{"title":"Internal or External Parasiticides for Dogs - Pipettes and Pills","description":"","products":[{"product_id":"pipeta-antiparazitara-advantix-pentru-caini-de-la-pana-la","title":"Advantix antiparasitic pipette for dogs weighing from to","description":"\u003cp\u003e\u003cstrong\u003eAdvantix is an external antiparasitic product containing imidacloprid and permethrin, and is highly effective in treating flea and tick infestations for one month after a single application.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e\nEach dose (pipette) contains:\u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePipette\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eImidacloprid\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePermethrin\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eE321\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e40 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e200 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e0.4 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2000 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e4.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eExcipients: Butylated hydroxytoluene 1.0 mg\/ml (E321, as an antioxidant):\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003cbr\u003e\nFor the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).\u003cbr\u003e\nFleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product\u003cbr\u003e\ncan be used as part of a treatment strategy against flea allergy dermatitis (FAD).\u003cbr\u003e\nThe product exhibits acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes\u003cbr\u003e\nricinus) or three weeks (Dermacentor reticulatus) against tick infestations.\u003cbr\u003e\nTicks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore,\u003cbr\u003e\nit is recommended to remove ticks present on the dog at the time of treatment to prevent them from attacking and feeding on blood.\u003cbr\u003e\nOne treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three\u003cbr\u003e\nweeks (Phlebotomus perniciosus), against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks, and against stable flies\u003cbr\u003e\n(Stomoxys calcitrans) for four weeks.\u003cbr\u003e\nSandflies Phlebotomus perniciosus 3 weeks\u003cbr\u003e\nPhlebotomus papatasi 2 weeks\u003cbr\u003e\nMosquitoes Aedes aegypti 2 weeks\u003cbr\u003e\nCulex pipiens 4 weeks\u003cbr\u003e\nStable fly Stomoxys calcitrans 4 weeks\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003cbr\u003e\nIn the absence of available data, the product should not be used in puppies younger than 7 weeks.\u003cbr\u003e\nDo not use in cases of known hypersensitivity to the active substances.\u003cbr\u003e\nDo not use in cats.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse reactions\u003c\/strong\u003e\u003cbr\u003e\nTransient skin sensitivity (with increased itching, alopecia and erythema at the application site) or apathy may rarely occur.\u003cbr\u003e\nPoisoning in dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as\u003cbr\u003e\ntremors and apathy may also appear. Symptomatic treatment should be applied under veterinary supervision. There is no specific antidote.\u003cbr\u003e\nIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species\u003c\/strong\u003e\u003cbr\u003e\nDogs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage for each species, route(s) of administration and method of administration\u003c\/strong\u003e\u003cbr\u003e\nDosing regimen:\u003cbr\u003e\nThe minimum recommended dose is: 10 mg\/kg body weight (b.w.) imidacloprid and 50 mg\/kg body weight (b.w.) permethrin, equivalent to\u003cbr\u003e\n0.1ml\/kg b.w. \u003cstrong\u003eAdvantix spot-on solution for dogs.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDog's weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg\/kg b.w.) Permethrin (mg\/kg b.w.)\u003c\/p\u003e\n\u003cp\u003e\u0026gt;25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80\u003cbr\u003e\n\u0026gt; 40 kg the appropriate combination of pipettes should be used\u003c\/p\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%; height: 147px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 42px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 42px; text-align: center;\"\u003eDog's weight (kg)\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 42px; text-align: center;\"\u003ePipette size to be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 42px; text-align: center;\"\u003eVolume (ml)\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 42px; text-align: center;\"\u003eImidacloprid(mg\/kg b.w.)\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 42px; text-align: center;\"\u003ePermethrin (mg\/kg b.w.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026lt;=4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003eminimum 10\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003eminimum 50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;4 kg - 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;10 kg - 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;25 kg - 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 16\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 80\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt; 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003ethe appropriate combination of pipettes should be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTo reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in\u003cbr\u003e\nthe same family or household must be treated with appropriate products. For fleas originating from the animal's environment,\u003cbr\u003e\nthe additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure\u003cbr\u003e\nto water, the product's efficacy decreases. Even in this case, it should not be treated more frequently than once a week. If it is\u003cbr\u003e\nnecessary to wash the animal with shampoo, it is advisable to apply Advantix spot-on solution for dogs two weeks later\u003cbr\u003e\nto ensure the product's efficacy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod of administration.\u003c\/strong\u003e\u003cbr\u003e\nRemove a pipette from the package. Hold the pipette upright, twist the cap and remove it. Turn the cap upside down and use it to\u003cbr\u003e\nunseal the pipette (by twisting and pressing on the seal, as shown in the photo).\u003cbr\u003e\nFor dogs weighing 10 kg or less:\u003cbr\u003e\nWith the dog standing, part the fur between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and\u003cbr\u003e\nempty the contents of the pipette by firmly squeezing it several times. Apply only to intact skin.\u003cbr\u003e\nFor dogs weighing more than 10 kg:\u003cbr\u003e\nWith the dog standing, the entire content of the Advantix spot-on solution for dogs pipette will be applied evenly in four places,\u003cbr\u003e\nstarting from between the shoulder blades and extending to the base of the tail. At each spot, part the fur until the skin is visible. Apply the tip of the pipette to the skin and\u003cbr\u003e\ngently squeeze to release some of the solution onto the skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommendations for correct administration\u003c\/strong\u003e\u003cbr\u003e\nFor external use only.\u003cbr\u003e\nApply only to intact skin.\u003cbr\u003e\nDo not apply a large amount of solution in one spot, as this may run off onto the dog's sides.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWithdrawal period\u003c\/strong\u003e\u003cbr\u003e\nNot applicable.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for storage\u003c\/strong\u003e\u003cbr\u003e\nKeep out of the sight and reach of children.\u003cbr\u003e\nDo not freeze.\u003cbr\u003e\nAfter opening the aluminum pouch, store in a dry place and do not store above 30°C.\u003cbr\u003e\nThe abbreviation used for the expiry date on the label, pipette and pouch is EXP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003cbr\u003e\nThe content of the pipette must not come into contact with the eyes or mouth of the treated dog.\u003cbr\u003e\nPay attention to the correct administration of the product as described in the Method of administration section. In particular, oral ingestion\u003cbr\u003e\nby licking the application site or contact with other animals should be avoided.\u003cbr\u003e\nDo not use in cats.\u003cbr\u003e\nThis product is highly toxic to cats and can cause death due to the physiological particularities of cats,\u003cbr\u003e\nwhich are unable to metabolize certain compounds including permethrin. To prevent accidental exposure of\u003cbr\u003e\ncats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.\u003cbr\u003e\nMeasures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek\u003cbr\u003e\nimmediate veterinary assistance if this occurs.\u003cbr\u003e\nConsult your veterinarian before using this product in sick and debilitated animals.\u003cbr\u003e\nAs the product is dangerous for aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters\u003cbr\u003e\nfor at least 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003cbr\u003e\nAvoid contact with skin, eyes or mouth. Do not eat, drink or smoke during product application.\u003cbr\u003e\nWash hands thoroughly after product application.\u003cbr\u003e\nIf the product accidentally gets on the skin, immediately wash the area with soap and water.\u003cbr\u003e\nPeople with known skin sensitivity may be particularly sensitive to this product.\u003cbr\u003e\nIf the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is\u003cbr\u003e\naccidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.\u003cbr\u003e\nTreated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs in the\u003cbr\u003e\nevening, for example. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for the disposal of unused product or waste, if applicable\u003c\/strong\u003e\u003cbr\u003e\nAfter use, put the cap back on the pipette. Any unused veterinary medicinal product or waste derived from the use of such\u003cbr\u003e\nproducts must be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther information\u003c\/strong\u003e\u003cbr\u003e\nAdvantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.\u003cbr\u003e\nThis combination acts as an insecticide, acaricide and repellent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImidacloprid\u003c\/strong\u003e is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified\u003cbr\u003e\nas a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to its\u003cbr\u003e\nefficacy against adult fleas, the larvicidal efficacy of the substance for areas in the animal's habitat has also been demonstrated.\u003cbr\u003e\nThe product provides repellent (anti-feeding) action against ticks, sandflies and mosquitoes, thereby preventing\u003cbr\u003e\nparasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or\u003cbr\u003e\nCVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).\u003cbr\u003e\nIt can be used during pregnancy and lactation.\u003cbr\u003e\nThe solvent in \u003cstrong\u003eAdvantix spot-on solution for dogs\u003c\/strong\u003e may stain certain materials such as leather, fabrics, plastic and finished surfaces. Allow\u003cbr\u003e\nthe application site to dry before contact with such materials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003cbr\u003e\nPipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml\u003cbr\u003e\nBlister containing 1, 2, 3, 4 or 6 individual pipettes.\u003cbr\u003e\nNot all package sizes may be marketed.\u003cbr\u003e\nFor any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorisation holder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMarketing Authorisation Holder\u003c\/strong\u003e\u003cbr\u003e\nBayer Animal Health GmbH, D-51368 Leverkusen, Germany\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"4 kg","offer_id":57393783701836,"sku":"ADV100","price":59.0,"currency_code":"RON","in_stock":true},{"title":"10 kg","offer_id":57393783734604,"sku":"ADV250","price":70.0,"currency_code":"RON","in_stock":true},{"title":"25 kg","offer_id":57393783767372,"sku":"ADV400","price":77.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advantix-1x1ml-4kg-10kg-2018.jpg?v=1777294940"},{"product_id":"set-4-pipete-antiparazitare-advantix-pentru-caini-de-la-pana-la","title":"Set of 4 Advantix antiparasitic pipettes, for dogs weighing up to","description":"\u003cp\u003e\u003cstrong\u003eAdvantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e\nEach dose (pipette) contains:\u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePipette\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eImidacloprid\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePermethrin\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eE321\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e40 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e200 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e0.4 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2000 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e4.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eExcipients: Butylated hydroxytoluene 1.0 mg\/ml (E321, as antioxidant):\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003cbr\u003e\nFor the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).\u003cbr\u003e\nFleas on the dog are killed within one day after treatment. One treatment prevents future flea infestations for four weeks. The product\u003cbr\u003e\ncan be used as part of a treatment strategy for flea allergy dermatitis (FAD).\u003cbr\u003e\nThe product has acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes\u003cbr\u003e\nricinus) or three weeks (Dermacentor reticulatus) against tick infestations.\u003cbr\u003e\nTicks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore, it is\u003cbr\u003e\nrecommended to remove ticks present on the dog at the time of treatment to prevent them from attacking and feeding on blood.\u003cbr\u003e\nOne treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three\u003cbr\u003e\nweeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks and for stable flies\u003cbr\u003e\n(Stomoxys calcitrans) for four weeks.\u003cbr\u003e\nSandflies Phlebotomus perniciosus 3 weeks\u003cbr\u003e\nPhlebotomus papatasi 2 weeks\u003cbr\u003e\nMosquitoes Aedes aegypti 2 weeks\u003cbr\u003e\nCulex pipiens 4 weeks\u003cbr\u003e\nStable fly Stomoxys calcitrans 4 weeks\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003cbr\u003e\nIn the absence of available data, the product should not be used on puppies younger than 7 weeks.\u003cbr\u003e\nDo not use in cases of known hypersensitivity to the active substances.\u003cbr\u003e\nDo not use on cats.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse reactions\u003c\/strong\u003e\u003cbr\u003e\nRarely, transient dermal sensitivity (with increased pruritus, alopecia and erythema at the application site) or apathy may occur.\u003cbr\u003e\nPoisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as\u003cbr\u003e\ntremors and apathy may also occur. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.\u003cbr\u003e\nIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species\u003c\/strong\u003e\u003cbr\u003e\nDogs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage for each species, route(s) of administration and method of administration\u003c\/strong\u003e\u003cbr\u003e\nDosing scheme:\u003cbr\u003e\nThe minimum recommended dose is: 10 mg\/kg body weight (b.w.) imidacloprid and 50 mg\/kg body weight (b.w.) permethrin, equivalent to\u003cbr\u003e\n0.1ml\/kg b.w.\u003cstrong\u003e Advantix spot-on solution for dogs.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDog weight (kg) \u0026nbsp; \u0026nbsp; Pipette size to be used \u0026nbsp; \u0026nbsp; Volume (ml) \u0026nbsp; \u0026nbsp; Imidacloprid (mg\/kg b.w.) \u0026nbsp; \u0026nbsp; Permethrin (mg\/kg b.w.)\u003c\/p\u003e\n\u003cp\u003e\u0026gt;25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80\u003cbr\u003e\n\u0026gt; 40 kg, the appropriate combination of pipettes should be used\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%; height: 147px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 42px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 42px; text-align: center;\"\u003eDog weight (kg)\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 42px; text-align: center;\"\u003ePipette size to be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 42px; text-align: center;\"\u003eVolume (ml)\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 42px; text-align: center;\"\u003eImidacloprid (mg\/kg b.w.)\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 42px; text-align: center;\"\u003ePermethrin (mg\/kg b.w.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026lt;=4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003eminimum 10\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003eminimum 50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;4 kg - 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;10 kg - 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;25 kg - 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 16\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 80\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt; 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003ethe appropriate combination of pipettes should be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTo reduce re-infestations with new fleas, it is recommended that all dogs in a household be treated. Other pets in\u003cbr\u003e\nthe same family or household must be treated with appropriate products. For fleas originating from the animal's environment,\u003cbr\u003e\nthe additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure\u003cbr\u003e\nto water, the efficacy of the product decreases. Even in this case, it should not be treated more frequently than once a week. If it is\u003cbr\u003e\nnecessary to shampoo the animal, it is advisable to apply Advantix spot-on solution for dogs after two weeks\u003cbr\u003e\nto ensure the efficacy of the product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod of administration.\u003c\/strong\u003e\u003cbr\u003e\nRemove one pipette from the package. Hold the pipette upright, twist and remove the cap. Turn the cap upside down and use it to break the seal of the pipette (by twisting and pressing on the seal, as shown in the photo).\u003cbr\u003e\nFor dogs weighing 10 kg or less:\u003cbr\u003e\nWith the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and\u003cbr\u003e\nsqueeze firmly several times to empty the contents of the pipette. Apply only to unbroken skin.\u003cbr\u003e\nFor dogs weighing more than 10 kg:\u003cbr\u003e\nWith the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four places,\u003cbr\u003e\nstarting between the shoulder blades and extending to the base of the tail. At each site, part the hair until the skin is visible. Apply the tip of the pipette to the skin and\u003cbr\u003e\ngently squeeze to release some of the solution onto the skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommendations for correct administration\u003c\/strong\u003e\u003cbr\u003e\nFor external use only.\u003cbr\u003e\nApply only to unbroken skin.\u003cbr\u003e\nDo not apply a large amount of solution in one place as it may run down the sides of the dog.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWithdrawal period\u003c\/strong\u003e\u003cbr\u003e\nNot applicable.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for storage\u003c\/strong\u003e\u003cbr\u003e\nKeep out of the sight and reach of children.\u003cbr\u003e\nDo not freeze.\u003cbr\u003e\nAfter opening the aluminum pouch, store in a dry place and do not store above 30°C.\u003cbr\u003e\nThe abbreviation used for the expiry date on the label, pipette and pouch is EXP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003cbr\u003e\nThe contents of the pipette must not come into contact with the eyes and mouth of the treated dog.\u003cbr\u003e\nPay attention to the correct administration of the product as described in the \"Method of administration\" section. In particular, oral ingestion\u003cbr\u003e\nby licking the application site or contact with other animals should be avoided.\u003cbr\u003e\nDo not use on cats.\u003cbr\u003e\nThis product is highly toxic to cats and can cause death due to the physiological peculiarities of cats\u003cbr\u003e\nwho are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of\u003cbr\u003e\ncats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.\u003cbr\u003e\nMeasures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek\u003cbr\u003e\nimmediate veterinary assistance if this happens.\u003cbr\u003e\nConsult your veterinarian before using this product on sick and debilitated animals.\u003cbr\u003e\nAs the product is dangerous to aquatic organisms, treated dogs must not be allowed to enter any surface water\u003cbr\u003e\nfor at least 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003cbr\u003e\nAvoid contact with skin, eyes or mouth. Do not eat, drink or smoke during product application.\u003cbr\u003e\nWash hands thoroughly after product application.\u003cbr\u003e\nIf the product accidentally gets on the skin, wash the area immediately with soap and water.\u003cbr\u003e\nPeople with known skin sensitivity may be particularly sensitive to this product.\u003cbr\u003e\nIf the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is\u003cbr\u003e\naccidentally swallowed, seek immediate medical advice and show the product leaflet to the doctor.\u003cbr\u003e\nTreated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for\u003cbr\u003e\nexample, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for the disposal of unused product or waste materials, if any\u003c\/strong\u003e\u003cbr\u003e\nAfter use, replace the cap on the pipette. Any unused veterinary medicinal product or waste material derived from the use of such\u003cbr\u003e\nproducts should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther information\u003c\/strong\u003e\u003cbr\u003e\nAdvantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.\u003cbr\u003e\nThis combination acts as an insecticide, acaricide and repellent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImidacloprid\u003c\/strong\u003e is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified\u003cbr\u003e\nas chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to\u003cbr\u003e\nits efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for sites in the animal's habitat.\u003cbr\u003e\nThe product provides repellent (anti-feeding) action against ticks, sandflies and mosquitoes, thereby preventing\u003cbr\u003e\nparasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or\u003cbr\u003e\nCVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).\u003cbr\u003e\nIt can be used during gestation and lactation.\u003cbr\u003e\nThe solvent in \u003cstrong\u003eAdvantix spot-on solution for dogs\u003c\/strong\u003e may stain certain materials such as leather, fabrics, plastic and finished surfaces. Allow\u003cbr\u003e\nthe application site to dry before contact with such materials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003cbr\u003e\nPipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml\u003cbr\u003e\nBlister containing 1, 2, 3, 4 or 6 individual pipettes.\u003cbr\u003e\nNot all package sizes may be marketed.\u003cbr\u003e\nFor any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorisation holder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMarketing Authorisation Holder\u003c\/strong\u003e\u003cbr\u003e\nBayer Animal Health GmbH, D-51368 Leverkusen, Germany\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"4 kg","offer_id":57393783800140,"sku":"ADV100-SET4","price":220.0,"currency_code":"RON","in_stock":true},{"title":"10 kg","offer_id":57393783832908,"sku":"ADV250-SET4","price":253.0,"currency_code":"RON","in_stock":true},{"title":"25 kg","offer_id":57393783865676,"sku":"ADV400-SET4","price":284.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/set-4-Advantix-1x1ml-4kg-10kg-2018.png?v=1777294941"},{"product_id":"frontline-tri-act-caini-40-60-kg-3-pipete","title":"Frontline Tri-Act Dogs 40-60 kg (3 pipettes)","description":"\u003cp\u003e\u003cstrong\u003eLiquid antiparasitic solution for cutaneous application packaged in single-use pipettes\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003e\u003cstrong\u003ePACKAGE LEAFLET FOR \u003c\/strong\u003e\u003cstrong\u003eCardboard box with 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs 40-60 kg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSTATEMENT OF THE ACTIVE SUBSTANCES AND OTHER INGREDIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpot-on solution.\u003c\/p\u003e\n\u003cp\u003eClear, colourless to yellow-brown solution.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive substances\/Excipients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSee section \"dosage for each target species\"\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTARGET SPECIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDogs\u003c\/p\u003e\n\u003cp\u003eCaution!!!\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the site where the veterinary medicinal product has been applied to dogs. In case of such exposure, seek veterinary advice immediately.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINDICATION (INDICATIONS)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea and\/or tick infestations when repellent (anti-feeding) activity against sandflies, flies and\/or mosquitoes is required.\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of infestations with fleas \u003cem\u003eCtenocephalides felis\u003c\/em\u003e and prevention of infestations with fleas \u003cem\u003eCtenocephalides canis\u003c\/em\u003e. The product kills \u003cem\u003eC. felis\u003c\/em\u003e fleas on the animal within 24 hours. A single\u003c\/p\u003e\n\u003cp\u003etreatment prevents new flea infestation for 4 weeks. The product can be part of a treatment strategy for the control of flea allergy dermatitis if this diagnosis has been\u003c\/p\u003e\n\u003cp\u003eestablished by the veterinarian.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent efficacy against ticks (\u003cem\u003eDermacentor reticulatus\u003c\/em\u003e) starting from 7 days and up to 4 weeks after treatment. However, a single tick can attach and detach within the first 24 hours after infestation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003eThe product has immediate acaricidal efficacy against \u003cem\u003eRhipicephalus sanguineus\u003c\/em\u003e and \u003cem\u003eIxodes ricinus\u003c\/em\u003e species, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003eThe product has persistent acaricidal efficacy against ticks (\u003cem\u003eIxodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus\u003c\/em\u003e) for 4 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (\u003cem\u003ePhlebotomus perniciosus\u003c\/em\u003e) and for 4 weeks against mosquitoes (\u003cem\u003eCulex pipiens\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003eThe product has persistent insecticidal efficacy against sandflies (\u003cem\u003ePhlebotomus perniciosus\u003c\/em\u003e) for 3 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product repels and kills stable flies (\u003cem\u003eStomoxys calcitrans\u003c\/em\u003e) for five weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDo not use on sick or convalescing animals.\u003c\/p\u003e\n\u003cp\u003eDo not use on cats and rabbits as it can cause adverse reactions and even death.\u003c\/p\u003e\n\u003cp\u003eDo not use in case of known hypersensitivity to the active substance or to any of the excipients.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVERSE REACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAmong the very rare suspected adverse reactions, transient skin reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.\u003c\/p\u003e\n\u003cp\u003eMild hypersalivation and vomiting may occur if the product is ingested, if the animal licks the application site.\u003c\/p\u003e\n\u003cp\u003eIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND \u003c\/strong\u003e\u003cstrong\u003eMETHOD OF ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTopical administration to the skin (spot-on).\u003c\/p\u003e\n\u003cp\u003eThe following table defines which pipette should be used depending on the dog's weight:\u003c\/p\u003e\n\u003cp\u003eActive ingredients Excipients\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs. Volume of dosed unit. Fipronil (mg) Permethrin (mg) Butylated hydroxytoluene (E321) (mg)\u003c\/p\u003e\n\u003cp\u003eVery small dogs 2-5kg 0.5 33.8 252.4 0.563\u003c\/p\u003e\n\u003cp\u003eSmall dogs 5-10kg 1 67.6 504.8 1.125\u003c\/p\u003e\n\u003cp\u003eMedium dogs 10-20kg 2 135.2 1009.6 2.250\u003c\/p\u003e\n\u003cp\u003eLarge dogs 20-40kg 4 270.4 2019.2 4.500\u003c\/p\u003e\n\u003cp\u003eXL dogs 40-60kg 6 405.6 3028.8 6.750\u003c\/p\u003e\n\u003cp\u003eDogs \u003e 60 kg Use the appropriate combination of pipettes\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment scheme\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product should be used after confirmation of infestation or risk of infestation with fleas and\/or ticks, along with the need for repellent (anti-feeding) activity against sandflies and\/or mosquitoes and\/or flies.\u003c\/p\u003e\n\u003cp\u003eDepending on the recurrence of infestation risk with these ectoparasites, treatment repetition can also be established. In these cases, the minimum treatment interval is at least 4 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRECOMMENDATIONS FOR CORRECT ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSelect the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg,\u003c\/p\u003e\n\u003cp\u003ethe necessary combination of pipettes should be used until the appropriate quantity for the dog's weight is reached.\u003c\/p\u003e\n\u003cp\u003eThe product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site.\u003c\/p\u003e\n\u003cp\u003eThese application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.\u003c\/p\u003e\n\u003cp\u003eRemove the blister foil from the packaging and detach one blister. Use scissors to cut the blister along the dotted line to remove the pipette, or fold the marked corner and tear it open.\u003c\/p\u003e\n\u003cp\u003eHold the pipette upright, away from your face or body, and cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the tip of the pipette on the skin.\u003c\/p\u003e\n\u003cp\u003eSqueeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.\u003c\/p\u003e\n\u003cp\u003eTo achieve the best results, ensure that the product is applied directly to the skin and not to the fur.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWITHDRAWAL PERIOD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNot applicable\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR STORAGE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKeep out of the sight and reach of children.\u003c\/p\u003e\n\u003cp\u003eStore in the original packaging.\u003c\/p\u003e\n\u003cp\u003eDo not store above 25 °C.\u003c\/p\u003e\n\u003cp\u003eDo not use after the expiry date stated on the packaging after \"EXP\". The expiry date refers to the last day of that month.