Shampoo specially formulated for repellent action against mosquitoes, flies, ticks and fleas
Formulated with tea tree and neem oil
Enriched with Quaternized Keratin complex, Vitamins C + E + Panthenol and natural extracts of Thyme and Chamomile. Free of insecticides and parabens.
Key ingredients:Quaternized Keratin, Vitamins C + E + Panthenol, Cajeput essential oil (white tea tree oil), neem oil, soothing extracts of chamomile and thyme. Does not contain insecticides and parabens.
Indications:Ideal for all breeds. For external use only. Use only on healthy skin.
Instructions for use:Distribute a sufficient dose of the product on wet fur, massage vigorously and spread over the fur, rinse with plenty of water.
Purifying cleansing treatment, ideal for use as a first shampoo to perform a sanitizing action
Specially designed for skin prone to oiliness and dandruff
Deep cleansing, odor removal, refreshing action for coat and skin
Key ingredients:natural extracts of Aloe Vera, White Willow and Propolis, Quaternized Keratin, Creatine and Vitamins C + E + Panthenol
Indications:Suitable for dogs and cats. Ideal for all breeds. For external use only.
How to use:Distribute a sufficient dose of product on wet coat, massage vigorously and distribute throughout the coat, rinse thoroughly with plenty of water.
OrganicVet SENSITIVE - Venison, cranberries, and pasta
Super-premium food with easily digestible ingredients, enriched with FOS, MOS, essential oils, vitamins, and minerals, ensuring a balanced diet and optimal digestion.
Yorkshire Terriers are very affectionate and have a strong character, and their long, silky blue-grey coat is incredibly similar to human hair. For continuous coat growth, Yorkshire Terriers need a daily diet with 35% protein. One of the unique characteristics of this breed is the absence of an undercoat. Because of this, even a small wound or a very slight blow can cause skin problems.
Yorkshire Terriers have small jaws and teeth that need protection. Due to frequent shedding, Yorkshire Terriers can become very agitated, and their food must be very palatable.
Your Yorkshire Terrier puppy has a particularly high life expectancy; some veterinarians and breeders have reported Yorkshire Terriers living up to 21 years. With advanced age, the risk of heart, kidney, and joint problems increases.
Royal Canin Yorkshire Terrier food has been specially designed for the unique characteristics of this breed.
Ingredients: poultry protein (dried), corn flour, rice, animal fat, vegetable protein isolate*, corn, animal protein (hydrolyzed), corn gluten, lignocellulose, dried beet pulp, fish oil, minerals, soybean oil, yeasts, fructo-oligosaccharides, yeast hydrolyzate (source of mannan-oligosaccharides), borage oil (0.1%), hydrolyzed crustaceans (source of glucosamine), marigold flower meal (source of lutein), hydrolyzed cartilage (source of chondroitin).
* L.I.P.: selected proteins, easily digestible, with high biological value.
Growing French Bulldogs need special nutrition during this short and intense period of development. Puppies' digestive systems are sensitive and can be easily upset. Therefore, this food contains easily digestible prebiotics and high-quality proteins that ensure the protection of the digestive system and help maintain a balanced intestinal flora.
French Bulldogs are very affectionate, intelligent, and playful dogs. They may seem stubborn and surly at first glance, but once you get to know them, you will discover their gentleness and charm. At the same time, these agile, strong dogs have well-developed muscle mass. Their compact body with accentuated muscles gives them their unique appearance, but it also means that their joints are sensitive and need special protection. The special shape of their head can cause breathing problems, preventing proper oxygenation of some parts of the body. This can cause, for example, flatulence.
French Bulldogs have developed a unique way of eating due to the special shape of their head and short jaw. This must be taken into account when feeding your puppy.
Royal Canin Breed French Bulldog Puppy is a dry food specially formulated for French Bulldogs up to 12 months of age.
Ingredients: rice, poultry protein (dried), wheat, vegetable protein isolate*, animal fat, animal protein (hydrolyzed), dried beet pulp, pork protein (dried), minerals, soybean oil, fish oil, fructooligosaccharides (0.34%), yeast hydrolysate (source of mannan-oligosaccharides), hydrolysate from crustaceans (source of glucosamine), yeast extract (source of beta-glucans), marigold flower meal (source of lutein), cartilage hydrolysate (source of chondroitin).
*L.I.P.: selected, easily digestible proteins with high biological value.
Advantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.
Composition
Each dose (pipette) contains:
Pipette
Imidacloprid
Permethrin
E321
Advantix spot-on solution for dogs up to 4 kg
0.4 ml
40 mg
200 mg
0.4 mg
Advantix spot-on solution for dogs from 4 kg to 10 kg
1.0 ml
100 mg
500 mg
1.0 mg
Advantix spot-on solution for dogs from 10 kg to 25 kg
2.5 ml
250 mg
1250 mg
2.5 mg
Advantix spot-on solution for dogs over 25 kg
4.0 ml
400 mg
2000 mg
4.0 mg
Excipients: Butylhydroxytoluene 1.0 mg/ml (E321, as an antioxidant):
Indications
For the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).
Fleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product
can be used as part of a treatment strategy against flea allergy dermatitis (FAD).
The product exhibits acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes
ricinus) or three weeks (Dermacentor reticulatus) against tick infestations.
Ticks already present on the dog may not be killed within two days of treatment and may remain attached and visible. Therefore, it is
recommended to remove ticks present on the dog at the time of treatment to prevent their attachment and blood feeding.
One treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three
weeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks and for stable flies
(Stomoxys calcitrans) for four weeks.
Sandflies Phlebotomus perniciosus 3 weeks
Phlebotomus papatasi 2 weeks
Mosquitoes Aedes aegypti 2 weeks
Culex pipiens 4 weeks
Stable fly Stomoxys calcitrans 4 weeks
Contraindications
In the absence of available data, the product should not be used in puppies younger than 7 weeks.
Do not use in cases of known hypersensitivity to the active substances.
Do not use in cats.
Adverse reactions
Transient dermal sensitivity (with increased pruritus, alopecia, and erythema at the application site) or apathy may rarely occur.
Poisoning in dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as
tremors and apathy may also appear. Symptomatic treatment should be applied under veterinary supervision. There is no specific antidote.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.
Target species
Dogs.
Dosage for each species, route(s) of administration, and method of administration
Dosing regimen:
The minimum recommended dose is: 10 mg/kg body weight (b.w.) imidacloprid and 50 mg/kg body weight (b.w.) permethrin, equivalent to
0.1ml/kg b.w. Advantix spot-on solution for dogs.
Dog weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg/kg b.w.) Permethrin (mg/kg b.w.)
>25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80
> 40 kg the appropriate combination of pipettes should be used
Dog weight (kg)
Pipette size to be used
Volume (ml)
Imidacloprid (mg/kg b.w.)
Permethrin (mg/kg b.w.)
<=4 kg
Advantix spot-on solution for dogs up to 4 kg
0.4 ml
minimum 10
minimum 50
>4 kg - 10 kg
Advantix spot-on solution for dogs from 4 kg to 10 kg
1.0 ml
10 - 25
50 - 125
>10 kg - 25 kg
Advantix spot-on solution for dogs from 10 kg to 25 kg
2.5 ml
10 - 25
50 - 125
>25 kg - 40 kg
Advantix spot-on solution for dogs over 25 kg
4.0 ml
10 - 16
50 - 80
> 40 kg
the appropriate combination of pipettes should be used
To reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in
the same family or household should be treated with appropriate products. For fleas originating from the animal's environment,
the additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is effective even if the animal is wet. However, prolonged exposure to water should be avoided. If prolonged exposure
to water occurs, the effectiveness of the product decreases. Even in this case, it should not be treated more frequently than once a week. If it is
necessary to shampoo the animal, it is advisable to apply Advantix spot-on solution for dogs after two weeks
to ensure the effectiveness of the product.
Method of administration.
Remove one pipette from the package. Hold the pipette upright, twist the cap, and remove it. Turn the cap upside down and use it to
unseal the pipette (by twisting and pressing on the seal, as shown in the photo).
For dogs weighing 10 kg or less:
With the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and
by firmly squeezing several times, empty the contents of the pipette. Apply only to uninjured skin.
For dogs weighing more than 10 kg:
With the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four places
starting from between the shoulder blades and extending to the base of the tail. At each spot, part the hair until the skin is visible. Apply the tip of the pipette to the skin and
gently squeeze to release some of the solution onto the skin.
Recommendations for correct administration
For external use only.
Apply only to uninjured skin.
Do not apply a large amount of solution in a single spot, as this may run off the sides of the dog.
Withdrawal period
Not applicable.
Special precautions for storage
Keep out of the sight and reach of children.
Do not freeze.
After opening the aluminum pouch, store in a dry place and do not store at temperatures above 30°C.
The abbreviation used for the expiry date on the label, pipette, and pouch is EXP.
Special precautions for use in animals
The contents of the pipette should not come into contact with the eyes or mouth of the treated dog.
Pay attention to the correct administration of the product as described in the "Method of administration" section. In particular, oral ingestion
by licking the application site or contact with other animals should be avoided.
Do not use in cats.
This product is highly toxic to cats and can cause death due to the physiological peculiarities of cats
which are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of
cats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.
Measures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek
immediate veterinary assistance if this occurs.
Consult your veterinarian before using this product in sick and debilitated animals.
As the product is dangerous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters
for at least 48 hours after treatment.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin, eyes, or mouth. Do not eat, drink, or smoke during product application.
Wash hands thoroughly after product application.
If the product accidentally gets on the skin, wash the area immediately with soap and water.
Individuals with known skin sensitivity may be particularly sensitive to this product.
If the product accidentally gets into the eyes, rinse the eyes with plenty of water. If skin or ocular symptoms persist, or the product is
accidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.
Treated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for
example, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.
Special precautions for the disposal of unused product or waste materials, if any
After use, place the cap back on the pipette. Any unused veterinary medicinal product or waste materials derived from the use of such
products should be disposed of in accordance with local requirements.
Other information
Advantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.
This combination acts as an insecticide, acaricide, and repellent.
Imidacloprid is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified
as a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to
its efficacy against adult fleas, the larvicidal efficacy of the substance for areas in the animal's habitat has also been demonstrated.
The product provides repellent (anti-feeding) action against ticks, sandflies, and mosquitoes, thereby preventing
parasite blood feeding and reducing the risk of transmitting vector-borne diseases (Canine Vector-Borne Disease or
CVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).
It can be used during pregnancy and lactation.
The solvent in Advantix spot-on solution for dogs may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow
the application site to dry before contact with such materials.
