Internal or External Parasiticides for Dogs - Pipettes and Pills

Advantix is an external antiparasitic product containing imidacloprid and permethrin, and is highly effective in treating flea and tick infestations for one month after a single application.

Composition
Each dose (pipette) contains:

Excipients: Butylated hydroxytoluene 1.0 mg/ml (E321, as an antioxidant):

Indications
For the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).
Fleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product
can be used as part of a treatment strategy against flea allergy dermatitis (FAD).
The product exhibits acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes
ricinus) or three weeks (Dermacentor reticulatus) against tick infestations.
Ticks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore,
it is recommended to remove ticks present on the dog at the time of treatment to prevent them from attacking and feeding on blood.
One treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three
weeks (Phlebotomus perniciosus), against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks, and against stable flies
(Stomoxys calcitrans) for four weeks.
Sandflies Phlebotomus perniciosus 3 weeks
Phlebotomus papatasi 2 weeks
Mosquitoes Aedes aegypti 2 weeks
Culex pipiens 4 weeks
Stable fly Stomoxys calcitrans 4 weeks

Contraindications
In the absence of available data, the product should not be used in puppies younger than 7 weeks.
Do not use in cases of known hypersensitivity to the active substances.
Do not use in cats.

Adverse reactions
Transient skin sensitivity (with increased itching, alopecia and erythema at the application site) or apathy may rarely occur.
Poisoning in dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as
tremors and apathy may also appear. Symptomatic treatment should be applied under veterinary supervision. There is no specific antidote.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

Target species
Dogs.

Dosage for each species, route(s) of administration and method of administration
Dosing regimen:
The minimum recommended dose is: 10 mg/kg body weight (b.w.) imidacloprid and 50 mg/kg body weight (b.w.) permethrin, equivalent to
0.1ml/kg b.w. Advantix spot-on solution for dogs.

Dog's weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg/kg b.w.) Permethrin (mg/kg b.w.)

>25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80
> 40 kg the appropriate combination of pipettes should be used

To reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in
the same family or household must be treated with appropriate products. For fleas originating from the animal's environment,
the additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure
to water, the product's efficacy decreases. Even in this case, it should not be treated more frequently than once a week. If it is
necessary to wash the animal with shampoo, it is advisable to apply Advantix spot-on solution for dogs two weeks later
to ensure the product's efficacy.

Method of administration.
Remove a pipette from the package. Hold the pipette upright, twist the cap and remove it. Turn the cap upside down and use it to
unseal the pipette (by twisting and pressing on the seal, as shown in the photo).
For dogs weighing 10 kg or less:
With the dog standing, part the fur between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and
empty the contents of the pipette by firmly squeezing it several times. Apply only to intact skin.
For dogs weighing more than 10 kg:
With the dog standing, the entire content of the Advantix spot-on solution for dogs pipette will be applied evenly in four places,
starting from between the shoulder blades and extending to the base of the tail. At each spot, part the fur until the skin is visible. Apply the tip of the pipette to the skin and
gently squeeze to release some of the solution onto the skin.

Recommendations for correct administration
For external use only.
Apply only to intact skin.
Do not apply a large amount of solution in one spot, as this may run off onto the dog's sides.

Withdrawal period
Not applicable.

Special precautions for storage
Keep out of the sight and reach of children.
Do not freeze.
After opening the aluminum pouch, store in a dry place and do not store above 30°C.
The abbreviation used for the expiry date on the label, pipette and pouch is EXP.

Special precautions for use in animals
The content of the pipette must not come into contact with the eyes or mouth of the treated dog.
Pay attention to the correct administration of the product as described in the Method of administration section. In particular, oral ingestion
by licking the application site or contact with other animals should be avoided.
Do not use in cats.
This product is highly toxic to cats and can cause death due to the physiological particularities of cats,
which are unable to metabolize certain compounds including permethrin. To prevent accidental exposure of
cats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.
Measures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek
immediate veterinary assistance if this occurs.
Consult your veterinarian before using this product in sick and debilitated animals.
As the product is dangerous for aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters
for at least 48 hours after treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin, eyes or mouth. Do not eat, drink or smoke during product application.
Wash hands thoroughly after product application.
If the product accidentally gets on the skin, immediately wash the area with soap and water.
People with known skin sensitivity may be particularly sensitive to this product.
If the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is
accidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.
Treated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs in the
evening, for example. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.

Special precautions for the disposal of unused product or waste, if applicable
After use, put the cap back on the pipette. Any unused veterinary medicinal product or waste derived from the use of such
products must be disposed of in accordance with local requirements.

Other information
Advantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.
This combination acts as an insecticide, acaricide and repellent.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified
as a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to its
efficacy against adult fleas, the larvicidal efficacy of the substance for areas in the animal's habitat has also been demonstrated.
The product provides repellent (anti-feeding) action against ticks, sandflies and mosquitoes, thereby preventing
parasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or
CVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).
It can be used during pregnancy and lactation.
The solvent in Advantix spot-on solution for dogs may stain certain materials such as leather, fabrics, plastic and finished surfaces. Allow
the application site to dry before contact with such materials.

Packaging:
Pipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml
Blister containing 1, 2, 3, 4 or 6 individual pipettes.
Not all package sizes may be marketed.
For any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorisation holder.

Marketing Authorisation Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany

Zerokeet Ectoparasite Control for dogs is a long-lasting product. Application is quite simple. Just dilute it in water in a 1:2 ratio and use a cotton swab to apply it all over the dog's body. The most common infestation areas are at the joints, on the neck, behind the ears, and at the tip of the tail. Applying this product helps effectively kill all adult ticks and fleas before they can lay eggs on the pet and continue to multiply.

Features: Kills all fleas and ticks in minutes. Prevents infestation. Easy to use.

For veterinary use only. Shake the bottle before use.

Specifications: Suitable for all dogs. Form - liquid

Composition: Each 10 ml contains (in g): Cedrus deodara 2.0, Pongamia glabara 0.50, Azadirachta indica 0.30, Acorus calamus 0.20, Eucalyptus globulus 0.20, Absorbent bases q.s.

Recommended dosage: Application on the entire body (dilution up to 1:2 in water) at weekly intervals until complete recovery. Zerokeet is applied once a day in cases of lesions, where present.

Other skin conditions - dilution 1:2 to 1:4 in water, depending on the severity of the condition.

Storage instructions: Store in a cool, dry place.

Advocate 250 Dogs (10 - 25 kg), 3 pipettes

Chemical composition:

• Imidacloprid : 100mg/ml
• Moxidectin: 25mg/ml

Pharmaceutical form:

Antiparasitic solution for cutaneous application.

Indications:

for the treatment and prevention of flea infestations (Ctenocephalides spp.).

• reduces the incidence of flea allergy dermatitis.
• larval stages are killed on the animal and in the surrounding environment of treated animals.

for the prevention of heartworm infestations (Dirofilaria immitis)

for the treatment and control of:

• roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).

• hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.

• whipworms Trichuris vulpis.

• generalized demodicosis Demodex canis.

• sarcoptic mange Sarcoptes scabiei.

• ear mites Otodectes cynotis.

• lice Trichodectes canis, Linognathus setosus for 6 weeks.

