over 5 kg body weight: 1 capsule/ 5 kg body weight/ day
Twist Off capsules are highly palatable and easy to administer even to cats. They ensure the quality and freshness of the ingredients, which can oxidize very quickly. Either the content or the capsule itself can be administered. The correct dosage and administration period depend on the individual needs of the animal and will be determined by a veterinarian.
Ingredients:
11.3.1 Tricalcium Phosphate, 11.2.1 Magnesium Oxide, 2.20.1 Soybean Oil, Vitamin B 7mg, Zinc 5mg, Vitamin E 6mg, Iron 1.5 mg, Magnesium 0.4mg, Copper 0.15mg, Folic Acid 0.1mg, Biotin 0.03mg, Vitamin B1 1.5mg, Vitamin B2 1.5mg, Vitamin B6 1mg, Vitamin B12 2µg, Vitamin A 200IU, Vitamin D3 25IU.
Description:
Especially recommended for:
Pregnant or lactating female dogs and cats
Kittens and puppies during growth
Animals fed home-cooked food, with low vitamin and nutrient intake
Elderly cats and dogs
Animals recovering from conditions that led to decreased appetite/food intake.
Animals suffering from digestive tract disorders, particularly malabsorption
Animals that, due to their lifestyle, require an increased intake of nutritional substances.
Packaging: bottle of 60 capsules
Storage conditions:
Store away from moisture and direct sunlight, at temperatures up to 25°C.
Analytical compounds:
Proteins 3.32%, Oils and fats 33.31%, Ash (including mineral compounds) 39.58%, Fiber 8.62%, Moisture 0.25%, Calcium 59.15g/kg, Phosphorus 42.4g/kg, Magnesium 29.71g/kg
Additional information:
CAUTION! For veterinary use only! Keep out of reach of children! Follow the instructions on the packaging. Contact your veterinarian before using or extending the use of this product, as dosage or method of use may change depending on the individual symptoms of the animal.
Ocuhealth is a food supplement in tablet form for dogs and cats of all ages.
The formula has been specially designed for pets with degenerative diseases that require ocular protection. It is based on alpha-lipoic acid, a powerful antioxidant that provides the necessary nutritional support in cases of cataracts or glaucoma.
The supplement can also be used as an adjunct in degenerative retinal lesions, frequently encountered in diabetic dogs or cats or those undergoing insulin treatment.
Composition: Taurine, sodium ascorbate (vitamin C), orange bioflavonoids, lipoic acid, blueberry extract, zinc methionine chelate, grape seed extract, lutein, l-selenomethionine, excipients.
Recommended dosage: Administer 1 tablet/10 kg body weight, mixed in wet food.
HemoVET 67mg - 60 Tablets - Treatment of anemia symptoms in dogs and cats
HemoVET 67mg - 60 Tablets - Treatment of anemia symptoms in dogs and cats
Hemovet 67mg is a product indicated for treating the symptoms of anemia in dogs and cats.
Ingredients:
Hemic Iron 30 mg
Copper 6 mg (Chelating Agent)
Vit B6-600
Vit B12-5
Folic Acid
Vit C 30 mg.
Dosage: 1 tablet/ 10 kg/ day
Packaging: 4 blisters x 15 Tablets
The animal should have fresh water available at all times.
Important: Consult your veterinarian for diagnosis, medication, or diet prescription based on your dog's (cat's) specific needs. This product is only available with a prescription.
Spray solution for dogs and cats with tindalized lactobacilli (Lactobacillus rhamnosus, Lactobacillus reuteri) and plant polyphenols, normalizing the skin's microbial population.
Linkskin Spray has a functional action, aimed at maintaining skin homeostasis and counteracting changes in the skin microbiota (e.g., during atopy, cutaneous hyperreactivity).
Ingredients
Tyndallized lactobacilli (Lactobacillus rhamnosus, Lactobacillus reuteri), vegetable polyphenols, dry tamarind extract, algae extracts, purified water.
Shake the bottle before use. Apply 1-2 times a day over the entire body surface to moisten the skin. For thick or long fur, apply to the hair. Do not rinse or dry. Repeat application for at least 15 days or as otherwise directed by your veterinarian.