Packaging:
Pipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml
Blister containing 1, 2, 3, 4, or 6 individual pipettes.
Not all package sizes may be marketed.
For any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorization holder.
Marketing Authorization Holder
Bayer Animal Health GmbH, D-51368 Leverkusen, Germany
Brit Care Senior, Salmon and Potato, Grain-Free is a complete and balanced, grain-free food for senior dogs of all breeds. It can also be successfully used for weight management in dogs prone to obesity.
Mottled red to reddish-brown, round (tablets for dogs 2-3.5 kg) or rectangular (tablets for dogs > 3.5-7.5 kg, tablets for dogs > 7.5-15 kg, tablets for dogs > 15-30 kg and tablets for dogs > 30-60 kg) chewable tablets.
CLINICAL PARTICULARS
Target species: Dogs
Indications for use, specifying the target species
For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is indicated.
Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.
Fleas and ticks must attach to the host and commence feeding to be exposed to the active substance.
Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancylostoma caninum and Ancylostoma braziliense) and whipworms (Trichuris vulpis).
Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.
Contraindications: Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
Parasites must start feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.
Resistance of parasites to any particular class of antiparasitics may develop following frequent, repeated use of a product of that class. Therefore, the use of this product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species to limit the possibility of future resistance selection.
Maintaining the efficacy of macrocyclic lactones is essential for the control of Dirofilaria immitis. To minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.
Only negative animals should be treated.
Special precautions for use
Special precautions for use in animals
In the absence of available data, treatment of puppies younger than 8 weeks of age and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinary surgeon.
Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administering NEXGARD SPECTRA. Infested dogs should be treated with an adulticide chosen by the veterinary surgeon to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.
The recommended dose should be strictly followed for Collie dogs or other related breeds.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
This product, if ingested, can cause gastrointestinal disturbances.
Keep the tablets in the blister and the blister in the carton until use.
In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.
Wash hands after use.
Adverse reactions (frequency and seriousness)
In clinical studies, no serious adverse reactions were attributed to the combination of afoxolaner with milbemycin oxime. Less frequent reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus were observed. These reactions generally resolved spontaneously and were of short duration.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- Common (more than 1 but less than 10 animals in 100 animals)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals)
- Rare (more than 1 but less than 10 animals in 10,000 animals)
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Laboratory studies in rats and rabbits have not shown any teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinary surgeon.
Interaction with other medicinal products or other forms of interaction
Milbemycin oxime is a substrate of p-glycoprotein (P-gp), and can therefore interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.
Amounts to be administered and administration route
For oral administration.
Dosage:
The product should be administered at a dose of 2.50-5.36 mg/kg afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight in accordance with the following table:
Dog weight (kg)
Concentration and number of chewable tablets to be administered
NEXGARD SPECTRA
9 mg/ 2 mg
NEXGARD SPECTRA
19 mg/ 4 mg
NEXGARD SPECTRA
38 mg/ 8 mg
NEXGARD SPECTRA
75 mg/ 15 mg
NEXGARD SPECTRA
150 mg/ 30 mg
2-3.5
1
>3.5-7.5
1
>7.5-15
1
>15-30
1
>30-60
1
For dogs over 60 kg body weight, the appropriate combination of chewable tablets should be used.
Method of administration:
The tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly, they can be administered with food.
Treatment schedule:
The treatment schedule should be based on the veterinary diagnosis and the local epidemiological situation.
NEXGARD SPECTRA can be used as a seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.
Disease: Heartworm disease:
NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after their transmission by mosquitoes, therefore the product must be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should continue until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.
If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.
Dogs living in or travelling to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs aged 8 months or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.
Overdose (symptoms, emergency procedures, antidotes), if applicable
No adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.
Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.
Afoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of insect/mite GABA receptors versus those of mammals.
Afoxolaner is active against adult fleas as well as against some tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.
The product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Milbemycin oxime:
Milbemycin oxime is an antiparasitic endectocide belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a ratio of 20:80 for A3:A4). It is isolated from the fermentation of Streptomyces milbemycinicus.
Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (related to GABA and glycine receptors in vertebrates).
This leads to hyperpolarisation of the neuromuscular membrane and paralysis and death of the parasites.
Pharmacokinetic particulars
Afoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean peak plasma concentration (Cmax) was 1822 ± 165 ng/ml, 2-4 hours (Tmax) after a 2.5 mg/kg afoxolaner dose.
The volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.
Plasma concentrations of Milbemycin oxime increase rapidly in the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4 respectively. The mean peak plasma concentration (Cmax), after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A4.
The volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for A3 and A4 forms respectively. Both forms have a low clearance value of 75 ± 22 ml/h/kg for A3 and 41 ± 12 ml/h/kg for A4.
PHARMACEUTICAL PARTICULARS
List of excipients
Corn starch
Soy protein
Braised beef flavour
Povidone (E1201)
Macrogol 400
Macrogol 4000
Macrogol 15 hydroxystearate
Glycerol (E422)
Medium-chain triglycerides
Citric acid monohydrate (E330)
Butylhydroxytoluene (E321)
Incompatibilities: Not applicable.
Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Special precautions for storage: Keep the blister in the secondary packaging to protect from light.
Nature and composition of primary packaging
This veterinary medicinal product is individually packaged in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).
1 cardboard box containing one blister with 1, 3 or 6 chewable tablets.
Not all package sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.
