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2301 products
2301 products
Large Chicken Sushi Treats – 500g
Gourmet delight for dogs and cats – natural, protein-rich, and additive-free!
Turn every moment into a true feast with these sushi-style treats, made exclusively from premium quality chicken meat. With an attractive shape and a soft texture, they are perfect as a healthy reward or snack between meals.
🍗 Pure chicken meat – an excellent source of easily digestible protein
🍣 Large sushi shape – appetizing appearance and generous portion for chewing
🐾 For dogs and cats – delicious treat loved by all breeds
🌿 No artificial colors or preservatives – 100% natural
🧩 Soft texture – easy to chew, ideal for all ages
The 500g packaging provides a generous quantity for regular use or as a special reward.
INGREDIENTS:
60% chicken meat, 30%
cod skin, 8% wheat
powder, 2% glycerin
GUARANTEED ANALYSIS:
Crude protein Min. 36%
Crude fat Min. 2.0%
Crude fiber Max. 0.4%
Crude ash Max. 3.5%
Moisture Max. 20%
Duck Meat Rabbit Ear Treats – 500g
A unique and natural snack, loved by dogs and cats!
Treat your companion to a special snack: rabbit ears covered with duck meat, a unique combination, rich in protein, easily digestible and perfect for animals with food sensitivities.
🐇 Rabbit ears – a natural source of collagen, supporting joint and dental health
🦆 Tasty and hypoallergenic duck meat – ideal for animals with allergies to common proteins
🐾 Suitable for dogs and cats – irresistible taste and crunchy texture, perfect for chewing
🦴 Helps clean teeth – stimulates chewing and naturally reduces tartar
The 500g package is ideal for regular use, offering healthy and delicious rewards every day.
INGREDIENTS:
58% duck meat, 38%
rabbit ears, 2%
glycerin, 2% corn
starch
GUARANTEED ANALYSIS:
Crude protein Min. 35%
Crude fat Min. 1.0%
Crude fiber Max. 0.5%
Crude ash Max. 4.0%
Moisture Max. 18%
Chicken-Wrapped Calcium Bone Treats – 500g
Tasty and functional treats for dogs – supports teeth, bones, and daily energy!
Spoil your pet with a delicious and healthy snack! These chicken-wrapped calcium bone treats are specially created to offer a balanced combination of nutrition and chewing pleasure.
🦴 Calcium bone – contributes to strengthening teeth and bones, providing an additional intake of essential minerals
🍗 Tasty chicken meat – rich in quality protein, for supporting muscle mass and energy
✅ Suitable for dogs and cats – a delicious treat, adored by both species
🌿 No artificial additives or preservatives – only natural ingredients
💪 Stimulates active chewing – helps reduce tartar and maintain oral hygiene
The generous 500g package contains enough pieces for daily rewards or during training sessions.
INGREDIENTS:
58% chicken, 38%
bone calcium, 2% corn
starch, 2% glycerin
GUARANTEED ANALYSIS:
Crude Protein Min. 37%
Crude Fat Min. 1.0%
Crude Fiber Max. 0.4%
Crude Ash Max. 4.0%
Moisture Max.18%
Rawhide Pressed Bone Slippers – 500g
Natural delight for your dog, with care for teeth and the pleasure of chewing!
Indulge your furry friend with Pressed Bone Slippers, a natural, healthy, and delicious treat, perfect for any dog breed. Made from white rawhide, these slippers are a durable snack that contributes to your dog's oral hygiene, reducing plaque and tartar through active chewing.
✔️ 100% natural ingredients – no additives, preservatives, or artificial flavors
✔️ Durable texture – ideal for stimulating chewing and combating boredom
✔️ Supports dental health – helps natural teeth cleaning and strengthens gums
✔️ 500g packaging – enough for multiple rewarding sessions
Suitable for both small and medium dogs, the slippers can be offered as a snack between meals or as a training reward. They are tasty, safe, and loved by pets!
INGREDIENTS:
100% rawhide
GUARANTEED ANALYSIS:
Crude Protein Min. 58%
Crude Fat Min. 2.0%
Crude Fiber Max. 1.0%
Crude Ash Max. 4.5%
Moisture Max.18%
Yard Cable Set - 15m
- With this steel cable, you can give your dog the freedom of movement it needs while keeping it under control
- Made of durable steel, the PVC coating of the cable prevents rapid degradation (rusting) under the action of atmospheric conditions
- Includes tension release to protect the dog
- Suitable for dogs up to 30 kg
Cable length: 15 m
Leash length: 3 m
Warning: Keeping your dog tied up should be limited in time and only in situations that require it.
Julius K9 Training Collar - 50cm
- The perfect choice for dog training
- The ideal alternative to prong collars
- Made from a strong, rigid cord (3.5 mm)
- The choice of trainers for aggressive dogs or dogs with behavioral problems
- It is recommended to use with a short leash, without force
- When choosing the size, measure the dog's head, as the collar does not open
Length: 50cm
Nutritional supplement for dogs, designed for joint protection.
Composition/kg - Glucosamine hydrochloride (crustaceans) - 227.27 g, Tricalcium phosphate - 186.64 g, Chondroitin sulfate (bovine source) - 90.91 g, Corn maltodextrin - 84.99 g, Methylsulfonylmethane (MSM) - 56.82 g, Krill oil - 45.45 g, Wheat starch - 27.73 g, Standardized Collagen (poultry) - 18.18 g (Total Collagen - 4.09 g // Native Type II Collagen - 0.64 g), Calcium stearate - 8.77 g.