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL WARNING(S)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpecial warnings for each target species\u003c\/p\u003e\n\u003cp\u003eA single tick or a bite from a mosquito or sandfly may already be present on the animal. For this reason, the transmission of pathogens by these arthropods cannot be excluded if conditions are favourable.\u003c\/p\u003e\n\u003cp\u003eThe product remains effective against fleas when treated animals occasionally enter water (e.g. swimming, bathing). However, dogs should not be allowed to swim or be shampooed for 48 hours after treatment application.\u003c\/p\u003e\n\u003cp\u003eAvoid swimming or frequent shampooing of treated dogs as this may affect the maintenance of product efficacy.\u003c\/p\u003e\n\u003cp\u003eTo reduce re-infestation due to the appearance of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same area should be treated with a veterinary medicinal product suitable for their species.\u003c\/p\u003e\n\u003cp\u003eTo reduce the risk of environmental infestation, it is recommended to use additional appropriate treatment\u003c\/p\u003e\n\u003cp\u003efor the animals' environment, against fleas and their developmental stages.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection4\"\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn the absence of specific studies, the use of this product is not recommended for dogs younger than 8 weeks or weighing less than 2 kg.\u003c\/p\u003e\n\u003cp\u003eAvoid contact of the product with the animal's eyes.\u003c\/p\u003e\n\u003cp\u003eIt is very important to ensure that the product is applied in an area where the animal cannot lick the product, and also to ensure that animals do not lick each other after\u003c\/p\u003e\n\u003cp\u003etreatment.\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the site where the veterinary medicinal product has been applied to dogs. In case of such exposure, seek veterinary advice immediately.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor veterinary use only.\u003c\/p\u003e\n\u003cp\u003eThis product may cause skin and eye irritation. Therefore, contact of the product with skin or eyes should be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if the eyes become irritated during product administration, immediate thorough washing with water is recommended. If eye irritation persists, seek medical advice.\u003c\/p\u003e\n\u003cp\u003ePersons with known hypersensitivity to fipronil or\/and permethrin should avoid contact with this product.\u003c\/p\u003e\n\u003cp\u003eThe product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat while applying the product. Wash hands after use. In case of ingestion, rinse mouth with water and seek medical advice if you feel unwell.\u003c\/p\u003e\n\u003cp\u003eAs the excipient N-methylpyrrolidone may cause foetotoxicity and teratogenicity following prolonged exposure, pregnant women are advised to wear gloves to avoid contact with the product.\u003c\/p\u003e\n\u003cp\u003eAvoid handling the animal until the application site is dry; children should also not play with the animals until the fur is dry.\u003c\/p\u003e\n\u003cp\u003eTherefore, it is recommended that animals are not treated during the day but in the evening, and that treated animals sleep alone during the night, not with their owners and especially not with children.\u003c\/p\u003e\n\u003cp\u003eKeep pipettes in the original packaging and once used, empty pipettes should be disposed of immediately in an appropriate manner to prevent subsequent access.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product may be harmful to aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.\u003c\/p\u003e\n\u003cp\u003eUse during pregnancy and lactation\u003c\/p\u003e\n\u003cp\u003eLaboratory studies with fipronil and permethrin produced no teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eN-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.\u003c\/p\u003e\n\u003cp\u003eUse only after a benefit\/risk assessment by the veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOverdose\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSafety of use has been evaluated in healthy adult dogs treated with a dose up to 5 times higher than the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Known adverse reactions may include mild neurological symptoms, vomiting and diarrhoea. These symptoms are transient and usually disappear without treatment within 1-2 days. Animals should always be treated with the pipette corresponding to their weight.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR \u003c\/strong\u003e\u003cstrong\u003eWASTE, IF APPLICABLE\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection5\"\u003e\n\u003cp\u003eAny unused veterinary medicinal product or waste materials derived from such veterinary medicinal products\u003c\/p\u003e\n\u003cp\u003eshould be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003eDo not contaminate lakes, watercourses or drains with this product or empty pipettes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOTHER INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas in 24\u003c\/p\u003e\n\u003cp\u003ehours, ticks and lice in 48 hours after exposure.\u003c\/p\u003e\n\u003cp\u003ePermethrin belongs to type I pyrethroids, which are acaricides and insecticides with repellent activity.\u003c\/p\u003e\n\u003cp\u003ePermethrin in the product provides repellent activity against sandflies (\u003e80% for 4 weeks), mosquitoes and ticks.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394060067148,"sku":"FRONT4060","price":195.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Frontline-Tri-Act-Caini-40-60-kg-3-pipete-XL.jpg?v=1777296699"},{"product_id":"frontline-tri-act-caini-20-40-kg-3-pipete","title":"Frontline Tri-Act Dogs 20-40 kg (3 pipettes)","description":"\u003cp\u003e\u003cstrong\u003eLiquid anti-parasitic solution for cutaneous application, packaged in single-use pipettes\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003e\u003cstrong\u003ePACKAGE LEAFLET FOR \u003c\/strong\u003e\u003cstrong\u003eCardboard box with 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs 20-40 kg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDECLARATION OF THE ACTIVE SUBSTANCES AND OTHER INGREDIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpot-on solution.\u003c\/p\u003e\n\u003cp\u003eClear, colourless to brown-yellow solution.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive substances\/Excipients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSee section \"dosage for each target species\"\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTARGET SPECIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDogs\u003c\/p\u003e\n\u003cp\u003eWarning!!!\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species that may be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and urgently seek veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, immediately seek veterinary advice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINDICATION(S)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea and\/or tick infestations when repellent (anti-feeding) activity against sandflies, flies, and\/or mosquitoes is required.\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea infestations with \u003cem\u003eCtenocephalides felis\u003c\/em\u003e and the prevention of flea infestations with \u003cem\u003eCtenocephalides canis\u003c\/em\u003e. The product kills \u003cem\u003eC. felis\u003c\/em\u003e fleas on the animal within 24 hours. A single\u003c\/p\u003e\n\u003cp\u003etreatment prevents new flea infestations for 4 weeks. The product can be part of a treatment strategy for the control of flea allergy dermatitis if this diagnosis has\u003c\/p\u003e\n\u003cp\u003ebeen established by a veterinarian.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent efficacy against ticks (\u003cem\u003eDermacentor reticulatus)\u003c\/em\u003e starting from 7 days and lasting up to 4 weeks after treatment. However, a single tick may attach and detach within the first 24 hours after infestation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003eThe product has immediate acaricidal efficacy against \u003cem\u003eRhipicephalus sanguineus\u003c\/em\u003e and \u003cem\u003eIxodes ricinus\u003c\/em\u003e, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003eThe product has persistent acaricidal efficacy against ticks (\u003cem\u003eIxodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus)\u003c\/em\u003e for 4 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (\u003cem\u003ePhlebotomus perniciosus)\u003c\/em\u003e and for 4 weeks against mosquitoes (\u003cem\u003eCulex pipiens)\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp\u003eThe product has persistent insecticidal efficacy against sandflies (\u003cem\u003ePhlebotomus perniciosus)\u003c\/em\u003e for 3 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product repels and kills stable flies (\u003cem\u003eStomoxys calcitrans)\u003c\/em\u003e for five weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDo not use on sick or convalescent animals.\u003c\/p\u003e\n\u003cp\u003eDo not use on cats and rabbits as it may cause adverse reactions and even death.\u003c\/p\u003e\n\u003cp\u003eDo not use in cases of known hypersensitivity to the active substance or to any of the excipients.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVERSE REACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAmong the suspected, very rare adverse reactions reported after use were transient reactions\u003c\/p\u003e\n\u003cp\u003eon the skin at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized pruritus or alopecia. Also reported were hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremor, depression, other neurological reactions) or vomiting.\u003c\/p\u003e\n\u003cp\u003eSlight hypersalivation and vomiting may occur if the product is ingested, if the animal licks the application area.\u003c\/p\u003e\n\u003cp\u003eIf you notice any serious reactions or other effects not mentioned in this package leaflet, please inform your veterinary surgeon.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOSAGE FOR EACH SPECIES, ROUTE(S) AND \u003c\/strong\u003e\u003cstrong\u003eMETHOD OF ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTopical application to the skin (spot-on).\u003c\/p\u003e\n\u003cp\u003eThe following table defines which pipette should be used depending on the dog's weight:\u003c\/p\u003e\n\u003cp\u003eActive ingredients Excipients\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs Unit volume Fipronil (mg) Permethrin Butylhydroxytoluene\u003c\/p\u003e\n\u003cp\u003edosed (mg) (E321) (mg)\u003c\/p\u003e\n\u003cp\u003eVery small dogs 2-5kg 0.5 33.8 252.4 0.563\u003c\/p\u003e\n\u003cp\u003eSmall dogs 5-10kg 1 67.6 504.8 1.125\u003c\/p\u003e\n\u003cp\u003eMedium dogs 10-20kg 2 135.2 1009.6 2.250\u003c\/p\u003e\n\u003cp\u003eLarge dogs 20-40kg 4 270.4 2019.2 4.500\u003c\/p\u003e\n\u003cp\u003eXL dogs 40-60kg 6 405.6 3028.8 6.750\u003c\/p\u003e\n\u003cp\u003eDogs \u003e 60 kg Use the appropriate combination of pipettes\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment regimen\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product should be used following confirmation of infestation or risk of infestation with fleas and\/or ticks, simultaneously with the need for repellent (anti-feeding) activity against sandflies and\/or mosquitoes and\/or flies.\u003c\/p\u003e\n\u003cp\u003eDepending on the recurrence of the risk of infestation with these ectoparasites, treatment repetition can be established. In these cases, the minimum treatment interval is at least 4 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRECOMMENDATIONS FOR CORRECT ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSelect the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg, the necessary combination of pipettes should be used to achieve the appropriate amount for the dog's weight.\u003c\/p\u003e\n\u003cp\u003eThe product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site. These application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.\u003c\/p\u003e\n\u003cp\u003eRemove the blister foil from the package and detach one blister. Use scissors to cut the blister along the dotted line to remove the pipette or fold the marked corner and tear open.\u003c\/p\u003e\n\u003cp\u003eHold the pipette upright, away from your face or body, cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the pipette tip on the skin.\u003c\/p\u003e\n\u003cp\u003eSqueeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.\u003c\/p\u003e\n\u003cp\u003eTo achieve the best results, ensure that the product is applied directly to the skin and not to the fur.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWITHDRAWAL PERIOD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNot applicable\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR STORAGE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKeep out of the sight and reach of children.\u003c\/p\u003e\n\u003cp\u003eStore in the original packaging.\u003c\/p\u003e\n\u003cp\u003eDo not store above 25 °C\u003c\/p\u003e\n\u003cp\u003eDo not use after the expiry date stated on the packaging after \"EXP\". The expiry date refers to the last day of that month.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL WARNING(S)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpecial warnings for each target species\u003c\/p\u003e\n\u003cp\u003eA single tick may already be attached to the animal or a mosquito or sandfly bite may be present. For this reason, the transmission of pathogens by these arthropods cannot be excluded if conditions are favorable.\u003c\/p\u003e\n\u003cp\u003eThe product remains effective against fleas when treated animals occasionally enter water (e.g., swimming, bathing). However, dogs should not be allowed to swim or be shampooed for 48 hours after treatment application.\u003c\/p\u003e\n\u003cp\u003eAvoid frequent swimming or shampooing of treated dogs as this may affect the maintenance of product efficacy.\u003c\/p\u003e\n\u003cp\u003eIn order to reduce re-infestation due to the emergence of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same environment should be treated with a veterinary medicinal product suitable for their species.\u003c\/p\u003e\n\u003cp\u003eTo reduce the risk of environmental infestation, the use of an additional treatment is recommended\u003c\/p\u003e\n\u003cp\u003eappropriate to the environment in which the animals live, against fleas and their developmental stages.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection4\"\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn the absence of specific studies, the use of this product is not recommended for dogs less than 8 weeks of age or weighing less than 2 kg.\u003c\/p\u003e\n\u003cp\u003eAvoid contact of the product with the animal's eyes.\u003c\/p\u003e\n\u003cp\u003eIt is very important to ensure that the product is applied to an area where the animal cannot lick the product and also to ensure that animals do not lick each other after\u003c\/p\u003e\n\u003cp\u003etreatment.\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species that may be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and urgently seek veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, immediately seek veterinary advice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor veterinary use only.\u003c\/p\u003e\n\u003cp\u003eThis product may cause skin and eye irritation. Therefore, contact of the product with skin or eyes must be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if eyes become irritated during product administration, immediate thorough washing with water is recommended. If eye irritation persists, seek medical advice.\u003c\/p\u003e\n\u003cp\u003ePersons with known hypersensitivity to fipronil and\/or permethrin should avoid contact with this product.\u003c\/p\u003e\n\u003cp\u003eThe product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during product application. Wash hands after use. In case of ingestion, rinse mouth with water and seek medical advice if you feel unwell.\u003c\/p\u003e\n\u003cp\u003eAs the excipient N-methylpyrrolidone may cause foetotoxicity and teratogenicity following prolonged exposure, pregnant women are advised to wear gloves to avoid contact with the product.\u003c\/p\u003e\n\u003cp\u003eAvoid handling the animal until the application site has dried; also, children should not play with the animals until their fur is dry.\u003c\/p\u003e\n\u003cp\u003eTherefore, it is recommended that animals should not be treated during the day but in the evening, and during the night treated animals should sleep alone, not with owners and especially not with children.\u003c\/p\u003e\n\u003cp\u003eKeep pipettes in their original packaging and once used, empty pipettes should be disposed of immediately in an appropriate manner, to prevent further access.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product may have adverse effects on aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.\u003c\/p\u003e\n\u003cp\u003eUse during pregnancy and lactation\u003c\/p\u003e\n\u003cp\u003eLaboratory studies with fipronil and permethrin did not produce any teratogenic or embryotoxic effects. No studies have been performed with this product on animals during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eN-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.\u003c\/p\u003e\n\u003cp\u003eUse only after a benefit\/risk assessment by the veterinary surgeon.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOverdose\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSafety for use has been evaluated in healthy adult dogs treated with a dose up to 5 times higher\u003c\/p\u003e\n\u003cp\u003ethan the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks of age, treated once). Among the known adverse reactions, mild neurological symptoms,\u003c\/p\u003e\n\u003cp\u003evomiting, and diarrhoea may occur. These symptoms are transient and usually resolve without treatment within 1-2 days. Animals should always be treated with the pipette appropriate for their weight.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR \u003c\/strong\u003e\u003cstrong\u003eWASTE MATERIALS, IF APPLICABLE\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection5\"\u003e\n\u003cp\u003eAny unused veterinary medicinal product or waste materials derived from such products\u003c\/p\u003e\n\u003cp\u003eshould be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003eDo not contaminate lakes, watercourses or drains with this product or empty pipettes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOTHER INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas within 24\u003c\/p\u003e\n\u003cp\u003ehours, ticks and lice within 48 hours of exposure.\u003c\/p\u003e\n\u003cp\u003ePermethrin belongs to the Type I class of pyrethroids, which are acaricides and insecticides with repellent activity.\u003c\/p\u003e\n\u003cp\u003ePermethrin in the product provides repellent activity against sandflies (\u003e80% for 4 weeks), mosquitoes and ticks.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394060099916,"sku":"FRONT2040","price":174.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Frontline-Tri-Act-Caine-20-40-kg-3-pipete.jpg?v=1777296699"},{"product_id":"frontline-tri-act-caini-10-20-kg-3-pipete","title":"Frontline Tri-Act Dogs 10-20 kg (3 pipettes)","description":"\u003cp\u003e\u003cstrong\u003eLiquid antiparasitic solution for cutaneous application, packaged in single-dose pipettes\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003e\u003cstrong\u003ePACKAGE LEAFLET FOR \u003c\/strong\u003e\u003cstrong\u003eCardboard box with 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs 10-20 kg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDECLARATION OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpot-on solution.\u003c\/p\u003e\n\u003cp\u003eClear, colourless to brownish-yellow solution.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive substances\/Excipients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSee section \"Dosage for each target species\"\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTARGET SPECIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDogs\u003c\/p\u003e\n\u003cp\u003eCaution!!!\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species that may be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINDICATION (INDICATIONS)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea and\/or tick infestations when repellent (anti-feeding) activity against sandflies, flies, and\/or mosquitoes is required.\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea infestations with \u003cem\u003eCtenocephalides felis\u003c\/em\u003e and the prevention of flea infestations with \u003cem\u003eCtenocephalides canis\u003c\/em\u003e. The product kills \u003cem\u003eC. felis\u003c\/em\u003e fleas on the animal within 24 hours. A single\u003c\/p\u003e\n\u003cp\u003etreatment prevents new flea infestation for 4 weeks. The product can be part of the treatment strategy for the control of flea allergy dermatitis if this diagnosis has\u003c\/p\u003e\n\u003cp\u003ebeen established by a veterinarian.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent efficacy against ticks (\u003cem\u003eDermacentor reticulatus)\u003c\/em\u003e from 7 days up to 4 weeks after treatment. However, a single tick may attach and detach within the first 24 hours after infestation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003eThe product has immediate acaricidal efficacy against \u003cem\u003eRhipicephalus sanguineus\u003c\/em\u003e and \u003cem\u003eIxodes ricinus\u003c\/em\u003e species, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003eThe product has persistent acaricidal efficacy against ticks (\u003cem\u003eIxodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus)\u003c\/em\u003e for 4 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (\u003cem\u003ePhlebotomus perniciosus)\u003c\/em\u003e and for 4 weeks against mosquitoes (\u003cem\u003eCulex pipiens)\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp\u003eThe product has persistent insecticidal efficacy against sandflies (\u003cem\u003ePhlebotomus perniciosus)\u003c\/em\u003e for 3 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product repels and kills stable flies (\u003cem\u003eStomoxys calcitrans)\u003c\/em\u003e for five weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDo not use on sick or convalescing animals.\u003c\/p\u003e\n\u003cp\u003eDo not use on cats and rabbits as it may cause adverse reactions and even death.\u003c\/p\u003e\n\u003cp\u003eDo not use in cases of known hypersensitivity to the active substance or to any of the excipients.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVERSE REACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAmong the suspected, very rare adverse reactions, transient skin reactions at the application site (skin discolouration, local alopecia, pruritus, erythema) and generalised pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.\u003c\/p\u003e\n\u003cp\u003eMild hypersalivation and vomiting may occur if the product is ingested, for example, if the animal licks the application area.\u003c\/p\u003e\n\u003cp\u003eIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinary surgeon.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND \u003c\/strong\u003e\u003cstrong\u003eMETHOD OF ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTopical application on the skin (spot-on).\u003c\/p\u003e\n\u003cp\u003eThe following table defines which pipette should be used depending on the dog's weight:\u003c\/p\u003e\n\u003cp\u003eActive ingredients Excipients\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot- Volume of unit Fipronil (mg) Permethrin Butylhydroxytoluene\u003c\/p\u003e\n\u003cp\u003eon for dogs dosed (mg) (E321) (mg)\u003c\/p\u003e\n\u003cp\u003eVery small dogs 2-5kg 0.5 33.8 252.4 0.563\u003c\/p\u003e\n\u003cp\u003eSmall dogs 5-10kg 1 67.6 504.8 1.125\u003c\/p\u003e\n\u003cp\u003eMedium dogs 10-20kg 2 135.2 1009.6 2.250\u003c\/p\u003e\n\u003cp\u003eLarge dogs 20-40kg 4 270.4 2019.2 4.500\u003c\/p\u003e\n\u003cp\u003eXL dogs 40-60kg 6 405.6 3028.8 6.750\u003c\/p\u003e\n\u003cp\u003eDogs \u0026gt; 60 kg Use the appropriate combination of pipettes\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment regimen\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product should be used after confirmation of infestation or risk of infestation with fleas and\/or ticks, simultaneously with the need for repellent (anti-feeding) activity against sandflies and\/or mosquitoes and\/or flies.\u003c\/p\u003e\n\u003cp\u003eDepending on the recurrence of the risk of infestation with these ectoparasites, repeated treatment may be established. In these cases, the minimum treatment interval is at least 4 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVICE ON CORRECT ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSelect the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg, the necessary combination of pipettes should be used until the appropriate quantity for the dog's weight is reached.\u003c\/p\u003e\n\u003cp\u003eThe product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site. These application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.\u003c\/p\u003e\n\u003cp\u003eRemove the blister foil from the packaging and tear off one blister. Use scissors to cut the blister along the dotted line to remove the pipette or fold the marked corner and tear open.\u003c\/p\u003e\n\u003cp\u003eHold the pipette upright, away from your face or body, cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the pipette tip on the skin.\u003c\/p\u003e\n\u003cp\u003eSqueeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.\u003c\/p\u003e\n\u003cp\u003eFor best results, ensure the product is applied directly to the skin and not to the fur.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWITHDRAWAL PERIOD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNot applicable\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR STORAGE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKeep out of the sight and reach of children.\u003c\/p\u003e\n\u003cp\u003eStore in the original packaging.\u003c\/p\u003e\n\u003cp\u003eDo not store above 25 °C\u003c\/p\u003e\n\u003cp\u003eDo not use after the expiry date stated on the packaging after \"EXP\". The expiry date refers to the last day of that month.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL WARNING(S)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpecial warnings for each target species\u003c\/p\u003e\n\u003cp\u003eA single tick or a mosquito or sandfly bite may already be present on the animal. Therefore, the transmission of pathogens by these arthropods cannot be excluded if conditions are favourable.\u003c\/p\u003e\n\u003cp\u003eThe product remains effective against fleas when treated animals occasionally enter water (e.g., swimming, bathing). However, dogs should not be allowed to swim or be shampooed for 48 hours after treatment application.\u003c\/p\u003e\n\u003cp\u003eAvoid swimming or frequent shampooing of treated dogs as this may affect the maintenance of product efficacy.\u003c\/p\u003e\n\u003cp\u003eIn order to reduce re-infestation due to the emergence of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same environment should be treated with a veterinary medicinal product appropriate for their species.\u003c\/p\u003e\n\u003cp\u003eTo reduce the risk of environmental infestation, it is recommended to use an additional appropriate treatment for the environment in which the animals live, against fleas and their developmental stages.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection4\"\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn the absence of specific studies, the use of this product is not recommended for dogs less than 8 weeks old or weighing less than 2 kg.\u003c\/p\u003e\n\u003cp\u003eAvoid contact of the product with the animal's eyes.\u003c\/p\u003e\n\u003cp\u003eIt is very important to ensure that the product is applied in an area where the animal cannot lick the product, and also to ensure that animals do not lick each other after\u003c\/p\u003e\n\u003cp\u003etreatment.\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species that may be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor veterinary use only.\u003c\/p\u003e\n\u003cp\u003eThis product may cause skin and eye irritation. Consequently, contact of the product with skin or eyes should be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if eyes become irritated during administration of the product, immediate abundant washing with water is recommended. If ophthalmic irritation persists, seek medical advice.\u003c\/p\u003e\n\u003cp\u003ePersons with known hypersensitivity to fipronil and\/or permethrin should avoid contact with this product.\u003c\/p\u003e\n\u003cp\u003eThe product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during product application. Wash hands after use. In case of swallowing, rinse mouth with water and seek medical advice if you feel unwell.\u003c\/p\u003e\n\u003cp\u003eAs the excipient N-methylpyrrolidone may cause foetotoxicity and teratogenicity following prolonged exposure, it is recommended that pregnant women wear gloves to avoid contact with the product.\u003c\/p\u003e\n\u003cp\u003eAvoid handling the animal until the application site has dried. Children should also not play with the animals until the fur is dry.\u003c\/p\u003e\n\u003cp\u003eTherefore, it is recommended that animals are not treated during the day but in the evening, and treated animals should sleep alone during the night, not with owners and especially not with children.\u003c\/p\u003e\n\u003cp\u003eStore pipettes in the original packaging, and once used, empty pipettes should be disposed of immediately in an appropriate manner to prevent subsequent access.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product may adversely affect aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.\u003c\/p\u003e\n\u003cp\u003eUse during pregnancy and lactation\u003c\/p\u003e\n\u003cp\u003eLaboratory studies with fipronil and permethrin have not produced any teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eN-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.\u003c\/p\u003e\n\u003cp\u003eUse only based on a benefit\/risk assessment by the veterinary surgeon.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOverdose\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSafety of use was evaluated in healthy adult dogs treated with a dose up to 5 times the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Known adverse reactions may include mild neurological symptoms,\u003c\/p\u003e\n\u003cp\u003evomiting and diarrhoea. These symptoms are transient and usually resolve without treatment within 1-2 days. Animals should always be treated with the pipette appropriate for their weight.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR \u003c\/strong\u003e\u003cstrong\u003eWASTE MATERIALS, IF ANY\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection5\"\u003e\n\u003cp\u003eAny unused veterinary medicinal product or waste materials derived from such products\u003c\/p\u003e\n\u003cp\u003eshould be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003eDo not contaminate ponds, watercourses or ditches with this product or empty pipettes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOTHER INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas within 24 hours,\u003c\/p\u003e\n\u003cp\u003eticks and lice within 48 hours of exposure.