Marbled, red to reddish-brown, round (tablets for dogs weighing 2-3.5 kg) or rectangular (tablets for dogs weighing > 3.5-7.5 kg, tablets for dogs weighing > 7.5-15 kg, tablets for dogs weighing > 15-30 kg, and tablets for dogs weighing > 30-60 kg) tablets.
CLINICAL PARTICULARS
Target species: Dogs
Indications for use, specifying the target species
For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is indicated.
Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.
Fleas and ticks must attach to the host and begin feeding to be exposed to the active substance.
Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancyclostoma caninum and Ancyclostoma braziliense) and whipworms (Trichuris vulpis).
Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.
Contraindications: Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
Parasites must begin feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.
Resistance of parasites to a particular class of antiparasitic medicines may develop as a result of frequent use of a compound from that class. Therefore, the use of this product should be based on the evaluation of each case and local epidemiological information regarding the current susceptibility of the target species to limit the possibility of future selection of resistance.
Maintaining the efficacy of macrocyclic lactones is essential in the control of Dirofilaria immitis. To minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.
Only negative animals should be treated.
Special precautions for use
Special precautions for use in animals
In the absence of available data, treatment of puppies younger than 8 weeks and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinarian.
Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administering NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.
The recommended dose should be strictly followed for Collie dogs or other related breeds.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
This product, if ingested, may cause gastrointestinal disturbances.
Keep tablets in blisters and blisters in the box until use.
In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.
Wash hands after use.
Adverse reactions (frequency and seriousness)
In clinical studies, no serious adverse reactions attributable to the afoxolaner and milbemycin oxime combination were observed. Less common reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus were observed. These reactions generally resolved spontaneously and were short-lived.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- Common (more than 1 but less than 10 animals in 100 animals)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals)
- Rare (more than 1 but less than 10 animals in 10,000 animals)
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Laboratory studies in rats and rabbits have not shown teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use in accordance with the benefit-risk assessment by the veterinarian.
Interactions with other medicinal products or other forms of interaction
Milbemycin oxime is a substrate of p-glycoprotein (P-gp), and can therefore interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.
Amounts to be administered and administration route
For oral administration.
Dosage:
The product should be administered at a dose of 2.50-5.36 mg/kg of afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight according to the following table:
Dog weight (kg)
Concentration and number of chewable tablets to be administered
NEXGARD SPECTRA
9 mg/ 2 mg
NEXGARD SPECTRA
19 mg/ 4 mg
NEXGARD SPECTRA
38 mg/ 8 mg
NEXGARD SPECTRA
75 mg/ 15 mg
NEXGARD SPECTRA
150 mg/ 30 mg
2-3.5
1
>3.5-7.5
1
>7.5-15
1
>15-30
1
>30-60
1
For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.
Method of administration:
The tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.
Treatment regimen:
The treatment regimen should be based on veterinary diagnosis and the local epidemiological situation.
NEXGARD SPECTRA can be used as seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concomitantly infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.
Disease: Heartworm disease:
NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after transmission by mosquitoes, therefore the product should be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should be continued until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.
If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due to be administered.
Dogs living in or travelling to a heartworm region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs older than 8 months or more, living in heartworm endemic areas, be tested for adult heartworm infestation before being treated with a heartworm prevention product.
Overdose (symptoms, emergency procedures, antidotes), if applicable
No adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.
Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.
Afoxolaner acts by interacting with chloride ion channels, mainly those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thus blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of GABA receptors in insects/mites versus those in mammals.
Afoxolaner is active against adult fleas as well as some tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.
The product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Milbemycin oxime:
Milbemycin oxime is an antiparasitic endectocide belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a ratio of 20:80 for A3:A4). It is isolated from the fermentation of Streptomyces milbemycinicus.
Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (linked to GABA and glycine receptors in vertebrates).
This leads to hyperpolarization of the neuromuscular membrane and paralysis and death of parasites.
Pharmacokinetic particulars
Afoxolaner is absorbed very quickly systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (Cmax) was 1822 ± 165 ng/ml, 2-4 hours (Tmax) after a dose of 2.5 mg/kg afoxolaner.
The tissue distribution volume of Afoxolaner is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.
Plasma concentrations of Milbemycin oxime increase rapidly in the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4 respectively. The mean maximum plasma concentration (Cmax) after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A4.
The tissue distribution volume of Milbemycin oxime is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for A3 and A4 forms respectively. Both forms have a low clearance value of 75 ± 22 ml/h/kg for A3 and 41 ± 12 ml/h/kg for A4.
PHARMACEUTICAL PARTICULARS
List of excipients
Maize starch
Soya proteins
Braised beef flavour
Povidone (E1201)
Macrogol 400
Macrogol 4000
Macrogol 15 hydroxystearate
Glycerol (E422)
Medium-chain triglycerides
Citric acid monohydrate (E330)
Butylhydroxytoluene (E321)
Incompatibilities: Not applicable.
Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Special precautions for storage: Keep the blister in the secondary packaging to protect from light.
Nature and composition of primary packaging
This veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).
1 cardboard box containing one blister with 1, 3 and 6 chewable tablets.