Direne – 32 tablets contains:
Astragalus membranaceum (Astragalus) 25,000; Betula pendula (Birch) 25,000; Vaccinium macrocarpum (Cranberry) 12,500; Curcuma longa (Turmeric) 3000; Sophora Japonica (Quercetin) 12,500; 3rd Vitamins and Provitamins Vit. E (all-rac-α-tocopheryl acetate) 10,000; 1a Preservatives; E332 Potassium Citrate 50,000; 2k Microorganisms; Enterococcus faecium - 2x1010 cfu / g 10,000.
Recommended dosage:
Dogs: 1 tablet per 10 kg body weight, once a day, for at least 4 months
Cats: 1/2 tablet per 5 kg body weight, once a day, for at least 4 months
Direne – allows time for urea to decrease in the digestive tract, preventing gastric and duodenal ulcers, so that specific treatment for AKI can restart kidney functions. It also has a powerful analgesic and anti-inflammatory effect on the nephron.
Properties of DIRENE active ingredients:
Ganoderma Lucidum - mushroom with cortisone-like activity - reduces kidney inflammation!!! Demonstrated antioxidant effect! Effect similar to cortisone - acts slower, but just as precisely and without side effects. • Anti-inflammatory effects similar to Diclofenac (Soniamol, 2009) • Antiallergic action – antihistamine – contains triterpenoids • Eliminates the production of allergic antibodies – prevents the appearance of allergic reactions. • Protects renal endothelium against cellular degeneration in case of proteinuria.
Astragalus - Herbaceous plant – traditional Chinese medicine – immunostimulatory properties, ↑sodium excretion, reducing proteinuria. Effective in nephritis that does not respond to diuretics. Turmeric - Contains curcumin which inhibits Cox2 enzymes and implicitly prostaglandin formation => anti-inflammatory action.
Chitosan - polymer of D-Glucosamine, also obtained by alkaline deacetylation of chitin. Binds Phosphorus. Cranberry Extract - beneficial action on the lower urinary tract - prevents the adhesion of G- bacteria (E.coli, Proteus, Klebsiella, Enterobacter, Pseudomonas) to the mucous membrane of the urinary tract, ↓the amount of uric acid that could lead to the formation of urate crystals.
Quercetin - bioflavonoid – anti-inflammatory, antioxidant, protects against free radicals that lead to oxidative stress – frequent in kidney diseases.
Yucca Schidigera - Reduces nitrogen in the intestine and improves protein digestion
Birch - Very effective as a depurative due to its high potassium salt content. The ↑K/Na ratio stimulates urine elimination, without irritating the renal parenchyma, while Vit. C and betulinic acid prevent the formation of calculi.
Tri Digest is a dietary supplement in tablet form for dogs and cats. The product contains substances that stimulate the concomitant secretion of gastric juice, pancreatic juice, and bile.
The complex formula supports liver regeneration and regulates the urogenetic cycle, through which ammonia is excreted renally by producing urea. Thus, the tablets significantly contribute to the efficient digestion of carbohydrates, proteins, and fats extracted from food.
Betaine acts together with pepsin and normalizes gastric acidity, while artichoke extract increases the concentration of bile acids and stimulates circulation through the bile ducts. Phospholipids and ornithine are important for liver protection, helping to restore liver cells.
Composition: Betaine, artichoke, phospholipids, ornithine, licorice.
For cats: ½ tablet/day.
For dogs: 1 tablet/day per 15 kg body weight.
Liquid formula, high in calories, very palatable.
For dogs/cats with poor food intake and/or are underweight.
Additional source of energy, high-quality proteins, electrolytes, vitamins, and trace elements.
Can also be administered to convalescing animals when solid food cannot be given.
Administration:
80 ml/ 3 kg BW/ day
This is a nutritional supplement for dogs, intended for joint protection.
Inactive ingredients: brewer's yeast, carrot powder, microcrystalline cellulose, silicon dioxide, flavors, stearic acid, vegetable stearate, xanthophyll.