\u003c\/p\u003e\n\u003cp\u003ePermethrin belongs to the Type I pyrethroid class, which are acaricides and insecticides with repellent activity.\u003c\/p\u003e\n\u003cp\u003ePermethrin in the product provides repellent activity against sandflies (\u0026gt;80% for 4 weeks), mosquitoes and ticks.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394060394828,"sku":"FRONT1020","price":150.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Frontline-Tri-Act-Caini-10-20-kg-3-pipete-XL.jpg?v=1777296704"},{"product_id":"frontline-tri-act-caini-5-10-kg-3-pipete","title":"Frontline Tri-Act Dogs 5-10 kg (3 pipettes)","description":"\u003cp\u003e\u003cstrong\u003eLiquid antiparasitic solution for cutaneous application, packaged in single-use pipettes\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003e\u003cstrong\u003ePACKAGE LEAFLET FOR \u003c\/strong\u003e\u003cstrong\u003eCardboard box with 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs 5-10 kg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDECLARATION OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpot-on solution.\u003c\/p\u003e\n\u003cp\u003eClear, colorless to brownish-yellow solution.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive substances\/Excipients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSee \"dosage for each target species\" section\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTARGET SPECIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDogs\u003c\/p\u003e\n\u003cp\u003eCaution!!!\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and urgently seek veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the site where the veterinary medicinal product has been applied to dogs. In case of such exposure, seek veterinary advice immediately.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINDICATION(S)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea and\/or tick infestations when repellent (anti-feeding) activity against sandflies, stable flies and\/or mosquitoes is required.\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea infestations by \u003cem\u003eCtenocephalides felis\u003c\/em\u003e and the prevention of flea infestations by \u003cem\u003eCtenocephalides canis\u003c\/em\u003e. The product kills \u003cem\u003eC. felis\u003c\/em\u003e fleas on the animal within 24 hours. A single\u003c\/p\u003e\n\u003cp\u003etreatment prevents new flea infestations for 4 weeks. The product can be part of a treatment strategy for the control of flea allergy dermatitis if this diagnosis has\u003c\/p\u003e\n\u003cp\u003ebeen established by the veterinarian.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent efficacy against ticks (\u003cem\u003eDermacentor reticulatus\u003c\/em\u003e) starting from 7 days and up to 4 weeks after treatment. However, a single tick may attach and detach within the first 24 hours after infestation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003eThe product has immediate acaricidal efficacy against \u003cem\u003eRhipicephalus sanguineus\u003c\/em\u003e and \u003cem\u003eIxodes ricinus\u003c\/em\u003e, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003eThe product has persistent acaricidal efficacy against ticks (\u003cem\u003eIxodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus\u003c\/em\u003e) for 4 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (\u003cem\u003ePhlebotomus perniciosus\u003c\/em\u003e) and for 4 weeks against mosquitoes (\u003cem\u003eCulex pipiens\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003eThe product has persistent insecticidal efficacy against sandflies (\u003cem\u003ePhlebotomus perniciosus\u003c\/em\u003e) for 3 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product repels and kills stable flies (\u003cem\u003eStomoxys calcitrans\u003c\/em\u003e) for five weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDo not use on sick or convalescing animals.\u003c\/p\u003e\n\u003cp\u003eDo not use on cats and rabbits as it may cause adverse reactions and even death.\u003c\/p\u003e\n\u003cp\u003eDo not use in cases of known hypersensitivity to the active substance or to any of the excipients.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVERSE REACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAmong the suspected, very rare adverse reactions reported after use, transient reactions have occurred\u003c\/p\u003e\n\u003cp\u003eon the skin at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalized pruritus or alopecia. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.\u003c\/p\u003e\n\u003cp\u003eMild hypersalivation and vomiting may occur if the product is ingested, if the animal licks the application site.\u003c\/p\u003e\n\u003cp\u003eIf you notice any serious reactions or other effects not mentioned in this package leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND \u003c\/strong\u003e\u003cstrong\u003eMETHOD OF ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTopical application to the skin (spot-on).\u003c\/p\u003e\n\u003cp\u003eThe following table defines which pipette should be used depending on the dog's weight:\u003c\/p\u003e\n\u003cp\u003eActive Ingredients Excipients\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on Volume of unit Fipronil (mg) Permethrin Butylhydroxytoluene\u003c\/p\u003e\n\u003cp\u003esolution for dogs dosed (mg) (E321) (mg)\u003c\/p\u003e\n\u003cp\u003eVery small dogs 2-5kg 0.5 33.8 252.4 0.563\u003c\/p\u003e\n\u003cp\u003eSmall dogs 5-10kg 1 67.6 504.8 1.125\u003c\/p\u003e\n\u003cp\u003eMedium dogs 10-20kg 2 135.2 1009.6 2.250\u003c\/p\u003e\n\u003cp\u003eLarge dogs 20-40kg 4 270.4 2019.2 4.500\u003c\/p\u003e\n\u003cp\u003eXL dogs 40-60kg 6 405.6 3028.8 6.750\u003c\/p\u003e\n\u003cp\u003eDogs \u0026gt; 60 kg Use the appropriate combination of pipettes\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment schedule\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product should be used after confirmation of infestation or risk of infestation with fleas and\/or ticks, simultaneously with the need for repellent (anti-feeding) activity against sandflies and\/or mosquitoes and\/or stable flies.\u003c\/p\u003e\n\u003cp\u003eDepending on the recurrence of the risk of infestation with these ectoparasites, repeated treatment may also be established. In these cases, the minimum treatment interval is at least 4 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVICE ON CORRECT ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChoose the pipette appropriate for the dog's weight. For dogs weighing over 60 kg, the necessary combination of pipettes should be used until the amount appropriate for the dog's weight is reached.\u003c\/p\u003e\n\u003cp\u003eThe product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site.\u003c\/p\u003e\n\u003cp\u003eThese application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.\u003c\/p\u003e\n\u003cp\u003eRemove the blister foil from the package and detach one blister. Use scissors to cut the blister along the dotted line to remove the pipette or fold the marked corner and tear open.\u003c\/p\u003e\n\u003cp\u003eHold the pipette upright, away from your face or body, cut the tip of the pipette with scissors. Part the dog's fur so that the skin is visible. Position the tip of the pipette on the skin.\u003c\/p\u003e\n\u003cp\u003eSqueeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.\u003c\/p\u003e\n\u003cp\u003eTo obtain the best results, make sure to apply the product directly to the skin and not to the fur.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWAITING PERIOD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNot applicable\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR STORAGE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKeep out of the sight and reach of children.\u003c\/p\u003e\n\u003cp\u003eStore in the original packaging.\u003c\/p\u003e\n\u003cp\u003eDo not store above 25 °C\u003c\/p\u003e\n\u003cp\u003eDo not use after the expiry date stated on the packaging after \"EXP\". The expiry date refers to the last day of that month.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL WARNING(S)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpecial warnings for each target species\u003c\/p\u003e\n\u003cp\u003eA single tick or a bite from a mosquito or sandfly may already be present on the animal. For this reason, the transmission of pathogens by these arthropods cannot be excluded, if conditions are favorable.\u003c\/p\u003e\n\u003cp\u003eThe product remains effective against fleas when treated animals occasionally enter water (e.g. swimming, bathing). However, dogs should not be allowed to swim and should not be shampooed for 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003eAvoid swimming or frequent shampooing of treated dogs as this may affect the maintenance of the product's efficacy.\u003c\/p\u003e\n\u003cp\u003eTo reduce re-infestation due to the appearance of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same area should be treated with a veterinary medicinal product suitable for their species.\u003c\/p\u003e\n\u003cp\u003eTo reduce the risk of environmental infestation, it is recommended to use an additional treatment\u003c\/p\u003e\n\u003cp\u003eappropriate for the environment in which the animals live, against fleas and their developmental stages.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection4\"\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn the absence of specific studies, the use of this product is not recommended for dogs less than 8 weeks old or weighing less than 2 kg.\u003c\/p\u003e\n\u003cp\u003eAvoid contact of the product with the animal's eyes.\u003c\/p\u003e\n\u003cp\u003eIt is very important to ensure that the product is applied in an area where the animal cannot lick the product and also to ensure that animals do not lick each other after\u003c\/p\u003e\n\u003cp\u003etreatment.\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolize certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and urgently seek veterinary advice. To prevent accidental exposure of cats to this product, keep cats separate from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the site where the veterinary medicinal product has been applied to dogs. In case of such exposure, seek veterinary advice immediately.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor veterinary use only.\u003c\/p\u003e\n\u003cp\u003eThis product can cause skin and eye irritation. Therefore, contact of the product with the skin or eyes must be avoided.\u003c\/p\u003e\n\u003cp\u003eDo not open the pipette near or towards the face. If accidentally sprayed into the eyes or if the eyes become irritated during administration of the product, immediate rinsing with plenty of water is recommended. If ocular irritation persists, seek medical advice.\u003c\/p\u003e\n\u003cp\u003ePersons with known hypersensitivity to fipronil and\/or permethrin should avoid contact with this product.\u003c\/p\u003e\n\u003cp\u003eThe product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during product application. Wash hands after use. In case of ingestion, rinse mouth with water and seek medical advice if you feel unwell.\u003c\/p\u003e\n\u003cp\u003eAs the excipient N-methylpyrrolidone can cause fetotoxicity and teratogenicity after prolonged exposure, it is recommended that pregnant women wear gloves to avoid contact with the product.\u003c\/p\u003e\n\u003cp\u003eAvoid handling the animal until the application site is dry; children should also not play with the animals until their fur is dry.\u003c\/p\u003e\n\u003cp\u003eTherefore, it is recommended that animals are not treated during the day but in the evening, and during the night, treated animals should sleep alone, not with owners and especially not with children.\u003c\/p\u003e\n\u003cp\u003eKeep pipettes in the original packaging and once used, empty pipettes must be disposed of immediately in an appropriate manner, to prevent subsequent access.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product can be harmful to aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.\u003c\/p\u003e\n\u003cp\u003eUse during pregnancy and lactation\u003c\/p\u003e\n\u003cp\u003eLaboratory studies with fipronil and permethrin produced no teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eN-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.\u003c\/p\u003e\n\u003cp\u003eUse only after a benefit\/risk assessment by the veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOverdose\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSafety of use has been evaluated in healthy adult dogs treated with a dose up to 5 times higher\u003c\/p\u003e\n\u003cp\u003ethan the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Known adverse reactions may include mild neurological symptoms,\u003c\/p\u003e\n\u003cp\u003evomiting and diarrhea. These symptoms are transient and usually disappear without treatment within 1-2 days. Animals should always be treated with the pipette corresponding to their weight.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR \u003c\/strong\u003e\u003cstrong\u003eWASTE, IF APPLICABLE\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection5\"\u003e\n\u003cp\u003eAny unused veterinary medicinal product or waste derived from the use of such products\u003c\/p\u003e\n\u003cp\u003emust be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003eDo not contaminate lakes, watercourses or drains with this product or empty pipettes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOTHER INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas within 24 hours, ticks and lice within 48 hours of exposure.\u003c\/p\u003e\n\u003cp\u003ePermethrin belongs to the Type I pyrethroid class, which are acaricides and insecticides with repellent activity.\u003c\/p\u003e\n\u003cp\u003ePermethrin in the product provides repellent activity against sandflies (\u0026gt;80% for 4 weeks), mosquitoes and ticks.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394060689740,"sku":"FRONT510","price":138.59,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Frontline-Tri-Act-Caini-5-10-kg-3-pipete-XL.jpg?v=1777296707"},{"product_id":"frontline-tri-act-caini-2-5kg-3-pipete","title":"Frontline Tri-Act Dogs 2-5kg (3 pipettes)","description":"\u003cp\u003e\u003cstrong\u003eLiquid antiparasitic solution for cutaneous application, packaged in single-use pipettes\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cdiv class=\"WordSection1\"\u003e\n\u003cp\u003e\u003cstrong\u003ePACKAGE LEAFLET FOR \u003c\/strong\u003e\u003cstrong\u003eCardboard box with 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs 2-5 kg\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDECLARATION OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpot-on solution.\u003c\/p\u003e\n\u003cp\u003eClear, colourless to brownish-yellow solution.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eActive substances\/Excipients:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSee section \"dosage for each target species\"\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTARGET SPECIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDogs\u003c\/p\u003e\n\u003cp\u003eCaution!!!\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separated from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eINDICATION (INDICATIONS)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of flea and\/or tick infestations when repellent (anti-feeding) activity against sandflies, stable flies and\/or mosquitoes is needed.\u003c\/p\u003e\n\u003cp\u003eFor the treatment and prevention of \u003cem\u003eCtenocephalides felis\u003c\/em\u003e flea infestations and the prevention of \u003cem\u003eCtenocephalides canis\u003c\/em\u003e flea infestations. The product kills \u003cem\u003eC. felis\u003c\/em\u003e fleas on the animal within 24 hours. A single\u003c\/p\u003e\n\u003cp\u003etreatment prevents a new flea infestation for 4 weeks. The product can be part of a treatment strategy for the control of flea allergy dermatitis if this diagnosis has\u003c\/p\u003e\n\u003cp\u003ebeen established by a veterinarian.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent efficacy against ticks (\u003cem\u003eDermacentor reticulatus\u003c\/em\u003e) starting from 7 days and up to 4 weeks after treatment. However, a single tick may attach and detach within the first 24 hours after infestation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection2\"\u003e\n\u003cp\u003eThe product has immediate acaricidal efficacy against \u003cem\u003eRhipicephalus sanguineus\u003c\/em\u003e and \u003cem\u003eIxodes ricinus\u003c\/em\u003e species, but if ticks are present at the time of application, they may not die within the first 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003eThe product has persistent acaricidal efficacy against ticks (\u003cem\u003eIxodes ricinus, Dermacentor reticulatus, Rhipicephalus sanguineus\u003c\/em\u003e) for 4 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product has repellent (anti-feeding) efficacy for 3 weeks against sandflies (\u003cem\u003ePhlebotomus perniciosus\u003c\/em\u003e) and for 4 weeks against mosquitoes (\u003cem\u003eCulex pipiens\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003eThe product has persistent insecticidal efficacy against sandflies (\u003cem\u003ePhlebotomus perniciosus\u003c\/em\u003e) for 3 weeks.\u003c\/p\u003e\n\u003cp\u003eThe product repels and kills stable flies (\u003cem\u003eStomoxys calcitrans\u003c\/em\u003e) for five weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCONTRAINDICATIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDo not use on sick or convalescent animals.\u003c\/p\u003e\n\u003cp\u003eDo not use on cats and rabbits as it may cause adverse reactions and even death.\u003c\/p\u003e\n\u003cp\u003eDo not use in cases of known hypersensitivity to the active substance or to any of the excipients.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVERSE REACTIONS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAmong the very rare suspected adverse reactions, transient reactions at the application site (skin discoloration, local alopecia, pruritus, erythema) and generalised pruritus or alopecia have been reported after use. Hypersalivation, reversible neurological reactions (increased sensitivity to stimuli, hyperactivity, muscle tremors, depression, other neurological reactions) or vomiting have also been reported.\u003c\/p\u003e\n\u003cp\u003eSlight hypersalivation and vomiting may occur if the product is ingested, should the animal lick the application area.\u003c\/p\u003e\n\u003cp\u003eIf you notice any serious reactions or other effects not mentioned in this package leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDOSAGE FOR EACH SPECIES, ROUTE(S) AND METHOD OF ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTopical administration to the skin (spot-on).\u003c\/p\u003e\n\u003cp\u003eThe following table defines which pipette should be used depending on the dog's weight:\u003c\/p\u003e\n\u003cp\u003eActive ingredients                    Excipients\u003c\/p\u003e\n\u003cp\u003eFrontline Tri-Act spot-on solution for dogs                              Dosed unit volume                                           Fipronil (mg)                  Permethrin (mg)               Butylhydroxytoluene (E321) (mg)\u003c\/p\u003e\n\u003cp\u003eVery small dogs 2-5kg                    0.5                    33.8                    252.4                       0.563\u003c\/p\u003e\n\u003cp\u003eSmall dogs 5-10kg                1                     67.6                    504.8                      1.125\u003c\/p\u003e\n\u003cp\u003eMedium dogs 10-20kg           2                    135.2                  1009.6                     2.250\u003c\/p\u003e\n\u003cp\u003eLarge dogs 20-40kg             4                    270.4                  2019.2                    4.500\u003c\/p\u003e\n\u003cp\u003eXL dogs 40-60kg                6                    405.6                  3028.8                     6.750\u003c\/p\u003e\n\u003cp\u003eDogs \u0026gt; 60 kg                                                   Use the appropriate combination of pipettes\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection3\"\u003e\n\u003cp\u003e\u003cstrong\u003eTreatment scheme\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product should be used after confirming infestation or risk of infestation with fleas and\/or ticks, concurrently with the need for repellent (anti-feeding) activity against sandflies and\/or mosquitoes and\/or stable flies.\u003c\/p\u003e\n\u003cp\u003eDepending on the recurrence of the risk of infestation with these ectoparasites, repeated treatment may be established. In these cases, the minimum treatment interval is at least 4 weeks.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eADVICE ON CORRECT ADMINISTRATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChoose the appropriate pipette for the dog's weight. For dogs weighing more than 60 kg, the necessary combination of pipettes will be used until the appropriate quantity for the dog's weight is reached.\u003c\/p\u003e\n\u003cp\u003eThe product should be applied in two areas where the dog cannot reach, so that it cannot lick the application site.\u003c\/p\u003e\n\u003cp\u003eThese application sites are one at the base of the neck above the shoulder blades and the other on the midline of the neck between the base of the skull and the shoulder blades.\u003c\/p\u003e\n\u003cp\u003eRemove the blister foil from the package and peel off a blister. Use scissors to cut the blister along the dotted line to remove the pipette or fold the marked corner and tear open.\u003c\/p\u003e\n\u003cp\u003eHold the pipette upright, away from your face or body, cut the tip of the pipette with scissors. Part the dog's fur until the skin is visible. Position the tip of the pipette on the skin.\u003c\/p\u003e\n\u003cp\u003eSqueeze the pipette and apply approximately half of the content to the midline of the dog's neck, between the base of the skull and the shoulder blades. Repeat the application at the base of the neck, above the shoulder blades, emptying the pipette.\u003c\/p\u003e\n\u003cp\u003eTo achieve the best results, make sure you apply the product directly to the skin and not to the fur.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWITHDRAWAL PERIOD\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eNot applicable\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR STORAGE\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eKeep out of the sight and reach of children.\u003c\/p\u003e\n\u003cp\u003eStore in the original packaging.\u003c\/p\u003e\n\u003cp\u003eDo not store above 25 °C\u003c\/p\u003e\n\u003cp\u003eDo not use after the expiry date stated on the packaging after \"EXP\". The expiry date refers to the last day of that month.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL WARNING(S)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSpecial warnings for each target species\u003c\/p\u003e\n\u003cp\u003eA single tick or a mosquito or sandfly bite may already be attached to the animal. For this reason, the transmission of pathogens by these arthropods cannot be excluded if conditions are favourable.\u003c\/p\u003e\n\u003cp\u003eThe product remains effective against fleas when treated animals occasionally enter water (e.g. swimming, bathing). However, dogs should not be allowed to swim and should not be shampooed for 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003eAvoid frequent swimming or shampooing of treated dogs as this may affect the maintenance of product efficacy.\u003c\/p\u003e\n\u003cp\u003eTo reduce re-infestation due to the emergence of new fleas, it is recommended that all dogs in the household be treated. Animals living in the same space should be treated with a veterinary medicinal product suitable for their species.\u003c\/p\u003e\n\u003cp\u003eTo reduce the risk of environmental infestation, it is recommended to use additional appropriate environmental treatment\u003c\/p\u003e\n\u003cp\u003eagainst fleas and their developmental stages.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection4\"\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn the absence of specific studies, the use of this product is not recommended for dogs younger than 8 weeks or weighing less than 2 kg.\u003c\/p\u003e\n\u003cp\u003eAvoid contact of the product with the animal's eyes.\u003c\/p\u003e\n\u003cp\u003eIt is very important to ensure that the product is applied in an area where the animal cannot lick the product and also to ensure that animals do not lick each other after\u003c\/p\u003e\n\u003cp\u003etreatment.\u003c\/p\u003e\n\u003cp\u003eDue to the unique physiology of cats, which are unable to metabolise certain compounds, including permethrin, this veterinary medicinal product can cause convulsions in this species, which can be fatal.\u003c\/p\u003e\n\u003cp\u003eIn case of accidental exposure, it is recommended to wash the cat with shampoo or soap and seek urgent veterinary advice. To prevent accidental exposure of cats to this product, keep cats separated from treated dogs until the application site is dry.\u003c\/p\u003e\n\u003cp\u003eIt is important that cats do not lick the application site of the veterinary medicinal product on dogs. In case of such exposure, seek immediate veterinary advice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFor veterinary use only.\u003c\/p\u003e\n\u003cp\u003eThis product may cause skin and eye irritation. Therefore, contact of the product with the skin or eyes must be avoided. Do not open the pipette near or towards the face. If accidentally sprayed into the eyes or if the eyes become irritated during product administration, immediate thorough washing with water is recommended. If ophthalmic irritation persists, seek medical advice.\u003c\/p\u003e\n\u003cp\u003ePersons with known hypersensitivity to fipronil and\/or permethrin should avoid contact with this product.\u003c\/p\u003e\n\u003cp\u003eThe product is harmful if swallowed. Avoid hand-to-mouth contact. Do not smoke, drink or eat during product application. Wash hands after use. In case of ingestion, rinse mouth with water and seek medical advice if you feel unwell.\u003c\/p\u003e\n\u003cp\u003eAs the excipient N-methylpyrrolidone can cause fetotoxicity and teratogenicity following prolonged exposure, pregnant women are advised to wear gloves to avoid contact with the product.\u003c\/p\u003e\n\u003cp\u003eAvoid handling the animal until the application site is dry; children should also not play with animals until their fur is dry.\u003c\/p\u003e\n\u003cp\u003eTherefore, it is recommended that animals are not treated during the day but in the evening, and that treated animals sleep alone during the night, not with their owners and especially not with children.\u003c\/p\u003e\n\u003cp\u003eKeep pipettes in the original packaging and, once used, empty pipettes must be disposed of immediately in an appropriate manner to prevent further access.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther precautions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe product can have harmful effects on aquatic organisms. Treated dogs should not be allowed to swim in watercourses for 2 days after treatment.\u003c\/p\u003e\n\u003cp\u003eUse during pregnancy and lactation\u003c\/p\u003e\n\u003cp\u003eLaboratory studies with fipronil and permethrin produced no teratogenic or embryotoxic effects. No studies have been conducted with this product on animals during pregnancy or lactation.\u003c\/p\u003e\n\u003cp\u003eN-methylpyrrolidone, an excipient of the veterinary medicinal product, has been shown to have a teratogenic effect in laboratory animals after repeated exposure to high doses.\u003c\/p\u003e\n\u003cp\u003eUse only based on a benefit\/risk assessment by the veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOverdose\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eSafety of use was evaluated in healthy adult dogs treated with a dose up to 5 times higher than the maximum recommended dose (treated 3 times at monthly intervals) and in puppies (8 weeks old, treated once). Among the known adverse reactions, mild neurological symptoms,\u003c\/p\u003e\n\u003cp\u003evomiting, and diarrhea may occur. These symptoms are transient and usually disappear without treatment within 1-2 days. Animals should always be treated with the pipette corresponding to their weight.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIAL, IF APPLICABLE\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"WordSection5\"\u003e\n\u003cp\u003eAny unused veterinary medicinal product or waste material derived from such products\u003c\/p\u003e\n\u003cp\u003emust be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003eDo not contaminate lakes, watercourses, or drains with this product or empty pipettes.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOTHER INFORMATION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFipronil is an insecticide and acaricide belonging to the phenylpyrazole family. Fipronil kills fleas in 24\u003c\/p\u003e\n\u003cp\u003ehours, ticks and lice in 48 hours after exposure.\u003c\/p\u003e\n\u003cp\u003ePermethrin belongs to type I pyrethroids, which are acaricides and insecticides with repellent activity.\u003c\/p\u003e\n\u003cp\u003ePermethrin in the product provides repellent activity against sandflies (\u0026gt;80% for 4 weeks), mosquitoes and ticks.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394060820812,"sku":"FRONT25","price":126.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Frontline-Tri-Act-Caini-2-5kg-3-pipete-XL.jpg?v=1777296709"},{"product_id":"advocate-400-caine-25-40-kg-3-pipete","title":"Advocate 400 Dog (25-40 kg), 3 pipettes","description":"\u003cp\u003e\u003cstrong\u003eAdvocate 400 Dogs (\u003e 25 kg), 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChemical composition:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImidacloprid: 100mg\/ml\u003c\/li\u003e\n\u003cli\u003eMoxidectin: 25mg\/ml\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePharmaceutical form:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAntiparasitic solution for cutaneous application.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003efor the treatment and prevention of flea infestations (Ctenocephalides spp.).\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ereduces the incidence of flea allergy dermatitis.\u003c\/li\u003e\n\u003cli\u003elarval stages are killed on the animal and in the surrounding environment of treated animals.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003efor the prevention of heartworm infestations (Dirofilaria immitis)\u003c\/p\u003e\n\u003cp\u003efor the treatment and control of:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eroundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ehookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ewhipworms Trichuris vulpis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003egeneralized demodicosis Demodex canis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003esarcoptic mange Sarcoptes scabiei.