Not all pack sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from the use of such products should be disposed of in accordance with local requirements.
for the treatment and prevention of flea infestations (Ctenocephalides spp.).
reduces the incidence of flea allergies.
larval stages are killed on the animal and in the surrounding environment of treated animals.
for the prevention of heartworm infestations (Dirofilaria immitis)
for the treatment and control of:
roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).
hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.
whipworms Trichuris vulpis.
generalized demodicosis Demodex canis.
sarcoptic mange Sarcoptes scabiei.
ear mites Otodectes cynotis.
lice Trichodectes canis. Linognathus setosus for 6 weeks.
Dosage and administration:
For dogs between 0 - 4 kg, one tube of Advocate 40 is used;
Administration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be done in several spots along the back.
The product is applied to the skin, avoiding contact with the dog's mouth or eyes.
The dog's skin must be intact and free of lesions.
It can be administered to pregnant or lactating bitches.
The product retains its effectiveness after bathing or exposure to rain.
To reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in the same family or household should be treated with appropriate products.
Contraindications:
Do not use in cats. Do not use in puppies under 7 weeks of age.
Other information:
for the prevention of heartworm infestation, treatment should begin one month before the mosquito season (the host that transmits the larvae) and continue once a month until the mosquito season passes.
for tapeworms (cestodes), internal antiparasitics should be used as ADVOCATE does not act on them, only on roundworms and hookworms.
for demodicosis, 2 to 4 monthly treatments are required for beneficial effects.
for mange (auricular, sarcoptic), a single treatment is necessary for complete elimination of parasites and signs of disease.
Important: Advocate 40 falls under the pharmacy category. Consult your veterinarian for diagnosis and prescription of medication according to the specific needs of your dog or cat.
for the treatment and prevention of flea infestations (Ctenocephalides spp.).
reduces the incidence of flea allergy dermatitis.
larval stages are killed on the animal and in the surrounding environment of treated animals.
for the prevention of heartworm infestations (Dirofilaria immitis)
for the treatment and control of:
roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).
hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.
whipworms Trichuris vulpis.
generalized demodicosis Demodex canis.
sarcoptic mange Sarcoptes scabiei.
ear mites Otodectes cynotis.
lice Trichodectes canis. Linognathus setosus for 6 weeks.
Dosage and administration:
For dogs under 40 kg, one tube is used, and for dogs over 40 kg, two tubes of Advocate 400 are used.
Administration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be done in several places along the back.
The product is applied to the skin, avoiding contact with the dog's mouth or eyes.
The dog's skin must be intact and without lesions.
It can be administered to pregnant or lactating bitches.
The product retains its efficacy after bathing or exposure to rain.
To reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in the same family or household should be treated with appropriate products.
Contraindications:
Not for use in cats.
Not for use in puppies under 7 weeks of age.
Further information:
for the prevention of heartworm infestation, it is recommended to start treatment one month before the mosquito season (the vector that transmits the larvae) begins and to continue once a month until the mosquito season ends.
for tapeworms (cestodes), it is recommended to use internal antiparasitics as ADVOCATE does not act on them, but only on roundworms and hookworms.
for demodicosis, 2 to 4 monthly treatments are necessary to achieve beneficial effects.
for mange (ear, sarcoptic), a single treatment is usually sufficient for complete elimination of parasites and signs of disease.
Important: Advocate 400 falls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication or diet according to your dog's (cat's) specific needs.
Liquid antiparasitic solution for cutaneous application, packaged in single-use pipettes.
PACKAGE LEAFLET FOR Cardboard box with 3 pipettes
Frontline Tri-Act spot-on solution for dogs 2-5 kg
DECLARATION OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS
Spot-on solution.
Clear, colourless to brownish-yellow solution.
Active substances/Excipients:
See section "dosage for each target species"
TARGET SPECIES
Dogs
Caution!!!
Due to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separated from treated dogs until the application site is dry.
It is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.
INDICATION (INDICATIONS)
For the treatment and prevention of flea and/or tick infestations when repellent (anti-feeding) activity against sandflies, stable flies and/or mosquitoes is needed.
For the treatment and prevention of Ctenocephalides felis flea infestations and the prevention of Ctenocephalides canis flea infestations. The product kills C. felis fleas on the animal within 24 hours. A single
treatment prevents a new flea infestation for 4 weeks. The product can be part of a treatment strategy for the control of flea allergy dermatitis if this diagnosis has
been established by a veterinarian.
The product has repellent efficacy against ticks (Dermacentor reticulatus) starting from 7 days and up to 4 weeks after treatment. However, a single tick may attach and detach within the first 24 hours after infestation.
The product has immediate acaricidal efficacy against Rhipicephalus sanguineus and Ixodes ricinus species, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.
The product has persistent acaricidal efficacy against ticks (Ixodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus) for 4 weeks.
The product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (Phlebotomus perniciosus) and for 4 weeks against mosquitoes (Culex pipiens).
The product has persistent insecticidal efficacy against sandflies (Phlebotomus perniciosus) for 3 weeks.
The product repels and kills stable flies (Stomoxys calcitrans) for five weeks.
CONTRAINDICATIONS
Do not use on sick or convalescent animals.
Do not use on cats and rabbits as it may cause adverse reactions and even death.
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
ADVERSE REACTIONS
Among the very rare suspected adverse reactions, transient reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalised pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.
Slight hypersalivation and vomiting may occur if the product is ingested, should the animal lick the application area.
If you notice any serious reactions or other effects not mentioned in this package leaflet, please inform your veterinarian.
DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION
Topical administration to the skin (spot-on).
