Sort by:
2745 products
2745 products
Vom Feinsten Junior offers the promise of delicious, healthy, and balanced nutrition of the highest quality for a dog's growth in the first year of life. This delicious pâté is specially adapted to the nutritional requirements of junior dogs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 63% meat and animal derivatives (30% beef, pork, 10% poultry), minerals.
- Protein: 11%
- Fat: 7%
- Crude fiber: 0.4%
- Crude ash: 1%
- Moisture: 80%
Feeding recommendations:
Age (Weeks) Weight Food quantity
10 0.9 kg 165 g
20 1.8 kg 200 g
> 30 2.55 kg 235 g
Metabolizable energy 0.43 MJ / 100g
Vom Feinsten Adult offers you the promise of delicious, healthy, and balanced nutrition of the highest quality for adult dogs aged 1 to 6 years. The careful selection and quality of meaty ingredients guarantee a unique culinary delight. This fine pâté provides all the essential nutrients an adult dog needs.
Composition: 63% meat and animal derivatives (pork, beef, poultry, 14% venison), minerals.
Ingredient Analysis:
| Proteins | 10.5 % |
| Fats | 4.5 % |
| Fibers | 0.4 % |
| Ash | 2.5 % |
| Moisture | 81 %. |
Feeding recommendation:
| Weight | g per day |
|---|---|
| 2 - 3 kg | 220 - 300 g |
| 5 - 10 kg | 440 - 750 g |
Metabolizable energy per 100g in MJ: 0.36
Nutritional additives per kilogram
- 150 IU 3a671
- 1 mg 3b406
- 26 mg 3b605
- 1.7 mg 3b503
- 0.4 mg 3b202
Other information:
- Contains drinking water. Drinking water is not a feed material and therefore cannot be listed in the declaration.
- Minerals are essential inorganic nutrients. A distinction is made between bulk and trace elements. Bulk elements occur in quantities over 50 mg / kg body weight; trace elements are below this level.
Vom Feinsten Junior offers the promise of delicious, healthy, and balanced nutrition at the highest quality level for a dog's growth in the first year of life. This delicious pâté is specially adapted to the nutritional requirements of junior dogs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 63% meat and animal derivatives (30% beef, pork, 10% poultry meat), minerals.
- Protein: 11%
- Fat: 7%
- Crude fiber: 0.4%
- Crude ash: 1%
- Moisture: 80%
Feeding recommendations:
Age (Weeks) Weight Food Quantity
10 0.9 kg 165 g
20 1.8 kg 200 g
> 30 2.55 kg 235 g
Metabolizable energy 0.43 MJ / 100g
Vom Feinsten Junior offers the promise of delicious, healthy, and balanced nutrition at the highest quality level for a dog's growth in the first year of life. This delicious pâté is specially adapted to the nutritional requirements of junior dogs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 63% meat and animal derivatives (20% poultry, pork, beef, 8% turkey heart), minerals.
- Protein: 11%
- Fat: 7%
- Crude fiber 0.4%
- Crude ash: 1%
- Moisture: 80%
Feeding recommendations:
Age (Weeks) Weight Food quantity
10 0.9 kg 165 g
20 1.8 kg 200 g
> 30 2.55 kg 235 g
Metabolizable energy 0.43 MJ / 100g
Vom Feinsten Junior offers the promise of delicious, healthy, and balanced nutrition at the highest quality level for puppy growth during the first year of life. This delicious pâté is specially adapted to the nutritional requirements of junior dogs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 63% meat and animal derivatives (pork, beef, poultry liver 15%), minerals.
- Protein: 11%
- Fat: 7%
- Crude fiber 0.5%
- Crude ash: 1%
- Moisture: 80%
Feeding recommendations:
Age (Weeks) Weight Food quantity
10 0.9 kg 165 g
20 1.8 kg 200 g
> 30 2.55 kg 235 g
Metabolizable energy 0.43 MJ / 100g
Vom Feinsten Adult offers you the promise of delicious, healthy, and balanced nutrition at the highest quality level for adult dogs aged 1 to 6 years. The careful selection and quality of meaty ingredients guarantee a unique culinary delight. This fine pâté provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 63% meat and animal derivatives (25% turkey, beef, pork, 8% lamb), minerals.