Dosage and administration:

• For dogs between 10 -25 kg, one tube of Advocate 250 is used.
• Administration is done in the dorsal area at the base of the neck for small dogs, and for larger dogs, it can be done in several places along the back.
• The product is applied to the skin, keeping it away from the dog's mouth or eyes.
• The dog's skin must be intact and free of lesions.
• It can be administered to pregnant or lactating bitches.
• The product retains its efficacy after bathing or exposure to rain.
• To reduce re-infestations with new fleas, it is recommended to treat all dogs in a family (household). Other pets in the same family or household should be treated with appropriate products.

Contraindications:

• Not for use in cats.
• Not for use in puppies under 7 weeks of age.

Other information:

• to prevent heartworm infestation, it is advisable to start treatment one month before the mosquito season begins (the host that transmits the larvae) and continue once a month until the mosquito season passes.
• for tapeworms, it is advisable to use internal antiparasitics as ADVOCATE does not act on them but only on roundworms and hookworms.
• for demodicosis, 2 to 4 monthly treatments are required for beneficial effects.
• for mange (ear, sarcoptic), a single treatment is necessary for complete elimination of parasites and signs of disease.

Important: Advocate 250 falls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication, or diet according to the specific needs of your dog (cat).

Amflee 268 MG is an antiparasitic pipette for medium-sized dogs, weighing between 20 and 40 kilograms, which prevents and treats flea and tick infestations.

1 pipette (2.68 ml) contains:

• Active substance: Fipronil 268 mg.
• Other substances: Butylhydroxyanisole (E320) 0.54 mg Butylhydroxytoluene (E321) 0.27 mg

Used for:

• Treatment and prevention of infestations with fleas (Ctenocephalides spp), ticks (Rhipicephalus spp, Dermacentor spp, Ixodes spp.), and infestations with biting lice Trichodectes canis in dogs.
• The product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.
• The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD), if it has been previously diagnosed by a veterinarian.

Contraindications:

• do not administer to puppies younger than 8 weeks or weighing less than 2 kg
• do not administer to sick animals (systemic diseases, fever) or those in convalescence
• do not administer to rabbits due to the risk of serious adverse reactions or even death
• do not administer to cats, as it may lead to overdose
• do not administer in cases of hypersensitivity to the active substance or any of the excipients.

PRECAUTIONS:

• Ticks on animals must be removed before using the product to reduce the risk of transmissible diseases.
• The product should be applied in a secluded area where the animal cannot lick.
• It is recommended to avoid bathing or immersion in water for 2 days after product application and to avoid bathing more frequently than once a week.
• Emollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of protection against fleas to approximately 5 weeks.
• Weekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the product's efficacy against fleas, as shown in a long-term 6-week study.
• Ticks may appear sporadically. Thus, complete exclusion of disease infection under unfavorable conditions is impossible. Generally, ticks will die within 24 - 48 hours after infestation without feeding on the animal's blood.
• Avoid contact of the product with the animal's eyes.
• Dogs should not be allowed to swim in running water for 2 days after application.
• The product may cause irritation of the mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.
• Individuals with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.
• In case of contact, wash hands with soap and water.
• In case of accidental contact with eyes, wash thoroughly with clean water.
• Wash hands after use.
• Do not touch treated animals and do not let children play with them until the application site has dried. Therefore, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially children.
• Do not smoke, drink, or eat while applying the product.

Possible adverse reactions:

• If animals lick themselves, short-term hypersalivation may occur, mainly due to the excipients.
• Extremely rare adverse reactions: transient skin reactions at the application site (discoloration and hair loss, pruritus and erythema) and generalized pruritus with alopecia.
• Exceptionally, after use, reversible neurological symptoms (hyperesthesia, depression, nervousness), hypersalivation, or vomiting have been observed.

Administration:

• In the absence of product safety studies, the minimum interval between treatments is 4 weeks.
• Monthly treatment is recommended if there is an increased risk of repeated flea infestations, if dogs are allergic to flea bites, and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once, at intervals of two or three months.
• Route of administration: External application on the skin (spot-on use).
• Method of administration: Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap over and place the other end of the cap on the single-dose pipette. Push and twist the cap to pierce the seal, then remove the cap from the single-dose pipette. Part the animal's hair in the area between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and press the pipette several times to empty the contents directly onto the skin, in a single spot.

PHARMACEUTICAL FORM

Chewable tablets.

Red to reddish-brown marbled, round (tablets for 2-3.5 kg dogs) or rectangular (tablets for >3.5-7.5 kg dogs, >7.5-15 kg dogs, >15-30 kg dogs and >30-60 kg dogs) tablets.

CLINICAL PARTICULARS

Target species: Dogs

Indications for use, specifying the target species

For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is also indicated.

Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.

Fleas and ticks must attach to the host and begin feeding to be exposed to the active substance.

Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancyclostoma caninum and Ancyclostoma braziliense) and whipworms (Trichuris vulpis).

Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.

Contraindications: Do not use in cases of hypersensitivity to the active substances or to any of the excipients.

Special warnings for each target species

Parasites must begin feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.

Resistance of parasites to a particular class of antiparasitic drugs may develop as a result of frequent use of a compound from that class. Therefore, the use of this product should be based on evaluation of each individual case and local epidemiological information regarding the current susceptibility of the target species to limit the possibility of future selection of resistance.

Maintaining the efficacy of macrocyclic lactones is essential in controlling Dirofilaria immitis. To minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.

Special precautions for use

Special precautions for use in animals

In the absence of available data, treatment of puppies younger than 8 weeks and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinary surgeon.

Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administering NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinary surgeon to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.

The recommended dose must be strictly followed for Collie dogs or other related breeds.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

• This product may cause gastrointestinal upset if ingested.
• Keep tablets in blisters and blister in carton until use.
• In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.
• Wash hands after use.

Adverse reactions (frequency and seriousness)

In clinical studies, no serious adverse reactions attributable to the afoxolaner-milbemycin oxime combination were observed. Less frequent reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus were observed. These reactions generally resolved on their own and were short-lived.

The frequency of adverse reactions is defined using the following convention:

- Very common (more than 1 in 10 animals treated show adverse reactions)

- Common (more than 1 but less than 10 animals in 100 animals)

- Uncommon (more than 1 but less than 10 animals in 1,000 animals)

- Rare (more than 1 but less than 10 animals in 10,000 animals)

- Very rare (less than 1 animal in 10,000 animals, including isolated reports).

Use during pregnancy or lactation

Laboratory studies in rats and rabbits have not shown teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinary surgeon.

Interactions with other medicinal products or other forms of interaction

Milbemycin oxime is a substrate of P-glycoprotein (P-gp), and can therefore interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.

Amounts to be administered and administration route

For oral administration.

Dosage:

The product should be administered at a dose of 2.50-5.36 mg/kg afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight according to the following table:

For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.

Method of administration:

The tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.

Treatment schedule:

The treatment schedule should be based on the veterinary diagnosis and the local epidemiological situation.

NEXGARD SPECTRA can be used as seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.

Disease: Heartworm disease:

NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after their transmission by mosquitoes, so the product should be administered at regular monthly intervals throughout the vector season, starting one month after the first exposure to mosquitoes. Treatment should be continued until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.

If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.

Dogs living in or travelling to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs 8 months of age or older, living in heartworm endemic areas, be tested for adult heartworm infestation before being treated with a heartworm prevention product.