Additives/kg: Nutritional Additives:
Vitamins, pro-vitamins, and chemically well-defined substances with similar effect: Vitamin C (ascorbic acid) (3a300) - 22.73 g.
Trace element compounds: Zinc sulfate monohydrate (3b605) - 13.64 g (Zn - 4.96 g), Manganese sulfate monohydrate (3b503) - 2.82 g (Mn - 0.91 g).
Sensory additives: Flavoring compounds: Poultry flavors - 92.95 g.
Well-defined botanical natural products: Harpagophytum procumbens extract, Devil's claw (root) - 2.18 g.
Technological additives: Gelling agent: Microcrystalline cellulose (E460) - 100.82 g
Anti-caking agent: Colloidal silica (E 551b) - 5.73 g
Analytical constituents: Crude protein - 26.4%, Crude fats and oils - 7.7%, Crude fiber - 17.1%, Crude ash - 4.2%, Moisture - 3.2%.
Composition per tablet: Glucosamine Hydrochloride - 500 mg, Chondroitin Sulfate - 200 mg, Methylsulfonylmethane (MSM) - 125 mg, Krill oil - 100 mg, Vitamin C - 50 mg, Standardized collagen - 40 mg, Zinc sulfate monohydrate - 30 mg, Manganese sulfate monohydrate - 6.2 mg, Harpagophytum procumbens extract - 4.8 mg.
Administration method:
Can be given with food or administered directly into the animal's mouth.
Animals between 25 and 40 kg: 1 tablet per day
Animals over 40 kg: 2 tablets per day
Store in a dry place in the original packaging, at temperatures below 25°C.
Keep away from direct sunlight and heat.
Keep out of reach of children.
INTEGRA PROTECT Sensitive has been specially developed for dogs with food intolerances, whose main symptoms are itching and diarrhea. Strict limitation of the use of animal and vegetable protein sources can help. INTEGRA PROTECT Sensitive contains only two protein sources: chicken and parsnip.
- Multifunctional: prevention of food intolerances and kidney stones.
- One animal protein source: chicken
- One vegetable protein source: parsnip
Ingredients: Chicken (60%), parsnip (5%), calcium carbonate, rapeseed oil (0.5%), sodium chloride.
- Protein: 95%
- Fat: 6%
- Crude fiber: 0.8%
- Crude ash: 1.8%
- Moisture: 80%
Feeding recommendations:
Cat's weight g / day
2-5 kg 195 to 385 g
6-9 kg 440 to 600 g
Metabolizable energy: 0.39 MJ / 100g
Vom Feinsten Adult offers you the promise of delicious, healthy, and balanced nutrition of the highest quality for adult dogs aged 1 to 6 years. The careful selection and quality of meaty ingredients guarantee a unique culinary delight. This fine pâté provides all the essential nutrients an adult dog needs.
Composition: 49% meat and animal derivatives (20% poultry, pork, beef), fish and fish derivatives (14% cod), minerals.
Ingredient analysis:
| Protein | 10.5 % |
| Fat | 4.5 % |
| Fiber | 0.4 % |
| Ash | 2.5 % |
| Moisture | 81 %. |
Feeding recommendation:
| Weight | g per day |
|---|---|
| 2 - 3 kg | 220 - 300 g |
| 5 - 10 kg | 440 - 750 g |
Metabolizable energy per 100g in MJ: 0.36
Nutritional additives per kilogram
- 150 IU 3a671
- 1 mg 3b406
- 26 mg 3b605
- 1.7 mg 3b503
- 0.4 mg 3b202
Other information:
- Contains drinking water. Drinking water is not a feed material and therefore cannot be listed in the declaration.
- Minerals are essential inorganic nutrients. A distinction is made between bulk and trace elements. Bulk elements occur in quantities over 50 mg/kg body weight; trace elements are below this level.
Vom Feinsten Adult offers you the promise of delicious, healthy, and balanced nutrition at the highest quality level for adult dogs aged 1 to 6 years. The careful selection and quality of meaty ingredients guarantee a unique culinary delight. This fine pâté provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- Carefully selected meat ingredients
- No soy, no sugar
Ingredients: 63% meat and animal derivatives (pork, beef, poultry, 8% rabbit), minerals.
- Protein: 10.4%
- Fat: 4.5%
- Crude fiber: 0.4%
- Crude ash: 2.5%
- Moisture: 81%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 260 g 300 g
5 kg 380 g 440 g
10 kg 640 g 740 g
Metabolizable energy 0.36 MJ / 100g
GranCarno® Original Adult provides delicious, healthy and balanced nutrition at the highest level for adult dogs aged 1 to 6 years. Fresh, meaty ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- Soy-free, grain-free
Ingredients: 50% beef (lung, liver, meat, heart, kidney, udder), 18% venison, calcium carbonate.
- Protein: 11%
- Fat: 8.5%
- Crude fiber: 0.5%
- Crude ash: 1.8%
- Moisture: 78%
Feeding recommendations:
Dog weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
GranCarno Senior represents delicious, healthy, and balanced nutrition at the highest level for adult dogs aged 7 years and older. Selected fresh, meaty ingredients guarantee the incomparable taste that dogs appreciate so much. GranCarno Senior provides all the essential nutrients a senior dog needs and is specially adapted to the specific requirements of older dogs.
