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2301 products
2301 products
QUALITATIVE AND QUANTITATIVE COMPOSITION
Each chewable tablet contains:
Active substances:
|
NEXGARD SPECTRA |
Afoxolaner (mg) |
Milbemycin oxime (mg) |
| chewable tablets for dogs 2-3.5 kg | 9.375 | 1.875 |
PHARMACEUTICAL FORM
Chewable tablets.
Mottled red to reddish-brown, round (tablets for dogs 2-3.5 kg) or rectangular (tablets for dogs > 3.5-7.5 kg, tablets for dogs > 7.5-15 kg, tablets for dogs > 15-30 kg and tablets for dogs > 30-60 kg) chewable tablets.
CLINICAL PARTICULARS
Target species: Dogs
Indications for use, specifying the target species
For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is indicated.
Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.
Fleas and ticks must attach to the host and commence feeding to be exposed to the active substance.
Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancylostoma caninum and Ancylostoma braziliense) and whipworms (Trichuris vulpis).
Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.
Contraindications: Do not use in case of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
Parasites must start feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.
Resistance of parasites to any particular class of antiparasitics may develop following frequent, repeated use of a product of that class. Therefore, the use of this product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species to limit the possibility of future resistance selection.
Maintaining the efficacy of macrocyclic lactones is essential for the control of Dirofilaria immitis. To minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.
Only negative animals should be treated.
Special precautions for use
Special precautions for use in animals
In the absence of available data, treatment of puppies younger than 8 weeks of age and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinary surgeon.
Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administering NEXGARD SPECTRA. Infested dogs should be treated with an adulticide chosen by the veterinary surgeon to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.
The recommended dose should be strictly followed for Collie dogs or other related breeds.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
- This product, if ingested, can cause gastrointestinal disturbances.
- Keep the tablets in the blister and the blister in the carton until use.
- In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.
- Wash hands after use.
Adverse reactions (frequency and seriousness)
In clinical studies, no serious adverse reactions were attributed to the combination of afoxolaner with milbemycin oxime. Less frequent reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus were observed. These reactions generally resolved spontaneously and were of short duration.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- Common (more than 1 but less than 10 animals in 100 animals)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals)
- Rare (more than 1 but less than 10 animals in 10,000 animals)
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Laboratory studies in rats and rabbits have not shown any teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinary surgeon.
Interaction with other medicinal products or other forms of interaction
Milbemycin oxime is a substrate of p-glycoprotein (P-gp), and can therefore interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.
Amounts to be administered and administration route
For oral administration.
Dosage:
The product should be administered at a dose of 2.50-5.36 mg/kg afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight in accordance with the following table:
| Dog weight (kg) | Concentration and number of chewable tablets to be administered | ||||
|
NEXGARD SPECTRA 9 mg/ 2 mg |
NEXGARD SPECTRA 19 mg/ 4 mg |
NEXGARD SPECTRA 38 mg/ 8 mg |
NEXGARD SPECTRA 75 mg/ 15 mg |
NEXGARD SPECTRA 150 mg/ 30 mg |
|
|
2-3.5 |
1 |
|
|
|
|
|
>3.5-7.5 |
|
1 |
|
|
|
|
>7.5-15 |
|
|
1 |
|
|
|
>15-30 |
|
|
|
1 |
|
|
>30-60 |
|
|
|
|
1 |
For dogs over 60 kg body weight, the appropriate combination of chewable tablets should be used.
Method of administration:
The tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly, they can be administered with food.
Treatment schedule:
The treatment schedule should be based on the veterinary diagnosis and the local epidemiological situation.
NEXGARD SPECTRA can be used as a seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.
Disease: Heartworm disease:
NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after their transmission by mosquitoes, therefore the product must be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should continue until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.
If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.
Dogs living in or travelling to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs aged 8 months or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.
Overdose (symptoms, emergency procedures, antidotes), if applicable
No adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.
Withdrawal period: Not applicable.
PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.
ATC veterinary code: QP54AB51
Pharmacodynamic properties
Afoxolaner:
Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.
Afoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of insect/mite GABA receptors versus those of mammals.
Afoxolaner is active against adult fleas as well as against some tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.
The product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Milbemycin oxime:
Milbemycin oxime is an antiparasitic endectocide belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a ratio of 20:80 for A3:A4). It is isolated from the fermentation of Streptomyces milbemycinicus.
Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (related to GABA and glycine receptors in vertebrates).
This leads to hyperpolarisation of the neuromuscular membrane and paralysis and death of the parasites.
Pharmacokinetic particulars
Afoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean peak plasma concentration (Cmax) was 1822 ± 165 ng/ml, 2-4 hours (Tmax) after a 2.5 mg/kg afoxolaner dose.
The volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.
Plasma concentrations of Milbemycin oxime increase rapidly in the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4 respectively. The mean peak plasma concentration (Cmax), after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A4.
The volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for A3 and A4 forms respectively. Both forms have a low clearance value of 75 ± 22 ml/h/kg for A3 and 41 ± 12 ml/h/kg for A4.
PHARMACEUTICAL PARTICULARS
List of excipients
- Corn starch
- Soy protein
- Braised beef flavour
- Povidone (E1201)
- Macrogol 400
- Macrogol 4000
- Macrogol 15 hydroxystearate
- Glycerol (E422)
- Medium-chain triglycerides
- Citric acid monohydrate (E330)
- Butylhydroxytoluene (E321)
Incompatibilities: Not applicable.
Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Special precautions for storage: Keep the blister in the secondary packaging to protect from light.
Nature and composition of primary packaging
This veterinary medicinal product is individually packaged in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).
1 cardboard box containing one blister with 1, 3 or 6 chewable tablets.
Not all package sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.
Advocate 40 Dogs (0 - 4 kg), 3 pipettes
Chemical composition:
- Imidacloprid: 100mg/ml
- Moxidectin: 25mg/ml
Pharmaceutical form:
- Antiparasitic solution for cutaneous application.
Indications:
for the treatment and prevention of flea infestations (Ctenocephalides spp.).
- reduces the incidence of flea allergies.
- larval stages are killed on the animal and in the surrounding environment of treated animals.
for the prevention of heartworm infestations (Dirofilaria immitis)
for the treatment and control of:
- roundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).
- hookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.
- whipworms Trichuris vulpis.
- generalized demodicosis Demodex canis.
- sarcoptic mange Sarcoptes scabiei.
- ear mites Otodectes cynotis.
- lice Trichodectes canis. Linognathus setosus for 6 weeks.
Dosage and administration:
- For dogs between 0 - 4 kg, one tube of Advocate 40 is used;
- Administration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be done in several spots along the back.
- The product is applied to the skin, avoiding contact with the dog's mouth or eyes.
- The dog's skin must be intact and free of lesions.
- It can be administered to pregnant or lactating bitches.
- The product retains its effectiveness after bathing or exposure to rain.
- To reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in the same family or household should be treated with appropriate products.
Contraindications:
- Do not use in cats. Do not use in puppies under 7 weeks of age.
Other information:
- for the prevention of heartworm infestation, treatment should begin one month before the mosquito season (the host that transmits the larvae) and continue once a month until the mosquito season passes.
- for tapeworms (cestodes), internal antiparasitics should be used as ADVOCATE does not act on them, only on roundworms and hookworms.
- for demodicosis, 2 to 4 monthly treatments are required for beneficial effects.
- for mange (auricular, sarcoptic), a single treatment is necessary for complete elimination of parasites and signs of disease.
Important: Advocate 40 falls under the pharmacy category. Consult your veterinarian for diagnosis and prescription of medication according to the specific needs of your dog or cat.
Liquid antiparasitic solution for cutaneous application, packaged in single-use pipettes.
PACKAGE LEAFLET FOR Cardboard box with 3 pipettes
Frontline Tri-Act spot-on solution for dogs 2-5 kg
DECLARATION OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS
Spot-on solution.
Clear, colourless to brownish-yellow solution.
Active substances/Excipients:
See section "dosage for each target species"
TARGET SPECIES
Dogs
Caution!!!
Due to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separated from treated dogs until the application site is dry.
It is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.
INDICATION (INDICATIONS)
For the treatment and prevention of flea and/or tick infestations when repellent (anti-feeding) activity against sandflies, stable flies and/or mosquitoes is needed.