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eear mites Otodectes cynotis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003elice Trichodectes canis. Linognathus setosus for 6 weeks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDosage and administration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor dogs under 40 kg, one tube is used, and for dogs over 40 kg, two tubes of Advocate 400 are used.\u003c\/li\u003e\n\u003cli\u003eAdministration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be done in several places along the back.\u003c\/li\u003e\n\u003cli\u003eThe product is applied to the skin, avoiding contact with the dog's mouth or eyes.\u003c\/li\u003e\n\u003cli\u003eThe dog's skin must be intact and without lesions.\u003c\/li\u003e\n\u003cli\u003eIt can be administered to pregnant or lactating bitches.\u003c\/li\u003e\n\u003cli\u003eThe product retains its efficacy after bathing or exposure to rain.\u003c\/li\u003e\n\u003cli\u003eTo reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in the same family or household should be treated with appropriate products.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNot for use in cats.\u003c\/li\u003e\n\u003cli\u003eNot for use in puppies under 7 weeks of age.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFurther information:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003efor the prevention of heartworm infestation, it is recommended to start treatment one month before the mosquito season (the vector that transmits the larvae) begins and to continue once a month until the mosquito season ends.\u003c\/li\u003e\n\u003cli\u003efor tapeworms (cestodes), it is recommended to use internal antiparasitics as ADVOCATE does not act on them, but only on roundworms and hookworms.\u003c\/li\u003e\n\u003cli\u003efor demodicosis, 2 to 4 monthly treatments are necessary to achieve beneficial effects.\u003c\/li\u003e\n\u003cli\u003efor mange (ear, sarcoptic), a single treatment is usually sufficient for complete elimination of parasites and signs of disease.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eImportant: Advocate 400\u003c\/strong\u003e falls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication or diet according to your dog's (cat's) specific needs.\u003c\/p\u003e\n\u003cdiv\u003e\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394061902156,"sku":"ADVO2540","price":375.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advocate-400-Caine-25-kg-3-pipete.jpg?v=1777296719"},{"product_id":"advocate-250-caine-10-25-kg-3-pipete","title":"Advocate 250 Dog (10 - 25 kg), 3 pipettes","description":"\u003cp\u003e\u003cstrong\u003eAdvocate 250 Dogs (10 - 25 kg), 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChemical composition:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImidacloprid : 100mg\/ml\u003c\/li\u003e\n\u003cli\u003eMoxidectin: 25mg\/ml\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePharmaceutical form:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eAntiparasitic solution for cutaneous application.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003efor the treatment and prevention of flea infestations (Ctenocephalides spp.).\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ereduces the incidence of flea allergy dermatitis.\u003c\/li\u003e\n\u003cli\u003elarval stages are killed on the animal and in the surrounding environment of treated animals.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003efor the prevention of heartworm infestations (Dirofilaria immitis)\u003c\/p\u003e\n\u003cp\u003efor the treatment and control of:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eroundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ehookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ewhipworms Trichuris vulpis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003egeneralized demodicosis Demodex canis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003esarcoptic mange Sarcoptes scabiei.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eear mites Otodectes cynotis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003elice Trichodectes canis, Linognathus setosus for 6 weeks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDosage and administration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor dogs between 10 -25 kg, one tube of Advocate 250 is used.\u003c\/li\u003e\n\u003cli\u003eAdministration is done in the dorsal area at the base of the neck for small dogs, and for larger dogs, it can be done in several places along the back.\u003c\/li\u003e\n\u003cli\u003eThe product is applied to the skin, keeping it away from the dog's mouth or eyes.\u003c\/li\u003e\n\u003cli\u003eThe dog's skin must be intact and free of lesions.\u003c\/li\u003e\n\u003cli\u003eIt can be administered to pregnant or lactating bitches.\u003c\/li\u003e\n\u003cli\u003eThe product retains its efficacy after bathing or exposure to rain.\u003c\/li\u003e\n\u003cli\u003eTo reduce re-infestations with new fleas, it is recommended to treat all dogs in a family (household). Other pets in the same family or household should be treated with appropriate products.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eNot for use in cats.\u003c\/li\u003e\n\u003cli\u003eNot for use in puppies under 7 weeks of age.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eOther information:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eto prevent heartworm infestation, it is advisable to start treatment one month before the mosquito season begins (the host that transmits the larvae) and continue once a month until the mosquito season passes.\u003c\/li\u003e\n\u003cli\u003efor tapeworms, it is advisable to use internal antiparasitics as ADVOCATE does not act on them but only on roundworms and hookworms.\u003c\/li\u003e\n\u003cli\u003efor demodicosis, 2 to 4 monthly treatments are required for beneficial effects.\u003c\/li\u003e\n\u003cli\u003efor mange (ear, sarcoptic), a single treatment is necessary for complete elimination of parasites and signs of disease.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eImportant: Advocate 250\u003c\/strong\u003e falls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication, or diet according to the specific needs of your dog (cat).\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394061934924,"sku":"ADVO1025","price":333.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advocate-250-Caine-10-25-kg-3-pipete.jpg?v=1777296720"},{"product_id":"advocate-100-caine-4-10-kg-3-pipete","title":"Advocate 100 Dog (4 - 10 kg), 3 pipettes","description":"\u003cp\u003e\u003cstrong\u003eAdvocate 100 for Dogs (4 - 10 kg), 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChemical composition:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImidacloprid: 100mg\/ml\u003c\/li\u003e\n\u003cli\u003eMoxidectin: 25mg\/ml\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePharmaceutical form:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAntiparasitic solution for cutaneous application.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003efor the treatment and prevention of flea infestations (Ctenocephalides spp.).\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ereduces the incidence of flea allergy dermatitis.\u003c\/li\u003e\n\u003cli\u003elarval stages are killed on the animal and in the surrounding environment of treated animals.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003efor the prevention of heartworm infestations (Dirofilaria immitis)\u003c\/p\u003e\n\u003cp\u003efor the treatment and control of:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eroundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ehookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ewhipworms Trichuris vulpis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003egeneralized demodicosis Demodex canis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003esarcoptic mange Sarcoptes scabiei.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eear mites Otodectes cynotis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003elice Trichodectes canis. Linognathus setosus for 6 weeks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDosage and administration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor dogs weighing between 4 - 10 kg, one tube of Advocate 100 is used;\u003c\/li\u003e\n\u003cli\u003eAdministration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be applied in several places along the back.\u003c\/li\u003e\n\u003cli\u003eThe product is applied to the skin, keeping it away from contact with the dog's mouth or eyes.\u003c\/li\u003e\n\u003cli\u003eThe dog's skin must be intact and without lesions.\u003c\/li\u003e\n\u003cli\u003eIt can be administered to pregnant or lactating bitches.\u003c\/li\u003e\n\u003cli\u003eThe product retains its efficacy after bathing or exposure to rain.\u003c\/li\u003e\n\u003cli\u003eTo reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in the same family or household should be treated with appropriate products.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDo not use on cats.\u003c\/li\u003e\n\u003cli\u003eDo not use on puppies younger than 7 weeks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eOther information:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003efor the prevention of heartworm infestation, treatment should begin one month before the mosquito season (the host that transmits the larvae) and continue once a month until the mosquito season passes.\u003c\/li\u003e\n\u003cli\u003efor intestinal tapeworms (teniae), it is recommended to use internal antiparasitics because ADVOCATE does not act on them, only on roundworms and hookworms.\u003c\/li\u003e\n\u003cli\u003efor demodicosis, 2 to 4 monthly treatments are necessary to achieve beneficial effects.\u003c\/li\u003e\n\u003cli\u003efor mange (ear, sarcoptic), a single treatment is necessary for complete elimination of parasites and disease signs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eImportant: Advocate 100 \u003c\/strong\u003efalls under the pharmacy category. Consult your veterinarian for diagnosis, prescription of medication, or diet according to your dog's (cat's) specific needs.\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394062229836,"sku":"ADVO410","price":303.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advocate-100-Caine-4-10-kg-3-pipete.jpg?v=1777296725"},{"product_id":"advocate-40-caine-0-4-kg-3-pipete","title":"Advocate 40 Dog (0 - 4 kg), 3 pipettes","description":"\u003cp\u003e\u003cstrong\u003eAdvocate 40 Dogs (0 - 4 kg), 3 pipettes\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChemical composition:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eImidacloprid: 100mg\/ml\u003c\/li\u003e\n\u003cli\u003eMoxidectin: 25mg\/ml\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePharmaceutical form:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eAntiparasitic solution for cutaneous application.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eIndications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003efor the treatment and prevention of flea infestations (Ctenocephalides spp.).\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ereduces the incidence of flea allergies.\u003c\/li\u003e\n\u003cli\u003elarval stages are killed on the animal and in the surrounding environment of treated animals.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003efor the prevention of heartworm infestations (Dirofilaria immitis)\u003c\/p\u003e\n\u003cp\u003efor the treatment and control of:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eroundworms Toxocara canis, T. leonina (including L1 larval stage and immature adult forms).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ehookworms Ancylostoma caninum, A. braziliense, Uncinaria stenocephala.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003ewhipworms Trichuris vulpis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003egeneralized demodicosis Demodex canis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003esarcoptic mange Sarcoptes scabiei.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003eear mites Otodectes cynotis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003elice Trichodectes canis. Linognathus setosus for 6 weeks.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDosage and administration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFor dogs between 0 - 4 kg, one tube of Advocate 40 is used;\u003c\/li\u003e\n\u003cli\u003eAdministration is done in the dorsal area at the base of the neck for small dogs, and for large dogs, it can be done in several spots along the back.\u003c\/li\u003e\n\u003cli\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe product is applied to the skin, avoiding contact with the dog's mouth or eyes.\u003c\/li\u003e\n\u003cli\u003e\n\u003c\/li\u003e\n\u003cli\u003eThe dog's skin must be intact and free of lesions.\u003c\/li\u003e\n\u003cli\u003e\n\u003c\/li\u003e\n\u003cli\u003eIt can be administered to pregnant or lactating bitches.\u003c\/li\u003e\n\u003cli\u003eThe product retains its effectiveness after bathing or exposure to rain.\u003c\/li\u003e\n\u003cli\u003eTo reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in the same family or household should be treated with appropriate products.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDo not use in cats. Do not use in puppies under 7 weeks of age.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eOther information:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003efor the prevention of heartworm infestation, treatment should begin one month before the mosquito season (the host that transmits the larvae) and continue once a month until the mosquito season passes.\u003c\/li\u003e\n\u003cli\u003efor tapeworms (cestodes), internal antiparasitics should be used as ADVOCATE does not act on them, only on roundworms and hookworms.\u003c\/li\u003e\n\u003cli\u003efor demodicosis, 2 to 4 monthly treatments are required for beneficial effects.\u003c\/li\u003e\n\u003cli\u003efor mange (auricular, sarcoptic), a single treatment is necessary for complete elimination of parasites and signs of disease.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eImportant: Advocate 40 \u003c\/strong\u003efalls under the pharmacy category. Consult your veterinarian for diagnosis and prescription of medication according to the specific needs of your dog or cat.\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394062491980,"sku":"ADVO4","price":267.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advocate-40-Caine-0-4-kg-3-pipete.jpg?v=1777296728"},{"product_id":"nexgard-spectra-m-7-5-15-kg-3-comprimate","title":"NexGard Spectra M (7.5 - 15 kg), 3 tablets","description":"\u003cdiv class=\"std\"\u003e\n\u003cp\u003e\u003cstrong\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eEach chewable tablet contains:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eActive substances:\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e\n\u003cp align=\"center\"\u003eAfoxolaner\u003c\/p\u003e\n\u003cp align=\"center\"\u003e(mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e\n\u003cp align=\"center\"\u003eMilbemycin oxime (mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003echewable tablets for dogs weighing 7.5-15 kg\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e37.50\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e7.50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003ePHARMACEUTICAL FORM\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMarbled, red to reddish-brown, round (tablets for dogs weighing 2-3.5 kg) or rectangular (tablets for dogs weighing \u003e 3.5-7.5 kg, tablets for dogs weighing \u003e 7.5-15 kg, tablets for dogs weighing \u003e 15-30 kg, and tablets for dogs weighing \u003e 30-60 kg) tablets.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCLINICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species: \u003c\/strong\u003eDogs\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIndications for use, specifying the target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and\/or treatment of gastrointestinal nematode infestations is indicated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of flea infestations (\u003cem\u003eCtenocephalides felis\u003c\/em\u003e and \u003cem\u003eC. canis\u003c\/em\u003e) in dogs for 5 weeks. Treatment of tick infestations (\u003cem\u003eDermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus\u003c\/em\u003e) in dogs for 4 weeks.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFleas and ticks must attach to the host and begin feeding to be exposed to the active substance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of adult gastrointestinal nematode infestations of the following species: roundworms (\u003cem\u003eToxocara canis \u003c\/em\u003eand \u003cem\u003eToxocara leonina\u003c\/em\u003e), hookworms (\u003cem\u003eAncyclostoma caninum \u003c\/em\u003eand \u003cem\u003eAncyclostoma braziliense\u003c\/em\u003e) and whipworms (\u003cem\u003eTrichuris vulpis\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003ePrevention of heartworm disease (\u003cem\u003eDirofilaria immitis \u003c\/em\u003elarval stage) if administered monthly.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eContraindications: \u003c\/strong\u003eDo not use in cases of hypersensitivity to the active substances or to any of the excipients.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial warnings for each target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eParasites must begin feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eResistance of parasites to a particular class of antiparasitic medicines may develop as a result of frequent use of a compound from that class. Therefore, the use of this product should be based on the evaluation of each case and local epidemiological information regarding the current susceptibility of the target species to limit the possibility of future selection of resistance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMaintaining the efficacy of macrocyclic lactones is essential in the control of \u003cem\u003eDirofilaria immitis\u003c\/em\u003e. To minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eOnly negative animals should be treated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for use in animals\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn the absence of available data, treatment of puppies younger than 8 weeks and\/or dogs weighing less than 2 kg should only be carried out based on a risk\/benefit assessment by the veterinarian.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in heartworm endemic areas should be tested for adult heartworm infestation before administering NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe recommended dose should be strictly followed for Collie dogs or other related breeds.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis product, if ingested, may cause gastrointestinal disturbances.\u003c\/li\u003e\n\u003cli\u003eKeep tablets in blisters and blisters in the box until use.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAdverse reactions (frequency and seriousness)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn clinical studies, no serious adverse reactions attributable to the afoxolaner and milbemycin oxime combination were observed. Less common reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus were observed. These reactions generally resolved spontaneously and were short-lived.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe frequency of adverse reactions is defined using the following convention:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Common (more than 1 but less than 10 animals in 100 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Uncommon (more than 1 but less than 10 animals in 1,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Rare (more than 1 but less than 10 animals in 10,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very rare (less than 1 animal in 10,000 animals, including isolated reports).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eUse during pregnancy, lactation or lay\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eLaboratory studies in rats and rabbits have not shown teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use in accordance with the benefit-risk assessment by the veterinarian.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eInteractions with other medicinal products or other forms of interaction\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is a substrate of p-glycoprotein (P-gp), and can therefore interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAmounts to be administered and administration route\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor oral administration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDosage:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product should be administered at a dose of 2.50-5.36 mg\/kg of afoxolaner and 0.50-1.07 mg\/kg milbemycin oxime body weight according to the following table:\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\" valign=\"top\" width=\"97\"\u003e\u003cstrong\u003eDog weight (kg)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd colspan=\"5\" valign=\"top\" width=\"522\"\u003e\u003cstrong\u003eConcentration and number of chewable tablets to be administered\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e9 mg\/ 2 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e19 mg\/ 4 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e38 mg\/ 8 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e75 mg\/ 15 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e150 mg\/ 30 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e2-3.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003e3.5-7.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003e7.5-15\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003e15-30\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003e30-60\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp align=\"left\"\u003e For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMethod of administration:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment regimen:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe treatment regimen should be based on veterinary diagnosis and the local epidemiological situation.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA can be used as seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concomitantly infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cem\u003eDisease: Heartworm disease:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA kills \u003cem\u003eDirofilaria immitis \u003c\/em\u003elarvae for one month after transmission by mosquitoes, therefore the product should be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should be continued until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIf replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due to be administered.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in or travelling to a heartworm region may be infested with adult heartworms. No therapeutic effect against adult \u003cem\u003eDirofilaria immitis \u003c\/em\u003ehas been established. Therefore, it is recommended that all dogs older than 8 months or more, living in heartworm endemic areas, be tested for adult heartworm infestation before being treated with a heartworm prevention product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eOverdose (symptoms, emergency procedures, antidotes), if applicable\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNo adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eWithdrawal period: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACOLOGICAL PROPERTIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eVeterinary ATC code: QP54AB51\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacodynamic properties\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is an insecticide and acaricide belonging to the isoxazoline family.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner acts by interacting with chloride ion channels, mainly those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thus blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects\/mites and mammals is a consequence of the characteristic sensitivity of GABA receptors in insects\/mites versus those in mammals.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is active against adult fleas as well as some tick species such as \u003cem\u003eRhipicephalus sanguineus, Dermacentor reticulatus \u003c\/em\u003eand \u003cem\u003eD. variabilis, Ixodes ricinus \u003c\/em\u003eand \u003cem\u003eI. scapularis, Amblyomma americanum \u003c\/em\u003eand \u003cem\u003eHaemaphysalis longicornis.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is an antiparasitic endectocide belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A\u003csub\u003e4 \u003c\/sub\u003eand milbemycin A\u003csub\u003e3\u003c\/sub\u003e (in a ratio of 20:80 for A\u003csub\u003e3\u003c\/sub\u003e:A\u003csub\u003e4\u003c\/sub\u003e). It is isolated from the fermentation of \u003cem\u003eStreptomyces milbemycinicus\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (linked to GABA and glycine receptors in vertebrates).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThis leads to hyperpolarization of the neuromuscular membrane and paralysis and death of parasites.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacokinetic particulars\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is absorbed very quickly systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e) was 1822 ± 165 ng\/ml, 2-4 hours (T\u003csub\u003emax\u003c\/sub\u003e) after a dose of 2.5 mg\/kg afoxolaner.\u003c\/p\u003e\n\u003cp\u003eThe tissue distribution volume of Afoxolaner is 2.6 ± 0.6 l\/kg and the clearance value is 5.0 ± 1.2 ml\/h\/kg. The half-life is approximately 2 weeks in dogs.\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePlasma concentrations of Milbemycin oxime increase rapidly in the first 1-2 hours (T\u003csub\u003emax\u003c\/sub\u003e) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A\u003csub\u003e3\u003c\/sub\u003e and 65% for A\u003csub\u003e4\u003c\/sub\u003e respectively. The mean maximum plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e) after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng\/ml for A\u003csub\u003e3\u003c\/sub\u003e, 3.3 ± 1.4 days and 246 ± 71 ng\/ml for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe tissue distribution volume of Milbemycin oxime is 2.7 ± 0.4 and 2.6 ± 0.6 l\/kg for A\u003csub\u003e3\u003c\/sub\u003e and A\u003csub\u003e4\u003c\/sub\u003e forms respectively. Both forms have a low clearance value of 75 ± 22 ml\/h\/kg for A\u003csub\u003e3\u003c\/sub\u003e and 41 ± 12 ml\/h\/kg for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACEUTICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eList of excipients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMaize starch\u003c\/li\u003e\n\u003cli\u003eSoya proteins\u003c\/li\u003e\n\u003cli\u003eBraised beef flavour\u003c\/li\u003e\n\u003cli\u003ePovidone (E1201)\u003c\/li\u003e\n\u003cli\u003eMacrogol 400\u003c\/li\u003e\n\u003cli\u003eMacrogol 4000\u003c\/li\u003e\n\u003cli\u003eMacrogol 15 hydroxystearate\u003c\/li\u003e\n\u003cli\u003eGlycerol (E422)\u003c\/li\u003e\n\u003cli\u003eMedium-chain triglycerides\u003c\/li\u003e\n\u003cli\u003eCitric acid monohydrate (E330)\u003c\/li\u003e\n\u003cli\u003eButylhydroxytoluene (E321)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIncompatibilities: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eShelf life: \u003c\/strong\u003eShelf life of the veterinary medicinal product as packaged for sale: 2 years\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for storage: \u003c\/strong\u003eKeep the blister in the secondary packaging to protect from light.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eNature and composition of primary packaging\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003eThis veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar\/PVC\/Alu).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e 1 cardboard box containing one blister with 1, 3 and 6 chewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNot all pack sizes may be marketed.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAny unused veterinary medicinal product or waste materials derived from the use of such products should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"std\"\u003e\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394062590284,"sku":"NEX7515","price":199.03,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Nexgard-Spectra-M-7.5-15-kg-3-comprimate.jpg?v=1777296730"},{"product_id":"nexgard-spectra-s-3-5-7-5-kg-3-comprimate","title":"Nexgard Spectra S (3.5 - 7.5 kg), 3 tablets","description":"\u003cdiv class=\"std\"\u003e\n\u003cp\u003e\u003cstrong\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eEach chewable tablet contains:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eActive substances:\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e\n\u003cp align=\"center\"\u003eAfoxolaner\u003c\/p\u003e\n\u003cp align=\"center\"\u003e(mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e\n\u003cp align=\"center\"\u003eMilbemycin oxime (mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003echewable tablets for dogs weighing 3.5-7.5 kg\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e18.75\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e3.75\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003ePHARMACEUTICAL FORM\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eRed to reddish-brown mottled, round (tablets for dogs weighing 2-3.5 kg) or rectangular (tablets for dogs weighing \u003e 3.5-7.5 kg, tablets for dogs weighing \u003e 7.5-15 kg, tablets for dogs weighing \u003e 15-30 kg, and tablets for dogs weighing \u003e 30-60 kg) tablets.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCLINICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species: \u003c\/strong\u003eDogs\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIndications for use, specifying the target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and\/or treatment of gastrointestinal nematode infestations is indicated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of flea infestations (\u003cem\u003eCtenocephalides felis\u003c\/em\u003e and \u003cem\u003eC. canis\u003c\/em\u003e) in dogs for 5 weeks. Treatment of tick infestations (\u003cem\u003eDermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus\u003c\/em\u003e) in dogs for 4 weeks.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFleas and ticks must attach to the host and commence feeding to be exposed to the active substance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of adult gastrointestinal nematode infestations of the following species: roundworms (\u003cem\u003eToxocara canis \u003c\/em\u003eand \u003cem\u003eToxocara leonina\u003c\/em\u003e), hookworms (\u003cem\u003eAncyclostoma caninum \u003c\/em\u003eand \u003cem\u003eAncyclostoma braziliense\u003c\/em\u003e) and whipworms (\u003cem\u003eTrichuris vulpis\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003ePrevention of heartworm disease (\u003cem\u003eDirofilaria immitis \u003c\/em\u003elarval stage) if administered monthly.