- Protein: 10.5%
- Fat: 4.5%
- Crude fiber 0.4%
- Crude ash: 2.5%
- Moisture: 81%
Feeding recommendations:
dog weight low activity high activity
3 kg 260 g 300 g
5 kg 380 g 440 g
10 kg 640 g 740 g
Metabolizable energy 0.36 MJ / 100g
GranCarno® Original Adult provides delicious, healthy, and balanced nutrition of the highest standard for adult dogs aged 1 to 6 years. Fresh, meat-based ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult supplies all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 41% beef (heart, meat, liver, udder, kidney), 27% lamb (lung, liver, liver), calcium carbonate.
- Protein: 11%
- Fat: 8.5%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 77%
Feeding recommendations:
Dog weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
GranCarno Senior represents delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 7 and over. Selected fresh and meaty ingredients guarantee the incomparable taste that dogs appreciate so much. GranCarno Senior provides all the essential nutrients a senior dog needs and is specially adapted to the particular requirements of older dogs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 41% beef (heart, meat, liver, udder, kidney), 27% lamb (lungs, tripe, liver), calcium carbonate.
- Protein: 11%
- Fat: 8.5%
- Crude fiber 0.5%
- Crude ash: 1.8%
- Moisture: 77%
Feeding recommendations:
Dog's weight, low activity, normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
GranCarno® Original Adult offers delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 1 to 6 years. The fresh, meat-based ingredients guarantee the incomparable taste that dogs appreciate so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 68% beef (heart, meat, lung, liver, udder, kidney), calcium carbonate.
- Protein: 11%
- Fat: 8.5%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 78%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
GranCarno® Original Adult provides delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 1 to 6 years. Fresh, meat-based ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 56% beef (meat, liver, lungs, heart, kidneys, udder), 12% duck hearts, calcium carbonate, sodium chloride
- protein 10%
- fat 7%
- fiber 0.5%
- ash 1.8%
- moisture 78%
Feeding recommendations:
Dog's weight high activity low activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
Oncovet I is a food supplement in tablet form, for dogs and cats of all ages. The product is indicated for oncological conditions in pets with nutritional deficiencies that are difficult to compensate. In these cases, the normal functions of the body are severely compromised, requiring an antioxidant and nutritional adjuvant for the elimination of tumor cells.
It is also beneficial during chemotherapy and radiotherapy, as well as before and after surgical operations. Thanks to the included amino acids (L-glutamine), the formula alleviates the side effects of these treatments, strengthens the immune system and reduces the risk of recurrence.
Silymarin, pomegranate extract, green tea and grape seeds have a strong antioxidant and immunomodulatory effect, fighting against free radicals and protecting cells from further damage. It is recommended to combine with Oncovet II.
Composition: Glutamic acid, silymarin, pomegranate, green tea, turmeric, grape seeds, L-selenomethionine, excipients.
Administer 1 tablet/10 kg body weight, twice a day.
Neurovet Antioxidant Supplement for Dogs and Cats, formulated with vitamins and amino acids that protect and strengthen nerve cells.
Neurovet is a supplement with a high content of antioxidants and essential nutrients for pets with neurological problems.
The supplement is especially recommended for elderly animals and aids in recovery after certain neurological pathologies (vestibular disease, disc herniation).
Neurovet is a good adjuvant in the treatment of epilepsy, stress, or behavioral disorders in pets.
The supplement supports mental function and reduces the aging of brain cells.
Ingredients: L-Phenylalanine 75 mg, vitamin B1 (Thiamine) 50 mg, L-carnitine L-tartrate 50 mg, L-Tryptophan 50 mg, vitamin E 50 IU, micronized soy 20 mg, vitamin B6 (Pyridoxine) 20 mg, vitamin B12 (cyanocobalamin) 300 mcg, excipients.
Recommended dosage:
1 tablet / twice a day / 10 kg body weight.
For antioxidant support, the dose can be halved.
CESAR has created a collection of high-quality recipes, for 100% delicious and 100% complete food, that your dog will love... making every meal a truly shared joy.