The following table defines which pipette should be used depending on the dog's weight:
Active ingredients Excipients
Frontline Tri-Act spot-on solution for dogs Dosed unit volume Fipronil (mg) Permethrin (mg) Butylhydroxytoluene (E321) (mg)
Very small dogs 2-5kg 0.5 33.8 252.4 0.563
Small dogs 5-10kg 1 67.6 504.8 1.125
Medium dogs 10-20kg 2 135.2 1009.6 2.250
Large dogs 20-40kg 4 270.4 2019.2 4.500
XL dogs 40-60kg 6 405.6 3028.8 6.750
Dogs > 60 kg Use the appropriate combination of pipettes
Treatment scheme
The product should be used after confirming infestation or risk of infestation with fleas and/or ticks, concurrently with the need for repellent (anti-feeding) activity against sandflies and/or mosquitoes and/or stable flies.
Depending on the recurrence of the risk of infestation with these ectoparasites, repeated treatment may be established. In these cases, the minimum treatment interval is at least 4 weeks.
ADVICE ON CORRECT ADMINISTRATION
Choose the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg, the necessary combination of pipettes will be used until the appropriate quantity for the dog's weight is reached.
The product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site.
These application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.
Remove the blister foil from the package and peel off a blister. Use scissors to cut the blister along the dotted line to remove the pipette or fold the marked corner and tear open.
Hold the pipette upright, away from your face or body, cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the tip of the pipette on the skin.
Squeeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.
To achieve the best results, make sure you apply the product directly to the skin and not to the fur.
WITHDRAWAL PERIOD
Not applicable
SPECIAL PRECAUTIONS FOR STORAGE
Keep out of the sight and reach of children.
Store in the original packaging.
Do not store above 25 °C
Do not use after the expiry date stated on the packaging after "EXP". The expiry date refers to the last day of that month.
SPECIAL WARNING(S)
Special warnings for each target species
A single tick or a mosquito or sandfly bite may already be attached to the animal. For this reason, the transmission of pathogens by these arthropods cannot be excluded if conditions are favourable.
The product remains effective against fleas when treated animals occasionally enter water (e.g. swimming, bathing). However, dogs should not be allowed to swim and should not be shampooed for 48 hours after treatment.
Avoid frequent swimming or shampooing of treated dogs as this may affect the maintenance of product efficacy.
To reduce re-infestation due to the emergence of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same space should be treated with a veterinary medicinal product suitable for their species.
To reduce the risk of environmental infestation, it is recommended to use additional appropriate environmental treatment
against fleas and their developmental stages.
Special precautions for use in animals
In the absence of specific studies, the use of this product is not recommended for dogs younger than 8 weeks or weighing less than 2 kg.
Avoid contact of the product with the animal's eyes.
It is very important to ensure that the product is applied in an area where the animal cannot lick the product and also to ensure that animals do not lick each other after
treatment.
Due to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separated from treated dogs until the application site is dry.
It is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
For veterinary use only.
This product may cause skin and eye irritation. Therefore, contact of the product with the skin or eyes must be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if the eyes become irritated during product administration, immediate thorough washing with water is recommended. If ophthalmic irritation persists, seek medical advice.
Persons with known hypersensitivity to fipronil and/or permethrin should avoid contact with this product.
The product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during product application. Wash hands after use. In case of ingestion, rinse mouth with water and seek medical advice if you feel unwell.
As the excipient N-methylpyrrolidone can cause fetotoxicity and teratogenicity following prolonged exposure, pregnant women are advised to wear gloves to avoid contact with the product.
Avoid handling the animal until the application site is dry; children should also not play with animals until their fur is dry.
Therefore, it is recommended that animals are not treated during the day but in the evening, and that treated animals sleep alone during the night, not with their owners and especially not with children.
Keep pipettes in the original packaging and, once used, empty pipettes must be disposed of immediately in an appropriate manner to prevent further access.
Other precautions
The product can have harmful effects on aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.
Use during pregnancy and lactation
Laboratory studies with fipronil and permethrin produced no teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.
N-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.
Use only based on a benefit/risk assessment by the veterinarian.
Overdose
Safety of use was evaluated in healthy adult dogs treated with a dose up to 5 times higher than the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Among the known adverse reactions, mild neurological symptoms,
vomiting, and diarrhea may occur. These symptoms are transient and usually disappear without treatment within 1-2 days. Animals should always be treated with the pipette corresponding to their weight.
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIAL, IF APPLICABLE
Any unused veterinary medicinal product or waste material derived from such products
must be disposed of in accordance with local requirements.
Do not contaminate lakes, watercourses, or drains with this product or empty pipettes.
OTHER INFORMATION
Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas in 24
hours, ticks and lice in 48 hours after exposure.
Permethrin belongs to type I pyrethroids, which are acaricides and insecticides with repellent activity.
Permethrin in the product provides repellent activity against sandflies (>80% for 4 weeks), mosquitoes and ticks.
Brit Care Adult Medium Breed Lamb and Rice is a super-premium dry food for adult medium-sized dogs (over 1 year old). Brit Care Adult Medium Breed Lamb and Rice contains a high level of vitamin E and selenium, forming a powerful antioxidant complex that protects cell membranes from free radical damage and thus prevents aging.
The recommended daily amount shown in the feeding table should be divided into 1-2 daily portions throughout the day. Serve the food dry or moistened with lukewarm water. When administering Brit Care for the first time, mix it with the previous food and gradually increase the portion of Brit Care over 7 days. The daily amount may vary depending on your dog's environment, activity, and age. Always ensure your dog has fresh drinking water.