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eContraindications: \u003c\/strong\u003eDo not use in cases of hypersensitivity to the active substances or to any of the excipients.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial warnings for each target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eParasites must commence feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eResistance of parasites to a particular class of antiparasitic medicinal product may develop following frequent use of a compound from that class. Therefore, the use of this product should be based on an assessment of each individual case and on local epidemiological information about the current susceptibility of the target species to limit the possibility of future selection for resistance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMaintaining the efficacy of macrocyclic lactones is essential for the control of \u003cem\u003eDirofilaria immitis\u003c\/em\u003e. To minimise the risk of resistance selection, it is recommended to test dogs for circulating antigens and blood microfilariae at the start of each preventative treatment period.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eOnly negative animals should be treated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for use in animals\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn the absence of available data, treatment of puppies younger than 8 weeks of age and\/or dogs weighing less than 2 kg should only be carried out based on a risk\/benefit assessment by the veterinarian.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in heartworm endemic areas should be tested for adult heartworm infestation before administration of NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe recommended dose must be strictly followed in Collie dogs or other related breeds.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis product may cause gastrointestinal disturbances if ingested.\u003c\/li\u003e\n\u003cli\u003eKeep tablets in blisters and the blister in the carton until use.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental ingestion, especially by children, seek medical advice immediately and show the product label to the physician.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAdverse reactions (frequency and seriousness)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn clinical studies, no serious adverse reactions were attributed to the combination of afoxolaner and milbemycin oxime. Infrequent reactions such as vomiting, diarrhoea, lethargy, anorexia, and pruritus were observed. These reactions generally resolved spontaneously and were of short duration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe frequency of adverse reactions is defined using the following convention:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Common (more than 1 but less than 10 animals in 100 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Uncommon (more than 1 but less than 10 animals in 1,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Rare (more than 1 but less than 10 animals in 10,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very rare (less than 1 animal in 10,000 animals, including isolated reports).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eUse during pregnancy, lactation or lay\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eLaboratory studies conducted on rats and rabbits have not shown any teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinarian.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eInteractions with other medicinal products and other forms of interaction\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is a substrate of P-glycoprotein (P-gp), thus it may interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAmounts to be administered and administration route\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor oral administration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDosage:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product should be administered at a dose of 2.50-5.36 mg\/kg afoxolaner and 0.50-1.07 mg\/kg milbemycin oxime body weight according to the following table:\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\" valign=\"top\" width=\"97\"\u003e\u003cstrong\u003eDog weight (kg)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd colspan=\"5\" valign=\"top\" width=\"522\"\u003e\u003cstrong\u003eConcentration and number of chewable tablets to be administered\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e9 mg\/ 2 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e19 mg\/ 4 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e38 mg\/ 8 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e75 mg\/ 15 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e150 mg\/ 30 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e2-3.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;3.5-7.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;7.5-15\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;15-30\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;30-60\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp align=\"left\"\u003e For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMethod of administration:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment regimen:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe treatment regimen should be based on the veterinary diagnosis and the local epidemiological situation.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA can be used as seasonal preventative treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cem\u003eDisease: Heartworm disease:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA kills \u003cem\u003eDirofilaria immitis \u003c\/em\u003elarvae for one month after their transmission by mosquitoes, therefore the product must be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should continue until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIf replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should start on the day the previous medication was due to be administered.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in or having travelled to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult \u003cem\u003eDirofilaria immitis \u003c\/em\u003ehas been established. Therefore, it is recommended that all dogs 8 months of age or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eOverdose (symptoms, emergency procedures, antidotes), if applicable\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNo adverse reactions were observed in healthy puppies older than 8 weeks after 6 treatments with 5 times the maximum dose.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eWithdrawal periods: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACOLOGICAL PROPERTIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eATC veterinary code: QP54AB51\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacodynamic properties\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is an insecticide and acaricide belonging to the isoxazoline family.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and death of insects and mites. The selective toxicity of afoxolaner between insects\/mites and mammals is a consequence of the characteristic sensitivity of insect\/mite GABA receptors versus those of mammals.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is active against adult fleas as well as some tick species such as \u003cem\u003eRhipicephalus sanguineus, Dermacentor reticulatus \u003c\/em\u003eand \u003cem\u003eD. variabilis, Ixodes ricinus \u003c\/em\u003eand \u003cem\u003eI. scapularis, Amblyomma americanum \u003c\/em\u003eand \u003cem\u003eHaemaphysalis longicornis.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is an endectocidal antiparasitic belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A\u003csub\u003e4 \u003c\/sub\u003eand milbemycin A\u003csub\u003e3\u003c\/sub\u003e (in a 20:80 ratio for A\u003csub\u003e3\u003c\/sub\u003e:A\u003csub\u003e4\u003c\/sub\u003e). It is isolated from the fermentation of \u003cem\u003eStreptomyces milbemycinicus\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-gated chloride ion channels (related to GABA and glycine receptors in vertebrates).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThis leads to hyperpolarisation of the neuromuscular membrane and to the paralysis and death of the parasites.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacokinetic particulars\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e) was 1822 ± 165 ng\/ml, at 2-4 hours (T\u003csub\u003emax\u003c\/sub\u003e) after a dose of 2.5 mg\/kg afoxolaner.\u003c\/p\u003e\n\u003cp\u003eThe volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l\/kg and the clearance value is 5.0 ± 1.2 ml\/h\/kg. The half-life is approximately 2 weeks in dogs.\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePlasma concentrations of Milbemycin oxime increase rapidly within the first 1-2 hours (T\u003csub\u003emax\u003c\/sub\u003e) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A\u003csub\u003e3\u003c\/sub\u003e and 65% for A\u003csub\u003e4\u003c\/sub\u003e respectively. The mean maximum plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e), after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng\/ml for A\u003csub\u003e3\u003c\/sub\u003e, 3.3 ± 1.4 days and 246 ± 71 ng\/ml for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l\/kg for form A\u003csub\u003e3\u003c\/sub\u003e and A\u003csub\u003e4\u003c\/sub\u003e respectively. Both forms have a low clearance value of 75 ± 22 ml\/h\/kg for A\u003csub\u003e3\u003c\/sub\u003e and 41 ± 12 ml\/h\/kg for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACEUTICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eList of excipients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMaize starch\u003c\/li\u003e\n\u003cli\u003eSoy protein\u003c\/li\u003e\n\u003cli\u003eBraised beef flavour\u003c\/li\u003e\n\u003cli\u003ePovidone (E1201)\u003c\/li\u003e\n\u003cli\u003eMacrogol 400\u003c\/li\u003e\n\u003cli\u003eMacrogol 4000\u003c\/li\u003e\n\u003cli\u003eMacrogol 15 hydroxystearate\u003c\/li\u003e\n\u003cli\u003eGlycerol (E422)\u003c\/li\u003e\n\u003cli\u003eMedium-chain triglycerides\u003c\/li\u003e\n\u003cli\u003eCitric acid monohydrate (E330)\u003c\/li\u003e\n\u003cli\u003eButylhydroxytoluene (E321)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIncompatibilities: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eShelf life: \u003c\/strong\u003eShelf life of the veterinary medicinal product as packaged for sale: 2 years\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for storage: \u003c\/strong\u003eKeep the blister in the outer carton to protect from light.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eNature and composition of primary packaging\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003eThis veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar\/PVC\/Alu).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e1 carton box containing one blister with 1, 3 and 6 chewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNot all package sizes may be marketed.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAny unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394062623052,"sku":"NEX3575","price":169.13,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Nexgard-Spectra-S-3.5-7.5-kg-3-comprimate.jpg?v=1777296730"},{"product_id":"nexgard-spectra-xs-2-3-5-kg-3-comprimate","title":"Nexgard Spectra XS (2 - 3.5 kg), 3 tablets","description":"\u003cdiv class=\"std\"\u003e\n\u003cp\u003e\u003cstrong\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eEach chewable tablet contains:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eActive substances:\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e\n\u003cp align=\"center\"\u003eAfoxolaner\u003c\/p\u003e\n\u003cp align=\"center\"\u003e(mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e\n\u003cp align=\"center\"\u003eMilbemycin oxime (mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003echewable tablets for dogs 2-3.5 kg\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e9.375\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e1.875\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003ePHARMACEUTICAL FORM\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMottled red to reddish-brown, round (tablets for dogs 2-3.5 kg) or rectangular (tablets for dogs \u0026gt; 3.5-7.5 kg, tablets for dogs \u0026gt; 7.5-15 kg, tablets for dogs \u0026gt; 15-30 kg and tablets for dogs \u0026gt; 30-60 kg) chewable tablets.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCLINICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species: \u003c\/strong\u003eDogs\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIndications for use, specifying the target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and\/or treatment of gastrointestinal nematode infestations is indicated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of flea infestations (\u003cem\u003eCtenocephalides felis\u003c\/em\u003e and \u003cem\u003eC. canis\u003c\/em\u003e) in dogs for 5 weeks. Treatment of tick infestations (\u003cem\u003eDermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus\u003c\/em\u003e) in dogs for 4 weeks.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFleas and ticks must attach to the host and commence feeding to be exposed to the active substance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of adult gastrointestinal nematode infestations of the following species: roundworms (\u003cem\u003eToxocara canis\u003c\/em\u003e and \u003cem\u003eToxocara leonina\u003c\/em\u003e), hookworms (\u003cem\u003eAncylostoma caninum\u003c\/em\u003e and \u003cem\u003eAncylostoma braziliense\u003c\/em\u003e) and whipworms (\u003cem\u003eTrichuris vulpis\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003ePrevention of heartworm disease (\u003cem\u003eDirofilaria immitis\u003c\/em\u003e larval stage) if administered monthly.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eContraindications: \u003c\/strong\u003eDo not use in case of hypersensitivity to the active substances or to any of the excipients.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial warnings for each target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eParasites must start feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eResistance of parasites to any particular class of antiparasitics may develop following frequent, repeated use of a product of that class. Therefore, the use of this product should be based on the assessment of each individual case and on local epidemiological information about the current susceptibility of the target species to limit the possibility of future resistance selection.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMaintaining the efficacy of macrocyclic lactones is essential for the control of \u003cem\u003eDirofilaria immitis\u003c\/em\u003e. To minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eOnly negative animals should be treated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for use in animals\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn the absence of available data, treatment of puppies younger than 8 weeks of age and\/or dogs weighing less than 2 kg should only be carried out based on a risk\/benefit assessment by the veterinary surgeon.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in heartworm endemic areas should be tested for adult heartworm infestation before administering NEXGARD SPECTRA. Infested dogs should be treated with an adulticide chosen by the veterinary surgeon to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe recommended dose should be strictly followed for Collie dogs or other related breeds.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis product, if ingested, can cause gastrointestinal disturbances.\u003c\/li\u003e\n\u003cli\u003eKeep the tablets in the blister and the blister in the carton until use.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAdverse reactions (frequency and seriousness)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn clinical studies, no serious adverse reactions were attributed to the combination of afoxolaner with milbemycin oxime. Less frequent reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus were observed. These reactions generally resolved spontaneously and were of short duration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe frequency of adverse reactions is defined using the following convention:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Common (more than 1 but less than 10 animals in 100 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Uncommon (more than 1 but less than 10 animals in 1,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Rare (more than 1 but less than 10 animals in 10,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very rare (less than 1 animal in 10,000 animals, including isolated reports).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eUse during pregnancy, lactation or lay\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eLaboratory studies in rats and rabbits have not shown any teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinary surgeon.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eInteraction with other medicinal products or other forms of interaction\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is a substrate of p-glycoprotein (P-gp), and can therefore interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAmounts to be administered and administration route\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor oral administration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDosage:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product should be administered at a dose of 2.50-5.36 mg\/kg afoxolaner and 0.50-1.07 mg\/kg milbemycin oxime body weight in accordance with the following table:\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\" valign=\"top\" width=\"97\"\u003e\u003cstrong\u003eDog weight (kg)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd colspan=\"5\" valign=\"top\" width=\"522\"\u003e\u003cstrong\u003eConcentration and number of chewable tablets to be administered\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e9 mg\/ 2 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e19 mg\/ 4 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e38 mg\/ 8 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e75 mg\/ 15 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e150 mg\/ 30 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e2-3.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;3.5-7.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;7.5-15\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;15-30\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;30-60\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp align=\"left\"\u003e For dogs over 60 kg body weight, the appropriate combination of chewable tablets should be used.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMethod of administration:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly, they can be administered with food.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment schedule:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe treatment schedule should be based on the veterinary diagnosis and the local epidemiological situation.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA can be used as a seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cem\u003eDisease: Heartworm disease:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA kills \u003cem\u003eDirofilaria immitis\u003c\/em\u003e larvae for one month after their transmission by mosquitoes, therefore the product must be administered at regular monthly intervals throughout the vector-prone periods, starting from the month after the first exposure to mosquitoes. Treatment should continue until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIf replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in or travelling to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult \u003cem\u003eDirofilaria immitis\u003c\/em\u003e has been established. Therefore, it is recommended that all dogs aged 8 months or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eOverdose (symptoms, emergency procedures, antidotes), if applicable\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNo adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eWithdrawal period: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACOLOGICAL PROPERTIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eATC veterinary code: QP54AB51\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacodynamic properties\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is an insecticide and acaricide belonging to the isoxazoline family.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects\/mites and mammals is a consequence of the characteristic sensitivity of insect\/mite GABA receptors versus those of mammals.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is active against adult fleas as well as against some tick species such as \u003cem\u003eRhipicephalus sanguineus, Dermacentor reticulatus\u003c\/em\u003e and \u003cem\u003eD. variabilis, Ixodes ricinus\u003c\/em\u003e and \u003cem\u003eI. scapularis, Amblyomma americanum\u003c\/em\u003e and \u003cem\u003eHaemaphysalis longicornis.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is an antiparasitic endectocide belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A\u003csub\u003e4\u003c\/sub\u003e and milbemycin A\u003csub\u003e3\u003c\/sub\u003e (in a ratio of 20:80 for A\u003csub\u003e3\u003c\/sub\u003e:A\u003csub\u003e4\u003c\/sub\u003e). It is isolated from the fermentation of \u003cem\u003eStreptomyces milbemycinicus\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (related to GABA and glycine receptors in vertebrates).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThis leads to hyperpolarisation of the neuromuscular membrane and paralysis and death of the parasites.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacokinetic particulars\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean peak plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e) was 1822 ± 165 ng\/ml, 2-4 hours (T\u003csub\u003emax\u003c\/sub\u003e) after a 2.5 mg\/kg afoxolaner dose.\u003c\/p\u003e\n\u003cp\u003eThe volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l\/kg and the clearance value is 5.0 ± 1.2 ml\/h\/kg. The half-life is approximately 2 weeks in dogs.\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePlasma concentrations of Milbemycin oxime increase rapidly in the first 1-2 hours (T\u003csub\u003emax\u003c\/sub\u003e) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A\u003csub\u003e3\u003c\/sub\u003e and 65% for A\u003csub\u003e4\u003c\/sub\u003e respectively. The mean peak plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e), after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng\/ml for A\u003csub\u003e3\u003c\/sub\u003e, 3.3 ± 1.4 days and 246 ± 71 ng\/ml for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l\/kg for A\u003csub\u003e3\u003c\/sub\u003e and A\u003csub\u003e4\u003c\/sub\u003e forms respectively. Both forms have a low clearance value of 75 ± 22 ml\/h\/kg for A\u003csub\u003e3\u003c\/sub\u003e and 41 ± 12 ml\/h\/kg for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACEUTICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eList of excipients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCorn starch\u003c\/li\u003e\n\u003cli\u003eSoy protein\u003c\/li\u003e\n\u003cli\u003eBraised beef flavour\u003c\/li\u003e\n\u003cli\u003ePovidone (E1201)\u003c\/li\u003e\n\u003cli\u003eMacrogol 400\u003c\/li\u003e\n\u003cli\u003eMacrogol 4000\u003c\/li\u003e\n\u003cli\u003eMacrogol 15 hydroxystearate\u003c\/li\u003e\n\u003cli\u003eGlycerol (E422)\u003c\/li\u003e\n\u003cli\u003eMedium-chain triglycerides\u003c\/li\u003e\n\u003cli\u003eCitric acid monohydrate (E330)\u003c\/li\u003e\n\u003cli\u003eButylhydroxytoluene (E321)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIncompatibilities: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eShelf life: \u003c\/strong\u003eShelf life of the veterinary medicinal product as packaged for sale: 2 years\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for storage: \u003c\/strong\u003eKeep the blister in the secondary packaging to protect from light.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eNature and composition of primary packaging\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003eThis veterinary medicinal product is individually packaged in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar\/PVC\/Alu).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e1 cardboard box containing one blister with 1, 3 or 6 chewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNot all package sizes may be marketed.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAny unused veterinary medicinal product or waste materials derived from such products should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394062852428,"sku":"NEX235","price":153.53,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Nexgard-Spectra-XS-2-3.5-kg-3-comprimate.jpg?v=1777296735"},{"product_id":"nexgard-spectra-xl-30-60-kg-3-comprimate","title":"Nexgard Spectra XL (30 - 60 kg), 3 tablets","description":"\u003cdiv class=\"std\"\u003e\n\u003cp\u003e\u003cstrong\u003eQUALITATIVE AND QUANTITATIVE COMPOSITION\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eEach chewable tablet contains:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eActive substances:\u003c\/strong\u003e\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e\n\u003cp align=\"center\"\u003eAfoxolaner\u003c\/p\u003e\n\u003cp align=\"center\"\u003e(mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e\n\u003cp align=\"center\"\u003eMilbemycin oxime (mg)\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"319\"\u003echewable tablets for dogs 7.5-15 kg\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"113\"\u003e150.00\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"132\"\u003e30.00\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003ePHARMACEUTICAL FORM\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMottled red to reddish-brown tablets, round (tablets for\u003c\/p\u003e\n\u003cp align=\"left\"\u003edogs 2-3.5 kg) or rectangular (tablets for dogs \u0026gt; 3.5-7.5 kg, tablets for dogs \u0026gt; 7.5-15 kg, tablets for dogs \u0026gt; 15-30 kg and tablets for dogs \u0026gt; 30-60 kg).\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCLINICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species: \u003c\/strong\u003eDogs\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIndications for use, specifying the target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and\/or treatment of gastrointestinal nematode infestations is indicated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of flea infestations (\u003cem\u003eCtenocephalides felis\u003c\/em\u003e and \u003cem\u003eC. canis\u003c\/em\u003e) in dogs for 5 weeks. Treatment of tick infestations (\u003cem\u003eDermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus\u003c\/em\u003e) in dogs for 4 weeks.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFleas and ticks must attach to the host and commence feeding to be exposed to the active substance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of adult gastrointestinal nematode infestations of the following species: roundworms (\u003cem\u003eToxocara canis \u003c\/em\u003eand \u003cem\u003eToxocara leonina\u003c\/em\u003e), hookworms (\u003cem\u003eAncyclostoma caninum \u003c\/em\u003eand \u003cem\u003eAncyclostoma braziliense\u003c\/em\u003e) and whipworms (\u003cem\u003eTrichuris vulpis\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003ePrevention of heartworm disease (\u003cem\u003eDirofilaria immitis \u003c\/em\u003elarval stage) if administered monthly.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eContraindications: \u003c\/strong\u003eDo not use in case of hypersensitivity to the active substances or to any of the excipients.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial warnings for each target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eParasites need to start feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eResistance of parasites to any particular class of antiparasitic medicinal products may develop following frequent, repeated use of a compound of that class. Therefore, the use of this product should be based on an individual case assessment and local epidemiological information about the current susceptibility of the target species to limit the possibility of future selection of resistance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMaintaining the efficacy of macrocyclic lactones is essential for the control of \u003cem\u003eDirofilaria immitis\u003c\/em\u003e. To minimise the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the start of each preventative treatment period.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eOnly negative animals should be treated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for use in animals\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn the absence of available data, treatment of puppies younger than 8 weeks and\/or dogs weighing less than 2 kg should only be carried out based on a risk\/benefit assessment by the veterinarian.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in heartworm endemic areas should be tested for adult heartworm infestation before administration of NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinarian to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe recommended dose should be strictly followed in Collie breed dogs or other related breeds.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis product, if ingested, can cause gastrointestinal disturbances.\u003c\/li\u003e\n\u003cli\u003eKeep the tablets in the blister and the blister in the carton until use.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental ingestion, especially by children, seek medical advice immediately and show the product label to the physician.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAdverse reactions (frequency and seriousness)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn clinical studies, no serious adverse reactions attributable to the combination of afoxolaner with milbemycin oxime were observed. Less common reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus have been observed. These reactions generally resolved spontaneously and were of short duration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe frequency of adverse reactions is defined using the following convention:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Common (more than 1 but less than 10 animals in 100 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Uncommon (more than 1 but less than 10 animals in 1,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Rare (more than 1 but less than 10 animals in 10,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very rare (less than 1 animal in 10,000 animals, including isolated reports).