Active ingredients per tablet:
- Glucosamine HCl 500 mg
- Chondroitin Sulfate 200 mg
- Methylsulfonylmethane (MSM) 200 mg
- Vitamin C 150 mg
- Calcium 100 mg
- Phosphorus 83 mg
- Magnesium 46.65 mg
- Potassium 12.44 mg
- Niacinamide 10 mg
- Vitamin E 2 I.U.
- Para-amino benzoic acid 3.75 mg
- Lipase (3.75 USP Units) 3.75 mg
- Manganese (sulfate) 3.5 mg
- Iron (proteinate) 3 mg
- Lecithin 2.5 mg
- Choline (bitartrate) 2.5 mg
- Betaine 2.5 mg
- DL-Methionine 2.5 mg
- d-Pantothenic acid 2 mg
- Pepsin (6.75 USP Units) 2.25 mg
- Bromelain (1.35 GD Units) 2.25 mg
- Vitamin B6 2 mg
- Inositol 2 mg
- Linoleic acid 2 mg
- Vitamin A 1000 I.U.
- Zinc (gluconate) 1.5 mg
- Proteases (20 HUT Units) 1.13 mg
- Vitamin D3 100 I.U.
- Vitamin B1 1 mg
- Pyridoxine HCl 0.2 mg
- Iodine (from algae) 0.05 mg
- Cobalt (carbonate) 0.03 mg
- Copper (gluconate) 0.0025 mg
- Folic acid 0.002 mg
- Biotin 0.002 mg
- Vitamin B12 0.002 mg
- Chromium (picolinate) 0.002 mg
- Selenium (sodium selenite) 0.002 mg
- Vitamin K 0.001 mg
- Riboflavin 1 mg
Dosage:
- ½ tablet daily for dogs weighing under 13.5 kg.
- 1 tablet daily for dogs weighing between 14 – 40 kg.
- 2 tablets daily for dogs weighing over 40 kg.
If administering more than 1 tablet, it is recommended to divide the required amount into 2 doses, morning and evening.
Packaging: K9 Complete Motion is packaged in a bottle of 120 tablets
Lot / Expiry: check packaging
Antimicrobial dental formula - activates, releases, and destroys microbes & microorganisms that cause bad breath.
Eliminates bacteria responsible for plaque formation and volatile, foul-smelling sulfur compounds.
Whitens teeth
Restores enamel
Protects gums and helps prevent and/or treat gingivitis.
Instantly freshens breath
Eliminates bacterial deposits from the water bowl
Improves overall oral health
Eliminates plaque and tartar
Helps combat periodontal disease without brushing and without adverse effects on tissues affected by periodontitis.
No ALCOHOL, SUGARS, SURFACTANTS or HARSH DETERGENTS
No INTENSE MINT FLAVOR
Does NOT cause stains
Can be safely administered long-term
Dosage: 1 teaspoon / 250 ml drinking water
Apply directly into the oral cavity - Ideal for use on the go or between brushings.
Instantly eliminates bad breath
Reduces dental stains and discolorations
Supports gum health
Destroys tartar and plaque
Dedicated to dogs & cats
Liquid formula against excessive shedding!
Guaranteed results in 3-6 weeks!
Norwegian anchovy oil
Norwegian sardine oil
Zinc
Biotin
Linseed oil
Wheat germ oil
Vitamins: A, E, D, B6
Add to food, 1 teaspoon/day
Tasty (chicken flavor) and easy to administer
The ideal Omega-3/Omega-6 ratio, antioxidants, vitamins and minerals to combat excessive shedding.
Strengthens optimal skin and coat health.
For maximum and rapid efficiency, it is recommended to use SHED-X shampoos concurrently.
Zerokeet Ectoparasite Control for dogs is a long-lasting product. Application is quite simple. Just dilute it in water in a 1:2 ratio and use a cotton swab to apply it all over the dog's body. The most common infestation areas are at the joints, on the neck, behind the ears, and at the tip of the tail. Applying this product helps effectively kill all adult ticks and fleas before they can lay eggs on the pet and continue to multiply.
Features: Kills all fleas and ticks in minutes. Prevents infestation. Easy to use.
For veterinary use only. Shake the bottle before use.