- 100% fresh meat ingredients
- grain-free, soy-free
- no artificial colors, no preservatives
Ingredients: 53% beef (meat, liver, lung, heart, kidney, udder), 15% turkey hearts, calcium carbonate, 0.2% salmon oil.
- Protein: 11%
- Fat content: 8%
- Crude ash: 2%
- Crude fiber: 0.5%
- Moisture: 77.5%
Feeding recommendations:
Dog's weight Low activity Normal activity
3 kg 160 g 190 g
5 kg 230 g 275 g
10 kg 390 g 460 g
15 kg 530 g 620 g
20 kg 655 g 800 g
25 kg 780 g 925 g
30 kg 890 g 1045 g
40 kg 1100 g 1300 g
60 kg 1500 g 1760 g
Metabolizable energy: 0.49 MJ/100g
GranCarno® Original Adult offers delicious, healthy, and balanced nutrition of the highest standard for adult dogs aged 1 to 6 years. Fresh, meat-based ingredients guarantee the incomparable taste that dogs love so much. GranCarno Original Adult provides all the essential nutrients an adult dog needs.
- No artificial colors or preservatives
- 100% fresh meat ingredients
- No soy, no grains
Ingredients: 53% beef (lung, heart, meat, liver, kidney, udder), 15% turkey (heart, neck), calcium carbonate.
- Protein: 10%
- Fat: 7.5%
- Crude fiber 0.5%
- Crude ash: 1.8%
- Moisture: 78%
Feeding recommendations:
Dog's weight low activity normal activity
3 kg 180 g 210 g
5 kg 265 g 300 g
10 kg 450 g 515 g
15 kg 610 g 700 g
20 kg 760 g 870 g
25 kg 895 g 1030 g
30 kg 1025 g 1180 g
40 kg 1275 g 1465 g
60 kg 1725 g 1985 g
Metabolizable energy 0.46 MJ / 100g
HILL'S SCIENCE PLAN Light Large Breed Adult dog food with chicken is a perfectly balanced food for less active adult large breed dogs that require a low-calorie diet to maintain optimal weight and a healthy lifestyle.
- Satiety control. Keeps your dog full between meals.
- Omega 6 and vitamin E for coat.
- L-carnitine and reduced calorie level to help maintain body weight.
Recommended for:
Adult large breed dogs aged 1-5 years, with an ideal weight of 25 kg+.
Not recommended for:
Puppies, pregnant or lactating bitches, or mature dogs. During pregnancy or lactation, bitches should consume HILL'S SCIENCE PLAN Puppy food.
Additional information:
Great-tasting nutrition for a long and happy life. Because every moment you spend together is special, we strive to give you as many as possible. With healthy ingredients and the right nutrients, HILL'S SCIENCE PLAN is prepared to give your dog the nutrition it needs for health and happiness throughout its life.
We prepare pet food with the highest quality ingredients. These ingredients must meet our strict purity and nutrient content requirements, which exceed industry standards.
FEEDING GUIDE
USEFUL TIPS
- Adjust the amount of food needed to maintain optimal weight. If you are unsure, consult your veterinarian.
- First time using this food? Mix increasing amounts of the new food with decreasing amounts of the old food for 7 days.
- Ensure fresh water is always available!
- Pet nutritional needs may change with age. Consult your veterinarian at each check-up.
- To prevent choking, keep packaging out of reach of pets and children.
Feeding Guide
| Body weight (kg) | Grams dry food |
| 25 | 350 |
| 30 | 400 |
| 40 | 500 |
| 50 | 590 |
| 60 | 675 |
| 70 | 760 |
| 80 + | 10 per kg |
MIXED FEEDING GUIDE
| Body weight (kg) | Cans 370g | Grams dry food |
| 25 | 1 | 250 |
| 30 | 2 | 200 |
| 40 | 2 | 300 |
| 50 | 2 | 390 |
| 60 | 2 | 475 |
| 70 | 2 | 560 |
| 80+ | 2 | 8 per kg |
INGREDIENTS
COMPOSITION: maize, pea bran, chicken and turkey meal, maize gluten meal, hydrolysate, dried beet pulp, animal fat, cellulose, vegetable oil, minerals, flaxseed, pork cartilage (source of chondroitin sulphate), crustacean hydrolysate (source of glucosamine).
AVERAGE CALORIC AND NUTRITIONAL CONTENT
3125 kcal/kg (312 kcal/100g)
| Nutrient | Dry matter % |
| Protein | 24.4 |
| Fat | 11.4 |
| Fibre | 13.0 |
| Carbohydrates (nitrogen-free extract) | 45.6 |
| Calcium | 0.93 |
| Phosphorus | 0.65 |
| Sodium | 0.27 |
| Potassium | 0.79 |
| Magnesium | 0.137 |
| L-carnitine | 365.6 ppm |
| Vitamin C | 116 ppm |
| Vitamin E | 385 IU/kg |
| Omega-6 fatty acids | 3.11 |
| Ash | 5.7 |
| Beta-carotene | 3.64 ppm |
| Vitamin A | 12147 IU/kg |
| Vitamin D | 850 IU/kg |
SCIENCE PLAN ADULT LARGE BREED dog food with chicken (chicken 7%, total poultry 10%) is a complete food for large/giant dogs (over 25 kg), aged between 1-5 years.