Brit Premium by Nature Junior S is a premium food recommended for junior puppies (1 - 2 months) of small breeds (1-10 kg). It can be consumed by pregnant and lactating female dogs.
Composition: chicken meat 55% (dehydrated 30%, boneless 25%), chicken fat (preserved with tocopherols), oats, wheat, salmon oil (2%), corn, dried apples, hydrolyzed chicken liver, brewer's yeast, collagen, crustacean shells (source of glucosamine, 260 mg/kg), cartilage (a source of chondroitin, 180 mg/kg), herbs and fruits (cloves, citrus, rosemary, turmeric, 150 mg/kg), mannan-oligosaccharides (150 mg/kg), fructo-oligosaccharides (100 mg/kg), Mojave yucca (100 mg/kg), dried chamomile (90 mg/kg), green mussels (a source of glycosaminoglycan (60 mg/kg), dried blueberries (60 mg/kg).
Feeding guide: The food can be served dry or softened in a little lukewarm water. For junior dogs - the recommended daily nutritional intake presented in a feeding table should be divided into 2–3 equal portions throughout the day. When serving Brit Premium for the first time, use smaller amounts and mix with the previous food; then gradually increase the portion of Brit Premium. Always provide your dog with fresh drinking water.
Nutritional additives per kg: vitamin A (3a672a) 20,000 IU, vitamin D3 (E671) 1,200 IU, vitamin E (α-tocopherol) (3a700) 500 mg, biotin (3a880) 0.6 mg, choline chloride (3a890) 600 mg, zinc chelate of amino acids hydrate (3b606) 90 mg, ferrous chelate of amino acids, hydrate (E1) 80 mg, manganese chelate of amino acids, hydrate (E5) 35 mg, potassium iodide (3b201) 0.65 mg, cupric chelate of amino acids, hydrate (E4) 15 mg, organic form of selenium produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU approved antioxidants: tocopherol extract from vegetable oils (1b306), ascorbyl palmitate (1b304) & rosemary extract.
Metabolizable energy: 4,050 kcal/kg. To be consumed before the date written on the packaging. Store in a dry and cool place, avoid direct sunlight. Reseal after opening.
Brit Premium by Nature Sport is a complete food for adult dogs with increased energy needs, such as hunting dogs, mushing dogs, and guard dogs. The product can also be used during periods of convalescence.
Composition: chicken 50% (dehydrated 30%, deboned 20%), oats, chicken fat (preserved with tocopherols), wheat, corn, salmon oil (2%), hydrolyzed chicken liver, brewer's yeast, dried apples, collagen, crustacean shells (source of glucosamine, 260 mg/kg), cartilage (a source of chondroitin, 180 mg/kg), herbs and fruits (cloves, citrus, rosemary, turmeric, 150 mg/kg), mannan-oligosaccharides
(150 mg/kg), fructo-oligosaccharides (100 mg/kg), Mojave yucca (100 mg/kg), dried chamomile (90 mg/kg), green mussels (a source of glycosaminoglycans (60 mg/kg), dried blueberries (60 mg/kg).
Feeding Guide: The food can be served dry or moistened with a little warm water. Designed for dogs with high energy consumption, the recommended daily amount shown in the feeding table should be divided into several smaller portions throughout the day, depending on the dog's energy consumption. Adjust the daily amount according to activity. The recommended daily amounts are shown in the feeding table. When serving Brit Premium for the first time, use smaller amounts and mix with the previous food; then gradually increase the portion of Brit Premium. Always ensure your dog has fresh drinking water.
Nutritional Additives per kg: vitamin A (3a672a) 20,000 IU, vitamin D3 (E671) 1,200 IU, vitamin E (α-tocopherol) (3a700) 500 mg, biotin (3a880) 0.6 mg, choline chloride (3a890) 600 mg, zinc chelate of amino acids hydrate (3b606) 90 mg, ferrous chelate of amino acids, hydrate (E1) 80 mg, manganese chelate of amino acids, hydrate (E5) 35 mg, potassium iodide (3b201) 0.65 mg, cupric chelate of amino acids, hydrate (E4) 15 mg, organic form of selenium
produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU approved antioxidants: tocopherol extract from vegetable oils (1b306), ascorbyl palmitate (1b304) & rosemary extract.
Metabolizable energy: 4,200 kcal/kg. Best before the date indicated on the package. Store in a cool, dry place, away from direct sunlight. Reseal after opening.
Feeding Guide: Food can be served dry or moistened in a little warm water. For junior dogs - the recommended daily nutritional intake shown in the feeding table should be divided into 2-3 equal portions throughout the day. Recommended daily amounts are shown in the feeding table. When serving Brit Premium for the first time, use smaller amounts and mix with previous food; then gradually increase the portion of Brit Premium. Always ensure your dog has fresh drinking water. ANALYTICAL CONSTITUENTS: crude protein 28.0%, fat content 16.0%, moisture 10.0%, crude ash 7.2%, crude fiber 2.0%, calcium 1.5%, phosphorus 1.1%, omega-3 0.2%, omega-6 1.8%.