Overdose (symptoms, emergency procedures, antidotes), if applicable

No adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.

PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.

ATC veterinary code: QP54AB51

Pharmacodynamic properties

Afoxolaner:

Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.

Afoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfers of chloride ions across the cell membrane. This results in uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of insect/mite GABA receptors versus those of mammals.

Afoxolaner is active against adult fleas and some tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.

The product kills fleas before egg laying and thus prevents contamination of the home. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).

Milbemycin oxime:

Milbemycin oxime is an antiparasitic endectocide belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a 20:80 ratio for A3:A4). It is isolated from the fermentation of Streptomyces milbemycinicus.

Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (linked to GABA and glycine receptors in vertebrates).

This leads to neuromuscular membrane hyperpolarisation and paralysis and death of parasites.

Pharmacokinetic particulars

Afoxolaner is absorbed very quickly systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (Cmax) was 1822 ± 165 ng/ml, 2-4 hours (Tmax) after a dose of 2.5 mg/kg afoxolaner.

The volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.

Plasma concentrations of Milbemycin oxime increase rapidly within the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4 respectively. The mean maximum plasma concentration (Cmax) after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A4.

The volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for form A3 and A4 respectively. Both forms have a low clearance value of 75 ± 22 ml/h/kg for A3 and 41 ± 12 ml/h/kg for A4.

PHARMACEUTICAL PARTICULARS

List of excipients

• Maize starch
• Soya proteins
• Braised beef flavour
• Povidone (E1201)
• Macrogol 400
• Macrogol 4000
• Macrogol 15 hydroxystearate
• Glycerol (E422)
• Medium chain triglycerides
• Citric acid monohydrate (E330)
• Butylhydroxytoluene (E321)

Incompatibilities: Not applicable.

Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years

Special precautions for storage: Keep the blister in the secondary packaging to protect from light.

Nature and composition of primary packaging

This veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).

1 cardboard box containing one blister with 1, 3 and 6 chewable tablets.

Not all pack sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from the use of such products should be disposed of in accordance with local requirements.

Advantix is an external antiparasitic product containing imidacloprid and permethrin, and is highly effective in treating flea and tick infestations for one month after a single application.

Composition
Each dose (pipette) contains:

Excipients: Butylated hydroxytoluene 1.0 mg/ml (E321, as antioxidant):

Indications
For the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).
Fleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product
can be used as part of a treatment strategy against flea allergy dermatitis (FAD).
The product has acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes
ricinus) or three weeks (Dermacentor reticulatus) against tick infestations.
Ticks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore, it is
recommended to remove ticks present on the dog at the time of treatment to prevent them from attaching and feeding.
One treatment provides repellent (anti-feeding) action against sand flies for two weeks (Phlebotomus papatasi) or three
weeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks and against stable flies
(Stomoxys calcitrans) for four weeks.
Sandflies Phlebotomus perniciosus 3 weeks
Phlebotomus papatasi 2 weeks
Mosquitoes Aedes aegypti 2 weeks
Culex pipiens 4 weeks
Stable flies Stomoxys calcitrans 4 weeks

Contraindications
In the absence of available data, the product should not be used in puppies younger than 7 weeks.
Do not use in cases of known hypersensitivity to the active substances.
Do not use in cats.

Adverse reactions
Transient skin sensitivity (with increased pruritus, alopecia, and erythema at the application site) or apathy may rarely occur.
Poisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as
tremors and apathy may also occur. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

Target species
Dogs.

Dosage for each species, route(s) of administration and method of administration
Dosing regimen:
The minimum recommended dose is: 10 mg/kg body weight (b.w.) imidacloprid and 50 mg/kg body weight (b.w.) permethrin, equivalent to
0.1ml/kg b.w. Advantix spot-on solution for dogs.

Dog weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg/kg b.w.) Permethrin (mg/kg b.w.)

>25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80
> 40 kg use the appropriate combination of pipettes

To reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in
the same family or household should be treated with appropriate products. For fleas originating from the animal's environment,
the additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure
to water, the efficacy of the product decreases. Even in this case, it should not be treated more frequently than once a week. If
the animal needs to be shampooed, it is advisable to apply Advantix spot-on solution for dogs after two weeks
to ensure the product's efficacy.

Method of administration.
Remove one pipette from the package. Hold the pipette upright, twist the cap and remove it. Turn the cap upside down and use it
to seal the pipette (by twisting and pressing on the seal, as shown in the picture).
For dogs weighing 10 kg or less:
With the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and
by squeezing firmly several times, empty the contents of the pipette. Apply only to unbroken skin.
For dogs weighing more than 10 kg:
With the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four spots,
starting between the shoulder blades and extending to the base of the tail. At each spot, part the hair until the skin is visible. Apply the tip of the pipette to the skin and
gently squeeze to release some of the solution onto the skin.

Recommendations for correct administration
For external use only.
Apply only to unbroken skin.
Do not apply a large amount of solution in one spot, as it may run down the sides of the dog.

Withdrawal period
Not applicable.

Special precautions for storage
Keep out of the sight and reach of children.
Do not freeze.
After opening the aluminum pouch, store in a dry place and do not store above 30°C.
The abbreviation used for the expiry date on the label, pipette, and pouch is EXP.

Special precautions for use in animals
The content of the pipette must not come into contact with the eyes and mouth of the treated dog.
Pay attention to the correct administration of the product as described in the "Method of administration" section. In particular, oral ingestion
by licking the application site or contact with other animals should be avoided.
Do not use on cats.
This product is highly toxic to cats and can cause death due to the physiological peculiarities of cats
who are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of
cats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.
Measures should be taken to prevent cats from licking the application site of dogs that have been treated with this product. Seek
immediate veterinary assistance if this occurs.
Consult your veterinarian before using this product in sick and debilitated animals.
Since the product is hazardous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters
for at least 48 hours after treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin, eyes, or mouth. Do not eat, drink, or smoke during product application.
Wash hands thoroughly after product application.
If the product accidentally comes into contact with skin, wash the area immediately with soap and water.
Individuals with known skin sensitivity may be particularly sensitive to this product.
If the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is
accidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.
Treated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for
example, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.

Special precautions for the disposal of unused product or waste materials, if applicable
After use, place the cap back on the pipette. Any unused veterinary medicinal product or waste materials derived from such products
should be disposed of in accordance with local requirements.

Other information
Advantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.
This combination acts as an insecticide, acaricide, and repellent.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl compound group. Chemically, it can be classified
as chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to
its efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for areas in the animal's habitat.
The product provides repellent (anti-feeding) action against ticks, sand flies, and mosquitoes, thereby preventing
parasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or
CVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).
It can be used during pregnancy and lactation.
The solvent in Advantix spot-on solution for dogs may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow
the application site to dry before contact with such materials.

Packaging:
Pipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml
Blister containing 1, 2, 3, 4, or 6 individual pipettes.
Not all pack sizes may be marketed.
For any information about this veterinary medicinal product, please contact the local representative of the marketing authorization holder.

Marketing Authorization Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany

Advocate 100 for Dogs (4 - 10 kg), 3 pipettes

Chemical composition:

• Imidacloprid: 100mg/ml
• Moxidectin: 25mg/ml

Pharmaceutical form:

• Antiparasitic solution for cutaneous application.

Indications:

for the treatment and prevention of flea infestations (Ctenocephalides spp.).

• reduces the incidence of flea allergy dermatitis.
• larval stages are killed on the animal and in the surrounding environment of treated animals.

for the prevention of heartworm infestations (Dirofilaria immitis)

for the treatment and control of:

• roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).

• hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.

• whipworms Trichuris vulpis.

• generalized demodicosis Demodex canis.

• sarcoptic mange Sarcoptes scabiei.

• ear mites Otodectes cynotis.

• lice Trichodectes canis. Linognathus setosus for 6 weeks.

Dosage and administration:

• For dogs weighing between 4 - 10 kg, one tube of Advocate 100 is used;
• Administration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be applied in several places along the back.
• The product is applied to the skin, keeping it away from contact with the dog's mouth or eyes.
• The dog's skin must be intact and without lesions.
• It can be administered to pregnant or lactating bitches.
• The product retains its efficacy after bathing or exposure to rain.
• To reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in the same family or household should be treated with appropriate products.

Contraindications:

• Do not use on cats.
• Do not use on puppies younger than 7 weeks.

Other information:

• for the prevention of heartworm infestation, treatment should begin one month before the mosquito season (the host that transmits the larvae) and continue once a month until the mosquito season passes.
• for intestinal tapeworms (teniae), it is recommended to use internal antiparasitics because ADVOCATE does not act on them, only on roundworms and hookworms.
• for demodicosis, 2 to 4 monthly treatments are necessary to achieve beneficial effects.
• for mange (ear, sarcoptic), a single treatment is necessary for complete elimination of parasites and disease signs.

Important: Advocate 100 falls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication, or diet according to your dog's (cat's) specific needs.

Advantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.

Composition
Each dose (pipette) contains:

Excipients: Butylhydroxytoluene 1.0 mg/ml (E321, as an antioxidant):

Indications
For the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).
Fleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product
can be used as part of a treatment strategy against flea allergy dermatitis (FAD).
The product exhibits acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes
ricinus) or three weeks (Dermacentor reticulatus) against tick infestations.
Ticks already present on the dog may not be killed within two days of treatment and may remain attached and visible. Therefore, it is
recommended to remove ticks present on the dog at the time of treatment to prevent their attachment and blood feeding.
One treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three
weeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks and for stable flies
(Stomoxys calcitrans) for four weeks.
Sandflies Phlebotomus perniciosus 3 weeks
Phlebotomus papatasi 2 weeks
Mosquitoes Aedes aegypti 2 weeks
Culex pipiens 4 weeks
Stable fly Stomoxys calcitrans 4 weeks

Contraindications
In the absence of available data, the product should not be used in puppies younger than 7 weeks.
Do not use in cases of known hypersensitivity to the active substances.
Do not use in cats.

Adverse reactions
Transient dermal sensitivity (with increased pruritus, alopecia, and erythema at the application site) or apathy may rarely occur.
Poisoning in dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as
tremors and apathy may also appear. Symptomatic treatment should be applied under veterinary supervision. There is no specific antidote.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

Target species
Dogs.

Dosage for each species, route(s) of administration, and method of administration
Dosing regimen:
The minimum recommended dose is: 10 mg/kg body weight (b.w.) imidacloprid and 50 mg/kg body weight (b.w.) permethrin, equivalent to
0.1ml/kg b.w. Advantix spot-on solution for dogs.

Dog weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg/kg b.w.) Permethrin (mg/kg b.w.)

>25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80
> 40 kg the appropriate combination of pipettes should be used

To reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in
the same family or household should be treated with appropriate products. For fleas originating from the animal's environment,
the additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is effective even if the animal is wet. However, prolonged exposure to water should be avoided. If prolonged exposure
to water occurs, the effectiveness of the product decreases. Even in this case, it should not be treated more frequently than once a week. If it is
necessary to shampoo the animal, it is advisable to apply Advantix spot-on solution for dogs after two weeks
to ensure the effectiveness of the product.

Method of administration.
Remove one pipette from the package. Hold the pipette upright, twist the cap, and remove it. Turn the cap upside down and use it to
unseal the pipette (by twisting and pressing on the seal, as shown in the photo).
For dogs weighing 10 kg or less:
With the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and
by firmly squeezing several times, empty the contents of the pipette. Apply only to uninjured skin.
For dogs weighing more than 10 kg:
With the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four places
starting from between the shoulder blades and extending to the base of the tail. At each spot, part the hair until the skin is visible. Apply the tip of the pipette to the skin and
gently squeeze to release some of the solution onto the skin.

Recommendations for correct administration
For external use only.
Apply only to uninjured skin.
Do not apply a large amount of solution in a single spot, as this may run off the sides of the dog.

Withdrawal period
Not applicable.

Special precautions for storage
Keep out of the sight and reach of children.
Do not freeze.
After opening the aluminum pouch, store in a dry place and do not store at temperatures above 30°C.
The abbreviation used for the expiry date on the label, pipette, and pouch is EXP.

Special precautions for use in animals
The contents of the pipette should not come into contact with the eyes or mouth of the treated dog.
Pay attention to the correct administration of the product as described in the "Method of administration" section. In particular, oral ingestion
by licking the application site or contact with other animals should be avoided.
Do not use in cats.
This product is highly toxic to cats and can cause death due to the physiological peculiarities of cats
which are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of
cats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.
Measures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek
immediate veterinary assistance if this occurs.
Consult your veterinarian before using this product in sick and debilitated animals.
As the product is dangerous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters
for at least 48 hours after treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin, eyes, or mouth. Do not eat, drink, or smoke during product application.
Wash hands thoroughly after product application.
If the product accidentally gets on the skin, wash the area immediately with soap and water.
Individuals with known skin sensitivity may be particularly sensitive to this product.
If the product accidentally gets into the eyes, rinse the eyes with plenty of water. If skin or ocular symptoms persist, or the product is
accidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.
Treated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for
example, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.

Special precautions for the disposal of unused product or waste materials, if any
After use, place the cap back on the pipette. Any unused veterinary medicinal product or waste materials derived from the use of such
products should be disposed of in accordance with local requirements.

Other information
Advantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.
This combination acts as an insecticide, acaricide, and repellent.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified
as a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to
its efficacy against adult fleas, the larvicidal efficacy of the substance for areas in the animal's habitat has also been demonstrated.
The product provides repellent (anti-feeding) action against ticks, sandflies, and mosquitoes, thereby preventing
parasite blood feeding and reducing the risk of transmitting vector-borne diseases (Canine Vector-Borne Disease or
CVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).
It can be used during pregnancy and lactation.
The solvent in Advantix spot-on solution for dogs may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow
the application site to dry before contact with such materials.

Packaging:
Pipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml
Blister containing 1, 2, 3, 4, or 6 individual pipettes.
Not all package sizes may be marketed.
For any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorization holder.

Marketing Authorization Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany

Advocate 40 Dogs (0 - 4 kg), 3 pipettes

Chemical composition:

• Imidacloprid: 100mg/ml
• Moxidectin: 25mg/ml

Pharmaceutical form:

• Antiparasitic solution for cutaneous application.

Indications:

for the treatment and prevention of flea infestations (Ctenocephalides spp.).

• reduces the incidence of flea allergies.
• larval stages are killed on the animal and in the surrounding environment of treated animals.

for the prevention of heartworm infestations (Dirofilaria immitis)

for the treatment and control of:

• roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).

• hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.

• whipworms Trichuris vulpis.

• generalized demodicosis Demodex canis.

• sarcoptic mange Sarcoptes scabiei.

• ear mites Otodectes cynotis.

• lice Trichodectes canis. Linognathus setosus for 6 weeks.

Dosage and administration:

• For dogs between 0 - 4 kg, one tube of Advocate 40 is used;
• Administration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be done in several spots along the back.
• The product is applied to the skin, avoiding contact with the dog's mouth or eyes.
• The dog's skin must be intact and free of lesions.
• It can be administered to pregnant or lactating bitches.
• The product retains its effectiveness after bathing or exposure to rain.
• To reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in the same family or household should be treated with appropriate products.

Contraindications:

• Do not use in cats. Do not use in puppies under 7 weeks of age.

Other information:

• for the prevention of heartworm infestation, treatment should begin one month before the mosquito season (the host that transmits the larvae) and continue once a month until the mosquito season passes.
• for tapeworms (cestodes), internal antiparasitics should be used as ADVOCATE does not act on them, only on roundworms and hookworms.
• for demodicosis, 2 to 4 monthly treatments are required for beneficial effects.
• for mange (auricular, sarcoptic), a single treatment is necessary for complete elimination of parasites and signs of disease.

Important: Advocate 40 falls under the pharmacy category. Consult your veterinarian for diagnosis and prescription of medication according to the specific needs of your dog or cat.

Advocate 400 Dogs (> 25 kg), 3 pipettes

Chemical composition:

• Imidacloprid: 100mg/ml
• Moxidectin: 25mg/ml

Pharmaceutical form:

• Antiparasitic solution for cutaneous application.

Indications:

for the treatment and prevention of flea infestations (Ctenocephalides spp.).

• reduces the incidence of flea allergy dermatitis.
• larval stages are killed on the animal and in the surrounding environment of treated animals.

for the prevention of heartworm infestations (Dirofilaria immitis)

for the treatment and control of:

• roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).

• hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.

• whipworms Trichuris vulpis.

• generalized demodicosis Demodex canis.

• sarcoptic mange Sarcoptes scabiei.

• ear mites Otodectes cynotis.

• lice Trichodectes canis. Linognathus setosus for 6 weeks.

Dosage and administration:

• For dogs under 40 kg, one tube is used, and for dogs over 40 kg, two tubes of Advocate 400 are used.
• Administration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be done in several places along the back.
• The product is applied to the skin, avoiding contact with the dog's mouth or eyes.
• The dog's skin must be intact and without lesions.
• It can be administered to pregnant or lactating bitches.
• The product retains its efficacy after bathing or exposure to rain.
• To reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in the same family or household should be treated with appropriate products.

Contraindications:

• Not for use in cats.
• Not for use in puppies under 7 weeks of age.

Further information:

• for the prevention of heartworm infestation, it is recommended to start treatment one month before the mosquito season (the vector that transmits the larvae) begins and to continue once a month until the mosquito season ends.
• for tapeworms (cestodes), it is recommended to use internal antiparasitics as ADVOCATE does not act on them, but only on roundworms and hookworms.
• for demodicosis, 2 to 4 monthly treatments are necessary to achieve beneficial effects.
• for mange (ear, sarcoptic), a single treatment is usually sufficient for complete elimination of parasites and signs of disease.

Important: Advocate 400 falls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication or diet according to your dog's (cat's) specific needs.

Liquid antiparasitic solution for cutaneous application, packaged in single-use pipettes.

Liquid antiparasitic solution for cutaneous application, packaged in single-use pipettes.

Liquid antiparasitic solution for cutaneous application, packaged in single-dose pipettes.

Liquid antiparasitic solution for cutaneous application packaged in single-use pipettes.

Advantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.

Composition
Each dose (pipette) contains:

Excipients: Butylated hydroxytoluene 1.0 mg/ml (E321, as antioxidant):

Indications
For the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).
Fleas on the dog are killed within one day after treatment. One treatment prevents future flea infestations for four weeks. The product
can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
The product has acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes
ricinus) or three weeks (Dermacentor reticulatus) against tick infestations.
Ticks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore, it is
recommended to remove ticks present on the dog at the time of treatment to prevent them from attacking and feeding on blood.
One treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three
weeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks and for stable flies
(Stomoxys calcitrans) for four weeks.
Sandflies Phlebotomus perniciosus 3 weeks
Phlebotomus papatasi 2 weeks
Mosquitoes Aedes aegypti 2 weeks
Culex pipiens 4 weeks
Stable fly Stomoxys calcitrans 4 weeks

Contraindications
In the absence of available data, the product should not be used on puppies younger than 7 weeks.
Do not use in cases of known hypersensitivity to the active substances.
Do not use on cats.

Adverse reactions
Rarely, transient dermal sensitivity (with increased pruritus, alopecia and erythema at the application site) or apathy may occur.
Poisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as
tremors and apathy may also occur. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

Target species
Dogs.

Dosage for each species, route(s) of administration and method of administration
Dosing scheme:
The minimum recommended dose is: 10 mg/kg body weight (b.w.) imidacloprid and 50 mg/kg body weight (b.w.) permethrin, equivalent to
0.1ml/kg b.w. Advantix spot-on solution for dogs.

Dog weight (kg)     Pipette size to be used     Volume (ml)     Imidacloprid (mg/kg b.w.)     Permethrin (mg/kg b.w.)

>25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80
> 40 kg, the appropriate combination of pipettes should be used

To reduce re-infestations with new fleas, it is recommended that all dogs in a household be treated. Other pets in
the same family or household must be treated with appropriate products. For fleas originating from the animal's environment,
the additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure
to water, the efficacy of the product decreases. Even in this case, it should not be treated more frequently than once a week. If it is
necessary to shampoo the animal, it is advisable to apply Advantix spot-on solution for dogs after two weeks
to ensure the efficacy of the product.

Method of administration.
Remove one pipette from the package. Hold the pipette upright, twist and remove the cap. Turn the cap upside down and use it to break the seal of the pipette (by twisting and pressing on the seal, as shown in the photo).
For dogs weighing 10 kg or less:
With the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and
squeeze firmly several times to empty the contents of the pipette. Apply only to unbroken skin.
For dogs weighing more than 10 kg:
With the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four places,
starting between the shoulder blades and extending to the base of the tail. At each site, part the hair until the skin is visible. Apply the tip of the pipette to the skin and
gently squeeze to release some of the solution onto the skin.

Recommendations for correct administration
For external use only.
Apply only to unbroken skin.
Do not apply a large amount of solution in one place as it may run down the sides of the dog.

Withdrawal period
Not applicable.

Special precautions for storage
Keep out of the sight and reach of children.
Do not freeze.
After opening the aluminum pouch, store in a dry place and do not store above 30°C.
The abbreviation used for the expiry date on the label, pipette and pouch is EXP.