INGREDIENTS
Composition: meat and animal derivatives (45%, including 4% turkey, 4% beef), cereals, minerals, derivatives of vegetable origin, vegetable protein extracts.
ADDITIVES
Additives per Kg: Nutritional additives: vitamin D3 150 IU, calcium iodate, anhydrous 0.39mg, copper sulphate, pentahydrate 4.1mg, iron sulphate, monohydrate 10mg, manganese sulphate, monohydrate 5.6 mg, zinc sulphate, monohydrate 44.5mg.
ANALYSIS
Analytical constituents (%):
Protein 9,
Fat content 5.5,
Inorganic matter 2,
Crude fiber 0.3,
Moisture 81.
BENEFITS
1. 100% complete, delicious and healthy dog food: for 100% mealtime joy
2. CESAR Classics are those timeless and authentic dog food recipes, lovingly created by Cesar for over 25 years
3. 150g tray, with meat chunks in compact mass or jelly
4. Quality pet food, with carefully selected ingredients
5. Delicious dog food recipes, with no added sugars, no artificial colors or flavors
FEEDING GUIDE
Feeding instructions: feed daily with: 2½ cans for a 5kg dog, 3 cans for a 7kg dog
and 4 cans for a 10kg dog. It is recommended to offer your dog a mix of wet and dry food, proportionally reducing the amount offered of each type of food. Make sure the transition to a new type of food is done gradually. A bowl of fresh water should always be available. Serve at room temperature. Once opened, the product should be stored in the refrigerator.
It is a range of authentic and timeless recipes, lovingly created over 25 years.
Large and tender pieces that will transform every meal for your dog into moments of joy for him... and for you.
And because all CESAR recipes are healthy and provide 100% complete nutrition, your dog can enjoy them whenever you wish.
GranCarno Exotic offers a delicious, healthy, and balanced diet at the highest level for adult dogs aged 1 to 6 years. Unusual food ingredients, such as buffalo, ostrich, or kangaroo, provide a special taste experience and more variety in the bowl. GranCarno Exotic provides all the essential nutrients an adult dog needs.
- 100% fresh ingredients
- Grain-free, soy-free
- No artificial colors and preservatives
Ingredients: Meat and animal derivatives (58% beef, 15% kangaroo), broth, minerals.
- Protein: 10%
- Fat: 7%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 78%
Feeding recommendations:
Dog weight g / day
1 – 4 kg 90 – 250 g
5 kg 300 g
7 kg 375 g
9 kg 500 g
Metabolizable energy 0.46 MJ / 100g
GranCarno® Original Adult provides delicious, healthy and balanced nutrition at the highest level for adult dogs aged 1 to 6 years. The fresh, meat-based ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 58% beef (heart, meat, lung, liver, udder, kidney), 10% rabbit meat, 0.5% parsley.
- Protein: 11%
- Fat: 7.5%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 78%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
INTEGRA PROTECT Sensitive has been specially developed for dogs with food intolerances, whose main symptoms are itching and diarrhea. Strictly limiting the use of animal and vegetable protein sources can help. INTEGRA PROTECT Sensitive contains only two protein sources: lamb and amaranth.
- Only one animal protein source: lamb
- Prevents the formation of kidney stones
- Only one vegetable protein source: amaranth
Ingredients: Lamb (58%), amaranth (2.5%), calcium carbonate, rapeseed oil (0.4%), sodium chloride.
- Protein: 9%
- Fat: 8%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 78%
Feeding recommendations:
Dog weight g / day
3-7 years 200-400 g
12-17 years 600-800g
Metabolizable energy 0.47 MJ / 100g
Medium-sized dogs are often more robust and agile than other dogs. They have a wide range of activities, they can be quiet family dogs or high-performance dogs. Family dogs tend to gain weight and need a carefully measured amount of food, while performance dogs (e.g., hunting or racing dogs) have high energy requirements. Dogs that rummage through bushes, play in the water, etc., need extra protection for their skin and coat.
Medium-sized dogs that spend a lot of time outdoors are more prone to infections and need a strong immune system.
Royal Canin Medium Puppy dry food is designed according to the special characteristics of growing medium-sized dogs (11 - 25 kg) over 2 months old.
