Products for Dogs

From 94,47 lei

One type of food does not suit all dogs. That's why, when creating recipes, Royal Canin takes into account the specific needs for each age, breed, size, activity level, and lifestyle. Very large puppies need food adapted to individual requirements. Why? The large size of giant breed dogs gives them a very imposing presence, but they often suffer from bone, joint, and digestive system ailments. In addition, giant breed puppies go through two growth stages, with muscles developing mainly in the second phase, from 8 to 18/24 months. Royal Canin Giant Junior special food is specifically designed to meet the needs of this growth stage. Royal Canin Giant Junior for giant breed puppies from 8 to 18/24 months contains an exclusive combination of nutrients that help maintain your puppies' digestive health, and prebiotics support the balance of intestinal flora and good stool quality. The balanced energy intake and the minerals calcium and phosphorus contribute to good bone and joint mineralization. In addition, antioxidants and prebiotics strengthen the giant puppies' natural defense system.

Ingredients:
poultry protein (dried), corn, corn flour, rice, vegetable protein isolate*, animal fat, whole wheat flour, beet pulp, animal protein (hydrolyzed), minerals, fish oil, soybean oil, yeasts, fructo-oligo-saccharides, psyllium (husks and seeds), yeast hydrolysate (source of mannan-oligo-saccharides), yeast extract (source of beta-glucans), marigold flower meal (source of lutein), crustacean hydrolysate (source of glucosamine), cartilage hydrolysate (source of chondroitin).
*L.I.P.: selected, high-quality proteins, easily digestible, with high biological value.

Additives:

Nutritional additives: vitamin A (16,500 IU/kg), vitamin D3 (1,100 IU/kg), vitamin E (340 mg/kg), E1 (35 mg/kg), E2 (3.5 mg/kg), E4 (11 mg/kg), E5 , E6 (128 mg/kg), E8 (0.06 mg/kg).
Technological additives: Clinoptilolite of sedimentary origin (10 g/kg).
Sensory additives: Yucca extract (125 mg/kg). Preservatives: Antioxidants.

Analysis

protein	31.0 %
fat	16.0 %
fiber	1.3 %
ash	7.4 %
calcium	1.26 %
phosphorus	1.0 %
L-carnitine	300.0 mg/kg

Feeding recommendation

Age in months	Adult weight 45 kg	Adult weight 60 kg	Adult weight 75 kg	Adult weight 90 kg	Adult weight 100 kg
8	593 g	741 g	877 g	1005 g	1087 g
9	554 g	697 g	873 g	1004 g	1087 g
10	518 g	654 g	823 g	963 g	1042 g
11	473 g	610 g	770 g	910 g	985 g
12	431 g	571 g	717 g	863 g	936 g
13	428 g	535 g	674 g	812 g	879 g
14	424 g	532 g	632 g	764 g	827 g
18	Giant Adult	526 g	626 g	720 g	779 g
24	Giant Adult	Giant Adult	Giant Adult	Giant Adult	Giant Adult

Delivery in 3-6 days

Royal Canin Maxi Puppy Dry Dog Food

From 123,49 lei

One type of food does not suit all dogs. That's why, when creating recipes, Royal Canin takes into account the specific needs for each age, breed, size, activity level, and lifestyle. Large breed puppies need food adapted to specific requirements. Why? Large breed dogs go through a long growth period during which they are sensitive to feeding errors. Especially too high a caloric intake can lead to accelerated growth. This can cause irreparable damage to the bone structure. Therefore, a diet with a high energy content should be avoided during the growth period.

Only special food that satisfies their moderate energy needs can be suitable for this type of puppy. Royal Canin Maxi Puppy food for large breed puppies (26 - 44 kg) up to 15 months is formulated to provide the correct balance of energy and nutrition for your puppies' size, breed, and activity level. The combination of nutrients supports digestive safety through highly digestible L.I.P. proteins and ensures balanced intestinal flora thanks to FOS and MOS prebiotics. Additionally, the antioxidant complex strengthens their immune system, and the balanced content of minerals and energy contributes to proper bone mineralization.

Ingredients: poultry protein (dried), rice, corn flour, vegetable protein isolate*, animal fat, wheat flour, animal protein (hydrolyzed), beet pulp, corn gluten, minerals, vegetable fibers, soybean oil, fructo-oligosaccharides (0.34 %), psyllium husks and seeds, yeast hydrolysate , yeast extracts , marigold extract , crustacean hydrolysate , cartilage hydrolysate .
* L.I.P.: specially selected, easily digestible proteins with high biological value.