Specifications: Suitable for all dogs. Form - liquid
Composition: Each 10 ml contains (in g): Cedrus deodara 2.0, Pongamia glabara 0.50, Azadirachta indica 0.30, Acorus calamus 0.20, Eucalyptus globulus 0.20, Absorbent bases q.s.
Recommended dosage: Application on the entire body (dilution up to 1:2 in water) at weekly intervals until complete recovery. Zerokeet is applied once a day in cases of lesions, where present.
Other skin conditions - dilution 1:2 to 1:4 in water, depending on the severity of the condition.
Storage instructions: Store in a cool, dry place.
QUALITATIVE AND QUANTITATIVE COMPOSITION
Each chewable tablet contains:
Active substances:
|
NEXGARD SPECTRA |
Afoxolaner (mg) |
Milbemycin oxime (mg) |
| chewable tablets for dogs weighing 3.5-7.5 kg | 18.75 | 3.75 |
PHARMACEUTICAL FORM
Chewable tablets.
Red to reddish-brown mottled, round (tablets for dogs weighing 2-3.5 kg) or rectangular (tablets for dogs weighing > 3.5-7.5 kg, tablets for dogs weighing > 7.5-15 kg, tablets for dogs weighing > 15-30 kg, and tablets for dogs weighing > 30-60 kg) tablets.
CLINICAL PARTICULARS
Target species: Dogs
Indications for use, specifying the target species
For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is indicated.
Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.
Fleas and ticks must attach to the host and commence feeding to be exposed to the active substance.
Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancyclostoma caninum and Ancyclostoma braziliense) and whipworms (Trichuris vulpis).
Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.
Contraindications: Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
Parasites must commence feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.
Resistance of parasites to a particular class of antiparasitic medicinal product may develop following frequent use of a compound from that class. Therefore, the use of this product should be based on an assessment of each individual case and on local epidemiological information about the current susceptibility of the target species to limit the possibility of future selection for resistance.
Maintaining the efficacy of macrocyclic lactones is essential for the control of Dirofilaria immitis. To minimise the risk of resistance selection, it is recommended to test dogs for circulating antigens and blood microfilariae at the start of each preventative treatment period.
Only negative animals should be treated.
Special precautions for use
Special precautions for use in animals
In the absence of available data, treatment of puppies younger than 8 weeks of age and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinarian.
Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administration of NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.
The recommended dose must be strictly followed in Collie dogs or other related breeds.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
- This product may cause gastrointestinal disturbances if ingested.
- Keep tablets in blisters and the blister in the carton until use.
- In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label to the physician.
- Wash hands after use.
Adverse reactions (frequency and seriousness)
In clinical studies, no serious adverse reactions were attributed to the combination of afoxolaner and milbemycin oxime. Infrequent reactions such as vomiting, diarrhoea, lethargy, anorexia, and pruritus were observed. These reactions generally resolved spontaneously and were of short duration.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- Common (more than 1 but less than 10 animals in 100 animals)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals)
- Rare (more than 1 but less than 10 animals in 10,000 animals)
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Laboratory studies conducted on rats and rabbits have not shown any teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinarian.
Interactions with other medicinal products and other forms of interaction
Milbemycin oxime is a substrate of P-glycoprotein (P-gp), thus it may interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.
Amounts to be administered and administration route
For oral administration.
Dosage:
The product should be administered at a dose of 2.50-5.36 mg/kg afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight according to the following table:
| Dog weight (kg) | Concentration and number of chewable tablets to be administered | ||||
|
NEXGARD SPECTRA 9 mg/ 2 mg |
NEXGARD SPECTRA 19 mg/ 4 mg |
NEXGARD SPECTRA 38 mg/ 8 mg |
NEXGARD SPECTRA 75 mg/ 15 mg |
NEXGARD SPECTRA 150 mg/ 30 mg |
|
|
2-3.5 |
1 |
|
|
|
|
|
>3.5-7.5 |
|
1 |
|
|
|
|
>7.5-15 |
|
|
1 |
|
|
|
>15-30 |
|
|
|
1 |
|
|
>30-60 |
|
|
|
|
1 |
For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.