Ingredients: poultry protein (dried), animal fats, maize, vegetable protein isolate*, dried beet pulp, whole wheat flour, rice, animal protein (hydrolysed), wheat, maize flour, fish oil, yeast, soya oil, minerals, fructo-oligo-saccharides (0.34 %), yeast hydrolysate (source of mannan-oligosaccharides), yeast extract (source of beta-glucans), marigold meal (source of lutein).
* L.I.P.: specially selected, easily digestible proteins with high biological value.
Additives
-
Nutritional additives:
vitamin A (16,000 IU/kg), vitamin D3 (1,000 IU/kg), vitamin E (520 mg/kg), E1(45 mg/kg), E2 (4.5 mg/kg), E4 (14 mg/kg), E5 (59 mg/kg), E6 (123 mg/kg), E8 (0.08 mg/kg). -
Technological additives:
Clinoptilolite of sedimentary origin (10 g/kg). -
Sensory additives:
Yucca extract (125 mg/kg). Preservatives, antioxidants.
Analysis
| protein | 32.0 % |
| fat | 20.0 % |
| fibre | 1.6 % |
| ash | 7.9 % |
Feeding recommendation
| Age in months | 11 kg | 14 kg | 18 kg | 22 kg | 25 kg |
| 2 months | 155 g | 184 g | 217 g | 237 g | 244 g |
| 3 months | 182 g | 216 g | 259 g | 288 g | 300 g |
| 4 months | 194 g | 232 g | 279 g | 311 g | 325 g |
| 5 months | 197 g | 236 g | 285 g | 324 g | 347 g |
| 6 months | 197 g | 236 g | 285 g | 332 g | 366 g |
| 8 months | 159 g | 204 g | 247 g | 298 g | 330 g |
| 10 months | 141 g | 169 g | 205 g | 239 g | 264 g |
| 12 months | Medium Adult | Medium Adult | 202 g | 235 g | 261 g |
| 13 months | Medium Adult | Medium Adult | Medium Adult | Medium Adult | 259 |
Vom Feinsten Adult offers you the promise of delicious, healthy, and balanced nutrition at the highest quality level for adult dogs aged 1 to 6 years. The careful selection and quality of the meaty ingredients guarantee a unique culinary delight. This fine pâté provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 54% turkey, 4% cheese, calcium, sodium chloride.
- Protein: 10.5%
- Fat: 4.5%
- Crude fiber: 0.4%
- Crude ash: 2%
- Moisture: 81%
Feeding recommendations:
Dog's weight Low activity High activity
3 kg 260 g 300 g
5 kg 380 g 440 g
10 kg 640 g 740 g
Metabolizable energy 0.36 MJ / 100g
INTEGRA PROTECT Sensitive was specially developed for dogs with food intolerances, whose main symptoms are itching and diarrhea. Strict limitation of the use of animal and vegetable protein sources can help. INTEGRA PROTECT Sensitive contains only two protein sources: chicken and parsnip.
- Multifunctional: prevention of food intolerances and kidney stones.
- One single animal protein source: chicken
- One single vegetable protein source: parsnip
Ingredients: Chicken (60%), parsnip (5%), calcium carbonate, rapeseed oil (0.5%), sodium chloride.
- Protein: 9.5%
- Fat: 6%
- Crude fiber: 0.8%
- Crude ash: 1.8%
- Moisture: 80%
Feeding recommendations:
Cat's weight g / day
2-5 kg 195 to 385 g
6-9 kg 440 to 600 g
Metabolizable energy 0.39 MJ / 100g
Vom Feinsten Senior offers the promise of delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 7 and over. The careful selection and quality of meat ingredients ensure a unique culinary delight. This fine pâté provides all essential nutrients needed by a senior dog and is specially adapted to the particular requirements of older dogs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 63% meat and animal derivatives (30% poultry, beef, pork, 8% lamb), minerals.