Additives:

Nutritional additives:
Vitamin A (15,500 IU/kg), Vitamin D3 (1,000 IU/kg), Vitamin E (480 mg/kg), E1 (42 mg/kg), E2 (4.2 mg/kg), E4 (13 mg/kg), E5 , E6 (132 mg/kg), E8 (0.07 mg/kg).
Technological additives:
Clinoptilolite of sedimentary origin (10 g/kg).
Sensory additives:
Yucca extract (125 mg/kg).Preservatives: Antioxidants.

Analysis

protein	30.0 %
fat	16.0 %
fiber	2.4 %
ash	7.7 %

Feeding recommendation

Age in months	26 kg	30 kg	35 kg	40 kg	44 kg
2 months	266 g	276 g	288 g	300 g	309 g
3 months	329 g	346 g	367 g	389 g	406 g
4 months	357 g	377 g	402 g	428 g	448 g
5 months	383 g	416 g	457 g	498 g	531 g
6 months	407 g	453 g	508 g	561 g	603 g
8 months	377 g	422 g	474 g	528 g	600 g
10 months	321 g	358 g	404 g	461 g	523 g
12 months	290 g	323 g	365 g	405 g	436 g
14 months	288 g	320 g	360 g	398 g	429 g
15 months	288 g	320 g	360 g	398 g	429 g
16 months	Maxi Adult	Maxi Adult	Maxi Adult	Maxi Adult	Maxi Adult

Delivery in 3-6 days

Zerokeet Ectoparasite Control, 100 ml

35,00 lei

Delivery in 3-6 days

Nexgard Spectra S (3.5 - 7.5 kg), 3 tablets

169,13 lei

QUALITATIVE AND QUANTITATIVE COMPOSITION

Each chewable tablet contains:

Active substances:

NEXGARD SPECTRA

Afoxolaner

(mg)

Milbemycin oxime (mg)

chewable tablets for dogs weighing 3.5-7.5 kg

18.75

3.75

PHARMACEUTICAL FORM

Chewable tablets.

Red to reddish-brown mottled, round (tablets for dogs weighing 2-3.5 kg) or rectangular (tablets for dogs weighing > 3.5-7.5 kg, tablets for dogs weighing > 7.5-15 kg, tablets for dogs weighing > 15-30 kg, and tablets for dogs weighing > 30-60 kg) tablets.

CLINICAL PARTICULARS

Target species: Dogs

Indications for use, specifying the target species

For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is indicated.

Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.

Fleas and ticks must attach to the host and commence feeding to be exposed to the active substance.

Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancyclostoma caninum and Ancyclostoma braziliense) and whipworms (Trichuris vulpis).

Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.

Contraindications: Do not use in cases of hypersensitivity to the active substances or to any of the excipients.

Special warnings for each target species

Parasites must commence feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.

Resistance of parasites to a particular class of antiparasitic medicinal product may develop following frequent use of a compound from that class. Therefore, the use of this product should be based on an assessment of each individual case and on local epidemiological information about the current susceptibility of the target species to limit the possibility of future selection for resistance.

Maintaining the efficacy of macrocyclic lactones is essential for the control of Dirofilaria immitis. To minimise the risk of resistance selection, it is recommended to test dogs for circulating antigens and blood microfilariae at the start of each preventative treatment period.

Only negative animals should be treated.

Special precautions for use

Special precautions for use in animals

In the absence of available data, treatment of puppies younger than 8 weeks of age and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinarian.

Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administration of NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.

The recommended dose must be strictly followed in Collie dogs or other related breeds.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

This product may cause gastrointestinal disturbances if ingested.
Keep tablets in blisters and the blister in the carton until use.
In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label to the physician.
Wash hands after use.

Adverse reactions (frequency and seriousness)

In clinical studies, no serious adverse reactions were attributed to the combination of afoxolaner and milbemycin oxime. Infrequent reactions such as vomiting, diarrhoea, lethargy, anorexia, and pruritus were observed. These reactions generally resolved spontaneously and were of short duration.

The frequency of adverse reactions is defined using the following convention:

- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)

- Common (more than 1 but less than 10 animals in 100 animals)

- Uncommon (more than 1 but less than 10 animals in 1,000 animals)

- Rare (more than 1 but less than 10 animals in 10,000 animals)

- Very rare (less than 1 animal in 10,000 animals, including isolated reports).