Method of administration:
The tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.
Treatment regimen:
The treatment regimen should be based on the veterinary diagnosis and the local epidemiological situation.
NEXGARD SPECTRA can be used as seasonal preventative treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.
Disease: Heartworm disease:
NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after their transmission by mosquitoes, therefore the product must be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should continue until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.
If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should start on the day the previous medication was due to be administered.
Dogs living in or having travelled to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs 8 months of age or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.
Overdose (symptoms, emergency procedures, antidotes), if applicable
No adverse reactions were observed in healthy puppies older than 8 weeks after 6 treatments with 5 times the maximum dose.
Withdrawal periods: Not applicable.
PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.
ATC veterinary code: QP54AB51
Pharmacodynamic properties
Afoxolaner:
Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.
Afoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of insect/mite GABA receptors versus those of mammals.
Afoxolaner is active against adult fleas as well as some tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.
The product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Milbemycin oxime:
Milbemycin oxime is an endectocidal antiparasitic belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a 20:80 ratio for A3:A4). It is isolated from the fermentation of Streptomyces milbemycinicus.
Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-gated chloride ion channels (related to GABA and glycine receptors in vertebrates).
This leads to hyperpolarisation of the neuromuscular membrane and to the paralysis and death of the parasites.
Pharmacokinetic particulars
Afoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (Cmax) was 1822 ± 165 ng/ml, at 2-4 hours (Tmax) after a dose of 2.5 mg/kg afoxolaner.
The volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.
Plasma concentrations of Milbemycin oxime increase rapidly within the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4 respectively. The mean maximum plasma concentration (Cmax), after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A4.
The volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for form A3 and A4 respectively. Both forms have a low clearance value of 75 ± 22 ml/h/kg for A3 and 41 ± 12 ml/h/kg for A4.
PHARMACEUTICAL PARTICULARS
List of excipients
- Maize starch
- Soy protein
- Braised beef flavour
- Povidone (E1201)
- Macrogol 400
- Macrogol 4000
- Macrogol 15 hydroxystearate
- Glycerol (E422)
- Medium-chain triglycerides
- Citric acid monohydrate (E330)
- Butylhydroxytoluene (E321)
Incompatibilities: Not applicable.
Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Special precautions for storage: Keep the blister in the outer carton to protect from light.
Nature and composition of primary packaging
This veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).
1 carton box containing one blister with 1, 3 and 6 chewable tablets.
Not all package sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.
The product is recommended for the treatment of dogs and cats suffering from dermatological conditions, with symptoms including dry and flaky skin, excessive hair loss. The formula maintains the optimal level of dermal functions, prevents skin dryness, has anti-edematous and anti-inflammatory properties, supports skin regeneration, and reduces sebum secretion.
Target species: dogs, cats
Method of administration:
Cats, Dogs under 15 kg body weight: 1 capsule/day
Dogs over 15 kg body weight: 2 capsules/day
Twist Off capsules are very palatable and easy to administer even to cats. They ensure the quality and freshness of ingredients, which can oxidize very quickly. Only the content or the capsule itself can be administered. The correct dosage and administration period depend on the individual needs of the animal and will be determined by a veterinarian.
Ingredients: Fish oil (source of Omega-3 fatty acids) 145mg, Cold-pressed Borage oil (Borago officinalis) (source of Omega-6 fatty acids) 145mg, Zinc 8mg, Vitamin B1 0.23mg, Vitamin B2 0.575mg, Vitamin B6 0.253mg, Vitamin B12 5.75µg, Biotin 1.15mg
Action:
Cold-pressed Borage oil (Borago officinalis) is an essential source of unsaturated Omega-6 fatty acids (linoleic acids and gamma-linoleic acids) which strengthen the skin's water retention function. These acids are part of the so-called ceramides, which form special plates within the intercellular spaces of the skin, thus preventing water penetration to the outside, between epidermal cells. The skin remains hydrated and flexible for longer.
Fish oil is an essential source of unsaturated Omega-3 fatty acids (EPA and DHA) which have anti-inflammatory and anti-edematous properties. They also contribute to the elasticity and flexibility of cell membranes. Supplementing with Omega-3 fatty acids allows for the reduction of the amount of anti-inflammatory drugs (including steroids) widely used in anti-itch therapies.
Zinc is the most important element involved in the process of healing, cell multiplication, and division, which plays an essential role in treating dermatological conditions. Zinc deficiency is responsible for dermatological disorders also called dermatoses.
The B vitamin group (B1, B2, B6, and B12) plays a vital role in the metabolism of essential unsaturated Omega-3 and Omega-6 fatty acids and in strengthening the skin's immune function.
Biotin is a B vitamin that, when administered orally, is transported directly to the sebaceous glands and then subsequently extracted to the skin surface. Its presence in the sebaceous glands partially contributes to the reduction of sebum secretion, which is especially beneficial for dogs suffering from seborrhea.
Packaging: bottle of 60/90 capsules
Storage conditions: Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C.
Analytical compounds: Proteins 4.57%, Oils and fats 64.1%, Ash (including mineral compounds) 10.85%, Moisture 1.06%, Fiber 0.05%.
Additional information:
ATTENTION! For veterinary use only! Keep out of reach of children! Follow the instructions on the packaging. Contact your veterinarian before using or extending the use of this product, as dosage or method of use may change depending on the individual symptoms of the animal.
Multi-directional action formula, indicated for dogs and cats with eye conditions.
Lutein, Zeaxanthin, DHA, Plant Polyphenols
Target species: dogs, cats
Twist Off capsules are highly palatable and easy to administer even to cats. They ensure the quality and freshness of ingredients, which can oxidize very quickly. Only the content can be administered, or the capsule as such. The correct dosage and administration period depend on the individual needs of the animal and will be determined by a veterinarian.
Description:
Lutein and zeaxanthin belong to xanthophylls, plant pigments from the carotenoid group. They play an important role in protecting the retina against changes caused by UV radiation and free radicals.
They are not produced by the body, which is why they require intake from food or supplements.
• Reduce the risk and intensity of certain retinal conditions, cataracts, and increase the efficiency of the immune system.
• Lutein, due to its ability to filter UV rays and its antioxidant properties, protects the retina against degeneration and thus improves VISION.
Omega 3 fatty acids are not synthesized by the body. Docosahexaenoic acid (DHA) has a strong anti-inflammatory effect, supports retinal health, protects against certain types of cataracts and degenerative retinal diseases. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) improve blood flow to the optic nerve, while protecting nerve cells against various damages caused by diabetes, reducing the risk of diabetic retinopathy. DHA and EPA are found in high concentrations in the structural membranes of the retina and contribute to maintaining vision and proper eye function.
Grape extract is rich in PROANTHOCYANIDIN antioxidants that eliminate free radicals, have anti-inflammatory properties and can inhibit the appearance of certain types of cataracts. Flavonoids from grapes increase the elasticity and density of capillaries in the eye structure, including the retina. Zinc is a trace element abundantly present in ocular tissues, particularly in the retina. It is an important component of the antioxidant system, which protects against reactive oxygen species. It also contributes to better irrigation of the eyeball and to the suppression of complementary activation from retinal pigments of epithelial cells.
Polyphenol compounds from green tea extract have a strong antioxidant effect that contributes to a significant reduction in oxidative stress and represent an excellent prophylactic solution against eye conditions.
Vitamin A accelerates the regeneration of the purple substance, a pigment responsible for vision after dark. In the retina, Vitamin A is converted into a photosensitive pigment necessary for vision in low light or darkness.
Vitamins C and E belong to the group of powerful antioxidants that protect ocular cells from the harmful effects of free radicals. Vitamin C also seals blood vessels.
Vitamins B2, B6 and B12 support red blood cell production and optimal functioning of the nervous system.
Vitamins B5 and B9 (folic acid) help reduce fatigue and overexertion.
Storage conditions:
Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C.
Additional information:
ATTENTION! For veterinary use only! Keep out of reach of children! Follow the instructions on the packaging. Contact your veterinarian before using or extending the use of this product, as dosage or method of use may change depending on the animal's individual symptoms.