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eUse during pregnancy, lactation or lay\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eLaboratory studies in rats and rabbits have not shown any teratogenic effects or any negative effects on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or in breeding dogs. Use only according to the benefit-risk assessment by the veterinarian.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eInteractions with other medicinal products and other forms of interaction\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is a substrate of P-glycoprotein (P-gp), and thus may interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAmounts to be administered and administration route\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor oral administration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDosage:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product should be administered at a dose of 2.50-5.36 mg\/kg afoxolaner and 0.50-1.07 mg\/kg milbemycin oxime body weight according to the following table:\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\" valign=\"top\" width=\"97\"\u003e\u003cstrong\u003eDog weight (kg)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd colspan=\"5\" valign=\"top\" width=\"522\"\u003e\u003cstrong\u003eConcentration and number of chewable tablets to be administered\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e9 mg\/ 2 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e19 mg\/ 4 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e38 mg\/ 8 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e75 mg\/ 15 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e150 mg\/ 30 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e2-3.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;3.5-7.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;7.5-15\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;15-30\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;30-60\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp align=\"left\"\u003e For dogs over 60 kg body weight, the appropriate combination of chewable tablets should be used.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMethod of administration:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe tablets are chewable and palatable to most dogs. If the dog does not accept the tablets directly, they can be administered with food.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment regimen:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe treatment regimen should be based on the veterinary diagnosis and local epidemiological situation.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA can be used as seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cem\u003eDisease: Heartworm disease:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA kills \u003cem\u003eDirofilaria immitis \u003c\/em\u003elarvae for one month after their transmission by mosquitoes, so the product should be administered at regular monthly intervals throughout the vector season, starting the month after the first exposure to mosquitoes. Treatment should continue until the month following the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIf replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in or travelling to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult \u003cem\u003eDirofilaria immitis \u003c\/em\u003ehas been established. Therefore, it is recommended that all dogs aged 8 months or older, living in heartworm endemic areas, be tested for adult heartworm infestation before being treated with a heartworm prevention product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eOverdose (symptoms, emergency procedures, antidotes), if applicable\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNo adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eWithdrawal period: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACOLOGICAL PROPERTIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eVeterinary ATC code: QP54AB51\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacodynamic properties\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is an insecticide and acaricide belonging to the isoxazoline family.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the gamma-aminobutyric acid (GABA) neurotransmitter, thereby blocking pre- and post-synaptic chloride ion transfers across the cell membrane. This results in uncontrolled activity of the central nervous system and death of insects and mites. The selective toxicity of afoxolaner between insects\/mites and mammals is a consequence of the characteristic sensitivity of insect\/mite GABA receptors versus those of mammals.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is active against adult fleas as well as several tick species such as \u003cem\u003eRhipicephalus sanguineus, Dermacentor reticulatus \u003c\/em\u003eand \u003cem\u003eD. variabilis, Ixodes ricinus \u003c\/em\u003eand \u003cem\u003eI. scapularis, Amblyomma americanum \u003c\/em\u003eand \u003cem\u003eHaemaphysalis longicornis.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product kills fleas before they lay eggs and thus prevents household contamination. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is an endectocidal antiparasitic belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A\u003csub\u003e4 \u003c\/sub\u003eand milbemycin A\u003csub\u003e3\u003c\/sub\u003e (in a ratio of 20:80 for A\u003csub\u003e3\u003c\/sub\u003e:A\u003csub\u003e4\u003c\/sub\u003e). It is isolated from the fermentation of \u003cem\u003eStreptomyces milbemycinicus\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (linked to GABA and glycine receptors in vertebrates).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThis leads to hyperpolarisation of the neuromuscular membrane and paralysis and death of the parasites.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacokinetic particulars\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e) was 1822 ± 165 ng\/ml, at 2-4 hours (T\u003csub\u003emax\u003c\/sub\u003e) after a dose of 2.5 mg\/kg afoxolaner.\u003c\/p\u003e\n\u003cp\u003eThe volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l\/kg and the clearance value is 5.0 ± 1.2 ml\/h\/kg. The half-life is approximately 2 weeks in dogs.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime plasma concentrations rise rapidly within the first 1-2 hours (T\u003csub\u003emax\u003c\/sub\u003e) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A\u003csub\u003e3\u003c\/sub\u003e and 65% for A\u003csub\u003e4\u003c\/sub\u003e, respectively. The mean maximum plasma concentration (C\u003csub\u003emax\u003c\/sub\u003e) after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng\/ml for A\u003csub\u003e3\u003c\/sub\u003e, 3.3 ± 1.4 days and 246 ± 71 ng\/ml for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l\/kg for A\u003csub\u003e3\u003c\/sub\u003e and A\u003csub\u003e4\u003c\/sub\u003e, respectively. Both forms have low clearance values of 75 ± 22 ml\/h\/kg for A\u003csub\u003e3\u003c\/sub\u003e and 41 ± 12 ml\/h\/kg for A\u003csub\u003e4\u003c\/sub\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACEUTICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eList of excipients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCorn starch\u003c\/li\u003e\n\u003cli\u003eSoy protein\u003c\/li\u003e\n\u003cli\u003eBraised beef flavour\u003c\/li\u003e\n\u003cli\u003ePovidone (E1201)\u003c\/li\u003e\n\u003cli\u003eMacrogol 400\u003c\/li\u003e\n\u003cli\u003eMacrogol 4000\u003c\/li\u003e\n\u003cli\u003eMacrogol 15 hydroxystearate\u003c\/li\u003e\n\u003cli\u003eGlycerol (E422)\u003c\/li\u003e\n\u003cli\u003eMedium chain triglycerides\u003c\/li\u003e\n\u003cli\u003eCitric acid monohydrate (E330)\u003c\/li\u003e\n\u003cli\u003eButylhydroxytoluene (E321)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIncompatibilities: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eShelf life: \u003c\/strong\u003eShelf life of the veterinary medicinal product as packaged for sale: 2 years\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for storage: \u003c\/strong\u003eKeep the blister in the secondary packaging to protect from light.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eNature and composition of primary packaging\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003eThis veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar\/PVC\/Alu).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e 1 cardboard box containing one blister with 1, 3 and 6 chewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNot all package sizes may be marketed.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAny unused veterinary medicinal product or waste materials derived from the use of such products should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"std\"\u003e\u003c\/div\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394065375564,"sku":"NEX3060","price":230.23,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Nexgard-Spectra-XL-30-60-kg-3-comprimate.jpg?v=1777296774"},{"product_id":"zerokeet-ectoparazit-control-100-ml","title":"Zerokeet Ectoparasite Control, 100 ml","description":"\u003cp\u003e\u003cstrong\u003eZerokeet Ectoparasite Control\u003c\/strong\u003e for dogs is a long-lasting product. Application is quite simple. Just dilute it in water in a 1:2 ratio and use a cotton swab to apply it all over the dog's body. The most common infestation areas are at the joints, on the neck, behind the ears, and at the tip of the tail. Applying this product helps effectively kill all adult ticks and fleas before they can lay eggs on the pet and continue to multiply.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFeatures: \u003c\/strong\u003eKills all fleas and ticks in minutes. Prevents infestation. Easy to use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor veterinary use only. Shake the bottle before use.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecifications:\u003c\/strong\u003e Suitable for all dogs. Form - liquid\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition: \u003c\/strong\u003eEach 10 ml contains (in g): Cedrus deodara 2.0, Pongamia glabara 0.50, Azadirachta indica 0.30, Acorus calamus 0.20, Eucalyptus globulus 0.20, Absorbent bases q.s.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended dosage: \u003c\/strong\u003eApplication on the entire body (dilution up to 1:2 in water) at weekly intervals until complete recovery. Zerokeet is applied once a day in cases of lesions, where present.\u003c\/p\u003e\n\u003cp\u003eOther skin conditions - dilution 1:2 to 1:4 in water, depending on the severity of the condition.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage instructions:\u003c\/strong\u003e Store in a cool, dry place.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394080416076,"sku":"ZEC100","price":35.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Zerokeet-Ectoparazit-Control-100-ml.jpg?v=1777296894"},{"product_id":"pipeta-antiparazitara-advantix-pentru-caini-pana-la-4kg","title":"Advantix antiparasitic pipette for dogs up to 4kg","description":"\u003cp\u003e\u003cstrong\u003eAdvantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e\nEach dose (pipette) contains:\u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePipette\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eImidacloprid\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePermethrin\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eE321\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e40 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e200 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e0.4 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2000 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e4.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eExcipients: Butylhydroxytoluene 1.0 mg\/ml (E321, as an antioxidant):\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003cbr\u003e\nFor the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).\u003cbr\u003e\nFleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product\u003cbr\u003e\ncan be used as part of a treatment strategy against flea allergy dermatitis (FAD).\u003cbr\u003e\nThe product exhibits acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes\u003cbr\u003e\nricinus) or three weeks (Dermacentor reticulatus) against tick infestations.\u003cbr\u003e\nTicks already present on the dog may not be killed within two days of treatment and may remain attached and visible. Therefore, it is\u003cbr\u003e\nrecommended to remove ticks present on the dog at the time of treatment to prevent their attachment and blood feeding.\u003cbr\u003e\nOne treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three\u003cbr\u003e\nweeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks and for stable flies\u003cbr\u003e\n(Stomoxys calcitrans) for four weeks.\u003cbr\u003e\nSandflies Phlebotomus perniciosus 3 weeks\u003cbr\u003e\nPhlebotomus papatasi 2 weeks\u003cbr\u003e\nMosquitoes Aedes aegypti 2 weeks\u003cbr\u003e\nCulex pipiens 4 weeks\u003cbr\u003e\nStable fly Stomoxys calcitrans 4 weeks\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003cbr\u003e\nIn the absence of available data, the product should not be used in puppies younger than 7 weeks.\u003cbr\u003e\nDo not use in cases of known hypersensitivity to the active substances.\u003cbr\u003e\nDo not use in cats.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse reactions\u003c\/strong\u003e\u003cbr\u003e\nTransient dermal sensitivity (with increased pruritus, alopecia, and erythema at the application site) or apathy may rarely occur.\u003cbr\u003e\nPoisoning in dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as\u003cbr\u003e\ntremors and apathy may also appear. Symptomatic treatment should be applied under veterinary supervision. There is no specific antidote.\u003cbr\u003e\nIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species\u003c\/strong\u003e\u003cbr\u003e\nDogs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage for each species, route(s) of administration, and method of administration\u003c\/strong\u003e\u003cbr\u003e\nDosing regimen:\u003cbr\u003e\nThe minimum recommended dose is: 10 mg\/kg body weight (b.w.) imidacloprid and 50 mg\/kg body weight (b.w.) permethrin, equivalent to\u003cbr\u003e\n0.1ml\/kg b.w. \u003cstrong\u003eAdvantix spot-on solution for dogs.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDog weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg\/kg b.w.) Permethrin (mg\/kg b.w.)\u003c\/p\u003e\n\u003cp\u003e\u0026gt;25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80\u003cbr\u003e\n\u0026gt; 40 kg the appropriate combination of pipettes should be used\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%; height: 147px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 42px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 42px; text-align: center;\"\u003eDog weight (kg)\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 42px; text-align: center;\"\u003ePipette size to be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 42px; text-align: center;\"\u003eVolume (ml)\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 42px; text-align: center;\"\u003eImidacloprid (mg\/kg b.w.)\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 42px; text-align: center;\"\u003ePermethrin (mg\/kg b.w.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026lt;=4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003eminimum 10\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003eminimum 50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;4 kg - 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;10 kg - 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;25 kg - 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 16\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 80\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt; 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003ethe appropriate combination of pipettes should be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTo reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in\u003cbr\u003e\nthe same family or household should be treated with appropriate products. For fleas originating from the animal's environment,\u003cbr\u003e\nthe additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is effective even if the animal is wet. However, prolonged exposure to water should be avoided. If prolonged exposure\u003cbr\u003e\nto water occurs, the effectiveness of the product decreases. Even in this case, it should not be treated more frequently than once a week. If it is\u003cbr\u003e\nnecessary to shampoo the animal, it is advisable to apply Advantix spot-on solution for dogs after two weeks\u003cbr\u003e\nto ensure the effectiveness of the product.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod of administration.\u003c\/strong\u003e\u003cbr\u003e\nRemove one pipette from the package. Hold the pipette upright, twist the cap, and remove it. Turn the cap upside down and use it to\u003cbr\u003e\nunseal the pipette (by twisting and pressing on the seal, as shown in the photo).\u003cbr\u003e\nFor dogs weighing 10 kg or less:\u003cbr\u003e\nWith the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and\u003cbr\u003e\nby firmly squeezing several times, empty the contents of the pipette. Apply only to uninjured skin.\u003cbr\u003e\nFor dogs weighing more than 10 kg:\u003cbr\u003e\nWith the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four places\u003cbr\u003e\nstarting from between the shoulder blades and extending to the base of the tail. At each spot, part the hair until the skin is visible. Apply the tip of the pipette to the skin and\u003cbr\u003e\ngently squeeze to release some of the solution onto the skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommendations for correct administration\u003c\/strong\u003e\u003cbr\u003e\nFor external use only.\u003cbr\u003e\nApply only to uninjured skin.\u003cbr\u003e\nDo not apply a large amount of solution in a single spot, as this may run off the sides of the dog.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWithdrawal period\u003c\/strong\u003e\u003cbr\u003e\nNot applicable.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for storage\u003c\/strong\u003e\u003cbr\u003e\nKeep out of the sight and reach of children.\u003cbr\u003e\nDo not freeze.\u003cbr\u003e\nAfter opening the aluminum pouch, store in a dry place and do not store at temperatures above 30°C.\u003cbr\u003e\nThe abbreviation used for the expiry date on the label, pipette, and pouch is EXP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003cbr\u003e\nThe contents of the pipette should not come into contact with the eyes or mouth of the treated dog.\u003cbr\u003e\nPay attention to the correct administration of the product as described in the \"Method of administration\" section. In particular, oral ingestion\u003cbr\u003e\nby licking the application site or contact with other animals should be avoided.\u003cbr\u003e\nDo not use in cats.\u003cbr\u003e\nThis product is highly toxic to cats and can cause death due to the physiological peculiarities of cats\u003cbr\u003e\nwhich are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of\u003cbr\u003e\ncats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.\u003cbr\u003e\nMeasures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek\u003cbr\u003e\nimmediate veterinary assistance if this occurs.\u003cbr\u003e\nConsult your veterinarian before using this product in sick and debilitated animals.\u003cbr\u003e\nAs the product is dangerous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters\u003cbr\u003e\nfor at least 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003cbr\u003e\nAvoid contact with skin, eyes, or mouth. Do not eat, drink, or smoke during product application.\u003cbr\u003e\nWash hands thoroughly after product application.\u003cbr\u003e\nIf the product accidentally gets on the skin, wash the area immediately with soap and water.\u003cbr\u003e\nIndividuals with known skin sensitivity may be particularly sensitive to this product.\u003cbr\u003e\nIf the product accidentally gets into the eyes, rinse the eyes with plenty of water. If skin or ocular symptoms persist, or the product is\u003cbr\u003e\naccidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.\u003cbr\u003e\nTreated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for\u003cbr\u003e\nexample, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for the disposal of unused product or waste materials, if any\u003c\/strong\u003e\u003cbr\u003e\nAfter use, place the cap back on the pipette. Any unused veterinary medicinal product or waste materials derived from the use of such\u003cbr\u003e\nproducts should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther information\u003c\/strong\u003e\u003cbr\u003e\nAdvantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.\u003cbr\u003e\nThis combination acts as an insecticide, acaricide, and repellent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImidacloprid\u003c\/strong\u003e is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified\u003cbr\u003e\nas a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to\u003cbr\u003e\nits efficacy against adult fleas, the larvicidal efficacy of the substance for areas in the animal's habitat has also been demonstrated.\u003cbr\u003e\nThe product provides repellent (anti-feeding) action against ticks, sandflies, and mosquitoes, thereby preventing\u003cbr\u003e\nparasite blood feeding and reducing the risk of transmitting vector-borne diseases (Canine Vector-Borne Disease or\u003cbr\u003e\nCVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).\u003cbr\u003e\nIt can be used during pregnancy and lactation.\u003cbr\u003e\nThe solvent in \u003cstrong\u003eAdvantix spot-on solution for dogs\u003c\/strong\u003e may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow\u003cbr\u003e\nthe application site to dry before contact with such materials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003cbr\u003e\nPipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml\u003cbr\u003e\nBlister containing 1, 2, 3, 4, or 6 individual pipettes.\u003cbr\u003e\nNot all package sizes may be marketed.\u003cbr\u003e\nFor any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorization holder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMarketing Authorization Holder\u003c\/strong\u003e\u003cbr\u003e\nBayer Animal Health GmbH, D-51368 Leverkusen, Germany\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394222235980,"sku":"ADV40","price":55.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advantix-1x0_4ml-sub-4kg-2018.jpg?v=1777298210"},{"product_id":"pipeta-antiparazitara-advantix-pentru-caini-de-peste-40-kg","title":"Advantix antiparasitic pipette for dogs over 40 kg","description":"\u003cp\u003e\u003cstrong\u003eAdvantix is an external antiparasitic product containing imidacloprid and permethrin, and is highly effective in treating flea and tick infestations for one month after a single application. \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e\nEach dose (pipette) contains:\u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePipette\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eImidacloprid\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePermethrin\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eE321\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e40 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e200 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e0.4 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2000 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e4.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eExcipients: Butylated hydroxytoluene 1.0 mg\/ml (E321, as antioxidant):\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003cbr\u003e\nFor the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).\u003cbr\u003e\nFleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product\u003cbr\u003e\ncan be used as part of a treatment strategy against flea allergy dermatitis (FAD).\u003cbr\u003e\nThe product has acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes\u003cbr\u003e\nricinus) or three weeks (Dermacentor reticulatus) against tick infestations.\u003cbr\u003e\nTicks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore, it is\u003cbr\u003e\nrecommended to remove ticks present on the dog at the time of treatment to prevent them from attaching and feeding.\u003cbr\u003e\nOne treatment provides repellent (anti-feeding) action against sand flies for two weeks (Phlebotomus papatasi) or three\u003cbr\u003e\nweeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks and against stable flies\u003cbr\u003e\n(Stomoxys calcitrans) for four weeks.\u003cbr\u003e\nSandflies Phlebotomus perniciosus 3 weeks\u003cbr\u003e\nPhlebotomus papatasi 2 weeks\u003cbr\u003e\nMosquitoes Aedes aegypti 2 weeks\u003cbr\u003e\nCulex pipiens 4 weeks\u003cbr\u003e\nStable flies Stomoxys calcitrans 4 weeks\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003cbr\u003e\nIn the absence of available data, the product should not be used in puppies younger than 7 weeks.\u003cbr\u003e\nDo not use in cases of known hypersensitivity to the active substances.\u003cbr\u003e\nDo not use in cats.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse reactions\u003c\/strong\u003e\u003cbr\u003e\nTransient skin sensitivity (with increased pruritus, alopecia, and erythema at the application site) or apathy may rarely occur.\u003cbr\u003e\nPoisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as\u003cbr\u003e\ntremors and apathy may also occur. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.\u003cbr\u003e\nIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species\u003c\/strong\u003e\u003cbr\u003e\nDogs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage for each species, route(s) of administration and method of administration\u003c\/strong\u003e\u003cbr\u003e\nDosing regimen:\u003cbr\u003e\nThe minimum recommended dose is: 10 mg\/kg body weight (b.w.) imidacloprid and 50 mg\/kg body weight (b.w.) permethrin, equivalent to\u003cbr\u003e\n0.1ml\/kg b.w. \u003cstrong\u003eAdvantix spot-on solution for dogs.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDog weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg\/kg b.w.) Permethrin (mg\/kg b.w.)\u003c\/p\u003e\n\u003cp\u003e\u0026gt;25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80\u003cbr\u003e\n\u0026gt; 40 kg use the appropriate combination of pipettes\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%; height: 147px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 42px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 42px; text-align: center;\"\u003eDog weight (kg)\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 42px; text-align: center;\"\u003ePipette size to be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 42px; text-align: center;\"\u003eVolume (ml)\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 42px; text-align: center;\"\u003eImidacloprid (mg\/kg b.w.)\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 42px; text-align: center;\"\u003ePermethrin (mg\/kg b.w.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026lt;=4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003eminimum 10\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003eminimum 50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;4 kg - 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;10 kg - 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;25 kg - 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 16\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 80\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt; 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003euse the appropriate combination of pipettes\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTo reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in\u003cbr\u003e\nthe same family or household should be treated with appropriate products. For fleas originating from the animal's environment,\u003cbr\u003e\nthe additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure\u003cbr\u003e\nto water, the efficacy of the product decreases. Even in this case, it should not be treated more frequently than once a week. If\u003cbr\u003e\nthe animal needs to be shampooed, it is advisable to apply Advantix spot-on solution for dogs after two weeks\u003cbr\u003e\nto ensure the product's efficacy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod of administration.\u003c\/strong\u003e\u003cbr\u003e\nRemove one pipette from the package. Hold the pipette upright, twist the cap and remove it. Turn the cap upside down and use it\u003cbr\u003e\nto seal the pipette (by twisting and pressing on the seal, as shown in the picture).\u003cbr\u003e\nFor dogs weighing 10 kg or less:\u003cbr\u003e\nWith the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and\u003cbr\u003e\nby squeezing firmly several times, empty the contents of the pipette. Apply only to unbroken skin.\u003cbr\u003e\nFor dogs weighing more than 10 kg:\u003cbr\u003e\nWith the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four spots,\u003cbr\u003e\nstarting between the shoulder blades and extending to the base of the tail. At each spot, part the hair until the skin is visible. Apply the tip of the pipette to the skin and\u003cbr\u003e\ngently squeeze to release some of the solution onto the skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommendations for correct administration\u003c\/strong\u003e\u003cbr\u003e\nFor external use only.\u003cbr\u003e\nApply only to unbroken skin.\u003cbr\u003e\nDo not apply a large amount of solution in one spot, as it may run down the sides of the dog.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWithdrawal period\u003c\/strong\u003e\u003cbr\u003e\nNot applicable.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for storage\u003c\/strong\u003e\u003cbr\u003e\nKeep out of the sight and reach of children.\u003cbr\u003e\nDo not freeze.\u003cbr\u003e\nAfter opening the aluminum pouch, store in a dry place and do not store above 30°C.\u003cbr\u003e\nThe abbreviation used for the expiry date on the label, pipette, and pouch is EXP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003cbr\u003e\nThe content of the pipette must not come into contact with the eyes and mouth of the treated dog.\u003cbr\u003e\nPay attention to the correct administration of the product as described in the \"Method of administration\" section. In particular, oral ingestion\u003cbr\u003e\nby licking the application site or contact with other animals should be avoided.\u003cbr\u003e\nDo not use on cats.\u003cbr\u003e\nThis product is highly toxic to cats and can cause death due to the physiological peculiarities of cats\u003cbr\u003e\nwho are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of\u003cbr\u003e\ncats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.\u003cbr\u003e\nMeasures should be taken to prevent cats from licking the application site of dogs that have been treated with this product. Seek\u003cbr\u003e\nimmediate veterinary assistance if this occurs.\u003cbr\u003e\nConsult your veterinarian before using this product in sick and debilitated animals.\u003cbr\u003e\nSince the product is hazardous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters\u003cbr\u003e\nfor at least 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003cbr\u003e\nAvoid contact with skin, eyes, or mouth. Do not eat, drink, or smoke during product application.\u003cbr\u003e\nWash hands thoroughly after product application.\u003cbr\u003e\nIf the product accidentally comes into contact with skin, wash the area immediately with soap and water.\u003cbr\u003e\nIndividuals with known skin sensitivity may be particularly sensitive to this product.\u003cbr\u003e\nIf the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is\u003cbr\u003e\naccidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.\u003cbr\u003e\nTreated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for\u003cbr\u003e\nexample, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for the disposal of unused product or waste materials, if applicable\u003c\/strong\u003e\u003cbr\u003e\nAfter use, place the cap back on the pipette. Any unused veterinary medicinal product or waste materials derived from such products\u003cbr\u003e\nshould be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther information\u003c\/strong\u003e\u003cbr\u003e\nAdvantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.\u003cbr\u003e\nThis combination acts as an insecticide, acaricide, and repellent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImidacloprid\u003c\/strong\u003e is an ectoparasiticide belonging to the chloronicotinyl compound group. Chemically, it can be classified\u003cbr\u003e\nas chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to\u003cbr\u003e\nits efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for areas in the animal's habitat.\u003cbr\u003e\nThe product provides repellent (anti-feeding) action against ticks, sand flies, and mosquitoes, thereby preventing\u003cbr\u003e\nparasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or\u003cbr\u003e\nCVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).\u003cbr\u003e\nIt can be used during pregnancy and lactation.\u003cbr\u003e\nThe solvent in \u003cstrong\u003eAdvantix spot-on solution for dogs\u003c\/strong\u003e may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow\u003cbr\u003e\nthe application site to dry before contact with such materials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003cbr\u003e\nPipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml\u003cbr\u003e\nBlister containing 1, 2, 3, 4, or 6 individual pipettes.\u003cbr\u003e\nNot all pack sizes may be marketed.\u003cbr\u003e\nFor any information about this veterinary medicinal product, please contact the local representative of the marketing authorization holder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMarketing Authorization Holder\u003c\/strong\u003e\u003cbr\u003e\nBayer Animal Health GmbH, D-51368 Leverkusen, Germany\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394222498124,"sku":"ADV600","price":82.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advantix-1x6ml-40kg-60kg-2019.jpg?v=1777298212"},{"product_id":"set-4-pipete-antiparazitare-advantix-pentru-caini-pana-la-4kg","title":"Set of 4 Advantix antiparasitic pipettes, for dogs up to 4kg","description":"\u003cp\u003e\u003cstrong\u003eAdvantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e\nEach dose (pipette) contains:\u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePipette\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eImidacloprid\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePermethrin\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eE321\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e40 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e200 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e0.4 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2000 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e4.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eExcipients: Butylhydroxytoluene 1.0 mg\/ml (E321, as an antioxidant):\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003cbr\u003e\nFor the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).\u003cbr\u003e\nFleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product\u003cbr\u003e\ncan be used as part of a treatment strategy against flea allergy dermatitis (FAD).\u003cbr\u003e\nThe product has acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes\u003cbr\u003e\nricinus) or three weeks (Dermacentor reticulatus) against tick infestations.\u003cbr\u003e\nTicks already present on the dog may not be killed within two days of treatment and may remain attached and visible. Therefore,\u003cbr\u003e\nit is recommended to remove ticks present on the dog at the time of treatment to prevent them from attaching and feeding.\u003cbr\u003e\nOne treatment provides repellent (anti-feeding) action against sandflies for two weeks (Phlebotomus papatasi) or three\u003cbr\u003e\nweeks (Phlebotomus perniciosus), against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks, and against stable flies\u003cbr\u003e\n(Stomoxys calcitrans) for four weeks.\u003cbr\u003e\nSandflies Phlebotomus perniciosus 3 weeks\u003cbr\u003e\nPhlebotomus papatasi 2 weeks\u003cbr\u003e\nMosquitoes Aedes aegypti 2 weeks\u003cbr\u003e\nCulex pipiens 4 weeks\u003cbr\u003e\nStable flies Stomoxys calcitrans 4 weeks\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003cbr\u003e\nIn the absence of available data, the product should not be used in puppies younger than 7 weeks.\u003cbr\u003e\nDo not use in known cases of hypersensitivity to the active substances.\u003cbr\u003e\nDo not use in cats.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse reactions\u003c\/strong\u003e\u003cbr\u003e\nTransient dermal sensitivity (with increased pruritus, alopecia and erythema at the application site) or apathy may rarely occur.\u003cbr\u003e\nPoisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such\u003cbr\u003e\nas tremors and apathy may also appear. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.\u003cbr\u003e\nIf you notice serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species\u003c\/strong\u003e\u003cbr\u003e\nDogs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage for each species, route(s) of administration and method of administration\u003c\/strong\u003e\u003cbr\u003e\nDosing regimen:\u003cbr\u003e\nThe minimum recommended dose is: 10 mg \/ kg body weight (b.w.) imidacloprid and 50 mg \/ kg body weight (b.w.) permethrin equivalent to\u003cbr\u003e\n0.1ml\/kg b.w.\u003cstrong\u003e Advantix spot-on solution for dogs.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDog weight (kg) \u0026nbsp; \u0026nbsp;Pipette size to be used \u0026nbsp; \u0026nbsp;Volume (ml) \u0026nbsp; \u0026nbsp;Imidacloprid (mg\/kg b.w.) \u0026nbsp; \u0026nbsp;Permethrin (mg\/kg b.w.)\u003c\/p\u003e\n\u003cp\u003e\u0026gt;25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80\u003cbr\u003e\n\u0026gt; 40 kg use the appropriate combination of pipettes\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%; height: 147px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 42px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 42px; text-align: center;\"\u003eDog weight (kg)\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 42px; text-align: center;\"\u003ePipette size to be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 42px; text-align: center;\"\u003eVolume (ml)\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 42px; text-align: center;\"\u003eImidacloprid (mg\/kg b.w.)\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 42px; text-align: center;\"\u003ePermethrin (mg\/kg b.w.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026lt;=4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003eminimum 10\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003eminimum 50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;4 kg - 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;10 kg - 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;25 kg - 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 16\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 80\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt; 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003euse the appropriate combination of pipettes\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTo reduce re-infestations with new fleas, it is recommended that all dogs in a family (household) be treated. Other pets in\u003cbr\u003e\nthe same family or household should be treated with appropriate products. For fleas originating from the animal's environment,\u003cbr\u003e\nthe additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is effective even if the animal is wet. However, prolonged exposure to water should be avoided. In case of prolonged exposure\u003cbr\u003e\nto water, the efficacy of the product decreases. Even in this case, treatment should not be more frequent than once a week. If\u003cbr\u003e\nthe animal needs to be shampooed, it is advisable to apply Advantix spot-on solution for dogs two weeks later\u003cbr\u003e\nto ensure the product's efficacy.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod of administration.\u003c\/strong\u003e\u003cbr\u003e\nRemove one pipette from the package. Hold the pipette upright, twist the cap and remove it. Turn the cap upside down and use it to\u003cbr\u003e\nunseal the pipette (by twisting and pressing on the seal, as shown in the photo).\u003cbr\u003e\nFor dogs weighing 10 kg or less:\u003cbr\u003e\nWith the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and\u003cbr\u003e\nby squeezing firmly several times, empty the contents of the pipette. Apply only to unbroken skin.\u003cbr\u003e\nFor dogs weighing more than 10 kg:\u003cbr\u003e\nWith the dog standing, the entire contents of the Advantix spot-on solution for dogs pipette will be applied evenly in four spots\u003cbr\u003e\nstarting between the shoulder blades and extending to the base of the tail. At each spot, part the hair until the skin is visible. Apply the tip of the pipette to the skin and\u003cbr\u003e\ngently squeeze to release some of the solution onto the skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommendations for correct administration\u003c\/strong\u003e\u003cbr\u003e\nFor external use only.\u003cbr\u003e\nApply only to unbroken skin.\u003cbr\u003e\nDo not apply a large amount of solution in one spot as this may run off the sides of the dog.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWithdrawal period\u003c\/strong\u003e\u003cbr\u003e\nNot applicable.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for storage\u003c\/strong\u003e\u003cbr\u003e\nKeep out of the reach and sight of children.\u003cbr\u003e\nDo not freeze.\u003cbr\u003e\nAfter opening the aluminum pouch, store in a dry place and do not store at a temperature higher than 30°C.\u003cbr\u003e\nThe abbreviation used for the expiry date on the label, pipette and pouch is EXP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003cbr\u003e\nThe contents of the pipette must not come into contact with the eyes and mouth of the treated dog.\u003cbr\u003e\nPay attention to the correct administration of the product as described in the \"Method of administration\" section. In particular, oral ingestion\u003cbr\u003e\nby licking the application site or contact with other animals should be avoided.\u003cbr\u003e\nDo not use in cats.\u003cbr\u003e\nThis product is highly toxic to cats and can cause death due to the physiological peculiarities of cats,\u003cbr\u003e\nwho are unable to metabolize certain compounds, including permethrin. To prevent accidental exposure of\u003cbr\u003e\ncats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.\u003cbr\u003e\nMeasures should be taken to prevent cats from licking the application site of dogs that have been treated with this product. Seek\u003cbr\u003e\nimmediate veterinary assistance if this occurs.\u003cbr\u003e\nConsult your veterinarian before using this product in sick and debilitated animals.\u003cbr\u003e\nAs the product is dangerous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface water\u003cbr\u003e\nfor at least 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003cbr\u003e\nAvoid contact with skin, eyes or mouth. Do not eat, drink, or smoke during product application.\u003cbr\u003e\nWash hands thoroughly after applying the product.\u003cbr\u003e\nIf the product accidentally gets on the skin, immediately wash the area with soap and water.\u003cbr\u003e\nIndividuals with known skin sensitivity may be particularly sensitive to this product.\u003cbr\u003e\nIf the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is\u003cbr\u003e\naccidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.\u003cbr\u003e\nTreated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs in the\u003cbr\u003e\nevening, for example. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for the disposal of unused product or waste materials, if any\u003c\/strong\u003e\u003cbr\u003e\nAfter use, replace the cap on the pipette. Any unused veterinary medicinal product or waste materials derived from such products\u003cbr\u003e\nshould be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther information\u003c\/strong\u003e\u003cbr\u003e\nAdvantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.\u003cbr\u003e\nThis combination acts as an insecticide, acaricide, and repellent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImidacloprid\u003c\/strong\u003e is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified\u003cbr\u003e\nas chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to\u003cbr\u003e\nits efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for areas in the animal's habitat.\u003cbr\u003e\nThe product provides repellent (anti-feeding) action against ticks, sandflies, and mosquitoes, thereby preventing\u003cbr\u003e\nparasite feeding and reducing the risk of transmitting vector-borne diseases (Canine Vector-Borne Disease or\u003cbr\u003e\nCVBD, such as borreliosis, rickettsiosis, ehrlichiosis, leishmaniasis).\u003cbr\u003e\nIt can be used during pregnancy and lactation.\u003cbr\u003e\nThe solvent in \u003cstrong\u003eAdvantix spot-on solution for dogs\u003c\/strong\u003e may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow\u003cbr\u003e\nthe application site to dry before contact with such materials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003cbr\u003e\nPipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml\u003cbr\u003e\nBlister containing 1, 2, 3, 4 or 6 individual pipettes.\u003cbr\u003e\nNot all pack sizes may be marketed.\u003cbr\u003e\nFor any information regarding this veterinary medicinal product, please contact the local representative of the marketing authorization holder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMarketing Authorization Holder\u003c\/strong\u003e\u003cbr\u003e\nBayer Animal Health GmbH, D-51368 Leverkusen, Germany\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394222858572,"sku":"ADV40-SET4","price":204.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Advantix-1x0_4ml-sub-4kg-2018_c3e5badd-aabd-48f2-a053-c68dc1455dbd.jpg?v=1777298216"},{"product_id":"set-4-pipete-antiparazitare-advantix-pentru-caini-de-peste-40-kg","title":"Set of 4 Advantix antiparasitic pipettes, for dogs over 40 kg","description":"\u003cp\u003e\u003cstrong\u003eAdvantix is an external antiparasitic product containing imidacloprid and permethrin, and is very effective in treating flea and tick infestations for one month after a single application.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003cbr\u003e\nEach dose (pipette) contains:\u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePipette\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eImidacloprid\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003ePermethrin\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003eE321\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e40 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e200 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e0.4 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e100 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e500 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e1250 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2.5 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e 4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e400 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e2000 mg\u003c\/td\u003e\n\u003ctd style=\"width: 162px; text-align: center;\"\u003e4.0 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eExcipients: Butylhydroxytoluene 1.0 mg\/ml (E321, as antioxidant):\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003cbr\u003e\nFor the treatment and prevention of flea infestation (Ctenocephalides canis, Ctenocephalides felis).\u003cbr\u003e\nFleas on dogs are killed within one day of treatment. One treatment prevents future flea infestations for four weeks. The product\u003cbr\u003e\ncan be used as part of a treatment strategy for flea allergy dermatitis (FAD).\u003cbr\u003e\nThe product exhibits acaricidal and repellent activity for up to four weeks (Rhipicephalus sanguineus, Ixodes\u003cbr\u003e\nricinus) or three weeks (Dermacentor reticulatus) against tick infestations.\u003cbr\u003e\nTicks already present on the dog may not be killed within two days after treatment and may remain attached and visible. Therefore, it is\u003cbr\u003e\nrecommended to remove ticks present on the dog at the time of treatment to prevent their attachment and blood feeding.\u003cbr\u003e\nOne treatment provides repellent (anti-feeding) action against sand flies for two weeks (Phlebotomus papatasi) or three\u003cbr\u003e\nweeks (Phlebotomus perniciosus) against mosquitoes for two (Aedes aegypti) and four (Culex pipiens) weeks, and against stable flies\u003cbr\u003e\n(Stomoxys calcitrans) for four weeks.\u003cbr\u003e\nSand flies Phlebotomus perniciosus 3 weeks\u003cbr\u003e\nPhlebotomus papatasi 2 weeks\u003cbr\u003e\nMosquitoes Aedes aegypti 2 weeks\u003cbr\u003e\nCulex pipiens 4 weeks\u003cbr\u003e\nStable fly Stomoxys calcitrans 4 weeks\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications\u003c\/strong\u003e\u003cbr\u003e\nIn the absence of available data, the product should not be used in puppies younger than 7 weeks.\u003cbr\u003e\nDo not use in cases of known hypersensitivity to the active substances.\u003cbr\u003e\nDo not use in cats.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdverse reactions\u003c\/strong\u003e\u003cbr\u003e\nTransient dermal sensitivity (with increased pruritus, alopecia, and erythema at the application site) or apathy may rarely occur.\u003cbr\u003e\nPoisoning of dogs after accidental ingestion may occur in rare cases. In these cases, neurological signs such as\u003cbr\u003e\ntremors and apathy may also appear. Symptomatic treatment should be applied under the supervision of a veterinarian. There is no specific antidote.\u003cbr\u003e\nIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species\u003c\/strong\u003e\u003cbr\u003e\nDogs.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDosage for each species, route(s) of administration and method of administration\u003c\/strong\u003e\u003cbr\u003e\nDosing schedule:\u003cbr\u003e\nThe minimum recommended dose is: 10 mg \/ kg body weight (b.w.) imidacloprid and 50 mg \/ kg body weight (b.w.) permethrin equivalent to\u003cbr\u003e\n0.1ml\/kg b.w.\u003cstrong\u003e Advantix spot-on solution for dogs.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDog weight (kg) Pipette size to be used Volume (ml) Imidacloprid (mg\/kg b.w.) Permethrin (mg\/kg b.w.)\u003c\/p\u003e\n\u003cp\u003e\u0026gt;25 kg - 40 kg Advantix spot-on solution for dogs over 25 kg 4.0 ml 10 - 16 50 - 80\u003cbr\u003e\n\u0026gt; 40 kg the appropriate combination of pipettes should be used\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ctable style=\"border-collapse: collapse; width: 100%; height: 147px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 42px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 42px; text-align: center;\"\u003eDog weight (kg)\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 42px; text-align: center;\"\u003ePipette size to be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 42px; text-align: center;\"\u003eVolume (ml)\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 42px; text-align: center;\"\u003eImidacloprid (mg\/kg b.w.)\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 42px; text-align: center;\"\u003ePermethrin (mg\/kg b.w.)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026lt;=4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs up to 4 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e 0.4 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003eminimum 10\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003eminimum 50\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;4 kg - 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 4 kg to 10 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e1.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;10 kg - 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs from 10 kg to 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e2.5 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 25\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 125\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt;25 kg - 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003eAdvantix spot-on solution for dogs over 25 kg\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e4.0 ml\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e10 - 16\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e50 - 80\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 21px;\"\u003e\n\u003ctd style=\"width: 16.1306%; height: 21px; text-align: center;\"\u003e\u0026gt; 40 kg\u003c\/td\u003e\n\u003ctd style=\"width: 34.1475%; height: 21px; text-align: center;\"\u003ethe appropriate combination of pipettes should be used\u003c\/td\u003e\n\u003ctd style=\"width: 10.9311%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 20%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 18.7908%; height: 21px; text-align: center;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003eTo reduce re-infestation with new fleas, it is recommended that all dogs in a household be treated. Other pets in\u003cbr\u003e\nthe same household must be treated with appropriate products. For fleas originating from the animal's environment,\u003cbr\u003e\nthe additional use of an appropriate product for the treatment against adult fleas and their developmental stages is recommended. The product is active even if the animal is wet. However, prolonged exposure to water should be avoided. If prolonged exposure\u003cbr\u003e\nto water occurs, the efficacy of the product decreases. Even in this case, treatment should not be more frequent than once a week. If\u003cbr\u003e\nthe animal needs to be washed with shampoo, it is best to apply Advantix spot-on solution for dogs after two weeks\u003cbr\u003e\nto ensure the product's effectiveness.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod of administration.\u003c\/strong\u003e\u003cbr\u003e\nRemove a pipette from the package. Hold the pipette upright, twist the cap, and remove it. Turn the cap upside down and use\u003cbr\u003e\nit to unseal the pipette (by twisting and pressing on the seal, as shown in the photo).\u003cbr\u003e\nFor dogs weighing 10 kg or less:\u003cbr\u003e\nWith the dog standing, part the hair between the shoulder blades until the skin is visible. Apply the tip of the pipette directly to the skin and\u003cbr\u003e\nby squeezing firmly several times, empty the contents of the pipette. Apply only to unbroken skin.\u003cbr\u003e\nFor dogs weighing more than 10 kg:\u003cbr\u003e\nWith the dog standing, the entire content of the Advantix spot-on solution pipette for dogs should be applied evenly in four places\u003cbr\u003e\nstarting between the shoulder blades and extending to the base of the tail. At each location, part the hair until the skin is visible. Apply the tip of the pipette to the skin and\u003cbr\u003e\ngently squeeze to release some of the solution onto the skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRecommendations for correct administration\u003c\/strong\u003e\u003cbr\u003e\nFor external use only.\u003cbr\u003e\nApply only to unbroken skin.\u003cbr\u003e\nDo not apply a large amount of solution in one spot as this may run down the sides of the dog.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWithdrawal period\u003c\/strong\u003e\u003cbr\u003e\nNot applicable.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for storage\u003c\/strong\u003e\u003cbr\u003e\nKeep out of the reach and sight of children.\u003cbr\u003e\nDo not freeze.\u003cbr\u003e\nAfter opening the aluminum pouch, store in a dry place and do not store at temperatures above 30°C.\u003cbr\u003e\nThe abbreviation used for the expiry date on the label, pipette, and pouch is EXP.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for use in animals\u003c\/strong\u003e\u003cbr\u003e\nThe content of the pipette should not come into contact with the eyes and mouth of the treated dog.\u003cbr\u003e\nPay attention to the correct administration of the product as described in the \"Method of administration\" section. In particular, oral ingestion\u003cbr\u003e\nby licking the application site or contact with other animals should be avoided.\u003cbr\u003e\nDo not use in cats.\u003cbr\u003e\nThis product is very toxic to cats and can cause death due to the physiological particularities of cats\u003cbr\u003e\nwhich are unable to metabolize certain compounds including permethrin. To prevent accidental exposure of\u003cbr\u003e\ncats to this product, treated dogs should be kept separate from cats after treatment until the application site is dry.\u003cbr\u003e\nMeasures should be taken to ensure that cats do not lick the application site of dogs that have been treated with this product. Seek\u003cbr\u003e\nimmediate veterinary assistance if this occurs.\u003cbr\u003e\nConsult your veterinarian before using this product in sick and debilitated animals.\u003cbr\u003e\nAs the product is hazardous to aquatic organisms, treated dogs must under no circumstances be allowed to enter any surface waters\u003cbr\u003e\nfor at least 48 hours after treatment.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/strong\u003e\u003cbr\u003e\nAvoid contact with skin, eyes, or mouth. Do not eat, drink, or smoke while applying the product.\u003cbr\u003e\nWash hands thoroughly after applying the product.\u003cbr\u003e\nIf the product accidentally gets on the skin, wash the area immediately with soap and water.\u003cbr\u003e\nIndividuals with known skin sensitivity may be particularly sensitive to this product.\u003cbr\u003e\nIf the product accidentally gets into the eyes, wash the eyes with plenty of water. If skin or eye symptoms persist, or the product is\u003cbr\u003e\naccidentally swallowed, seek immediate medical advice and show the doctor the product leaflet.\u003cbr\u003e\nTreated dogs should not be allowed to play, especially with children, until the application site is dry. To be safe, treat dogs, for\u003cbr\u003e\nexample, in the evening. In this case, treated dogs are not allowed to sleep with their owners, especially if they are children.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSpecial precautions for the disposal of unused product or waste materials, if any\u003c\/strong\u003e\u003cbr\u003e\nAfter use, replace the cap on the pipette. Any unused veterinary medicinal product or waste materials derived from such\u003cbr\u003e\nproducts should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOther information\u003c\/strong\u003e\u003cbr\u003e\nAdvantix spot-on solution for dogs is a topical ectoparasiticide containing imidacloprid and permethrin.\u003cbr\u003e\nThis combination acts as an insecticide, acaricide, and repellent.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImidacloprid\u003c\/strong\u003e is an ectoparasiticide belonging to the chloronicotinyl group of compounds. Chemically, it can be classified\u003cbr\u003e\nas a chloronicotinyl nitroguanidine. Imidacloprid is effective against adult fleas and their larval stages. In addition to\u003cbr\u003e\nits efficacy against adult fleas, the larvicidal efficacy of the substance has also been demonstrated for areas in the animal's habitat.\u003cbr\u003e\nThe product provides repellent (anti-feeding) action against ticks, sand flies, and mosquitoes, thus preventing\u003cbr\u003e\nparasite blood feeding and reducing the risk of transmission of vector-borne diseases (Canine Vector-Borne Disease or\u003cbr\u003e\nCVBD, such as Lyme disease, rickettsiosis, ehrlichiosis, leishmaniasis).\u003cbr\u003e\nIt can be used during gestation and lactation.\u003cbr\u003e\nThe solvent in \u003cstrong\u003eAdvantix spot-on solution for dogs\u003c\/strong\u003e may stain certain materials such as leather, fabrics, plastic, and finished surfaces. Allow\u003cbr\u003e\nthe application site to dry before contact with such materials.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePackaging:\u003c\/strong\u003e\u003cbr\u003e\nPipettes of 0.4 ml, 1.0 ml, 2.5 ml, 4.0 ml\u003cbr\u003e\nBlister containing 1, 2, 3, 4, or 6 individual pipettes.\u003cbr\u003e\nNot all pack sizes may be marketed.\u003cbr\u003e\nFor any information about this veterinary medicinal product, please contact the local representative of the marketing authorisation holder.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMarketing Authorisation Holder\u003c\/strong\u003e\u003cbr\u003e\nBayer Animal Health GmbH, D-51368 Leverkusen, Germany\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394224496972,"sku":"ADV600-SET4","price":295.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/Set-4-pipete-antiparazitare-Advantix-pentru-caini-de-peste-40-kg.png?v=1777298222"},{"product_id":"amflee-dog-134-mg-m-10-20-kg-x-10-pipete","title":"AMFLEE DOG 134 MG-M (10-20 KG) X 10 PIPETTES","description":"\u003cp\u003e\u003cstrong\u003eAmflee 134 MG\u003c\/strong\u003e is an antiparasitic pipette for medium-sized dogs weighing between 10-20 kg, which prevents and treats flea and tick infestations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1 pipette (1.34 ml)\u003c\/strong\u003e contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActive substance: Fipronil 134 mg.\u003c\/li\u003e\n\u003cli\u003eOther substances: Butylhydroxyanisole (E320) 0.27 mg Butylhydroxytoluene (E321) 0.13\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eUsed for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eTreatment and prevention of infestations with fleas (\u003cem\u003eCtenocephalides\u003c\/em\u003e spp), ticks (\u003cem\u003eRhipicephalus\u003c\/em\u003e spp, \u003cem\u003eDermacentor\u003c\/em\u003e spp, \u003cem\u003eIxodes\u003c\/em\u003e spp.) and infestations with biting lice \u003cem\u003eTrichodectes canis\u003c\/em\u003e in dogs.\u003c\/li\u003e\n\u003cli\u003eThe product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eThe product can be used as part of a treatment strategy for flea allergy dermatitis (FAD), if previously diagnosed by a veterinarian.