Use during pregnancy, lactation or lay

Laboratory studies conducted on rats and rabbits have not shown any teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinarian.

Interactions with other medicinal products and other forms of interaction

Milbemycin oxime is a substrate of P-glycoprotein (P-gp), thus it may interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.

Amounts to be administered and administration route

For oral administration.

Dosage:

The product should be administered at a dose of 2.50-5.36 mg/kg afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight according to the following table:

Dog weight (kg)	Concentration and number of chewable tablets to be administered
Dog weight (kg)	NEXGARD SPECTRA 9 mg/ 2 mg	NEXGARD SPECTRA 19 mg/ 4 mg	NEXGARD SPECTRA 38 mg/ 8 mg	NEXGARD SPECTRA 75 mg/ 15 mg	NEXGARD SPECTRA 150 mg/ 30 mg
2-3.5	1
>3.5-7.5		1
>7.5-15			1
>15-30				1
>30-60					1

For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.

Method of administration:

The tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.

Treatment regimen:

The treatment regimen should be based on the veterinary diagnosis and the local epidemiological situation.

NEXGARD SPECTRA can be used as seasonal preventative treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.

Disease: Heartworm disease:

NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after their transmission by mosquitoes, therefore the product must be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should continue until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.

If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should start on the day the previous medication was due to be administered.

Dogs living in or having travelled to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs 8 months of age or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.

Overdose (symptoms, emergency procedures, antidotes), if applicable

No adverse reactions were observed in healthy puppies older than 8 weeks after 6 treatments with 5 times the maximum dose.

Withdrawal periods: Not applicable.

PHARMACOLOGICAL PROPERTIES

Pharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.

ATC veterinary code: QP54AB51

Pharmacodynamic properties

Afoxolaner:

Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.

Afoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of insect/mite GABA receptors versus those of mammals.

Afoxolaner is active against adult fleas as well as some tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.

The product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).

Milbemycin oxime:

Milbemycin oxime is an endectocidal antiparasitic belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A₄and milbemycin A₃ (in a 20:80 ratio for A₃:A₄). It is isolated from the fermentation of Streptomyces milbemycinicus.

Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-gated chloride ion channels (related to GABA and glycine receptors in vertebrates).

This leads to hyperpolarisation of the neuromuscular membrane and to the paralysis and death of the parasites.

Pharmacokinetic particulars

Afoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (C_max) was 1822 ± 165 ng/ml, at 2-4 hours (T_max) after a dose of 2.5 mg/kg afoxolaner.

The volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.

Plasma concentrations of Milbemycin oxime increase rapidly within the first 1-2 hours (T_max) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A₃ and 65% for A₄ respectively. The mean maximum plasma concentration (C_max), after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A₃, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A₄.

The volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for form A₃ and A₄ respectively. Both forms have a low clearance value of 75 ± 22 ml/h/kg for A₃ and 41 ± 12 ml/h/kg for A₄.

PHARMACEUTICAL PARTICULARS

List of excipients

Maize starch
Soy protein
Braised beef flavour
Povidone (E1201)
Macrogol 400
Macrogol 4000
Macrogol 15 hydroxystearate
Glycerol (E422)
Medium-chain triglycerides
Citric acid monohydrate (E330)
Butylhydroxytoluene (E321)

Incompatibilities: Not applicable.

Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years

Special precautions for storage: Keep the blister in the outer carton to protect from light.

Nature and composition of primary packaging

This veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).

1 carton box containing one blister with 1, 3 and 6 chewable tablets.

Not all package sizes may be marketed.

Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.

Delivery in 3-6 days

Advocate 250 Caine (10 - 25 kg), 3 pipete

Advocate 250 Dog (10 - 25 kg), 3 pipettes

333,00 lei

Advocate 250 Dogs (10 - 25 kg), 3 pipettes

Chemical composition:

Imidacloprid : 100mg/ml
Moxidectin: 25mg/ml

Pharmaceutical form:

Antiparasitic solution for cutaneous application.

Indications:

for the treatment and prevention of flea infestations (Ctenocephalides spp.).

reduces the incidence of flea allergy dermatitis.
larval stages are killed on the animal and in the surrounding environment of treated animals.

for the prevention of heartworm infestations (Dirofilaria immitis)

for the treatment and control of:

roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).

hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.

whipworms Trichuris vulpis.

generalized demodicosis Demodex canis.

sarcoptic mange Sarcoptes scabiei.

ear mites Otodectes cynotis.

lice Trichodectes canis, Linognathus setosus for 6 weeks.