For the treatment and prevention of Ctenocephalides felis flea infestations and the prevention of Ctenocephalides canis flea infestations. The product kills C. felis fleas on the animal within 24 hours. A single
treatment prevents a new flea infestation for 4 weeks. The product can be part of a treatment strategy for the control of flea allergy dermatitis if this diagnosis has
been established by a veterinarian.
The product has repellent efficacy against ticks (Dermacentor reticulatus) starting from 7 days and up to 4 weeks after treatment. However, a single tick may attach and detach within the first 24 hours after infestation.
The product has immediate acaricidal efficacy against Rhipicephalus sanguineus and Ixodes ricinus species, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.
The product has persistent acaricidal efficacy against ticks (Ixodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus) for 4 weeks.
The product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (Phlebotomus perniciosus) and for 4 weeks against mosquitoes (Culex pipiens).
The product has persistent insecticidal efficacy against sandflies (Phlebotomus perniciosus) for 3 weeks.
The product repels and kills stable flies (Stomoxys calcitrans) for five weeks.
CONTRAINDICATIONS
Do not use on sick or convalescent animals.
Do not use on cats and rabbits as it may cause adverse reactions and even death.
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
ADVERSE REACTIONS
Among the very rare suspected adverse reactions, transient reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalised pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.
Slight hypersalivation and vomiting may occur if the product is ingested, should the animal lick the application area.
If you notice any serious reactions or other effects not mentioned in this package leaflet, please inform your veterinarian.
DOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION
Topical administration to the skin (spot-on).
The following table defines which pipette should be used depending on the dog's weight:
Active ingredients Excipients
Frontline Tri-Act spot-on solution for dogs Dosed unit volume Fipronil (mg) Permethrin (mg) Butylhydroxytoluene (E321) (mg)
Very small dogs 2-5kg 0.5 33.8 252.4 0.563
Small dogs 5-10kg 1 67.6 504.8 1.125
Medium dogs 10-20kg 2 135.2 1009.6 2.250
Large dogs 20-40kg 4 270.4 2019.2 4.500
XL dogs 40-60kg 6 405.6 3028.8 6.750
Dogs > 60 kg Use the appropriate combination of pipettes
Treatment scheme
The product should be used after confirming infestation or risk of infestation with fleas and/or ticks, concurrently with the need for repellent (anti-feeding) activity against sandflies and/or mosquitoes and/or stable flies.
Depending on the recurrence of the risk of infestation with these ectoparasites, repeated treatment may be established. In these cases, the minimum treatment interval is at least 4 weeks.
ADVICE ON CORRECT ADMINISTRATION
Choose the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg, the necessary combination of pipettes will be used until the appropriate quantity for the dog's weight is reached.
The product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site.
These application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.
Remove the blister foil from the package and peel off a blister. Use scissors to cut the blister along the dotted line to remove the pipette or fold the marked corner and tear open.
Hold the pipette upright, away from your face or body, cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the tip of the pipette on the skin.
Squeeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.
To achieve the best results, make sure you apply the product directly to the skin and not to the fur.
WITHDRAWAL PERIOD
Not applicable
SPECIAL PRECAUTIONS FOR STORAGE
Keep out of the sight and reach of children.
Store in the original packaging.
Do not store above 25 °C
Do not use after the expiry date stated on the packaging after "EXP". The expiry date refers to the last day of that month.
SPECIAL WARNING(S)
Special warnings for each target species
A single tick or a mosquito or sandfly bite may already be attached to the animal. For this reason, the transmission of pathogens by these arthropods cannot be excluded if conditions are favourable.
The product remains effective against fleas when treated animals occasionally enter water (e.g. swimming, bathing). However, dogs should not be allowed to swim and should not be shampooed for 48 hours after treatment.
Avoid frequent swimming or shampooing of treated dogs as this may affect the maintenance of product efficacy.
To reduce re-infestation due to the emergence of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same space should be treated with a veterinary medicinal product suitable for their species.
To reduce the risk of environmental infestation, it is recommended to use additional appropriate environmental treatment
against fleas and their developmental stages.
Special precautions for use in animals
In the absence of specific studies, the use of this product is not recommended for dogs younger than 8 weeks or weighing less than 2 kg.
Avoid contact of the product with the animal's eyes.
It is very important to ensure that the product is applied in an area where the animal cannot lick the product and also to ensure that animals do not lick each other after
treatment.
Due to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separated from treated dogs until the application site is dry.
It is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
For veterinary use only.
This product may cause skin and eye irritation. Therefore, contact of the product with the skin or eyes must be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if the eyes become irritated during product administration, immediate thorough washing with water is recommended. If ophthalmic irritation persists, seek medical advice.
Persons with known hypersensitivity to fipronil and/or permethrin should avoid contact with this product.
The product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during product application. Wash hands after use. In case of ingestion, rinse mouth with water and seek medical advice if you feel unwell.
As the excipient N-methylpyrrolidone can cause fetotoxicity and teratogenicity following prolonged exposure, pregnant women are advised to wear gloves to avoid contact with the product.
Avoid handling the animal until the application site is dry; children should also not play with animals until their fur is dry.
Therefore, it is recommended that animals are not treated during the day but in the evening, and that treated animals sleep alone during the night, not with their owners and especially not with children.
Keep pipettes in the original packaging and, once used, empty pipettes must be disposed of immediately in an appropriate manner to prevent further access.
Other precautions
The product can have harmful effects on aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.
Use during pregnancy and lactation
Laboratory studies with fipronil and permethrin produced no teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.
N-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.
Use only based on a benefit/risk assessment by the veterinarian.
Overdose
Safety of use was evaluated in healthy adult dogs treated with a dose up to 5 times higher than the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Among the known adverse reactions, mild neurological symptoms,
vomiting, and diarrhea may occur. These symptoms are transient and usually disappear without treatment within 1-2 days. Animals should always be treated with the pipette corresponding to their weight.
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIAL, IF APPLICABLE
Any unused veterinary medicinal product or waste material derived from such products
must be disposed of in accordance with local requirements.
Do not contaminate lakes, watercourses, or drains with this product or empty pipettes.
OTHER INFORMATION
Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas in 24
hours, ticks and lice in 48 hours after exposure.
Permethrin belongs to type I pyrethroids, which are acaricides and insecticides with repellent activity.
Permethrin in the product provides repellent activity against sandflies (>80% for 4 weeks), mosquitoes and ticks.
Liquid antiparasitic solution for cutaneous application, packaged in single-dose pipettes.
PACKAGE LEAFLET FOR Cardboard box with 3 pipettes
Frontline Tri-Act spot-on solution for dogs 10-20 kg
DECLARATION OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS
Spot-on solution.
Clear, colourless to brownish-yellow solution.
Active substances/Excipients:
See section "Dosage for each target species"
TARGET SPECIES
Dogs
Caution!!!
Due to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species that may be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.
It is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.
INDICATION (INDICATIONS)
For the treatment and prevention of flea and/or tick infestations when repellent (anti-feeding) activity against sandflies, flies, and/or mosquitoes is required.
For the treatment and prevention of flea infestations with Ctenocephalides felis and the prevention of flea infestations with Ctenocephalides canis. The product kills C. felis fleas on the animal within 24 hours. A single
treatment prevents new flea infestation for 4 weeks. The product can be part of the treatment strategy for the control of flea allergy dermatitis if this diagnosis has
been established by a veterinarian.
The product has repellent efficacy against ticks (Dermacentor reticulatus) from 7 days up to 4 weeks after treatment. However, a single tick may attach and detach within the first 24 hours after infestation.
The product has immediate acaricidal efficacy against Rhipicephalus sanguineus and Ixodes ricinus species, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.
The product has persistent acaricidal efficacy against ticks (Ixodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus) for 4 weeks.
The product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (Phlebotomus perniciosus) and for 4 weeks against mosquitoes (Culex pipiens).
The product has persistent insecticidal efficacy against sandflies (Phlebotomus perniciosus) for 3 weeks.
The product repels and kills stable flies (Stomoxys calcitrans) for five weeks.
CONTRAINDICATIONS
Do not use on sick or convalescing animals.
Do not use on cats and rabbits as it may cause adverse reactions and even death.
Do not use in cases of known hypersensitivity to the active substance or to any of the excipients.