FEEDING INSTRUCTIONS: Feed your pet the amount of food specified on the package; if necessary, adjust the quantity to maintain optimal weight. Using this food for the first time? Mix the new food with the current food, gradually reducing the amount of current food over a period of 7 days. Fresh water should be available at all times.
COMPOSITION: maize, wheat, chicken and turkey meal, soybean meal, animal fat, hydrolysate, maize gluten meal, vegetable oil, dried beet pulp, minerals, flaxseed, pork cartilage (source of chondroitin sulphate), crustacean hydrolysate (source of glucosamine).
ANALYTICAL CONSTITUENTS: Protein 20.8%, Fat 14.1%, Crude fibre 1.8%, Crude ash 4.7%, Calcium 0.69%, Phosphorus 0.59%, Sodium 0.27%, Potassium 0.72%, Magnesium 0.11%, Omega-6 fatty acids 3.5%; per kg: Vitamin A 9790IU, Vitamin D3 755IU, Vitamin E 600mg, Vitamin C 125mg, Beta-carotene 1.5 mg, Glucosamine 461mg, Chondroitin sulphate 487mg.
ADDITIVES PER KG: Nutritional additives: 3b103 (Iron) 74.2mg, 3b202 (Iodine) 1.2mg, 3b405 (Copper) 7.3mg, 3b502 (Manganese) 7.7mg, 3b603 (Zinc) 154mg, 3b801 (Selenium) 0.2mg; With natural antioxidant. Store in a cool, dry place. Protect from moisture.
Brit Care Junior, Large Breed, Lamb and Rice - Complete and balanced food for junior large breed dogs (over 25 kg).
Composition: lamb meat (42%), rice (36%), chicken fat (preserved with tocopherols), dried apples, salmon oil (3%), natural flavors, brewer's yeast, hydrolyzed crustaceans (source of glucosamine, 320 mg / kg), cartilage extract (source of chondroitin, 190 mg / kg), mannan-oligosaccharides (180 mg / kg), herbs and fruits (rosemary, cloves, citrus, turmeric 180 mg / kg), fructo-oligosaccharides (120 mg / kg), yucca schidigera (120 mg / kg), inulin (110 mg / kg), milk thistle (90 mg / kg).
Analytical constituents: crude protein 28%, fat content 14%, moisture 10%, crude ash 7.5%, crude fiber 2.5%, calcium 1.7%, phosphorus 1.3%.
Nutritional additives: vitamin A 23000 IU, vitamin D3 1800 IU, vitamin E (α-tocopherol) 600 mg, vitamin C 300 mg, choline chloride 700 mg, biotin 0.75 mg, vitamin B1 1.2 mg, vitamin B2 4.5 mg, niacinamide 15 mg, calcium pantothenate 12 mg, vitamin B6 1.2 mg, folic acid 0.6 mg, vitamin B12 0.05 mg, zinc 100 mg, iron 90 mg, manganese 45 mg, iodine 0.8 mg, copper 18 mg, selenium 0.3 mg.
Vom Feinsten Adult offers you the promise of delicious, healthy, and balanced nutrition at the highest quality level for adult dogs aged 1 to 6 years. The careful selection and quality of meaty ingredients guarantee a unique culinary delight. This fine pâté provides all the essential nutrients an adult dog needs.
Composition: 49% meat and animal derivatives (20% poultry, pork, beef), fish and fish derivatives (14% cod), minerals.
Ingredient analysis:
| Protein | 10.5 % |
| Fat | 4.5 % |
| Fibre | 0.4 % |
| Ash | 2.5 % |
| Moisture | 81 %. |
Feeding recommendation:
| Weight | g per day |
|---|---|
| 2 - 3 kg | 220 - 300 g |
| 5 - 10 kg | 440 - 750 g |
Metabolizable energy per 100g in MJ: 0.36
Nutritional additives per kilogram
- 150 IU 3a671
- 1 mg 3b406
- 26 mg 3b605
- 1.7 mg 3b503
- 0.4 mg 3b202
Other information:
- Contains drinking water. Drinking water is not a feed material and therefore cannot be listed in the declaration.
- Minerals are essential inorganic nutrients. A distinction is made between bulk and trace elements. Bulk elements occur in quantities above 50 mg / kg body weight; trace elements are below this level.
Zerokeet Ectoparasite Control for dogs is a long-lasting product. Application is quite simple. Just dilute it in water in a 1:2 ratio and use a cotton swab to apply it all over the dog's body. The most common infestation areas are at the joints, on the neck, behind the ears, and at the tip of the tail. Applying this product helps effectively kill all adult ticks and fleas before they can lay eggs on the pet and continue to multiply.
Features: Kills all fleas and ticks in minutes. Prevents infestation. Easy to use.
For veterinary use only. Shake the bottle before use.
Specifications: Suitable for all dogs. Form - liquid
Composition: Each 10 ml contains (in g): Cedrus deodara 2.0, Pongamia glabara 0.50, Azadirachta indica 0.30, Acorus calamus 0.20, Eucalyptus globulus 0.20, Absorbent bases q.s.
