Tris Nac, 120 ml
146,83 lei
Unit price perTris-NAC® is an innovative, synergistic combination of NAC and Tris-EDTA. It is used to prevent the formation of bacterial biofilm. Where this biofilm is already present, TRIS-NAC acts to destroy it!
Target species: dogs, cats
Description:
What is a biofilm?
An aggregate of cells embedded in an extracellular matrix of polymeric substances, which protects it from antibiotics, chemical products, and the body's immune processes. It can form on medical instruments as well as on animal tissue.
This aspect causes resistance to antibiotic therapy; in fact, bacteria in the biofilm can be 100-1000 times more resistant compared to "free" bacteria.
There are bacteria that can produce biofilms, including: Staphylococcus pseudintermedius, Pseudomonas
aeruginosa (particularly in cases of otitis in dogs, Figs. 1 and 2), Proteus Mirabilis, Escherichia coli. In the case of yeasts, Malassezia spp. is the one that can produce biofilm, especially in seborrheic dermatitis in dogs.
Treatment: topical therapy is the most innovative and involves both the use of effective substances and their combination to achieve a synergistic effect.
Tris-EDTA (Ethylenediaminetetraacetic Acid)
Bactericidal effect on bacteria that do not grow inside the biofilm (Ciofu et al, 2017); associated with Tromethamine (Tris), it destroys the bacterial cell walls and increases membrane penetration; it is very well tolerated, non-ototoxic and acts synergistically with chlorhexidine (Guardabassi et al, 2010); recently an in-vitro study demonstrated that Tris-EDTA in combination with antibiotics is a very effective support in cases of chronic otitis with Pseudomonas with hypothetical presence of biofilms (Pye et al, 2014).
NAC (N-acetylcysteine)
N-acetyl is a derivative of the amino acid cysteine, has mucolytic action, preventing the production of exopolysaccharides and thus weakening the EPS matrix. It has recently been used in eight clinical studies as supportive treatment to destroy mature biofilm and prevent its formation, proving a safe profile with excellent efficacy. The association of Tris-EDTA and NAC on the skin and in the ear before applying topical treatments such as chlorhexidine, antibiotics and synthetic antimicrobial peptides, allows increasing the permeability of mature biofilm and consequently its disintegration, thus solving the problem of bacterial resistance to classic treatments.
Storage conditions:
Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C.
Valid after unsealing: 50 days
Additional information:
- For topical use. Do not administer orally!
- Keep the bottle at room temperature, away from direct sunlight.
- Keep out of reach of children.
- After emptying, comply with current legislation for waste disposal.
Tris Nac, 120 ml
146,83 lei
Unit price perIn stock
Tris-NAC® is an innovative, synergistic combination of NAC and Tris-EDTA. It is used to prevent the formation of bacterial biofilm. Where this biofilm is already present, TRIS-NAC acts to destroy it!
Target species: dogs, cats
Description:
What is a biofilm?
An aggregate of cells embedded in an extracellular matrix of polymeric substances, which protects it from antibiotics, chemical products, and the body's immune processes. It can form on medical instruments as well as on animal tissue.
This aspect causes resistance to antibiotic therapy; in fact, bacteria in the biofilm can be 100-1000 times more resistant compared to "free" bacteria.
There are bacteria that can produce biofilms, including: Staphylococcus pseudintermedius, Pseudomonas
aeruginosa (particularly in cases of otitis in dogs, Figs. 1 and 2), Proteus Mirabilis, Escherichia coli. In the case of yeasts, Malassezia spp. is the one that can produce biofilm, especially in seborrheic dermatitis in dogs.
Treatment: topical therapy is the most innovative and involves both the use of effective substances and their combination to achieve a synergistic effect.
Tris-EDTA (Ethylenediaminetetraacetic Acid)
Bactericidal effect on bacteria that do not grow inside the biofilm (Ciofu et al, 2017); associated with Tromethamine (Tris), it destroys the bacterial cell walls and increases membrane penetration; it is very well tolerated, non-ototoxic and acts synergistically with chlorhexidine (Guardabassi et al, 2010); recently an in-vitro study demonstrated that Tris-EDTA in combination with antibiotics is a very effective support in cases of chronic otitis with Pseudomonas with hypothetical presence of biofilms (Pye et al, 2014).
NAC (N-acetylcysteine)
N-acetyl is a derivative of the amino acid cysteine, has mucolytic action, preventing the production of exopolysaccharides and thus weakening the EPS matrix. It has recently been used in eight clinical studies as supportive treatment to destroy mature biofilm and prevent its formation, proving a safe profile with excellent efficacy. The association of Tris-EDTA and NAC on the skin and in the ear before applying topical treatments such as chlorhexidine, antibiotics and synthetic antimicrobial peptides, allows increasing the permeability of mature biofilm and consequently its disintegration, thus solving the problem of bacterial resistance to classic treatments.
Storage conditions:
Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C.
Valid after unsealing: 50 days
Additional information:
- For topical use. Do not administer orally!
- Keep the bottle at room temperature, away from direct sunlight.
- Keep out of reach of children.
- After emptying, comply with current legislation for waste disposal.