Special precautions for use in animals
The contents of the pipette must not come into contact with the eyes and mouth of the treated dog.
Pay attention to the correct administration of the product as described in the "Method of administration" section. In particular, oral ingestion
by licking the application site or contact with other animals should be avoided.
Do not use on cats.
This product is highly toxic to cats and can cause death due to the physiological peculiarities of cats
who are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of
cats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.
Measures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek
immediate veterinary assistance if this happens.
Consult your veterinarian before using this product on sick and debilitated animals.
As the product is dangerous to aquatic organisms, treated dogs must not be allowed to enter any surface water
for at least 48 hours after treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin, eyes or mouth. Do not eat, drink or smoke during product application.
Wash hands thoroughly after product application.
If the product accidentally gets on the skin, wash the area immediately with soap and water.
People with known skin sensitivity may be particularly sensitive to this product.
If the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is
accidentally swallowed, seek immediate medical advice and show the product leaflet to the doctor.
Treated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for
example, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.

Special precautions for the disposal of unused product or waste materials, if any
After use, replace the cap on the pipette. Any unused veterinary medicinal product or waste material derived from the use of such
products should be disposed of in accordance with local requirements.

Other information
Advantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.
This combination acts as an insecticide, acaricide and repellent.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified
as chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to
its efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for sites in the animal's habitat.
The product provides repellent (anti-feeding) action against ticks, sandflies and mosquitoes, thereby preventing
parasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or
CVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).
It can be used during gestation and lactation.
The solvent in Advantix spot-on solution for dogs may stain certain materials such as leather, fabrics, plastic and finished surfaces. Allow
the application site to dry before contact with such materials.

Packaging:
Pipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml
Blister containing 1, 2, 3, 4 or 6 individual pipettes.
Not all package sizes may be marketed.
For any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorisation holder.

Marketing Authorisation Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany

Amflee 67 mg is an antiparasitic pipette for small dogs weighing between 2 and 10 kilograms, which prevents and treats flea and tick infestations.

1 pipette (0.67 ml) contains:

• Active substance: Fipronil 67 mg.
• Other substances: Butylhydroxyanisole (E320) 0.134 mg Butylhydroxytoluene (E321) 0.067 mg

Used for:

• Treatment and prevention of infestations with fleas (Ctenocephalides spp), ticks (Rhipicephalus spp, Dermacentor spp, Ixodes spp.) and infestations with biting lice Trichodectes canis in dogs.
• The product has a persistent insecticidal efficacy of up to 2 months against fleas and acaricidal efficacy of up to 4 weeks against ticks.
• The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD), if this has been previously diagnosed by the veterinarian.

Contraindications:

• Do not administer to puppies younger than 8 weeks or weighing less than 2 kg.
• Do not administer to sick animals (systemic diseases, fever) or those in convalescence.
• Do not administer to rabbits due to the risk of severe adverse reactions or even death.
• Do not administer to cats, as it may lead to overdose.
• Do not administer in case of hypersensitivity to the active substance or any of the excipients.

PRECAUTIONS:

• Ticks present on animals must be removed before using the product, to reduce the risk of transmissible diseases.
• It is recommended to avoid bathing or immersion in water for 2 days after applying the product and to avoid bathing more frequently than once a week, as studies investigating the efficacy of the product under these conditions have not been conducted.
• Emollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of protection against fleas to approximately 5 weeks.
• Weekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the efficacy of the product against fleas, as shown in a long-term 6-week study.
• Occasionally, ticks may appear. Thus, complete exclusion of infectious disease transmission by ticks is impossible if conditions are unfavorable. Usually, ticks will be killed and fall off the host within 24-48 hours after infestation, without feeding on the animal's blood. Sporadic attachment of ticks cannot be excluded during the product's efficacy period.
• Pet fleas often infest animal bedding, sleeping and resting places, such as carpets and soft furnishings, which must be regularly treated with appropriate insecticides and cleaned with a vacuum cleaner, in cases of massive infestations or at the beginning of control measures.
• Avoid contact of the product with the animal's eyes.
• It is important to ensure that the product is applied in a place where the animal cannot lick itself and that animals are prevented from licking each other after treatment.
• Dogs should not be allowed to swim in running water for 2 days after application.
• The product can cause irritation of mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.
• Persons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.
• In case of contact, wash hands with soap and water.
• In case of accidental contact with eyes, rinse thoroughly with clean water.
• Wash hands after use.
• Do not touch treated animals and do not let children play with them until the application site has dried. Therefore, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially children.
• Do not smoke, drink, or eat while applying the product.

Possible adverse reactions:

• If animals lick the application site, short-term hypersalivation may occur, mainly due to the nature of the excipients.
• After use, among extremely rare adverse reactions, transient skin reactions at the application site (skin discoloration and local alopecia, pruritus, erythema) and generalized pruritus or alopecia may be observed.
• Exceptionally, after use, hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous signs), respiratory signs, or vomiting have been observed.

Administration:

• In the absence of product safety studies, the minimum interval between treatments is 4 weeks.
• Monthly treatment is recommended if there is a high risk of repeated flea infestations, if dogs are allergic to flea bites, and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once every two or three months.
• Route of administration: External application to the skin (spot-on use).
• Method of administration: Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap upside down and place the other end of the cap on the single-dose pipette. Push and twist the cap to perforate the seal, then remove the cap from the single-dose pipette. Part the animal's hair in the area between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and squeeze the pipette several times to empty the contents directly onto the skin, in one spot.

Amflee 402 MG is an anti-parasitic pipette for very large dogs, weighing between 40 and 60 kilograms, that prevents and treats flea and tick infestations.

1 pipette (4.02 ml) contains:

• Active substance: Fipronil 402 mg.
• Other substances: Butylhydroxyanisole (E320) 0.80 mg Butylhydroxytoluene (E321) 0.40 mg

Used for:

• Treatment and prevention of infestations with fleas (Ctenocephalides spp), ticks (Rhipicephalus spp, Dermacentor spp, Ixodes spp.) and infestations with biting lice Trichodectes canis in dogs.
• The product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.
• The product can be used as part of a treatment strategy for allergic dermatitis caused by flea bites (FAD), if previously diagnosed by a veterinarian.

Contraindications:

• do not administer to puppies younger than 8 weeks or weighing less than 2 kg
• do not administer to sick animals (systemic diseases, fever) or those in convalescence
• do not administer to rabbits due to the risk of serious adverse reactions or even death
• do not administer to cats, as it may lead to overdose
• do not administer in case of hypersensitivity to the active substance or to any of the excipients.

PRECAUTIONS:

• Ticks present on animals should be removed before using the product, to reduce the risk of transmissible diseases.
• It is recommended to avoid bathing or immersion in water for 2 days after application of the product and to avoid bathing more frequently than once a week, as no studies have been conducted to investigate the effectiveness of the product under these conditions.
• Emollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of flea protection to approximately 5 weeks.
• Weekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the product's efficacy against fleas, as shown in a 6-week long-term study.
• Sporadic ticks may appear. Thus, it is impossible to completely exclude the transmission of infectious diseases by ticks, if conditions are unfavorable. As a rule, ticks will be killed and fall off the host within 24-48 hours after infestation, without feeding on the animal's blood. Sporadic tick attachment cannot be excluded during the product's efficacy period.
• Pet fleas often infest the animal's basket, places where animals sleep and rest, such as carpets and soft furnishings, which must be regularly treated with appropriate insecticides and cleaned with a vacuum cleaner, in cases of massive infestations or at the beginning of control measures.
• Avoid contact of the product with the animal's eyes.
• It is important to ensure that the product is applied in a place where the animal cannot lick itself, and it should be avoided that animals lick each other after treatment.
• Dogs should not be allowed to swim in running water for 2 days after application.
• The product can cause irritation of the mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.
• Persons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.
• In case of contact, wash hands with soap and water.
• In case of accidental eye contact, wash thoroughly with clean water.
• Wash hands after use.
• Do not touch treated animals and do not allow children to play with them until the application site has dried. Thus, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially with children.
• Do not smoke, drink, or eat while applying the product.

Possible adverse reactions:

• If animals lick the application site, short-term hypersalivation may occur, mainly due to the nature of the excipients.
• After use, extremely rare adverse reactions may include transient skin reactions at the application site (skin discoloration and local alopecia, pruritus, erythema) and generalized pruritus or alopecia.
• Exceptionally, after use, hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous signs), respiratory signs, or vomiting have been observed.

Administration:

• In the absence of product safety studies, the minimum interval between treatments is 4 weeks.
• Monthly treatment is recommended if there is a high risk of repeated flea infestations, if dogs are allergic to flea bites and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once every two or three months.
• Route of administration: External application to the skin (spot-on use).
• Method of administration: Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap over and place the other end of the cap on the single-dose pipette. Push and twist the cap to pierce the seal, then remove the cap from the single-dose pipette. Part the animal's fur between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and squeeze the pipette several times to empty the content directly onto the skin, in a single spot.

Amflee 134 MG is an antiparasitic pipette for medium-sized dogs weighing between 10-20 kg, which prevents and treats flea and tick infestations.

1 pipette (1.34 ml) contains:

• Active substance: Fipronil 134 mg.
• Other substances: Butylhydroxyanisole (E320) 0.27 mg Butylhydroxytoluene (E321) 0.13

Used for:

• Treatment and prevention of infestations with fleas (Ctenocephalides spp), ticks (Rhipicephalus spp, Dermacentor spp, Ixodes spp.) and infestations with biting lice Trichodectes canis in dogs.
• The product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.
• The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD), if previously diagnosed by a veterinarian.

Contraindications:

• Do not administer to puppies younger than 8 weeks or weighing less than 2 kg.
• Do not administer to sick animals (systemic diseases, fever) or those in convalescence.
• Do not administer to rabbits due to the risk of severe adverse reactions or even death.
• Do not administer to cats, as it may lead to overdose.
• Do not administer in case of hypersensitivity to the active substance or to any of the excipients.

Precautions:

• Ticks on animals should be removed before using the product to reduce the risk of transmissible diseases.
• The product should be applied in a secluded place where the animal cannot lick itself.
• It is recommended to avoid bathing or immersion in water for 2 days after applying the product and to avoid bathing more frequently than once a week.
• Emollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of flea protection to approximately 5 weeks.
• Weekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the efficacy of the product against fleas, as shown in a long-term 6-week study.
• Ticks may appear sporadically. Thus, complete exclusion of infection with diseases in unfavorable conditions is impossible. Generally, ticks will die within 24-48 hours after infestation without feeding on the animal's blood.
• Avoid contact of the product with the animal's eyes.
• Dogs should not be allowed to swim in running water for 2 days after application.
• The product can cause irritation to mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.
• Persons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.
• In case of contact, wash hands with soap and water.
• In case of accidental contact with eyes, wash thoroughly with clean water.
• Wash hands after use.
• Do not touch treated animals and do not let children play with them until the application site has dried. Thus, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially with children.
• Do not smoke, drink or eat while applying the product.

Possible adverse reactions:

• If animals lick themselves, short-term hypersalivation may occur, mainly due to the excipients.
• Extremely rare adverse reactions: transient skin reactions at the application site (discoloration and hair loss, itching and erythema) and generalized itching with alopecia.
• Exceptionally, after use, hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous signs), respiratory signs, or vomiting have been observed.

Administration:

• Remove the single-dose pipette from the triplex pouch.
• Hold the single-dose pipette upright, twist and pull off the cap.
• Turn the cap over and place the other end of the cap on the single-dose pipette.
• Push and twist the cap to perforate the seal, then remove the cap from the single-dose pipette.
• Part the animal's hair in the area between the shoulder blades to make the skin visible.
• Place the tip of the single-dose pipette on the skin and squeeze the pipette several times to empty the contents directly onto the skin, in one spot.

Advantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.

Composition
Each dose (pipette) contains:

Excipients: Butylhydroxytoluene 1.0 mg/ml (E321, as antioxidant):

Indications
For the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).
Fleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product
can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
The product exhibits acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes
ricinus) or three weeks (Dermacentor reticulatus) against tick infestations.
Ticks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore, it is
recommended to remove ticks present on the dog at the time of treatment to prevent their attachment and blood feeding.
One treatment provides repellent (anti-feeding) action against sand flies for two weeks (Phlebotomus papatasi) or three
weeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks, and against stable flies
(Stomoxys calcitrans) for four weeks.
Sand flies Phlebotomus perniciosus 3 weeks
Phlebotomus papatasi 2 weeks
Mosquitoes Aedes aegypti 2 weeks
Culex pipiens 4 weeks
Stable fly Stomoxys calcitrans 4 weeks

Contraindications
In the absence of available data, the product should not be used in puppies younger than 7 weeks.
Do not use in cases of known hypersensitivity to the active substances.
Do not use in cats.

Adverse reactions
Transient dermal sensitivity (with increased pruritus, alopecia, and erythema at the application site) or apathy may rarely occur.
Poisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as
tremors and apathy may also appear. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

Target species
Dogs.

Dosage for each species, route(s) of administration and method of administration
Dosing schedule:
The minimum recommended dose is: 10 mg / kg body weight (b.w.) imidacloprid and 50 mg / kg body weight (b.w.) permethrin equivalent to
0.1ml/kg b.w. Advantix spot-on solution for dogs.

Dog weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg/kg b.w.) Permethrin (mg/kg b.w.)

>25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80
> 40 kg the appropriate combination of pipettes should be used

To reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in
the same household must be treated with appropriate products. For fleas originating from the animal's environment,
the additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. If prolonged exposure
to water occurs, the efficacy of the product decreases. Even in this case, treatment should not be more frequent than once a week. If
the animal needs to be washed with shampoo, it is best to apply Advantix spot-on solution for dogs after two weeks
to ensure the product's effectiveness.

Method of administration.
Remove a pipette from the package. Hold the pipette upright, twist the cap, and remove it. Turn the cap upside down and use
it to unseal the pipette (by twisting and pressing on the seal, as shown in the photo).
For dogs weighing 10 kg or less:
With the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and
by squeezing firmly several times, empty the contents of the pipette. Apply only to unbroken skin.
For dogs weighing more than 10 kg:
With the dog standing, the entire content of the Advantix spot-on solution pipette for dogs should be applied evenly in four places
starting between the shoulder blades and extending to the base of the tail. At each location, part the hair until the skin is visible. Apply the tip of the pipette to the skin and
gently squeeze to release some of the solution onto the skin.

Recommendations for correct administration
For external use only.
Apply only to unbroken skin.
Do not apply a large amount of solution in one spot as this may run down the sides of the dog.