- Protein: 9.5%
- Fat: 4%
- Crude fiber: 0.5%
- Crude ash: 2%
- Moisture: 82%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 235 g 275 g
5 kg 345 g 400 g
10 kg 580 g 680 g
Metabolizable energy 0.33 MJ / 100g
GranCarno® Original Adult provides delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 1 to 6 years. Fresh, meat-based ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: Beef 38% (lung, meat, liver, kidney, udder, heart), 18% chicken (heart, neck, stomach), 6% turkey hearts, 6% game meat, calcium carbonate.
- Protein: 11%
- Fat: 8.5%
- Crude fiber 0.5%
- Crude ash: 1.8%
- Moisture: 77%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
GranCarno® Original Adult provides delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 1 to 6 years. Fresh, meat-based ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 38% beef (lung, meat, liver, kidney, udder, heart), 18% chicken (heart, neck, stomach), 6% turkey hearts, 6% game meat, calcium carbonate.
- Protein: 11%
- Fat: 8.5%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 77%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
GranCarno® Original Adult provides delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 1 to 6 years. Fresh meat ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 52% beef (lungs, heart, liver, meat, udder, kidneys), 12% salmon, 4% spinach, calcium carbonate.
- Protein: 11%
- Fat: 8.5%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 78%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
QUALITATIVE AND QUANTITATIVE COMPOSITION
Each chewable tablet contains:
Active substances:
|
NEXGARD SPECTRA |
Afoxolaner (mg) |
Milbemycin oxime (mg) |
| chewable tablets for dogs 7.5-15 kg | 150.00 | 30.00 |
PHARMACEUTICAL FORM
Chewable tablets.
Mottled red to reddish-brown tablets, round (tablets for
dogs 2-3.5 kg) or rectangular (tablets for dogs > 3.5-7.5 kg, tablets for dogs > 7.5-15 kg, tablets for dogs > 15-30 kg and tablets for dogs > 30-60 kg).
CLINICAL PARTICULARS
Target species: Dogs
Indications for use, specifying the target species
For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is indicated.
Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.
Fleas and ticks must attach to the host and commence feeding to be exposed to the active substance.
Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancyclostoma caninum and Ancyclostoma braziliense) and whipworms (Trichuris vulpis).
Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.
Contraindications: Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
Parasites need to start feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.
Resistance of parasites to any particular class of antiparasitic medicinal products may develop following frequent, repeated use of a compound of that class. Therefore, the use of this product should be based on an individual case assessment and local epidemiological information about the current susceptibility of the target species to limit the possibility of future selection of resistance.
Maintaining the efficacy of macrocyclic lactones is essential for the control of Dirofilaria immitis. To minimise the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the start of each preventative treatment period.
Only negative animals should be treated.
Special precautions for use
Special precautions for use in animals
In the absence of available data, treatment of puppies younger than 8 weeks and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinarian.
Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administration of NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.
The recommended dose should be strictly followed in Collie breed dogs or other related breeds.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
- This product, if ingested, can cause gastrointestinal disturbances.
- Keep the tablets in the blister and the blister in the carton until use.
- In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label to the physician.
- Wash hands after use.
Adverse reactions (frequency and seriousness)
In clinical studies, no serious adverse reactions attributable to the combination of afoxolaner with milbemycin oxime were observed. Less common reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus have been observed. These reactions generally resolved spontaneously and were of short duration.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- Common (more than 1 but less than 10 animals in 100 animals)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals)
- Rare (more than 1 but less than 10 animals in 10,000 animals)
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Laboratory studies in rats and rabbits have not shown any teratogenic effects or any negative effects on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or in breeding dogs. Use only according to the benefit-risk assessment by the veterinarian.
Interactions with other medicinal products and other forms of interaction
Milbemycin oxime is a substrate of P-glycoprotein (P-gp), and thus may interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.
Amounts to be administered and administration route
For oral administration.
Dosage:
The product should be administered at a dose of 2.50-5.36 mg/kg afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight according to the following table:
| Dog weight (kg) | Concentration and number of chewable tablets to be administered | ||||
|
NEXGARD SPECTRA 9 mg/ 2 mg |
NEXGARD SPECTRA 19 mg/ 4 mg |
NEXGARD SPECTRA 38 mg/ 8 mg |
NEXGARD SPECTRA 75 mg/ 15 mg |
NEXGARD SPECTRA 150 mg/ 30 mg |
|
|
2-3.5 |
1 |
|
|
|
|
|
>3.5-7.5 |
|
1 |
|
|
|
|
>7.5-15 |
|
|
1 |
|
|
|
>15-30 |
|
|
|
1 |
|
|
>30-60 |
|
|
|
|
1 |
For dogs over 60 kg body weight, the appropriate combination of chewable tablets should be used.