Recommended dosage: Application on the entire body (dilution up to 1:2 in water) at weekly intervals until complete recovery. Zerokeet is applied once a day in cases of lesions, where present.
Other skin conditions - dilution 1:2 to 1:4 in water, depending on the severity of the condition.
Storage instructions: Store in a cool, dry place.
QUALITATIVE AND QUANTITATIVE COMPOSITION
Each chewable tablet contains:
Active substances:
|
NEXGARD SPECTRA |
Afoxolaner (mg) |
Milbemycin oxime (mg) |
| chewable tablets for dogs weighing 3.5-7.5 kg | 18.75 | 3.75 |
PHARMACEUTICAL FORM
Chewable tablets.
Red to reddish-brown mottled, round (tablets for dogs weighing 2-3.5 kg) or rectangular (tablets for dogs weighing > 3.5-7.5 kg, tablets for dogs weighing > 7.5-15 kg, tablets for dogs weighing > 15-30 kg, and tablets for dogs weighing > 30-60 kg) tablets.
CLINICAL PARTICULARS
Target species: Dogs
Indications for use, specifying the target species
For the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and/or treatment of gastrointestinal nematode infestations is indicated.
Treatment of flea infestations (Ctenocephalides felis and C. canis) in dogs for 5 weeks. Treatment of tick infestations (Dermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus) in dogs for 4 weeks.
Fleas and ticks must attach to the host and commence feeding to be exposed to the active substance.
Treatment of adult gastrointestinal nematode infestations of the following species: roundworms (Toxocara canis and Toxocara leonina), hookworms (Ancyclostoma caninum and Ancyclostoma braziliense) and whipworms (Trichuris vulpis).
Prevention of heartworm disease (Dirofilaria immitis larval stage) if administered monthly.
Contraindications: Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
Special warnings for each target species
Parasites must commence feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.
Resistance of parasites to a particular class of antiparasitic medicinal product may develop following frequent use of a compound from that class. Therefore, the use of this product should be based on an assessment of each individual case and on local epidemiological information about the current susceptibility of the target species to limit the possibility of future selection for resistance.
Maintaining the efficacy of macrocyclic lactones is essential for the control of Dirofilaria immitis. To minimise the risk of resistance selection, it is recommended to test dogs for circulating antigens and blood microfilariae at the start of each preventative treatment period.
Only negative animals should be treated.
Special precautions for use
Special precautions for use in animals
In the absence of available data, treatment of puppies younger than 8 weeks of age and/or dogs weighing less than 2 kg should only be carried out based on a risk/benefit assessment by the veterinarian.
Dogs living in heartworm endemic areas should be tested for adult heartworm infestation before administration of NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.
The recommended dose must be strictly followed in Collie dogs or other related breeds.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
- This product may cause gastrointestinal disturbances if ingested.
- Keep tablets in blisters and the blister in the carton until use.
- In case of accidental ingestion, especially by children, seek medical advice immediately and show the product label to the physician.
- Wash hands after use.
Adverse reactions (frequency and seriousness)
In clinical studies, no serious adverse reactions were attributed to the combination of afoxolaner and milbemycin oxime. Infrequent reactions such as vomiting, diarrhoea, lethargy, anorexia, and pruritus were observed. These reactions generally resolved spontaneously and were of short duration.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- Common (more than 1 but less than 10 animals in 100 animals)
- Uncommon (more than 1 but less than 10 animals in 1,000 animals)
- Rare (more than 1 but less than 10 animals in 10,000 animals)
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
Use during pregnancy, lactation or lay
Laboratory studies conducted on rats and rabbits have not shown any teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinarian.
Interactions with other medicinal products and other forms of interaction
Milbemycin oxime is a substrate of P-glycoprotein (P-gp), thus it may interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.
Amounts to be administered and administration route
For oral administration.
Dosage:
The product should be administered at a dose of 2.50-5.36 mg/kg afoxolaner and 0.50-1.07 mg/kg milbemycin oxime body weight according to the following table:
| Dog weight (kg) | Concentration and number of chewable tablets to be administered | ||||
|
NEXGARD SPECTRA 9 mg/ 2 mg |
NEXGARD SPECTRA 19 mg/ 4 mg |
NEXGARD SPECTRA 38 mg/ 8 mg |
NEXGARD SPECTRA 75 mg/ 15 mg |
NEXGARD SPECTRA 150 mg/ 30 mg |
|
|
2-3.5 |
1 |
|
|
|
|
|
>3.5-7.5 |
|
1 |
|
|
|
|
>7.5-15 |
|
|
1 |
|
|
|
>15-30 |
|
|
|
1 |
|
|
>30-60 |
|
|
|
|
1 |
For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.
Method of administration:
The tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.
Treatment regimen:
The treatment regimen should be based on the veterinary diagnosis and the local epidemiological situation.
NEXGARD SPECTRA can be used as seasonal preventative treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.
Disease: Heartworm disease:
NEXGARD SPECTRA kills Dirofilaria immitis larvae for one month after their transmission by mosquitoes, therefore the product must be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should continue until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.
If replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should start on the day the previous medication was due to be administered.
Dogs living in or having travelled to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult Dirofilaria immitis has been established. Therefore, it is recommended that all dogs 8 months of age or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.