Dosage and administration:

For dogs between 10 -25 kg, one tube of Advocate 250 is used.
Administration is done in the dorsal area at the base of the neck for small dogs, and for larger dogs, it can be done in several places along the back.
The product is applied to the skin, keeping it away from the dog's mouth or eyes.
The dog's skin must be intact and free of lesions.
It can be administered to pregnant or lactating bitches.
The product retains its efficacy after bathing or exposure to rain.
To reduce re-infestations with new fleas, it is recommended to treat all dogs in a family (household). Other pets in the same family or household should be treated with appropriate products.

Contraindications:

Not for use in cats.
Not for use in puppies under 7 weeks of age.

Other information:

to prevent heartworm infestation, it is advisable to start treatment one month before the mosquito season begins (the host that transmits the larvae) and continue once a month until the mosquito season passes.
for tapeworms, it is advisable to use internal antiparasitics as ADVOCATE does not act on them but only on roundworms and hookworms.
for demodicosis, 2 to 4 monthly treatments are required for beneficial effects.
for mange (ear, sarcoptic), a single treatment is necessary for complete elimination of parasites and signs of disease.

Important: Advocate 250 falls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication, or diet according to the specific needs of your dog (cat).

Delivery in 3-6 days

Mancare uscata pentru caini, Brit Premium By Nature, Light, 3 Kg

Dry food for dogs, Brit Premium By Nature, Light, 3 Kg

48,67 lei

Delivery in 3-6 days

Mancare uscata pentru caini, Brit Premium By Nature, Adult S, 1 Kg

Mancare uscata pentru caini, Brit Premium By Nature, Adult S, 3 Kg

Dry dog food, Brit Premium By Nature, Adult S

From 24,69 lei

Brit Premium by Nature Adult S is a complete premium food, specially designed for small breed dogs (1-10 kg), with a high content of nutrients (50% meat) and an exceptional taste, due to plant and fruit extracts, which will satisfy even the most demanding dog.

Composition: chicken 50 % (dehydrated 30 %, deboned 20 %), oats, wheat, chicken fat (preserved with tocopherols), corn, dried apples, salmon oil (2 %), hydrolyzed chicken liver, brewer's yeast, collagen, crustacean shells (a source of glucosamine, 210 mg/kg), cartilage (a source of chondroitin, 150 mg/kg), herbs and fruits (cloves, citrus, rosemary, turmeric, 120 mg/kg), mannan-oligosaccharides (120 mg/kg), fructo-oligosaccharides (90 mg/kg), Mojave yucca (90 mg/kg), dried chamomile (80 mg/kg), green-lipped mussels (a source of glycosaminoglycan (50 mg/kg), dried blueberries (50 mg/kg).

Feeding guide: The food can be served dry or moistened in a little warm water. Small breeds need a higher energy intake, but have a smaller digestive tract and stomach. Taking this into account, the recommended daily amount shown in the feeding chart should be divided into 2-3 equal portions throughout the day.

The recommended daily amounts are presented in the feeding chart. When serving Brit Premium for the first time, use smaller amounts and mix with the previous food; then gradually increase the portion of Brit Premium. Always ensure your dog has fresh drinking water.

Analytical constituents: crude protein 28.0 %, fat content 16.0 %, moisture 10.0 %, crude ash 7.2 %, crude fibre 2.5 %, calcium 1.5 %, phosphorus 1.1 %, omega-3 0.2 %, omega-6 1.85 %.

Nutritional additives per kg: vitamin A (3a672a) 15,000 IU, vitamin D3 (E671) 1,000 IU, vitamin E (α-tocopherol) (3a700) 400 mg, biotin (3a880) 0.5 mg, choline chloride (3a890) 500 mg, zinc chelate of amino acids hydrate (3b606) 70 mg, ferrous chelate of amino acids, hydrate (E1) 60 mg, manganese chelate of amino acids, hydrate (E5) 30 mg, potassium iodide (3b201) 0.5 mg, cupric chelate of amino acids, hydrate (E4) 12 mg, organic form of selenium produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU approved antioxidants: tocopherol extract from vegetable oils (1b306), ascorbyl palmitate (1b304) & rosemary extract.

Metabolizable energy: 3,820 kcal/kg. Best before the date printed on the packaging. Store in a cool, dry place, away from direct sunlight. Reseal after opening.

Feeding chart: