Amflee 268 MG is an antiparasitic pipette for medium-sized dogs, weighing between 20 and 40 kilograms, which prevents and treats flea and tick infestations.

1 pipette (2.68 ml) contains:

• Active substance: Fipronil 268 mg.
• Other substances: Butylhydroxyanisole (E320) 0.54 mg Butylhydroxytoluene (E321) 0.27 mg

Used for:

• Treatment and prevention of infestations with fleas (Ctenocephalides spp), ticks (Rhipicephalus spp, Dermacentor spp, Ixodes spp.), and infestations with biting lice Trichodectes canis in dogs.
• The product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.
• The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD), if it has been previously diagnosed by a veterinarian.

Contraindications:

• do not administer to puppies younger than 8 weeks or weighing less than 2 kg
• do not administer to sick animals (systemic diseases, fever) or those in convalescence
• do not administer to rabbits due to the risk of serious adverse reactions or even death
• do not administer to cats, as it may lead to overdose
• do not administer in cases of hypersensitivity to the active substance or any of the excipients.

PRECAUTIONS:

• Ticks on animals must be removed before using the product to reduce the risk of transmissible diseases.
• The product should be applied in a secluded area where the animal cannot lick.
• It is recommended to avoid bathing or immersion in water for 2 days after product application and to avoid bathing more frequently than once a week.
• Emollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of protection against fleas to approximately 5 weeks.
• Weekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the product's efficacy against fleas, as shown in a long-term 6-week study.
• Ticks may appear sporadically. Thus, complete exclusion of disease infection under unfavorable conditions is impossible. Generally, ticks will die within 24 - 48 hours after infestation without feeding on the animal's blood.
• Avoid contact of the product with the animal's eyes.
• Dogs should not be allowed to swim in running water for 2 days after application.
• The product may cause irritation of the mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.
• Individuals with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.
• In case of contact, wash hands with soap and water.
• In case of accidental contact with eyes, wash thoroughly with clean water.
• Wash hands after use.
• Do not touch treated animals and do not let children play with them until the application site has dried. Therefore, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially children.
• Do not smoke, drink, or eat while applying the product.

Possible adverse reactions:

• If animals lick themselves, short-term hypersalivation may occur, mainly due to the excipients.
• Extremely rare adverse reactions: transient skin reactions at the application site (discoloration and hair loss, pruritus and erythema) and generalized pruritus with alopecia.
• Exceptionally, after use, reversible neurological symptoms (hyperesthesia, depression, nervousness), hypersalivation, or vomiting have been observed.

Administration:

• In the absence of product safety studies, the minimum interval between treatments is 4 weeks.
• Monthly treatment is recommended if there is an increased risk of repeated flea infestations, if dogs are allergic to flea bites, and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once, at intervals of two or three months.
• Route of administration: External application on the skin (spot-on use).
• Method of administration: Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap over and place the other end of the cap on the single-dose pipette. Push and twist the cap to pierce the seal, then remove the cap from the single-dose pipette. Part the animal's hair in the area between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and press the pipette several times to empty the contents directly onto the skin, in a single spot.