Overdose (symptoms, emergency procedures, antidotes), if applicable
No adverse reactions were observed in healthy puppies older than 8 weeks after 6 treatments with 5 times the maximum dose.
Withdrawal periods: Not applicable.
PHARMACOLOGICAL PROPERTIES
Pharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.
ATC veterinary code: QP54AB51
Pharmacodynamic properties
Afoxolaner:
Afoxolaner is an insecticide and acaricide belonging to the isoxazoline family.
Afoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and death of insects and mites. The selective toxicity of afoxolaner between insects/mites and mammals is a consequence of the characteristic sensitivity of insect/mite GABA receptors versus those of mammals.
Afoxolaner is active against adult fleas as well as some tick species such as Rhipicephalus sanguineus, Dermacentor reticulatus and D. variabilis, Ixodes ricinus and I. scapularis, Amblyomma americanum and Haemaphysalis longicornis.
The product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).
Milbemycin oxime:
Milbemycin oxime is an endectocidal antiparasitic belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a 20:80 ratio for A3:A4). It is isolated from the fermentation of Streptomyces milbemycinicus.
Milbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-gated chloride ion channels (related to GABA and glycine receptors in vertebrates).
This leads to hyperpolarisation of the neuromuscular membrane and to the paralysis and death of the parasites.
Pharmacokinetic particulars
Afoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (Cmax) was 1822 ± 165 ng/ml, at 2-4 hours (Tmax) after a dose of 2.5 mg/kg afoxolaner.
The volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l/kg and the clearance value is 5.0 ± 1.2 ml/h/kg. The half-life is approximately 2 weeks in dogs.
Plasma concentrations of Milbemycin oxime increase rapidly within the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4 respectively. The mean maximum plasma concentration (Cmax), after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng/ml for A4.
The volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l/kg for form A3 and A4 respectively. Both forms have a low clearance value of 75 ± 22 ml/h/kg for A3 and 41 ± 12 ml/h/kg for A4.
PHARMACEUTICAL PARTICULARS
List of excipients
- Maize starch
- Soy protein
- Braised beef flavour
- Povidone (E1201)
- Macrogol 400
- Macrogol 4000
- Macrogol 15 hydroxystearate
- Glycerol (E422)
- Medium-chain triglycerides
- Citric acid monohydrate (E330)
- Butylhydroxytoluene (E321)
Incompatibilities: Not applicable.
Shelf life: Shelf life of the veterinary medicinal product as packaged for sale: 2 years
Special precautions for storage: Keep the blister in the outer carton to protect from light.
Nature and composition of primary packaging
This veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar/PVC/Alu).
1 carton box containing one blister with 1, 3 and 6 chewable tablets.
Not all package sizes may be marketed.
Special precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products
Any unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.
The product is recommended for the treatment of dogs and cats suffering from dermatological conditions, with symptoms including dry and flaky skin, excessive hair loss. The formula maintains the optimal level of dermal functions, prevents skin dryness, has anti-edematous and anti-inflammatory properties, supports skin regeneration, and reduces sebum secretion.
Target species: dogs, cats
Method of administration:
Cats, Dogs under 15 kg body weight: 1 capsule/day
Dogs over 15 kg body weight: 2 capsules/day
Twist Off capsules are very palatable and easy to administer even to cats. They ensure the quality and freshness of ingredients, which can oxidize very quickly. Only the content or the capsule itself can be administered. The correct dosage and administration period depend on the individual needs of the animal and will be determined by a veterinarian.
Ingredients: Fish oil (source of Omega-3 fatty acids) 145mg, Cold-pressed Borage oil (Borago officinalis) (source of Omega-6 fatty acids) 145mg, Zinc 8mg, Vitamin B1 0.23mg, Vitamin B2 0.575mg, Vitamin B6 0.253mg, Vitamin B12 5.75µg, Biotin 1.15mg
Action:
Cold-pressed Borage oil (Borago officinalis) is an essential source of unsaturated Omega-6 fatty acids (linoleic acids and gamma-linoleic acids) which strengthen the skin's water retention function. These acids are part of the so-called ceramides, which form special plates within the intercellular spaces of the skin, thus preventing water penetration to the outside, between epidermal cells. The skin remains hydrated and flexible for longer.
Fish oil is an essential source of unsaturated Omega-3 fatty acids (EPA and DHA) which have anti-inflammatory and anti-edematous properties. They also contribute to the elasticity and flexibility of cell membranes. Supplementing with Omega-3 fatty acids allows for the reduction of the amount of anti-inflammatory drugs (including steroids) widely used in anti-itch therapies.
Zinc is the most important element involved in the process of healing, cell multiplication, and division, which plays an essential role in treating dermatological conditions. Zinc deficiency is responsible for dermatological disorders also called dermatoses.
The B vitamin group (B1, B2, B6, and B12) plays a vital role in the metabolism of essential unsaturated Omega-3 and Omega-6 fatty acids and in strengthening the skin's immune function.
Biotin is a B vitamin that, when administered orally, is transported directly to the sebaceous glands and then subsequently extracted to the skin surface. Its presence in the sebaceous glands partially contributes to the reduction of sebum secretion, which is especially beneficial for dogs suffering from seborrhea.
Packaging: bottle of 60/90 capsules
Storage conditions: Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C.