ADVERSE REACTIONS
Among the suspected, very rare adverse reactions, transient skin reactions at the application site (skin discolouration, local alopecia, pruritus, erythema) and generalised pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.
Mild hypersalivation and vomiting may occur if the product is ingested, for example, if the animal licks the application area.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
DOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND METHOD OF ADMINISTRATION
Topical application on the skin (spot-on).
The following table defines which pipette should be used depending on the dog's weight:
Active ingredients Excipients
Frontline Tri-Act spot- Volume of unit Fipronil (mg) Permethrin Butylhydroxytoluene
on for dogs dosed (mg) (E321) (mg)
Very small dogs 2-5kg 0.5 33.8 252.4 0.563
Small dogs 5-10kg 1 67.6 504.8 1.125
Medium dogs 10-20kg 2 135.2 1009.6 2.250
Large dogs 20-40kg 4 270.4 2019.2 4.500
XL dogs 40-60kg 6 405.6 3028.8 6.750
Dogs > 60 kg Use the appropriate combination of pipettes
Treatment regimen
The product should be used after confirmation of infestation or risk of infestation with fleas and/or ticks, simultaneously with the need for repellent (anti-feeding) activity against sandflies and/or mosquitoes and/or flies.
Depending on the recurrence of the risk of infestation with these ectoparasites, repeated treatment may be established. In these cases, the minimum treatment interval is at least 4 weeks.
ADVICE ON CORRECT ADMINISTRATION
Select the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg, the necessary combination of pipettes should be used until the appropriate quantity for the dog's weight is reached.
The product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site. These application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.
Remove the blister foil from the packaging and tear off one blister. Use scissors to cut the blister along the dotted line to remove the pipette or fold the marked corner and tear open.
Hold the pipette upright, away from your face or body, cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the pipette tip on the skin.
Squeeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.
For best results, ensure the product is applied directly to the skin and not to the fur.
WITHDRAWAL PERIOD
Not applicable
SPECIAL PRECAUTIONS FOR STORAGE
Keep out of the sight and reach of children.
Store in the original packaging.
Do not store above 25 °C
Do not use after the expiry date stated on the packaging after "EXP". The expiry date refers to the last day of that month.
SPECIAL WARNING(S)
Special warnings for each target species
A single tick or a mosquito or sandfly bite may already be present on the animal. Therefore, the transmission of pathogens by these arthropods cannot be excluded if conditions are favourable.
The product remains effective against fleas when treated animals occasionally enter water (e.g., swimming, bathing). However, dogs should not be allowed to swim or be shampooed for 48 hours after treatment application.
Avoid swimming or frequent shampooing of treated dogs as this may affect the maintenance of product efficacy.
In order to reduce re-infestation due to the emergence of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same environment should be treated with a veterinary medicinal product appropriate for their species.
To reduce the risk of environmental infestation, it is recommended to use an additional appropriate treatment for the environment in which the animals live, against fleas and their developmental stages.
Special precautions for use in animals
In the absence of specific studies, the use of this product is not recommended for dogs less than 8 weeks old or weighing less than 2 kg.
Avoid contact of the product with the animal's eyes.
It is very important to ensure that the product is applied in an area where the animal cannot lick the product, and also to ensure that animals do not lick each other after
treatment.
Due to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species that may be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.
It is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
For veterinary use only.
This product may cause skin and eye irritation. Consequently, contact of the product with skin or eyes should be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if eyes become irritated during administration of the product, immediate abundant washing with water is recommended. If ophthalmic irritation persists, seek medical advice.
Persons with known hypersensitivity to fipronil and/or permethrin should avoid contact with this product.
The product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during product application. Wash hands after use. In case of swallowing, rinse mouth with water and seek medical advice if you feel unwell.
As the excipient N-methylpyrrolidone may cause foetotoxicity and teratogenicity following prolonged exposure, it is recommended that pregnant women wear gloves to avoid contact with the product.
Avoid handling the animal until the application site has dried. Children should also not play with the animals until the fur is dry.
Therefore, it is recommended that animals are not treated during the day but in the evening, and treated animals should sleep alone during the night, not with owners and especially not with children.
Store pipettes in the original packaging, and once used, empty pipettes should be disposed of immediately in an appropriate manner to prevent subsequent access.
Other precautions
The product may adversely affect aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.
Use during pregnancy and lactation
Laboratory studies with fipronil and permethrin have not produced any teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.
N-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.
Use only based on a benefit/risk assessment by the veterinary surgeon.
Overdose
Safety of use was evaluated in healthy adult dogs treated with a dose up to 5 times the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Known adverse reactions may include mild neurological symptoms,
vomiting and diarrhoea. These symptoms are transient and usually resolve without treatment within 1-2 days. Animals should always be treated with the pipette appropriate for their weight.
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIALS, IF ANY
Any unused veterinary medicinal product or waste materials derived from such products
should be disposed of in accordance with local requirements.
Do not contaminate ponds, watercourses or ditches with this product or empty pipettes.
OTHER INFORMATION
Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas within 24 hours,
ticks and lice within 48 hours of exposure.
Permethrin belongs to the Type I pyrethroid class, which are acaricides and insecticides with repellent activity.
Permethrin in the product provides repellent activity against sandflies (>80% for 4 weeks), mosquitoes and ticks.
Liquid antiparasitic solution for cutaneous application packaged in single-use pipettes.
PACKAGE LEAFLET FOR Cardboard box with 3 pipettes
Frontline Tri-Act spot-on solution for dogs 40-60 kg
STATEMENT OF THE ACTIVE SUBSTANCES AND OTHER INGREDIENTS
Spot-on solution.
Clear, colourless to yellow-brown solution.
Active substances/Excipients:
See section "dosage for each target species"
TARGET SPECIES
Dogs
Caution!!!
Due to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.
It is important that cats do not lick the site where the veterinary medicinal product has been applied to dogs. In case of such exposure, seek veterinary advice immediately.
INDICATION (INDICATIONS)
For the treatment and prevention of flea and/or tick infestations when repellent (anti-feeding) activity against sandflies, flies and/or mosquitoes is required.
For the treatment and prevention of infestations with fleas Ctenocephalides felis and prevention of infestations with fleas Ctenocephalides canis. The product kills C. felis fleas on the animal within 24 hours. A single
treatment prevents new flea infestation for 4 weeks. The product can be part of a treatment strategy for the control of flea allergy dermatitis if this diagnosis has been
established by the veterinarian.
The product has repellent efficacy against ticks (Dermacentor reticulatus) starting from 7 days and up to 4 weeks after treatment. However, a single tick can attach and detach within the first 24 hours after infestation.
The product has immediate acaricidal efficacy against Rhipicephalus sanguineus and Ixodes ricinus species, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.
The product has persistent acaricidal efficacy against ticks (Ixodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus) for 4 weeks.
The product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (Phlebotomus perniciosus) and for 4 weeks against mosquitoes (Culex pipiens).
The product has persistent insecticidal efficacy against sandflies (Phlebotomus perniciosus) for 3 weeks.
The product repels and kills stable flies (Stomoxys calcitrans) for five weeks.
CONTRAINDICATIONS
Do not use on sick or convalescing animals.
Do not use on cats and rabbits as it can cause adverse reactions and even death.
Do not use in case of known hypersensitivity to the active substance or to any of the excipients.
ADVERSE REACTIONS
Among the very rare suspected adverse reactions, transient skin reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.
Mild hypersalivation and vomiting may occur if the product is ingested, if the animal licks the application site.
If you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.
DOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND METHOD OF ADMINISTRATION
Topical administration to the skin (spot-on).
The following table defines which pipette should be used depending on the dog's weight:
Active ingredients Excipients
Frontline Tri-Act spot-on solution for dogs. Volume of dosed unit. Fipronil (mg) Permethrin (mg) Butylated hydroxytoluene (E321) (mg)
Very small dogs 2-5kg 0.5 33.8 252.4 0.563
Small dogs 5-10kg 1 67.6 504.8 1.125
Medium dogs 10-20kg 2 135.2 1009.6 2.250
Large dogs 20-40kg 4 270.4 2019.2 4.500
XL dogs 40-60kg 6 405.6 3028.8 6.750
Dogs > 60 kg Use the appropriate combination of pipettes
Treatment scheme
The product should be used after confirmation of infestation or risk of infestation with fleas and/or ticks, along with the need for repellent (anti-feeding) activity against sandflies and/or mosquitoes and/or flies.
Depending on the recurrence of infestation risk with these ectoparasites, treatment repetition can also be established. In these cases, the minimum treatment interval is at least 4 weeks.
RECOMMENDATIONS FOR CORRECT ADMINISTRATION
Select the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg,
the necessary combination of pipettes should be used until the appropriate quantity for the dog's weight is reached.
The product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site.
These application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.
Remove the blister foil from the packaging and detach one blister. Use scissors to cut the blister along the dotted line to remove the pipette, or fold the marked corner and tear it open.
Hold the pipette upright, away from your face or body, and cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the tip of the pipette on the skin.
Squeeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.
To achieve the best results, ensure that the product is applied directly to the skin and not to the fur.
WITHDRAWAL PERIOD
Not applicable
SPECIAL PRECAUTIONS FOR STORAGE
Keep out of the sight and reach of children.
Store in the original packaging.
Do not store above 25 °C.
Do not use after the expiry date stated on the packaging after "EXP". The expiry date refers to the last day of that month.
SPECIAL WARNING(S)
Special warnings for each target species
A single tick or a bite from a mosquito or sandfly may already be present on the animal. For this reason, the transmission of pathogens by these arthropods cannot be excluded if conditions are favourable.
The product remains effective against fleas when treated animals occasionally enter water (e.g. swimming, bathing). However, dogs should not be allowed to swim or be shampooed for 48 hours after treatment application.
Avoid swimming or frequent shampooing of treated dogs as this may affect the maintenance of product efficacy.
To reduce re-infestation due to the appearance of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same area should be treated with a veterinary medicinal product suitable for their species.
To reduce the risk of environmental infestation, it is recommended to use additional appropriate treatment
for the animals' environment, against fleas and their developmental stages.
Special precautions for use in animals
In the absence of specific studies, the use of this product is not recommended for dogs younger than 8 weeks or weighing less than 2 kg.
Avoid contact of the product with the animal's eyes.
It is very important to ensure that the product is applied in an area where the animal cannot lick the product, and also to ensure that animals do not lick each other after
treatment.
Due to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.
In case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.
It is important that cats do not lick the site where the veterinary medicinal product has been applied to dogs. In case of such exposure, seek veterinary advice immediately.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
For veterinary use only.
This product may cause skin and eye irritation. Therefore, contact of the product with skin or eyes should be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if the eyes become irritated during product administration, immediate thorough washing with water is recommended. If eye irritation persists, seek medical advice.
Persons with known hypersensitivity to fipronil or/and permethrin should avoid contact with this product.
The product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat while applying the product. Wash hands after use. In case of ingestion, rinse mouth with water and seek medical advice if you feel unwell.
As the excipient N-methylpyrrolidone may cause foetotoxicity and teratogenicity following prolonged exposure, pregnant women are advised to wear gloves to avoid contact with the product.
Avoid handling the animal until the application site is dry; children should also not play with the animals until the fur is dry.
Therefore, it is recommended that animals are not treated during the day but in the evening, and that treated animals sleep alone during the night, not with their owners and especially not with children.
Keep pipettes in the original packaging and once used, empty pipettes should be disposed of immediately in an appropriate manner to prevent subsequent access.
Other precautions
The product may be harmful to aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.
Use during pregnancy and lactation
Laboratory studies with fipronil and permethrin produced no teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.
N-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.
Use only after a benefit/risk assessment by the veterinarian.
Overdose
Safety of use has been evaluated in healthy adult dogs treated with a dose up to 5 times higher than the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Known adverse reactions may include mild neurological symptoms, vomiting and diarrhoea. These symptoms are transient and usually disappear without treatment within 1-2 days. Animals should always be treated with the pipette corresponding to their weight.
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE, IF APPLICABLE
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products
should be disposed of in accordance with local requirements.
Do not contaminate lakes, watercourses or drains with this product or empty pipettes.
OTHER INFORMATION
Fipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas in 24
hours, ticks and lice in 48 hours after exposure.
Permethrin belongs to type I pyrethroids, which are acaricides and insecticides with repellent activity.
Permethrin in the product provides repellent activity against sandflies (>80% for 4 weeks), mosquitoes and ticks.
Orthomolecular nutrition for animals suffering from gum and oral mucosa conditions.
Dental diseases, especially periodontitis, affect a high percentage of dogs of various breeds and ages.
Bacteria and tartar accumulate in the oral cavity, generating free radicals and toxins. These will inflame soft tissues and damage teeth.
The GingiVet formula was created to heal gum wounds. In addition, the high antioxidant content blocks complications caused by free radicals.
Target species: dogs, cats
LYSINE
- Participates in the synthesis of collagen, antibodies, hormones, enzymes, etc. It is currently administered for nutritional support in feline herpesvirus infections.
GLYCINE
- It is the most important substance for collagen synthesis. It has antioxidant and anti-inflammatory properties at the level of the epithelial cells of the gums. Oral administration of glycine has been shown to reduce periodontal bone mass loss.
COENZYME Q10
- Essential antioxidant substance for mitochondrial metabolism. The gingival tissue of patients with periodontal diseases shows clear deficiencies of coenzyme Q10. Supplementation significantly improved their condition.
VITIS VINIFERA EXTRACT (grape seeds)
- Acts as a powerful antioxidant due to its levels of proanthocyanidins, which block free radicals involved in the development of periodontitis. Protects connective tissue from bacterial collagenase.
ALPHA-LIPOIC ACID
- Universal antioxidant that easily penetrates and crosses the cell membrane. It is fat and water-soluble. It also promotes the recycling of endogenous and exogenous antioxidants.
ZINC
- Zinc deficiency increases gum permeability, facilitating bacterial penetration. Zinc intake accelerates the healing of bleeding gum wounds.
FOLIC ACID
- Facilitates wound healing and reduces inflammation, strengthening the oral barrier against infections.
VITAMIN B-12
- Its levels are inversely proportional to periodontal diseases. It participates in wound healing, promotes the repair of bleeding gums.
L-SELENOMETHIONINE
- Exerts a remarkable antioxidant effect: it is a scavenger of reactive oxygen species and is part of antioxidant enzymes, such as GPx (glutathione peroxidase). In addition, it has demonstrated immunomodulatory properties.
Storage conditions:
Store in a dry place, away from direct sunlight, at temperatures up to 25°C.
Ingredients / tablet:
- L-Lysine: 400 mg,
- Glycine: 200 mg,
- Coenzyme Q10: 20 mg,
- Vitis vinifera (grape seed extract): 20 mg,
- Lipoic Acid: 10 mg,
- Zinc methionine chelate: 50 mg (Zinc: 10 mg),
- Folic Acid: 200 mcg,
- Vitamin B12: 100 mcg,
- L-Selenomethionine: 350 mcg (Selenium: 7 mcg),
- Excipients
Administration:
1 tab / 10 kg/ bw/ day
The dosage and method of administration depend on the individual needs of each animal and will be determined only by the veterinarian!
Product for dogs and cats suffering from digestive disorders and ailments.
The ingredients in the formula support the digestive juices in the stomach, pancreas, and liver.
Ingredients: L-ornithine aspartate, Lecithin, Calcium Phosphate, Licorice Extract (Glycyrrhiza L.), Magnesium Stearate, Stearic Acid.
Dosage: Dogs - 1 tablet / 15 kg BW, once a day; Cats - 1/2 tablet / animal, once a day.
HISTAMINE CONTROL NUTRITIONAL COFACTORS that support histamine neutralization. Allergic reactions occur as an exaggerated response of the body to the absorption of a foreign substance (allergen). At that moment, histamine is released, present in mast cells, cells concentrated in the skin and respiratory tract.
Histamine is the chemical mediator that appears following allergenic reactions, and consequently the main cause of symptoms caused by allergies. Antihistamines are substances that block the action of histamine. The most commonly used are corticosteroids, which, in addition to their anti-inflammatory action, also have an immunosuppressive role.
HISTAMINE CONTROL has been formulated based on natural substances with nutritional properties that can be used by the body to combat histamine. It can be recommended as an alternative or adjuvant in corticosteroid treatment. It regulates the immune system by reducing the body's immune reactions to allergenic factors.
1. INGREDIENTS: Each tablet contains: Quercetin 125 mg, Bromelain 50 mg, MSM 150 mg, Grape seed extract 75 mg, Dimethylglycine 50 mg, Ascorbic acid 125 mg, Zinc lactate 50 mg, Magnesium citrate 50 mg.
2. INDICATIONS: Neutralizes histamine production in allergic processes: food allergies, asthma, allergic rhinitis, eczema, and urticaria.
3. PROPERTIES: Quercetin - a bioflavonoid with antioxidant action. It compensates for the modulating activity of vitamin C in inflammatory processes. It inhibits both the enzymes involved in the appearance of prostaglandins and leukotrienes - the main mediators of inflammation, and the production of histamine by stabilizing the level of basophils and mast cells. It acts directly on the intestines to reduce allergenic symptoms caused by food. Researchers in Brazil and Korea have successfully protected animals from food allergies by administering Quercetin orally or by inhalation. Bromelain - a proteolytic enzyme extracted from the pineapple stem, primarily helps improve protein digestion. It activates anti-inflammatory prostaglandins and thus has a beneficial action on inflammation, edema, and pain caused by fibrinolysis. It has anti-inflammatory effects even in cases of ulcerative colitis. Many scientific studies have been published in the last 10 years, demonstrating that the anti-inflammatory and analgesic action of bromelain is as effective or more effective than that of synthetic anti-inflammatory drugs. MSM (methylsulfonylmethane) - a natural source of sulfur, acts as an adjuvant in treating allergies due to the fact that it blocks the attachment of histamine to sensitive mucosal tissues. Thus, it reduces the associated symptoms of respiratory allergies and successfully combats itching in cases of allergic dermatitis. Grape seed extract - has a special effect in combating inflammation that appears as an allergic response. Proanthocyanidins have increased antioxidant power against free radicals produced in lipid peroxidation processes. Dimethylglycine - a nutrient derived from glycine, which has regulatory properties on the immune system. It facilitates the absorption of oxygen into cells, neutralizing complex free radicals. Ascorbic acid - Vitamin C - a very powerful antioxidant against free radicals involved in inflammatory processes. It has an antihistamine effect and intervenes in the correction and proper functioning of the immune system. Zinc - a cofactor of superoxide dismutase, a reference antioxidant in the body, is involved in the formation of over 100 enzymatic processes. Zinc ions stabilize the plasma membrane of mast cells, reducing and modulating the release of histamine. Magnesium - magnesium deficiency studied in experimental animals (mice) is manifested by hyperemia, increased IgE, neutrophilia, or eosinophilia. It increases the level of pro-inflammatory cytokines, mast cell degranulation, histanemia, and splenomegaly.
4. ADMINISTRATION METHOD: Target animals: Dogs, cats. Administer orally, if possible, without mixing with food. 1 tablet / 10 kg body weight / twice a day. Small cats and dogs ½ tablet / twice a day.
5. PACKAGING: Plastic bottle - 60 tablets
6. STORAGE: Store in conditions protected from moisture and direct sunlight, at room temperature.
7. CAUTION! For veterinary use only! Keep out of reach of children! Please contact your veterinarian before recommending or using this product, as changes in dosage or method of use may occur depending on individual symptoms.
Tris-NAC® is an innovative, synergistic combination of NAC and Tris-EDTA. It is used to prevent the formation of bacterial biofilm. Where this biofilm is already present, TRIS-NAC acts to destroy it!
Target species: dogs, cats
Description:
What is a biofilm?
An aggregate of cells embedded in an extracellular matrix of polymeric substances, which protects it from antibiotics, chemical products, and the body's immune processes. It can form on medical instruments as well as on animal tissue.
This aspect causes resistance to antibiotic therapy; in fact, bacteria in the biofilm can be 100-1000 times more resistant compared to "free" bacteria.
There are bacteria that can produce biofilms, including: Staphylococcus pseudintermedius, Pseudomonas
aeruginosa (particularly in cases of otitis in dogs, Figs. 1 and 2), Proteus Mirabilis, Escherichia coli. In the case of yeasts, Malassezia spp. is the one that can produce biofilm, especially in seborrheic dermatitis in dogs.
Treatment: topical therapy is the most innovative and involves both the use of effective substances and their combination to achieve a synergistic effect.
Tris-EDTA (Ethylenediaminetetraacetic Acid)
Bactericidal effect on bacteria that do not grow inside the biofilm (Ciofu et al, 2017); associated with Tromethamine (Tris), it destroys the bacterial cell walls and increases membrane penetration; it is very well tolerated, non-ototoxic and acts synergistically with chlorhexidine (Guardabassi et al, 2010); recently an in-vitro study demonstrated that Tris-EDTA in combination with antibiotics is a very effective support in cases of chronic otitis with Pseudomonas with hypothetical presence of biofilms (Pye et al, 2014).
NAC (N-acetylcysteine)
N-acetyl is a derivative of the amino acid cysteine, has mucolytic action, preventing the production of exopolysaccharides and thus weakening the EPS matrix. It has recently been used in eight clinical studies as supportive treatment to destroy mature biofilm and prevent its formation, proving a safe profile with excellent efficacy. The association of Tris-EDTA and NAC on the skin and in the ear before applying topical treatments such as chlorhexidine, antibiotics and synthetic antimicrobial peptides, allows increasing the permeability of mature biofilm and consequently its disintegration, thus solving the problem of bacterial resistance to classic treatments.
Storage conditions:
Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C.
Valid after unsealing: 50 days
Additional information:
- For topical use. Do not administer orally!
- Keep the bottle at room temperature, away from direct sunlight.
- Keep out of reach of children.
- After emptying, comply with current legislation for waste disposal.
Ermidra Shampoo, 250 ml
Composition: Lactic acid, milk serum, glycolic sage extract, anionic surfactants, betaine, zinc gluconate, Epilobium Angustifolium extract (common names: Fireweed, Willowherb), perfume essences, preservatives, co-formulating agents, deionized water.
Indications: Ermidra Shampoo is indicated in all cases of skin inflammation and irritation (from scratching) associated with itching, as well as for physiologically hypersensitive skin.
Properties:
- Ermidra Shampoo gently and thoroughly cleanses the skin and coat.
- Zinc gluconate, betaine, and Epilobium spp extract act synergistically to soothe, refresh, and hydrate the skin, maintaining its physiological integrity.
How to use:
- Brush the dog or cat before bathing to remove excess dirt and dander.
- Shake the bottle well, thoroughly wet the coat, apply the product, and massage gently.
- Leave the foam in contact with the skin for 5-6 minutes, then rinse well with water.
- Initially, it is recommended to use 2-3 times/week. Ermidra can also be used on puppies.
Kalmvet 300mg - 60 Twist-Off Capsules is recommended for calming stress and anxiety in pets. The Twist-Off capsules are practical and easy to administer, even to cats. They ensure the quality and durability of fatty acids, which oxidize very quickly.
Properties and method of use:
Tryptophan is an amino acid precursor to the neurotransmitter called serotonin. An increase in the amount of tryptophan in the animal's diet will lead to an increase in its concentration in the brain, which will significantly boost the production of serotonin. Once released into the synaptic clefts, serotonin can bind to various subtypes of receptors. Through its action on these receptors located in different parts of the brain, serotonin controls several physiological functions, such as hormone release, pain perception, appetite, mood, and behavior.
Studies in dogs have shown that an increase in brain serotonin levels can reduce the occurrence of aggression and self-inflicted wounds and enhance the dog's stress resistance.
Chamomilla recutita (chamomile) provides anti-anxiety properties, among many other biological qualities. Apigenin, a component of chamomile extract, binds to benzodiazepine receptors and thus exhibits mild calming properties for both pain and anxiety. Besides apigenin, another compound in chamomile, namely gamma-aminobutyric acid (GABA), contains other substances that bind to benzodiazepine and GABA receptors in the brain, thus having the specific calming effect offered by chamomile.
Valeriana officinalis (valerian) is a plant known since ancient times for its calming and soothing properties. The mechanism of valerian's action is based on the presence of terpenes, primarily valerenic acids and gamma-aminobutyric acid (GABA). The active substances that make up valerian extract bind to several types of neurotransmitter receptors, including 5-HT%A, which are involved in regulating anxiety. The anti-anxiety effect conferred by valerian extract has been proven in many animal species and even in humans.
Dosage:
Dogs and cats up to 10kg/bw - 1 capsule/day
Dogs weighing 10-25kg/bw - 2 capsules/day
Dogs weighing over 25kg/bw - 3 capsules/day
Important: Consult your veterinarian for diagnosis, prescription of medication, or diet according to your dog's (cat's) specific needs. This product is dispensed only with a prescription.
Dia-Tab is a food supplement in tablet form for dogs with acute diarrhea. The product is an adjuvant in cases of acute intestinal absorption disorders. Pectins, derived from fruits, form a protective film on the intestinal mucosa.
Bentonite is a mineral with a water absorption capacity of up to 70%, and montmorillonite protects the digestive tract by capturing toxins. Fructo-oligosaccharides belong to the category of prebiotics and are responsible for restoring beneficial intestinal flora, while betaine acts together with pepsin and normalizes gastric acidity.
The formula also contains electrolytes to replace those lost during diarrheal episodes, ensuring prompt energy intake and complete restoration of the body's hydro-electrolyte balance.
Composition: Pectins, sugar, sodium chloride, potassium chloride, medicinal herbs, bentonite, montmorillonite, fructo-oligosaccharides (FOS), betaine, electrolytes.
Feeding recommendations
| Dog's weight (kg) | Recommended daily amount (tablets/day) |
| < 10 | ½ once a day, for 2-3 days |
| < 20 | 1 twice a day, for 2-3 days |
| > 20 | 1 three times a day, for 2-3 days |
Brit Care Adult Medium Breed Lamb and Rice is a super-premium dry food for adult medium-sized dogs (over 1 year old). Brit Care Adult Medium Breed Lamb and Rice contains a high level of vitamin E and selenium, forming a powerful antioxidant complex that protects cell membranes from free radical damage and thus prevents aging.
Composition
lamb meal (38%), rice (37%), chicken fat (preserved with tocopherols), dried apples, salmon oil (2%), natural flavors, brewer's yeast, hydrolyzed crustacean shells (source of glucosamine, 260 mg/kg), cartilage extract (a source of chondroitin, 160 mg/kg), mannan-oligosaccharides (150 mg/kg), herbs and fruits (cloves, citrus, turmeric, rosemary, 150 mg/kg), fructo-oligosaccharides (100 mg/kg), yucca schidigera (100 mg/kg), inulin (90 mg/kg), milk thistle (75 mg/kg).
Feeding Guide - Medium Breeds
The recommended daily amount shown in the feeding table should be divided into 1-2 daily portions throughout the day. Serve the food dry or moistened with lukewarm water. When administering Brit Care for the first time, mix it with the previous food and gradually increase the portion of Brit Care over 7 days. The daily amount may vary depending on your dog's environment, activity, and age. Always ensure your dog has fresh drinking water.
Analytical Constituents:
- Crude Protein 26.0 %
- Crude Fat 16.0 %
- Moisture 10.0 %
- Crude Ash 7.2 %
- Crude Fiber 2.5 %
- Calcium 1.6 %
- Phosphorus 1.3 %
Nutritional Additives per 1 kg:
- vitamin A (E672) 20 000 IU
- vitamin D3 (E671) 1 500 IU
- vitamin E (α-tocopherol) (3a700) 500 mg
- vitamin C (E300) 200 mg
- choline chloride 600 mg
- biotin 0.6 mg vitamin B1 1 mg
- vitamin B2 4 mg
- niacinamide (3a315) 12 mg
- calcium pantothenate 10 mg
- vitamin B6 (3a831) 1 mg
- folic acid (3a316) 0.5 mg
- vitamin B12 0.04 mg
- zinc (E6) 80 mg
- iron (E1) 70 mg
- manganese (E5) 35 mg
- iodine (E2) 0.65 mg
- copper (E4) 15 mg
- selenium (3b8.10) 0.25 mg
Metabolizable energy: 3,820 kcal/kg, Omega 3: 0.32 %, Omega 6: 1.90 %.
Brit Premium by Nature Junior S is a premium food recommended for junior puppies (1 - 2 months) of small breeds (1-10 kg). It can be consumed by pregnant and lactating female dogs.
Composition: chicken meat 55% (dehydrated 30%, boneless 25%), chicken fat (preserved with tocopherols), oats, wheat, salmon oil (2%), corn, dried apples, hydrolyzed chicken liver, brewer's yeast, collagen, crustacean shells (source of glucosamine, 260 mg/kg), cartilage (a source of chondroitin, 180 mg/kg), herbs and fruits (cloves, citrus, rosemary, turmeric, 150 mg/kg), mannan-oligosaccharides (150 mg/kg), fructo-oligosaccharides (100 mg/kg), Mojave yucca (100 mg/kg), dried chamomile (90 mg/kg), green mussels (a source of glycosaminoglycan (60 mg/kg), dried blueberries (60 mg/kg).
Feeding guide: The food can be served dry or softened in a little lukewarm water. For junior dogs - the recommended daily nutritional intake presented in a feeding table should be divided into 2–3 equal portions throughout the day. When serving Brit Premium for the first time, use smaller amounts and mix with the previous food; then gradually increase the portion of Brit Premium. Always provide your dog with fresh drinking water.
Analytical constituents: crude protein 32.0%, fat content 20.0%, moisture 10.0%, crude ash 6.8%, crude fiber 2.0%, calcium 1.5%, phosphorus 1.1%, omega-3 0.3%, omega-6 2.7%.
Nutritional additives per kg: vitamin A (3a672a) 20,000 IU, vitamin D3 (E671) 1,200 IU, vitamin E (α-tocopherol) (3a700) 500 mg, biotin (3a880) 0.6 mg, choline chloride (3a890) 600 mg, zinc chelate of amino acids hydrate (3b606) 90 mg, ferrous chelate of amino acids, hydrate (E1) 80 mg, manganese chelate of amino acids, hydrate (E5) 35 mg, potassium iodide (3b201) 0.65 mg, cupric chelate of amino acids, hydrate (E4) 15 mg, organic form of selenium produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU approved antioxidants: tocopherol extract from vegetable oils (1b306), ascorbyl palmitate (1b304) & rosemary extract.
Metabolizable energy: 4,050 kcal/kg. To be consumed before the date written on the packaging. Store in a dry and cool place, avoid direct sunlight. Reseal after opening.
Feeding Table:
| Adult dog weight (kg) | 1 | 3 | 5 | 7 | 10 |
| Dog age (in months) | daily quantity (g) | ||||
| 1-3 | 15 | 30 | 45 | 60 | 80 |
| 3-4 | 20 | 45 | 70 | 90 | 110 |
| 4-6 | 25 | 45 | 70 | 90 | 115 |
| 6-12 | 20 | 40 | 65 | 85 | 105 |
| 12+ | Adult S | ||||
Brit Premium by Nature Sport is a complete food for adult dogs with increased energy needs, such as hunting dogs, mushing dogs, and guard dogs. The product can also be used during periods of convalescence.
Composition: chicken 50% (dehydrated 30%, deboned 20%), oats, chicken fat (preserved with tocopherols), wheat, corn, salmon oil (2%), hydrolyzed chicken liver, brewer's yeast, dried apples, collagen, crustacean shells (source of glucosamine, 260 mg/kg), cartilage (a source of chondroitin, 180 mg/kg), herbs and fruits (cloves, citrus, rosemary, turmeric, 150 mg/kg), mannan-oligosaccharides
(150 mg/kg), fructo-oligosaccharides (100 mg/kg), Mojave yucca (100 mg/kg), dried chamomile (90 mg/kg), green mussels (a source of glycosaminoglycans (60 mg/kg), dried blueberries (60 mg/kg).
Feeding Guide: The food can be served dry or moistened with a little warm water. Designed for dogs with high energy consumption, the recommended daily amount shown in the feeding table should be divided into several smaller portions throughout the day, depending on the dog's energy consumption. Adjust the daily amount according to activity. The recommended daily amounts are shown in the feeding table. When serving Brit Premium for the first time, use smaller amounts and mix with the previous food; then gradually increase the portion of Brit Premium. Always ensure your dog has fresh drinking water.
Analytical Constituents: crude protein 31.0%, fat content 22.0%, moisture 10.0%, crude ash 7.0%, crude fiber 1.5%, calcium 1.5%, phosphorus 1.1%, omega-3 0.25%, omega-6 2.5%.
Nutritional Additives per kg: vitamin A (3a672a) 20,000 IU, vitamin D3 (E671) 1,200 IU, vitamin E (α-tocopherol) (3a700) 500 mg, biotin (3a880) 0.6 mg, choline chloride (3a890) 600 mg, zinc chelate of amino acids hydrate (3b606) 90 mg, ferrous chelate of amino acids, hydrate (E1) 80 mg, manganese chelate of amino acids, hydrate (E5) 35 mg, potassium iodide (3b201) 0.65 mg, cupric chelate of amino acids, hydrate (E4) 15 mg, organic form of selenium
produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU approved antioxidants: tocopherol extract from vegetable oils (1b306), ascorbyl palmitate (1b304) & rosemary extract.
Metabolizable energy: 4,200 kcal/kg. Best before the date indicated on the package. Store in a cool, dry place, away from direct sunlight. Reseal after opening.
Feeding Table:
| Dog's weight (kg) | 5 | 10 | 15 | 20 | 25 | 30 | 40 | 50 | 60 | 70 | 80 | 90 |
| Normal activity (g) | 60 | 110 | 140 | 180 | 210 | 250 | 310 | 360 | 410 | 460 | 520 | 570 |
| Excessive activity (g) | 70 | 130 | 180 | 210 | 250 | 280 | 350 | 420 | 480 | 530 | 570 | 620 |
Brit Premium by Nature Junior L is a complete food for large breed junior dogs aged 2-24 months with a mature weight between 25 – 55 kg.
Composition: chicken 45% (dehydrated 25%, deboned 20%), oats, wheat, chicken fat (preserved with tocopherols), corn, salmon oil (2%), dried apples, hydrolyzed chicken liver, brewer's yeast, crustacean shells (source of glucosamine, 260 mg/kg), cartilage (a source of chondroitin, 180 mg/kg), herbs and fruits (cloves, citrus, rosemary, turmeric, 150 mg/kg), mannan-oligosaccharides (150 mg/kg), fructo-oligosaccharides (100 mg/kg), Mojave yucca (100 mg/kg), dried chamomile (90 mg/kg), green-lipped mussels (a source of glycosaminoglycans (60 mg/kg), dried blueberries (60 mg/kg).
Feeding Guide: Food can be served dry or moistened in a little warm water. For junior dogs - the recommended daily nutritional intake shown in the feeding table should be divided into 2-3 equal portions throughout the day. Recommended daily amounts are shown in the feeding table. When serving Brit Premium for the first time, use smaller amounts and mix with previous food; then gradually increase the portion of Brit Premium. Always ensure your dog has fresh drinking water. ANALYTICAL CONSTITUENTS: crude protein 28.0%, fat content 16.0%, moisture 10.0%, crude ash 7.2%, crude fiber 2.0%, calcium 1.5%, phosphorus 1.1%, omega-3 0.2%, omega-6 1.8%.
Nutritional additives per kg: vitamin A (3a672a) 20,000 IU, vitamin D3 (E671) 1,200 IU, vitamin E (α-tocopherol) (3a700) 500 mg, biotin (3a880) 0.6 mg, choline chloride (3a890) 600 mg, zinc chelate of amino acids hydrate (3b606) 90 mg, ferrous chelate of amino acids, hydrate (E1) 80 mg, manganese chelate of amino acids, hydrate (E5) 35 mg, potassium iodide (3b201) 0.65 mg, cupric chelate of amino acids, hydrate (E4) 15 mg, organic form of selenium produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU approved antioxidants: tocopherol extracts from vegetable oils (1b306), ascorbyl palmitate (1b304) & rosemary extract.
Metabolizable energy: 3,850 kcal/kg. Best before the date indicated on the packaging. Store in a dry, cool place, away from direct sunlight. Reseal after opening.
Feeding Table:
| Adult dog weight (kg) | 25 | 30 | 35 | 40 | 45 |
| Dog's age (in months) | daily amount (g) | ||||
| 1-4 | 230 | 250 | 260 | 270 | 280 |
| 4-6 | 240 | 270 | 300 | 330 | 350 |
| 6-12 | 230 | 270 | 300 | 340 | 380 |
| 12-18 | 220 | 270 | 290 | 330 | 370 |
| 18-24 | 220 | 260 | 280 | 320 | 360 |
| 24+ | Adult L | ||||
Growing Chihuahua puppies need special food during their delicate growth period. The food must meet the nutritional needs of a developing puppy. It must ensure healthy joint development, a strong immune system, and optimal nutritional tolerance. The Chihuahua is the smallest dog in the world. Its small size makes it a popular companion, and it primarily lives indoors. Due to its compact body shape, the Chihuahua is agile, lively, and full of life. Attention must be paid to the food, especially as it needs to be suitable for the small jaw and teeth of this dog.
Royal Canin Breed Chihuahua Puppy has been developed for the characteristics and needs of Chihuahua puppies up to 8 months old.
Ingredients: poultry protein (dried), rice, animal fat, corn, vegetable protein isolate*, dried beet pulp, animal protein (hydrolyzed), soy oil, fish oil, lignocellulose, minerals, fructo-oligosaccharides, yeast hydrolyzate (source of mannan-oligosaccharides), yeast extract (source of beta-glucans), marigold flower meal (source of lutein).
*L.I.P.: selected proteins, easily digestible, with high biological value.
Additives
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Nutritional additives:
vitamin A (28,000 IU/kg), vitamin D3 (800 IU/kg), vitamin E (570 mg/kg), E1(39 mg/kg), E2 (3.9 mg/kg), E4 (12 mg/kg), E5 (51 mg/kg), E6 (107 mg/kg), E8 (0.08 mg/kg).
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Technological additives:
clinoptilolite of sedimentary origin: (10 g/kg)
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Sensory additives: Yucca extract: (125 mg/kg).
Contains preservatives and antioxidants.
Analysis
| protein | 30.0 % |
| fat | 20.0 % |
| fiber | 2.0 % |
| ash | 7.2 % |
Feeding recommendation
| Age in months | Adult weight 1 kg |
Adult weight 2 kg |
Adult weight 3.5 kg |
| 2 | 29 g | 49 g | 71 g |
| 3 | 32 g | 55 g | 80 g |
| 4 | 33 g | 56 g | 84 g |
| 5 | 33 g | 56 g | 84 g |
| 6 | 29 g | 48 g | 77 g |
| 7 | 24 g | 40 g | 69 g |
| 8 | 24 g | 40 g | 61 g |
The Yorkshire Terrier undergoes a short and intense growth period, and its delicate structure develops rapidly. At approximately 2 months, its development already reaches its peak. Towards the end of the growth period, the Yorkshire Terrier gains weight more slowly, and its bones strengthen. However, its nutritional needs will still be twice that of an adult dog.
The immune system of a growing Yorkshire Terrier is very sensitive, as its ability to produce antibodies is not yet sufficiently developed. Frequent changes in diet can negatively affect the puppy's intestinal flora, leading to sensitive digestion.
Royal Canin Breed Yorkshire Terrier Puppy dry food has been specially formulated considering the particular characteristics of dogs of this breed up to 10 months of age.
Ingredients: poultry protein (dried), rice, maize flour, animal fat, vegetable protein isolate*, dried beet pulp, animal protein (hydrolysed), minerals, soya oil, fish oil, yeasts, fructooligosaccharides (0.34%), yeast hydrolysate (source of mannan-oligosaccharides), borage oil, yeast extract (source of beta-glucans), marigold flower meal (source of lutein).
*L.I.P.: selected, easily digestible proteins with high biological value.
Additives
-
Nutritional additives:
vitamin A (29,000 IU/kg), vitamin D3 (800 IU/kg), vitamin E (590 mg/kg), E1(39 mg/kg), E2 (3.9 mg/kg), E4 (12 mg/kg), E5 (51 mg/kg), E6 (106 mg/kg), E8 (0.08 mg/kg).
-
Technological additives:
clinoptilolite of sedimentary origin: (10 g/kg).
-
Sensory additives: Yucca extract: (125 mg/kg).
Contains preservatives and antioxidants.
Analysis
| protein | 29.0 % |
| fat | 20.0 % |
| fibre | 1.3 % |
| ash | 7.7 % |
| EPA / DHA | 3.0 g/kg |
Feeding recommendation
| Age in months | Adult weight 2 kg |
Adult weight 3 kg |
Adult weight 4 kg |
| 2 | 49 g | 63 g | 78 g |
| 3 | 54 g | 71 g | 88 g |
| 4 | 55 g | 74 g | 92 g |
| 5 | 55 g | 75 g | 93 g |
| 6 | 48 g | 68 g | 84 g |
| 7 | 40 g | 61 g | 75 g |
| 8 | 39 g | 54 g | 67 g |
| 9 | 39 g | 54 g | 66 g |
| 10 | 39 g | 53 g | 65 g |
| 11 | Yorkshire Adult | Yorkshire Adult | Yorkshire Adult |
100% complete and balanced, Pedigree Vital Protection dry dog food is tasty and nutritious, perfect for everyday meals. Developed with the help of nutritionists and veterinarians at the Waltham Centre for Pet Nutrition, Pedigree dry dog food contains all the necessary nutrients to support optimal digestion, healthy skin and coat, as well as a strong immune system and good dental care. The special texture of the kibble helps clean and maintain the health of adult dogs' teeth and is ideal for supplementing their daily oral care routine.
Ingredients: cereals, meat and animal derivatives (20%, including 4% beef in red-brown kibble, including 4% poultry in brown kibble), oils and fats (including 0.4% sunflower oil), derivatives of vegetable origin (including 1% dried beet pulp), minerals.
Additives per kg: Antioxidants; Nutritional additives: Vitamin A: 13601 IU, Vitamin D₃: 1500 IU, Vitamin E: 450 mg, Cupric sulphate, pentahydrate: 20.8 mg, Manganous sulphate, monohydrate: 93.8 mg, Potassium iodide: 1.7 mg, Sodium selenite: 0.65 mg, Zinc sulphate monohydrate: 250 mg.
Analytical constituents (%): protein: 21; fat content: 13; inorganic matter: 7.5; crude fiber: 1.8.
Allow a transition period when changing the diet. Adjust the amount according to the dog's needs. For overweight dogs, we recommend reducing the daily amount offered. A bowl of fresh water should always be available. Keep closed, in a dry and cool place.
Pedigree Vital Protection Adult Dry Dog Food with Chicken and Vegetables - Small Breed 400 g
8,23 lei
Unit price perPedigree Vital Protection Adult Dry Dog Food with Chicken and Vegetables - Small Breed 400 g
8,23 lei
Unit price per100% complete and balanced, Pedigree Vital Protection Small Dogs dry food is tasty and nutritious, perfect for the daily meals of small breed dogs. Being smaller and particularly palatable, even for the pickiest puppies, the dry dog food kibbles can be easily chewed and savored. Developed with the help of nutritionists and veterinarians at the Waltham Centre for Pet Nutrition, Pedigree Small Dry Dog food contains all the necessary nutrients to support optimal digestion, skin and coat health, as well as a strong immune system and good dental care. Taking into account the specific needs of small dogs, the food also contributes to joint health, optimal body weight, and a healthy urinary tract. The special texture of the kibbles helps clean and maintain healthy teeth, being ideal for complementing the daily oral care routine.
Ingredients: cereals, meat and animal derivatives (20%, including 4% chicken in brown kibbles), oils and fats (including 0.5% sunflower oil), derivatives of vegetable origin (including 2% dried beet pulp), minerals (including 0.7% sodium tripolyphosphate as an active ingredient in brown kibbles), vegetables (4% carrot in orange kibbles, 4% peas in green kibbles), vegetable protein extracts.
Additives per kg: Antioxidants; Colorants of natural origin; Nutritional additives: Vitamin A: 15300 IU, Vitamin B#: 7.3 mg, Vitamin B#: 12.5 mg, Vitamin B#: 3.3 mg, Vitamin D: 1688 IU, Vitamin E: 150 mg, Cupric sulphate, pentahydrate: 28 mg, Manganous sulphate, monohydrate: 113 mg, Potassium iodide: 2.3 mg, Sodium selenite: 0.65 mg, Zinc sulphate monohydrate: 300 mg.
Analytical constituents (%): protein: 22; fat content: 13; inorganic matter: 8; crude fibre: 1.9; omega 6 fatty acids: 2.2; iron: 126 mg/kg.
Allow for a transition period when changing diet. Adjust the amount according to the dog's needs. For overweight dogs, we recommend reducing the daily amount offered. A bowl of fresh water should always be available. Store closed in a dry and cool place.
Indications: 100% complete and balanced, Pedigree Vital Protection dry food for dogs is tasty and nutritious, perfect for everyday meals. Developed with the help of nutritionists and veterinarians from the Waltham Centre for Pet Nutrition, Pedigree dry dog food contains all the necessary nutrients to support optimal digestion, healthy skin and coat, as well as a strong immune system and good dental care. The special texture of the kibbles helps clean and maintain the health of adult dogs' teeth and is ideal for complementing their daily oral care routine.
Ingredients: cereals, meat and animal derivatives (20%, including 4% beef in red-brown kibbles, including 4% poultry in brown kibbles), oils and fats (including 0.4% sunflower oil), derivatives of vegetable origin (including 1% dried beet pulp), minerals.
Antioxidants; Nutritional additives: Vitamin A: 13601 IU, Vitamin D3: 1500 IU, Vitamin E: 450 mg, Cupric sulphate, pentahydrate: 20.8 mg, Manganous sulphate, monohydrate: 93.8 mg, Potassium iodide: 1.7 mg, Sodium selenite: 0.65 mg, Zinc sulphate monohydrate: 250 mg.
protein: 21, fat content: 13; inorganic matter: 7.5; crude fiber: 1.8.
FEEDING GUIDE
5kg: 85g dry food/day or 50g dry food + 150g wet food/day;
10kg: 140g dry food/day or 95g dry food + 1/2 can wet food/day;
20kg: 240g dry food/day or 125g dry food + 1 1/4 cans wet food/day;
30kg: 325g dry food/day or 185g dry food + 1 1/2 cans wet food/day;
40kg: 405g dry food/day or 240g dry food + 1 3/4 cans wet food/day;
50kg: 475g dry food/day or 245g dry food + 2 1/2 cans wet food/day.
We recommend combining PEDIGREE dry food with PEDIGREE wet food. Allow a transition period when changing diet. Adjust the amount according to your dog's needs. For overweight dogs, we recommend reducing the daily amount offered. How to feed your dog? Visit our website or call our infoline service. A bowl of fresh water should always be available. Store closed, in a cool, dry place.
INTEGRA PROTECT ADIPOSITAS was specially created for overweight dogs. At the same time, this diet is grain-free and is therefore suitable for dogs with grain intolerance.
- Ideal for dogs with grain intolerance.
- Grain-free, soy-free
- 100% fresh meat ingredients
Ingredients: Meat and by-products (28% chicken, beef), vegetables (potatoes), vegetables, minerals 9%, protein, 3.5% fat, crude fiber 0.7%, crude ash 1.5%, moisture 83%
- Protein: 9%
- Fat: 3.5%
- Crude fiber 0.7%
- Crude ash: 1.5%
- Moisture: 83%
DENTASTICKS TREATS WITH MILK 500g
Ingredients: chicken 50%, starch: 40%, soy protein: 5%, sweet potato: 4%, milk: 1%, moisture: 14%
CHICKEN AND COD TREATS 500gr
Ingredients: Chicken: 70%, Cod: 20%, Glycerin: 3%, Soy protein: 5%, Sorbitol: 2%.
GranCarno Junior offers delicious, healthy, and balanced nutrition at the highest level for growing puppies in their first year. Selected fresh and meaty ingredients guarantee the incomparable taste that dogs appreciate so much. GranCarno Junior - with its smaller, puppy-appropriate meaty pieces - is specially adapted to the nutritional needs of growing puppies.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 53% pork (heart, liver, lungs, meat), 28.5% turkey broth, 15% turkey (heart, gizzard, neck), minerals, salmon oil, safflower oil.
-
protein: 11%
fat: 5%
crude fiber: 0.3%
crude ash: 2.4%
moisture: 79%
Nutritional additives per kg:
-
200 IU Vitamin D₃
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0.5 mg Copper (II) sulfate pentahydrate
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1.4 mg Manganous sulfate monohydrate
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25 mg Zinc sulfate monohydrate
