Amflee 402 MG is an anti-parasitic pipette for very large dogs, weighing between 40 and 60 kilograms, that prevents and treats flea and tick infestations.

1 pipette (4.02 ml) contains:

• Active substance: Fipronil 402 mg.
• Other substances: Butylhydroxyanisole (E320) 0.80 mg Butylhydroxytoluene (E321) 0.40 mg

Used for:

• Treatment and prevention of infestations with fleas (Ctenocephalides spp), ticks (Rhipicephalus spp, Dermacentor spp, Ixodes spp.) and infestations with biting lice Trichodectes canis in dogs.
• The product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.
• The product can be used as part of a treatment strategy for allergic dermatitis caused by flea bites (FAD), if previously diagnosed by a veterinarian.

Contraindications:

• do not administer to puppies younger than 8 weeks or weighing less than 2 kg
• do not administer to sick animals (systemic diseases, fever) or those in convalescence
• do not administer to rabbits due to the risk of serious adverse reactions or even death
• do not administer to cats, as it may lead to overdose
• do not administer in case of hypersensitivity to the active substance or to any of the excipients.

PRECAUTIONS:

• Ticks present on animals should be removed before using the product, to reduce the risk of transmissible diseases.
• It is recommended to avoid bathing or immersion in water for 2 days after application of the product and to avoid bathing more frequently than once a week, as no studies have been conducted to investigate the effectiveness of the product under these conditions.
• Emollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of flea protection to approximately 5 weeks.
• Weekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the product's efficacy against fleas, as shown in a 6-week long-term study.
• Sporadic ticks may appear. Thus, it is impossible to completely exclude the transmission of infectious diseases by ticks, if conditions are unfavorable. As a rule, ticks will be killed and fall off the host within 24-48 hours after infestation, without feeding on the animal's blood. Sporadic tick attachment cannot be excluded during the product's efficacy period.
• Pet fleas often infest the animal's basket, places where animals sleep and rest, such as carpets and soft furnishings, which must be regularly treated with appropriate insecticides and cleaned with a vacuum cleaner, in cases of massive infestations or at the beginning of control measures.
• Avoid contact of the product with the animal's eyes.
• It is important to ensure that the product is applied in a place where the animal cannot lick itself, and it should be avoided that animals lick each other after treatment.
• Dogs should not be allowed to swim in running water for 2 days after application.
• The product can cause irritation of the mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.
• Persons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.
• In case of contact, wash hands with soap and water.
• In case of accidental eye contact, wash thoroughly with clean water.
• Wash hands after use.
• Do not touch treated animals and do not allow children to play with them until the application site has dried. Thus, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially with children.
• Do not smoke, drink, or eat while applying the product.

Possible adverse reactions:

• If animals lick the application site, short-term hypersalivation may occur, mainly due to the nature of the excipients.
• After use, extremely rare adverse reactions may include transient skin reactions at the application site (skin discoloration and local alopecia, pruritus, erythema) and generalized pruritus or alopecia.
• Exceptionally, after use, hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous signs), respiratory signs, or vomiting have been observed.

Administration:

• In the absence of product safety studies, the minimum interval between treatments is 4 weeks.
• Monthly treatment is recommended if there is a high risk of repeated flea infestations, if dogs are allergic to flea bites and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once every two or three months.
• Route of administration: External application to the skin (spot-on use).
• Method of administration: Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap over and place the other end of the cap on the single-dose pipette. Push and twist the cap to pierce the seal, then remove the cap from the single-dose pipette. Part the animal's fur between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and squeeze the pipette several times to empty the content directly onto the skin, in a single spot.