Nutritional additives per kg: vitamin A (3a672a) 20,000 IU, vitamin D3 (E671) 1,200 IU, vitamin E (α-tocopherol) (3a700) 500 mg, biotin (3a880) 0.6 mg, choline chloride (3a890) 600 mg, zinc chelate of amino acids hydrate (3b606) 90 mg, ferrous chelate of amino acids, hydrate (E1) 80 mg, manganese chelate of amino acids, hydrate (E5) 35 mg, potassium iodide (3b201) 0.65 mg, cupric chelate of amino acids, hydrate (E4) 15 mg, organic form of selenium produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU approved antioxidants: tocopherol extracts from vegetable oils (1b306), ascorbyl palmitate (1b304) & rosemary extract.
Metabolizable energy: 3,850 kcal/kg. Best before the date indicated on the packaging. Store in a dry, cool place, away from direct sunlight. Reseal after opening.
SUPERPREMIUM, SUSTAINABLE AND ECOLOGICAL FOOD FOR HEALTHY DIGESTION, STRESS REDUCTION, IMPROVED PHYSICAL CONDITION AND IMMUNE SUPPORT. IDEAL FOR ADULT SMALL BREED DOGS. CONTAINS EASILY DIGESTIBLE AND NUTRITIONALLY VALUABLE PROTEINS, WITH COMPLETE AMINO ACIDS FOR EXCELLENT MUSCLE TONE AND HEALTHY TISSUES. THE GLUTEN-FREE FORMULA IS SUITABLE FOR ALL DOGS, WITHOUT THE RISK OF WEIGHT GAIN. ECOLOGICAL FOOD BASED ON SUSTAINABLE PROTEINS AND INGREDIENTS, WITH A LESS THAN 35% IMPACT ON THE ENVIRONMENT.
Antistress - L-tryptophan provides calming support in stressful situations, motherwort (Leonurus cardiaca) helps ease anxiety
Immunity - Probiotics and antioxidants boost the immune system and support digestive health
SUPERPREMIUM GRAIN-FREE FOOD TO SUPPORT SKIN AND COAT HEALTH, CIRCULATORY SYSTEM AND HEART, EXCELLENT PHYSICAL CONDITION AND IMMUNITY IN ADULT DOGS OF SMALL AND MEDIUM BREEDS. CONTAINS HIGH NUTRITIONAL VALUE PROTEINS AND FATTY ACIDS TO SUPPORT SKIN AND COAT HEALTH. THE GRAIN-FREE FORMULA IS IDEAL FOR DOGS WITH COATS THAT REQUIRE DEMANDING CARE, AS WELL AS FOR DOGS THAT NEED TO MAINTAIN OPTIMAL PHYSICAL CONDITION OR SHOW ADVERSE REACTIONS TO OTHER TYPES OF FOOD. FATTY ACIDS PLAY A CRUCIAL ROLE IN THE HEALTHY DEVELOPMENT OF PUPPIES AND YOUNG DOGS.
Muscles - Rich in omega-3 to stimulate muscle synthesis, contributing to faster recovery
Healthy Skin - Sea buckthorn contributes to kidney and urinary tract health.
Immunity - Probiotics and antioxidants boost the immune system and support digestive health
GRAIN-FREE SUPERPREMIUM FOOD FOR THE HEALTHY DEVELOPMENT OF PUPPIES AND SUPPORTING THEIR IMMUNITY. CONTAINS HIGH NUTRITIONAL VALUE PROTEINS AND FATTY ACIDS TO SUPPORT HEALTHY SKIN AND COAT, MENTAL ABILITIES AND PERFECT PHYSICAL CONDITION. THE GRAIN-FREE FORMULA IS IDEAL FOR DOGS WITH COATS THAT REQUIRE DEMANDING CARE, AS WELL AS FOR DOGS THAT NEED TO MAINTAIN OPTIMAL PHYSICAL CONDITION OR SHOW ADVERSE REACTIONS TO OTHER TYPES OF FOOD. FATTY ACIDS PLAY A CRUCIAL ROLE IN THE HEALTHY DEVELOPMENT OF PUPPIES AND YOUNG DOGS.
Healthy Growth - The ideal ratio of calories, calcium and phosphorus supports steady and healthy growth
Muscles - Rich in omega-3 to stimulate muscle synthesis, contributing to faster recovery
Immunity - Probiotics and antioxidants boost the immune system and support digestive health
SUPERPREMIUM HYPOALLERGENIC FOOD WITH A SINGLE SOURCE OF ANIMAL PROTEIN HAS BEEN DEVELOPED TO KEEP SHOW DOGS IN EXCELLENT CONDITION. OMEGA-3 FATTY ACIDS, SUCH AS ALA, EPA, AND DHA, INCREASE SKIN HYDRATION, CONTRIBUTING TO A HEALTHY AND SHINY COAT. L-TRYPTOPHAN PROVIDES CALMING SUPPORT IN STRESSFUL SITUATIONS, WHILE MOTHERWORT (LEONORUS CARDIACA) HELPS ALLEVIATE ANXIETY. THE FORMULA IS ENRICHED WITH PROBIOTICS FOR HEALTHY INTESTINAL MICROFLORA AND MILK THISTLE, WHICH SUPPORTS LIVER FUNCTION AND CLEANSES THE BODY OF HARMFUL TOXINS.
Stress control - L-tryptophan provides calming support in stressful situations
Skin & Coat - Lots of omega-3 to boost hair sheen and skin health
Immunity - Probiotics and antioxidants boost the immune system and support digestive health