Withdrawal period
Not applicable.

Special precautions for storage
Keep out of the reach and sight of children.
Do not freeze.
After opening the aluminum pouch, store in a dry place and do not store at temperatures above 30°C.
The abbreviation used for the expiry date on the label, pipette, and pouch is EXP.

Special precautions for use in animals
The content of the pipette should not come into contact with the eyes and mouth of the treated dog.
Pay attention to the correct administration of the product as described in the "Method of administration" section. In particular, oral ingestion
by licking the application site or contact with other animals should be avoided.
Do not use in cats.
This product is very toxic to cats and can cause death due to the physiological particularities of cats
which are unable to metabolize certain compounds including permethrin. To prevent accidental exposure of
cats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.
Measures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek
immediate veterinary assistance if this occurs.
Consult your veterinarian before using this product in sick and debilitated animals.
As the product is hazardous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters
for at least 48 hours after treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin, eyes, or mouth. Do not eat, drink, or smoke while applying the product.
Wash hands thoroughly after applying the product.
If the product accidentally gets on the skin, wash the area immediately with soap and water.
Individuals with known skin sensitivity may be particularly sensitive to this product.
If the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is
accidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.
Treated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for
example, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.

Special precautions for the disposal of unused product or waste materials, if any
After use, replace the cap on the pipette. Any unused veterinary medicinal product or waste materials derived from such
products should be disposed of in accordance with local requirements.

Other information
Advantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.
This combination acts as an insecticide, acaricide, and repellent.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified
as a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to
its efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for areas in the animal's habitat.
The product provides repellent (anti-feeding) action against ticks, sand flies, and mosquitoes, thus preventing
parasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or
CVBD, such as Lyme disease, rickettsiosis, ehrlichiosis, leishmaniasis).
It can be used during gestation and lactation.
The solvent in Advantix spot-on solution for dogs may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow
the application site to dry before contact with such materials.

Packaging:
Pipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml
Blister containing 1, 2, 3, 4, or 6 individual pipettes.
Not all pack sizes may be marketed.
For any information about this veterinary medicinal product, please contact the local representative of the marketing authorisation holder.

Marketing Authorisation Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany

Advantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.

Composition
Each dose (pipette) contains:

Excipients: Butylhydroxytoluene 1.0 mg/ml (E321, as an antioxidant):

Indications
For the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).
Fleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product
can be used as part of a treatment strategy against flea allergy dermatitis (FAD).
The product has acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes
ricinus) or three weeks (Dermacentor reticulatus) against tick infestations.
Ticks already present on the dog may not be killed within two days of treatment and may remain attached and visible. Therefore,
it is recommended to remove ticks present on the dog at the time of treatment to prevent them from attaching and feeding.
One treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three
weeks (Phlebotomus perniciosus), against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks, and against stable flies
(Stomoxys calcitrans) for four weeks.
Sandflies Phlebotomus perniciosus 3 weeks
Phlebotomus papatasi 2 weeks
Mosquitoes Aedes aegypti 2 weeks
Culex pipiens 4 weeks
Stable flies Stomoxys calcitrans 4 weeks

Contraindications
In the absence of available data, the product should not be used in puppies younger than 7 weeks.
Do not use in known cases of hypersensitivity to the active substances.
Do not use in cats.

Adverse reactions
Transient dermal sensitivity (with increased pruritus, alopecia and erythema at the application site) or apathy may rarely occur.
Poisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such
as tremors and apathy may also appear. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.
If you notice serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.

Target species
Dogs.

Dosage for each species, route(s) of administration and method of administration
Dosing regimen:
The minimum recommended dose is: 10 mg / kg body weight (b.w.) imidacloprid and 50 mg / kg body weight (b.w.) permethrin equivalent to
0.1ml/kg b.w. Advantix spot-on solution for dogs.

Dog weight (kg)    Pipette size to be used    Volume (ml)    Imidacloprid (mg/kg b.w.)    Permethrin (mg/kg b.w.)

>25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80
> 40 kg use the appropriate combination of pipettes

To reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in
the same family or household should be treated with appropriate products. For fleas originating from the animal's environment,
the additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is effective even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure
to water, the efficacy of the product decreases. Even in this case, treatment should not be more frequent than once a week. If
the animal needs to be shampooed, it is advisable to apply Advantix spot-on solution for dogs two weeks later
to ensure the product's efficacy.

Method of administration.
Remove one pipette from the package. Hold the pipette upright, twist the cap and remove it. Turn the cap upside down and use it to
unseal the pipette (by twisting and pressing on the seal, as shown in the photo).
For dogs weighing 10 kg or less:
With the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and
by squeezing firmly several times, empty the contents of the pipette. Apply only to unbroken skin.
For dogs weighing more than 10 kg:
With the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four spots
starting between the shoulder blades and extending to the base of the tail. At each spot, part the hair until the skin is visible. Apply the tip of the pipette to the skin and
gently squeeze to release some of the solution onto the skin.

Recommendations for correct administration
For external use only.
Apply only to unbroken skin.
Do not apply a large amount of solution in one spot as this may run off the sides of the dog.

Withdrawal period
Not applicable.

Special precautions for storage
Keep out of the reach and sight of children.
Do not freeze.
After opening the aluminum pouch, store in a dry place and do not store at a temperature higher than 30°C.
The abbreviation used for the expiry date on the label, pipette and pouch is EXP.

Special precautions for use in animals
The contents of the pipette must not come into contact with the eyes and mouth of the treated dog.
Pay attention to the correct administration of the product as described in the "Method of administration" section. In particular, oral ingestion
by licking the application site or contact with other animals should be avoided.
Do not use in cats.
This product is highly toxic to cats and can cause death due to the physiological peculiarities of cats,
who are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of
cats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.
Measures should be taken to prevent cats from licking the application site of dogs that have been treated with this product. Seek
immediate veterinary assistance if this occurs.
Consult your veterinarian before using this product in sick and debilitated animals.
As the product is dangerous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface water
for at least 48 hours after treatment.

Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin, eyes or mouth. Do not eat, drink, or smoke during product application.
Wash hands thoroughly after applying the product.
If the product accidentally gets on the skin, immediately wash the area with soap and water.
Individuals with known skin sensitivity may be particularly sensitive to this product.
If the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is
accidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.
Treated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs in the
evening, for example. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.

Special precautions for the disposal of unused product or waste materials, if any
After use, replace the cap on the pipette. Any unused veterinary medicinal product or waste materials derived from such products
should be disposed of in accordance with local requirements.

Other information
Advantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.
This combination acts as an insecticide, acaricide, and repellent.

Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified
as chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to
its efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for areas in the animal's habitat.
The product provides repellent (anti-feeding) action against ticks, sandflies, and mosquitoes, thereby preventing
parasite feeding and reducing the risk of transmitting vector-borne diseases (Canine Vector-Borne Disease or
CVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).
It can be used during pregnancy and lactation.
The solvent in Advantix spot-on solution for dogs may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow
the application site to dry before contact with such materials.

Packaging:
Pipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml
Blister containing 1, 2, 3, 4 or 6 individual pipettes.
Not all pack sizes may be marketed.
For any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorization holder.

Marketing Authorization Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany

Liquid anti-parasitic solution for cutaneous application, packaged in single-use pipettes.