Method of administration:
The tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly, they can be administered with food.
Treatment regimen:
The treatment regimen should be based on the veterinary diagnosis and local epidemiological situation.
NEXGARD SPECTRA can be used as seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.
Disease: Heartworm disease:
NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after their transmission by mosquitoes, so the product should be administered at regular monthly intervals throughout the vector season, starting the month after the first exposure to mosquitoes. Treatment should continue until the month following the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.
If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.
Dogs living in or travelling to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs aged 8 months or older, living in heartworm endemic areas, be tested for adult heartworm infestation before being treated with a heartworm prevention product.
Overdose (symptoms, emergency procedures, antidotes), if applicable
No adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.
Withdrawal period: Not applicable.
PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.
Veterinary ATC code: QP54AB51
Pharmacodynamic properties
Afoxolaner:
Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.
Afoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of insect/mite GABA receptors versus those of mammals.
Afoxolaner is active against adult fleas as well as several tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.
The product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Milbemycin oxime:
Milbemycin oxime is an endectocidal antiparasitic belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a ratio of 20:80 for A3:A4). It is isolated from the fermentation of Streptomyces milbemycinicus.
Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (linked to GABA and glycine receptors in vertebrates).
This leads to hyperpolarisation of the neuromuscular membrane and paralysis and death of the parasites.
Pharmacokinetic particulars
Afoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (Cmax) was 1822 ± 165 ng/ml, at 2-4 hours (Tmax) after a dose of 2.5 mg/kg afoxolaner.
The volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.
Milbemycin oxime plasma concentrations rise rapidly within the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4, respectively. The mean maximum plasma concentration (Cmax) after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A4.
The volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for A3 and A4, respectively. Both forms have low clearance values of 75 ± 22 ml/h/kg for A3 and 41 ± 12 ml/h/kg for A4.
PHARMACEUTICAL PARTICULARS
List of excipients
- Corn starch
- Soy protein
- Braised beef flavour
- Povidone (E1201)
- Macrogol 400
- Macrogol 4000
- Macrogol 15 hydroxystearate
- Glycerol (E422)
- Medium chain triglycerides
- Citric acid monohydrate (E330)
- Butylhydroxytoluene (E321)
Incompatibilities: Not applicable.
Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Special precautions for storage: Keep the blister in the secondary packaging to protect from light.
Nature and composition of primary packaging
This veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).
1 cardboard box containing one blister with 1, 3 and 6 chewable tablets.
Not all package sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from the use of such products should be disposed of in accordance with local requirements.
Folrex Pets Anti-inflammatory Supplement for Dogs and Cats, indicated in the therapy of dysplasia and osteoarthritis, for pain and inflammation relief.
Folrex Pets is a natural supplement that helps restore mobility and improves quality of life.
The supplement has an analgesic effect, without side effects, and has chondroprotective action, being indicated for pain control after orthopedic surgeries.
Folrex Pets can be administered long-term to pets, regardless of their age.
It is a good adjuvant in the therapy for arthritis, osteoarthritis, and dysplasia, being a supplement without contraindications.
Ingredients: hydrolyzed chitin 18 g, maltodextrin 0.15 g.
Nutritional additives: arginine 1.5 g, folic acid 0.99 mg, L-cysteine 0.75 g, liver flavor 0.6 g, potassium sorbate 0.3 g, sodium benzoate 0.3 g, water q.s.ad 150 ml.
Analytical constituents: protein 5.7g, carbohydrates 3.3 g, fat 0.23 g. Energy 38Kcal (159.1 Kj).
Recommended dosage:
Apply to the daily food portion.
Dogs and cats: 1 ml/ every 5 kg animal weight/ every 12 hours.
For other animal species 1 ml twice/ day.
The correct dosage and administration period depend on the individual needs of the animal and will be determined by a veterinarian.