Analytical compounds: Proteins 4.57%, Oils and fats 64.1%, Ash (including mineral compounds) 10.85%, Moisture 1.06%, Fiber 0.05%.
Additional information:
ATTENTION! For veterinary use only! Keep out of reach of children! Follow the instructions on the packaging. Contact your veterinarian before using or extending the use of this product, as dosage or method of use may change depending on the individual symptoms of the animal.
Multi-directional action formula, indicated for dogs and cats with eye conditions.
Lutein, Zeaxanthin, DHA, Plant Polyphenols
Target species: dogs, cats
Twist Off capsules are highly palatable and easy to administer even to cats. They ensure the quality and freshness of ingredients, which can oxidize very quickly. Only the content can be administered, or the capsule as such. The correct dosage and administration period depend on the individual needs of the animal and will be determined by a veterinarian.
Description:
Lutein and zeaxanthin belong to xanthophylls, plant pigments from the carotenoid group. They play an important role in protecting the retina against changes caused by UV radiation and free radicals.
They are not produced by the body, which is why they require intake from food or supplements.
• Reduce the risk and intensity of certain retinal conditions, cataracts, and increase the efficiency of the immune system.
• Lutein, due to its ability to filter UV rays and its antioxidant properties, protects the retina against degeneration and thus improves VISION.
Omega 3 fatty acids are not synthesized by the body. Docosahexaenoic acid (DHA) has a strong anti-inflammatory effect, supports retinal health, protects against certain types of cataracts and degenerative retinal diseases. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) improve blood flow to the optic nerve, while protecting nerve cells against various damages caused by diabetes, reducing the risk of diabetic retinopathy. DHA and EPA are found in high concentrations in the structural membranes of the retina and contribute to maintaining vision and proper eye function.
Grape extract is rich in PROANTHOCYANIDIN antioxidants that eliminate free radicals, have anti-inflammatory properties and can inhibit the appearance of certain types of cataracts. Flavonoids from grapes increase the elasticity and density of capillaries in the eye structure, including the retina. Zinc is a trace element abundantly present in ocular tissues, particularly in the retina. It is an important component of the antioxidant system, which protects against reactive oxygen species. It also contributes to better irrigation of the eyeball and to the suppression of complementary activation from retinal pigments of epithelial cells.
Polyphenol compounds from green tea extract have a strong antioxidant effect that contributes to a significant reduction in oxidative stress and represent an excellent prophylactic solution against eye conditions.
Vitamin A accelerates the regeneration of the purple substance, a pigment responsible for vision after dark. In the retina, Vitamin A is converted into a photosensitive pigment necessary for vision in low light or darkness.
Vitamins C and E belong to the group of powerful antioxidants that protect ocular cells from the harmful effects of free radicals. Vitamin C also seals blood vessels.
Vitamins B2, B6 and B12 support red blood cell production and optimal functioning of the nervous system.
Vitamins B5 and B9 (folic acid) help reduce fatigue and overexertion.
Storage conditions:
Store in a place protected from moisture and direct sunlight, at temperatures up to 25°C.
Additional information:
ATTENTION! For veterinary use only! Keep out of reach of children! Follow the instructions on the packaging. Contact your veterinarian before using or extending the use of this product, as dosage or method of use may change depending on the animal's individual symptoms.
Brit Care Puppy Lamb & Rice - Hypoallergenic formula with lamb and rice for all breeds of puppies and junior dogs (4 weeks - 12 months).
Composition:
lamb meal (45%), rice (30%), chicken fat (preserved with tocopherols), dried apples, salmon oil (3%), natural flavors, brewer's yeast, hydrolyzed crustacean shells (source of glucosamine, 320 mg/kg), cartilage extract (a source of chondroitin, 190 mg/kg), mannan-oligosaccharides (180 mg/kg), herbs and fruits (rosemary, cloves, citrus, turmeric, 180 mg/kg), fructo-oligosaccharides (120 mg/kg), yucca schidigera (120 mg/kg), inulin (110 mg/kg), milk thistle (90 mg/kg). Analytical constituents: crude protein 32%, fat content 18%, moisture 10%, crude ash 7.7%, crude fiber 2.5%, calcium 1.8%, phosphorus 1.3%.
Nutritional additives per kg:
vitamin A (E672) 23,000 IU, vitamin D3 (E671) 1,800 IU, vitamin E (α-tocopherol) (3a700) 600 mg, vitamin C (E300) 300 mg, choline chloride 700 mg, biotin 0.75 mg, vitamin B1 1.2 mg, vitamin B2 4.5 mg, niacinamide (3a315) 15 mg, calcium pantothenate 12 mg, vitamin B6 (3a831) 1.2 mg, folic acid (3a316) 0.6 mg, vitamin B12 0.05 mg, zinc (E6) 100 mg, iron (E1) 90 mg, manganese (E5) 45 mg, iodine (E2) 0.8 mg, copper (E4) 18 mg, selenium (3b8.10) 0.3 mg.
Metabolizable energy:
4,000 kcal/kg, Omega 3: 0.42%, Omega 6: 2.10%.
Feeding guide – puppies:
The recommended daily amount shown in the feeding table should be divided into 3-5 equal portions throughout the day. Serve the food dry or moistened with warm water. When administering Brit Care for the first time, mix it with the previous food and gradually increase the portion of Brit Care over 7 days. The daily amount may vary depending on your dog's environment, activity, and age. Always provide your dog with fresh drinking water. Best before the date indicated on the packaging. Store in a dry and cool place. Contains EU-approved antioxidants. Complete food for dogs.
Brit Premium by Nature Junior XL is a complete food for very large breed puppies (45 - 90 kg when adult) during their growth period (4 - 30 months) with 30% quality, easily digestible protein and 16% fat.
mg/kg), dried blueberries (60 mg/kg).Feeding guide: The food can be served dry or moistened with a little warm water. For junior dogs - the recommended daily nutrient intake shown in the feeding table should be divided into 2-3 equal portions throughout the day. The recommended daily quantities are shown in the feeding table. When serving Brit Premium for the first time, use smaller amounts and mix with previous food; then gradually increase the portion of Brit Premium. Always provide your dog with fresh drinking water.Analytical constituents: crude protein 31.0 %, fat content 16.0 %, moisture 10.0 %, crude ash 7.0 %, crude fiber 2.2 %, calcium 1.6 %, phosphorus 1.1 %, omega-3 0.2 %, omega-6 1.9 %.Nutritional additives per kg: vitamin A (3a672a) 20,000 IU, vitamin D3 (E671) 1,200 IU, vitamin E (α-tocopherol) (3a700) 500 mg, biotin (3a880) 0.6 mg, choline chloride (3a890) 600 mg, zinc chelate of amino acids hydrate (3b606) 90 mg, ferrous chelate of amino acids, hydrate (E1) 80 mg, manganese chelate of amino acids, hydrated (E5) 35 mg, potassium iodide (3b201) 0.65 mg, cupric chelate of amino acids, hydrate (E4) 15 mg, organic form of selenium produced by Saccharomyces cerevisiae CNCM I-3060 (3b8.10) 0.2 mg. Contains EU-approved antioxidants: tocopherol extracts from vegetable oils (1b306), ascorbyl palmitate
(1b304) & rosemary extract.Metabolizable energy: 3,860 kcal/kg. To be consumed before the date printed on the packaging. Store in a cool, dry place, avoid direct sunlight. Reseal after opening.
Feeding table:
| Adult dog weight (kg) | 45 | 50 | 60 | 70 | 80 | 90 |
| Dog's age (in months) | daily amount (g) | |||||
| 1-4 | 260 | 280 | 320 | 330 | 390 | 400 |
| 4-6 | 340 | 360 | 450 | 500 | 550 | 590 |
| 6-12 | 360 | 390 | 450 | 510 | 560 | 620 |
| 12-18 | 350 | 390 | 440 | 510 | 570 | 620 |
| 18-24 | 340 | 370 | 440 | 500 | 560 | 600 |
| 24-30 | 330 | 370 | 430 | 490 | 540 | 590 |
| 30+ | Adult XL | |||||
Brit Care Adult Medium Breed Lamb and Rice is a super-premium dry food for adult medium-sized dogs (over 1 year old). Brit Care Adult Medium Breed Lamb and Rice contains a high level of vitamin E and selenium, forming a strong antioxidant complex that protects cell membranes from free radicals and thus prevents aging.
Composition
lamb meat meal (38%), rice (37%), chicken fat (preserved with tocopherols), dried apples, salmon oil (2%), natural flavors, brewer's yeast, hydrolyzed crustacean shells (source of glucosamine, 260 mg/kg), cartilage extract (source of chondroitin, 160 mg/kg), mannan-oligosaccharides (150 mg/kg), herbs and fruits (cloves, citrus, turmeric, rosemary, 150 mg/kg), fructo-oligosaccharides (100 mg/kg), yucca schidigera (100 mg/kg), inulin (90 mg/kg), milk thistle (75 mg/kg).
Feeding Guide – Medium Breeds
The recommended daily amount shown in the feeding table should be divided into 1-2 daily portions throughout the day. Serve the food dry or moistened with lukewarm water. When administering Brit Care for the first time, mix it with the previous food and gradually increase the portion of Brit Care over 7 days. The daily amount may vary depending on your dog's environment, activity, and age. Always ensure your dog has fresh drinking water.
Analytical Constituents:
- Crude Protein 26.0%
- Crude Fat 16.0%
- Moisture 10.0%
- Crude Ash 7.2%
- Crude Fibre 2.5%
- Calcium 1.6%
- Phosphorus 1.3%
Nutritional Additives per 1 kg:
- vitamin A (E672) 20,000 IU
- vitamin D3 (E671) 1,500 IU
- vitamin E (α-tocopherol) (3a700) 500 mg
- vitamin C (E300) 200 mg
- choline chloride 600 mg
- biotin 0.6 mg vitamin B1 1 mg
- vitamin B2 4 mg
- niacinamide (3a315) 12 mg
- calcium pantothenate 10 mg
- vitamin B6 (3a831) 1 mg
- folic acid (3a316) 0.5 mg
- vitamin B12 0.04 mg
- zinc (E6) 80 mg
- iron (E1) 70 mg
- manganese (E5) 35 mg
- iodine (E2) 0.65 mg
- copper (E4) 15 mg
- selenium (3b8.10) 0.25 mg
Metabolizable energy: 3,820 kcal/kg, Omega 3: 0.32%, Omega 6: 1.90%.