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDo not administer to puppies younger than 8 weeks or weighing less than 2 kg.\u003c\/li\u003e\n\u003cli\u003eDo not administer to sick animals (systemic diseases, fever) or those in convalescence.\u003c\/li\u003e\n\u003cli\u003eDo not administer to rabbits due to the risk of severe adverse reactions or even death.\u003c\/li\u003e\n\u003cli\u003eDo not administer to cats, as it may lead to overdose.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eDo not administer in case of hypersensitivity to the active substance or to any of the excipients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePrecautions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTicks on animals should be removed before using the product to reduce the risk of transmissible diseases.\u003c\/li\u003e\n\u003cli\u003eThe product should be applied in a secluded place where the animal cannot lick itself.\u003c\/li\u003e\n\u003cli\u003eIt is recommended to avoid bathing or immersion in water for 2 days after applying the product and to avoid bathing more frequently than once a week.\u003c\/li\u003e\n\u003cli\u003eEmollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of flea protection to approximately 5 weeks.\u003c\/li\u003e\n\u003cli\u003eWeekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the efficacy of the product against fleas, as shown in a long-term 6-week study.\u003c\/li\u003e\n\u003cli\u003eTicks may appear sporadically. Thus, complete exclusion of infection with diseases in unfavorable conditions is impossible. Generally, ticks will die within 24-48 hours after infestation without feeding on the animal's blood.\u003c\/li\u003e\n\u003cli\u003eAvoid contact of the product with the animal's eyes.\u003c\/li\u003e\n\u003cli\u003eDogs should not be allowed to swim in running water for 2 days after application.\u003c\/li\u003e\n\u003cli\u003eThe product can cause irritation to mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.\u003c\/li\u003e\n\u003cli\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.\u003c\/li\u003e\n\u003cli\u003eIn case of contact, wash hands with soap and water.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental contact with eyes, wash thoroughly with clean water.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003cli\u003eDo not touch treated animals and do not let children play with them until the application site has dried. Thus, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially with children.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eDo not smoke, drink or eat while applying the product.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePossible adverse reactions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIf animals lick themselves, short-term hypersalivation may occur, mainly due to the excipients.\u003c\/li\u003e\n\u003cli\u003eExtremely rare adverse reactions: transient skin reactions at the application site (discoloration and hair loss, itching and erythema) and generalized itching with alopecia.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eExceptionally, after use, hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous signs), respiratory signs, or vomiting have been observed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRemove the single-dose pipette from the triplex pouch.\u003c\/li\u003e\n\u003cli\u003eHold the single-dose pipette upright, twist and pull off the cap.\u003c\/li\u003e\n\u003cli\u003eTurn the cap over and place the other end of the cap on the single-dose pipette.\u003c\/li\u003e\n\u003cli\u003ePush and twist the cap to perforate the seal, then remove the cap from the single-dose pipette.\u003c\/li\u003e\n\u003cli\u003ePart the animal's hair in the area between the shoulder blades to make the skin visible.\u003c\/li\u003e\n\u003cli\u003ePlace the tip of the single-dose pipette on the skin and squeeze the pipette several times to empty the contents directly onto the skin, in one spot.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394239078732,"sku":"MD73","price":199.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/amflee-dog-m-10-20kg_2865-removebg-preview.jpg?v=1777298387"},{"product_id":"amflee-dog-3-pipete-x-402-mg-xl-40-60kg","title":"AMFLEE DOG 3 PIPETTES X 402 MG - XL (40-60KG)","description":"\u003cp\u003e\u003cstrong\u003eAmflee 402 MG\u003c\/strong\u003e is an anti-parasitic pipette for very large dogs, weighing between 40 and 60 kilograms, that prevents and treats flea and tick infestations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1 pipette (4.02 ml)\u003c\/strong\u003e contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActive substance: Fipronil 402 mg.\u003c\/li\u003e\n\u003cli\u003eOther substances: Butylhydroxyanisole (E320) 0.80 mg Butylhydroxytoluene (E321) 0.40 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eUsed for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eTreatment and prevention of infestations with fleas (\u003cem\u003eCtenocephalides\u003c\/em\u003e spp), ticks (\u003cem\u003eRhipicephalus\u003c\/em\u003e spp, \u003cem\u003eDermacentor\u003c\/em\u003e spp, \u003cem\u003eIxodes\u003c\/em\u003e spp.) and infestations with biting lice \u003cem\u003eTrichodectes canis\u003c\/em\u003e in dogs.\u003c\/li\u003e\n\u003cli\u003eThe product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eThe product can be used as part of a treatment strategy for allergic dermatitis caused by flea bites (FAD), if previously diagnosed by a veterinarian.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003edo not administer to puppies younger than 8 weeks or weighing less than 2 kg\u003c\/li\u003e\n\u003cli\u003edo not administer to sick animals (systemic diseases, fever) or those in convalescence\u003c\/li\u003e\n\u003cli\u003edo not administer to rabbits due to the risk of serious adverse reactions or even death\u003c\/li\u003e\n\u003cli\u003edo not administer to cats, as it may lead to overdose\u003c\/li\u003e\n\u003cli class=\"last\"\u003edo not administer in case of hypersensitivity to the active substance or to any of the excipients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePRECAUTIONS:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eTicks present on animals should be removed before using the product, to reduce the risk of transmissible diseases.\u003c\/li\u003e\n\u003cli\u003eIt is recommended to avoid bathing or immersion in water for 2 days after application of the product and to avoid bathing more frequently than once a week, as no studies have been conducted to investigate the effectiveness of the product under these conditions.\u003c\/li\u003e\n\u003cli\u003eEmollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of flea protection to approximately 5 weeks.\u003c\/li\u003e\n\u003cli\u003eWeekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the product's efficacy against fleas, as shown in a 6-week long-term study.\u003c\/li\u003e\n\u003cli\u003eSporadic ticks may appear. Thus, it is impossible to completely exclude the transmission of infectious diseases by ticks, if conditions are unfavorable. As a rule, ticks will be killed and fall off the host within 24-48 hours after infestation, without feeding on the animal's blood. Sporadic tick attachment cannot be excluded during the product's efficacy period.\u003c\/li\u003e\n\u003cli\u003ePet fleas often infest the animal's basket, places where animals sleep and rest, such as carpets and soft furnishings, which must be regularly treated with appropriate insecticides and cleaned with a vacuum cleaner, in cases of massive infestations or at the beginning of control measures.\u003c\/li\u003e\n\u003cli\u003eAvoid contact of the product with the animal's eyes.\u003c\/li\u003e\n\u003cli\u003eIt is important to ensure that the product is applied in a place where the animal cannot lick itself, and it should be avoided that animals lick each other after treatment.\u003c\/li\u003e\n\u003cli\u003eDogs should not be allowed to swim in running water for 2 days after application.\u003c\/li\u003e\n\u003cli\u003eThe product can cause irritation of the mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.\u003c\/li\u003e\n\u003cli\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.\u003c\/li\u003e\n\u003cli\u003eIn case of contact, wash hands with soap and water.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental eye contact, wash thoroughly with clean water.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003cli\u003eDo not touch treated animals and do not allow children to play with them until the application site has dried. Thus, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially with children.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eDo not smoke, drink, or eat while applying the product.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePossible adverse reactions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eIf animals lick the application site, short-term hypersalivation may occur, mainly due to the nature of the excipients.\u003c\/li\u003e\n\u003cli\u003eAfter use, extremely rare adverse reactions may include transient skin reactions at the application site (skin discoloration and local alopecia, pruritus, erythema) and generalized pruritus or alopecia.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eExceptionally, after use, hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous signs), respiratory signs, or vomiting have been observed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIn the absence of product safety studies, the minimum interval between treatments is 4 weeks.\u003c\/li\u003e\n\u003cli\u003eMonthly treatment is recommended if there is a high risk of repeated flea infestations, if dogs are allergic to flea bites and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once every two or three months.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoute of administration:\u003c\/strong\u003e External application to the skin (spot-on use).\u003c\/li\u003e\n\u003cli class=\"last\"\u003e\n\u003cstrong\u003eMethod of administration:\u003c\/strong\u003e Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap over and place the other end of the cap on the single-dose pipette. Push and twist the cap to pierce the seal, then remove the cap from the single-dose pipette. Part the animal's fur between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and squeeze the pipette several times to empty the content directly onto the skin, in a single spot.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394239340876,"sku":"MD75","price":75.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/amflee-dog-xl40-60kg-x-1-pip.jpg?v=1777298388"},{"product_id":"nexgard-spectra-dog-l-15-30kg-3-comprimate","title":"Nexgard Spectra Dog L (15-30KG) - 3 chewables","description":"\u003cp\u003e\u003cstrong\u003ePHARMACEUTICAL FORM\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eChewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eRed to reddish-brown marbled, round (tablets for 2-3.5 kg dogs) or rectangular (tablets for \u0026gt;3.5-7.5 kg dogs, \u0026gt;7.5-15 kg dogs, \u0026gt;15-30 kg dogs and \u0026gt;30-60 kg dogs) tablets.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCLINICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTarget species: \u003c\/strong\u003eDogs\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIndications for use, specifying the target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor the treatment of flea and tick infestations in dogs when concurrent prevention of heartworm disease and\/or treatment of gastrointestinal nematode infestations is also indicated.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of flea infestations (\u003cem\u003eCtenocephalides felis\u003c\/em\u003e and \u003cem\u003eC. canis\u003c\/em\u003e) in dogs for 5 weeks. Treatment of tick infestations (\u003cem\u003eDermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus\u003c\/em\u003e) in dogs for 4 weeks.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFleas and ticks must attach to the host and begin feeding to be exposed to the active substance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment of adult gastrointestinal nematode infestations of the following species: roundworms (\u003cem\u003eToxocara canis\u003c\/em\u003e and \u003cem\u003eToxocara leonina\u003c\/em\u003e), hookworms (\u003cem\u003eAncyclostoma caninum\u003c\/em\u003e and \u003cem\u003eAncyclostoma braziliense\u003c\/em\u003e) and whipworms (\u003cem\u003eTrichuris vulpis\u003c\/em\u003e).\u003c\/p\u003e\n\u003cp\u003ePrevention of heartworm disease (\u003cem\u003eDirofilaria immitis\u003c\/em\u003e larval stage) if administered monthly.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eContraindications: \u003c\/strong\u003eDo not use in cases of hypersensitivity to the active substances or to any of the excipients.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial warnings for each target species\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eParasites must begin feeding on the host to be exposed to afoxolaner; therefore, the risk of transmission of infectious diseases cannot be excluded.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eResistance of parasites to a particular class of antiparasitic drugs may develop as a result of frequent use of a compound from that class. Therefore, the use of this product should be based on evaluation of each individual case and local epidemiological information regarding the current susceptibility of the target species to limit the possibility of future selection of resistance.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMaintaining the efficacy of macrocyclic lactones is essential in controlling \u003cem\u003eDirofilaria immitis\u003c\/em\u003e. To minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for use in animals\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn the absence of available data, treatment of puppies younger than 8 weeks and\/or dogs weighing less than 2 kg should only be carried out based on a risk\/benefit assessment by the veterinary surgeon.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in heartworm endemic areas should be tested for adult heartworm infestation before administering NEXGARD SPECTRA. Infested dogs should be treated with an adulticide at the discretion of the veterinary surgeon to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe recommended dose must be strictly followed for Collie dogs or other related breeds.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eThis product may cause gastrointestinal upset if ingested.\u003c\/li\u003e\n\u003cli\u003eKeep tablets in blisters and blister in carton until use.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAdverse reactions (frequency and seriousness)\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIn clinical studies, no serious adverse reactions attributable to the afoxolaner-milbemycin oxime combination were observed. Less frequent reactions such as vomiting, diarrhoea, lethargy, anorexia and pruritus were observed. These reactions generally resolved on their own and were short-lived.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe frequency of adverse reactions is defined using the following convention:\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very common (more than 1 in 10 animals treated show adverse reactions)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Common (more than 1 but less than 10 animals in 100 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Uncommon (more than 1 but less than 10 animals in 1,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Rare (more than 1 but less than 10 animals in 10,000 animals)\u003c\/p\u003e\n\u003cp align=\"left\"\u003e- Very rare (less than 1 animal in 10,000 animals, including isolated reports).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eUse during pregnancy or lactation\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eLaboratory studies in rats and rabbits have not shown teratogenic effects or any negative effect on the reproductive capacity of males and females. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. Use only according to the benefit-risk assessment by the veterinary surgeon.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eInteractions with other medicinal products or other forms of interaction\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is a substrate of P-glycoprotein (P-gp), and can therefore interact with other P-gp substrates (e.g., digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eAmounts to be administered and administration route\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eFor oral administration.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDosage:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product should be administered at a dose of 2.50-5.36 mg\/kg afoxolaner and 0.50-1.07 mg\/kg milbemycin oxime body weight according to the following table:\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\" valign=\"top\" width=\"97\"\u003e\u003cstrong\u003eDog weight (kg)\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd colspan=\"5\" valign=\"top\" width=\"522\"\u003e\u003cstrong\u003eConcentration and number of chewable tablets to be administered\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e9 mg\/ 2 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e19 mg\/ 4 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e38 mg\/ 8 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e75 mg\/ 15 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003eNEXGARD SPECTRA\u003c\/p\u003e\n\u003cp align=\"center\"\u003e150 mg\/ 30 mg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e2-3.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;3.5-7.5\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;7.5-15\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;15-30\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u0026gt;30-60\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\n\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e1\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp align=\"left\"\u003e For dogs over 60 kg body weight, the necessary combination of chewable tablets should be used.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMethod of administration:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe tablets are chewable and palatable for most dogs. If the dog does not accept the tablets directly, they can be administered with food.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eTreatment schedule:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe treatment schedule should be based on the veterinary diagnosis and the local epidemiological situation.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA can be used as seasonal preventive treatment against fleas and ticks (replacing treatment with a monovalent product acting only against fleas and ticks) in dogs concurrently infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cem\u003eDisease: Heartworm disease:\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNEXGARD SPECTRA kills \u003cem\u003eDirofilaria immitis\u003c\/em\u003e larvae for one month after their transmission by mosquitoes, so the product should be administered at regular monthly intervals throughout the vector season, starting one month after the first exposure to mosquitoes. Treatment should be continued until one month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended to administer the treatment on the same day of the month.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eIf replacing another heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eDogs living in or travelling to a heartworm endemic region may be infested with adult heartworms. No therapeutic effect against adult \u003cem\u003eDirofilaria immitis\u003c\/em\u003e has been established. Therefore, it is recommended that all dogs 8 months of age or older, living in heartworm endemic areas, be tested for adult heartworm infestation before being treated with a heartworm prevention product.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eOverdose (symptoms, emergency procedures, antidotes), if applicable\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNo adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACOLOGICAL PROPERTIES\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eATC veterinary code: QP54AB51\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacodynamic properties\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is an insecticide and acaricide belonging to the isoxazoline family.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner acts by interacting with chloride ion channels, primarily those with a binding site for the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfers of chloride ions across the cell membrane. This results in uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects\/mites and mammals is a consequence of the characteristic sensitivity of insect\/mite GABA receptors versus those of mammals.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is active against adult fleas and some tick species such as \u003cem\u003eRhipicephalus sanguineus, Dermacentor reticulatus\u003c\/em\u003e and \u003cem\u003eD. variabilis, Ixodes ricinus\u003c\/em\u003e and \u003cem\u003eI. scapularis, Amblyomma americanum\u003c\/em\u003e and \u003cem\u003eHaemaphysalis longicornis.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe product kills fleas before egg laying and thus prevents contamination of the home. It can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime:\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime is an antiparasitic endectocide belonging to the macrocyclic lactone group. Milbemycin oxime is a mixture of milbemycin A4 and milbemycin A3 (in a 20:80 ratio for A3:A4). It is isolated from the fermentation of \u003cem\u003eStreptomyces milbemycinicus\u003c\/em\u003e.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eMilbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases the membrane permeability of nematodes and insects to chloride ions through glutamate-controlled chloride ion channels (linked to GABA and glycine receptors in vertebrates).\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThis leads to neuromuscular membrane hyperpolarisation and paralysis and death of parasites.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePharmacokinetic particulars\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAfoxolaner is absorbed very quickly systemically. The absolute bioavailability obtained was 88%. The mean maximum plasma concentration (Cmax) was 1822 ± 165 ng\/ml, 2-4 hours (Tmax) after a dose of 2.5 mg\/kg afoxolaner.\u003c\/p\u003e\n\u003cp\u003eThe volume of distribution of Afoxolaner in tissues is 2.6 ± 0.6 l\/kg and the clearance value is 5.0 ± 1.2 ml\/h\/kg. The half-life is approximately 2 weeks in dogs.\u003c\/p\u003e\n\u003cp align=\"left\"\u003ePlasma concentrations of Milbemycin oxime increase rapidly within the first 1-2 hours (Tmax) indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A3 and 65% for A4 respectively. The mean maximum plasma concentration (Cmax) after oral administration was 1.6 ± 0.4 days and 42 ± 11 ng\/ml for A3, 3.3 ± 1.4 days and 246 ± 71 ng\/ml for A4.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eThe volume of distribution of Milbemycin oxime in tissues is 2.7 ± 0.4 and 2.6 ± 0.6 l\/kg for form A3 and A4 respectively. Both forms have a low clearance value of 75 ± 22 ml\/h\/kg for A3 and 41 ± 12 ml\/h\/kg for A4.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003ePHARMACEUTICAL PARTICULARS\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eList of excipients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eMaize starch\u003c\/li\u003e\n\u003cli\u003eSoya proteins\u003c\/li\u003e\n\u003cli\u003eBraised beef flavour\u003c\/li\u003e\n\u003cli\u003ePovidone (E1201)\u003c\/li\u003e\n\u003cli\u003eMacrogol 400\u003c\/li\u003e\n\u003cli\u003eMacrogol 4000\u003c\/li\u003e\n\u003cli\u003eMacrogol 15 hydroxystearate\u003c\/li\u003e\n\u003cli\u003eGlycerol (E422)\u003c\/li\u003e\n\u003cli\u003eMedium chain triglycerides\u003c\/li\u003e\n\u003cli\u003eCitric acid monohydrate (E330)\u003c\/li\u003e\n\u003cli\u003eButylhydroxytoluene (E321)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eIncompatibilities: \u003c\/strong\u003eNot applicable.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eShelf life: \u003c\/strong\u003eShelf life of the veterinary medicinal product as packaged for sale: 2 years\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eSpecial precautions for storage: \u003c\/strong\u003eKeep the blister in the secondary packaging to protect from light.\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003eNature and composition of primary packaging\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003eThis veterinary medicinal product is individually packed in thermoformed PVC blisters sealed on the back with aluminium foil (Aclar\/PVC\/Alu).\u003c\/p\u003e\n\u003cp align=\"left\"\u003e1 cardboard box containing one blister with 1, 3 and 6 chewable tablets.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eNot all pack sizes may be marketed.\u003c\/p\u003e\n\u003cp align=\"left\"\u003eSpecial precautions for the disposal of unused veterinary medicinal products or waste materials derived from the use of such products\u003c\/p\u003e\n\u003cp align=\"left\"\u003eAny unused veterinary medicinal product or waste materials derived from the use of such products should be disposed of in accordance with local requirements.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394239439180,"sku":"NEX153","price":225.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/nexgard-spectra-l-comprimat-caini-15-30kg_4979.jpg?v=1777298389"},{"product_id":"amflee-dog-3-pipete-x-67-mg-s-2-10-kg","title":"AMFLEE DOG 3 PIPETTES X 67 MG- S (2-10 KG)","description":"\u003cp\u003e\u003cstrong\u003eAmflee 67 mg\u003c\/strong\u003e is an antiparasitic pipette for small dogs weighing between 2 and 10 kilograms, which prevents and treats flea and tick infestations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1 pipette (0.67 ml)\u003c\/strong\u003e contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActive substance: Fipronil 67 mg.\u003c\/li\u003e\n\u003cli\u003eOther substances: Butylhydroxyanisole (E320) 0.134 mg Butylhydroxytoluene (E321) 0.067 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eUsed for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eTreatment and prevention of infestations with fleas (\u003cem\u003eCtenocephalides\u003c\/em\u003e spp), ticks (\u003cem\u003eRhipicephalus\u003c\/em\u003e spp, \u003cem\u003eDermacentor\u003c\/em\u003e spp, \u003cem\u003eIxodes\u003c\/em\u003e spp.) and infestations with biting lice \u003cem\u003eTrichodectes canis\u003c\/em\u003e in dogs.\u003c\/li\u003e\n\u003cli\u003eThe product has a persistent insecticidal efficacy of up to 2 months against fleas and acaricidal efficacy of up to 4 weeks against ticks.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eThe product can be used as part of a treatment strategy for flea allergy dermatitis (FAD), if this has been previously diagnosed by the veterinarian.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDo not administer to puppies younger than 8 weeks or weighing less than 2 kg.\u003c\/li\u003e\n\u003cli\u003eDo not administer to sick animals (systemic diseases, fever) or those in convalescence.\u003c\/li\u003e\n\u003cli\u003eDo not administer to rabbits due to the risk of severe adverse reactions or even death.\u003c\/li\u003e\n\u003cli\u003eDo not administer to cats, as it may lead to overdose.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eDo not administer in case of hypersensitivity to the active substance or any of the excipients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePRECAUTIONS:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eTicks present on animals must be removed before using the product, to reduce the risk of transmissible diseases.\u003c\/li\u003e\n\u003cli\u003eIt is recommended to avoid bathing or immersion in water for 2 days after applying the product and to avoid bathing more frequently than once a week, as studies investigating the efficacy of the product under these conditions have not been conducted.\u003c\/li\u003e\n\u003cli\u003eEmollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of protection against fleas to approximately 5 weeks.\u003c\/li\u003e\n\u003cli\u003eWeekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the efficacy of the product against fleas, as shown in a long-term 6-week study.\u003c\/li\u003e\n\u003cli\u003eOccasionally, ticks may appear. Thus, complete exclusion of infectious disease transmission by ticks is impossible if conditions are unfavorable. Usually, ticks will be killed and fall off the host within 24-48 hours after infestation, without feeding on the animal's blood. Sporadic attachment of ticks cannot be excluded during the product's efficacy period.\u003c\/li\u003e\n\u003cli\u003ePet fleas often infest animal bedding, sleeping and resting places, such as carpets and soft furnishings, which must be regularly treated with appropriate insecticides and cleaned with a vacuum cleaner, in cases of massive infestations or at the beginning of control measures.\u003c\/li\u003e\n\u003cli\u003eAvoid contact of the product with the animal's eyes.\u003c\/li\u003e\n\u003cli\u003eIt is important to ensure that the product is applied in a place where the animal cannot lick itself and that animals are prevented from licking each other after treatment.\u003c\/li\u003e\n\u003cli\u003eDogs should not be allowed to swim in running water for 2 days after application.\u003c\/li\u003e\n\u003cli\u003eThe product can cause irritation of mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.\u003c\/li\u003e\n\u003cli\u003ePersons with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.\u003c\/li\u003e\n\u003cli\u003eIn case of contact, wash hands with soap and water.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental contact with eyes, rinse thoroughly with clean water.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003cli\u003eDo not touch treated animals and do not let children play with them until the application site has dried. Therefore, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially children.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eDo not smoke, drink, or eat while applying the product.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePossible adverse reactions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eIf animals lick the application site, short-term hypersalivation may occur, mainly due to the nature of the excipients.\u003c\/li\u003e\n\u003cli\u003eAfter use, among extremely rare adverse reactions, transient skin reactions at the application site (skin discoloration and local alopecia, pruritus, erythema) and generalized pruritus or alopecia may be observed.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eExceptionally, after use, hypersalivation, reversible neurological symptoms (hyperesthesia, depression, nervous signs), respiratory signs, or vomiting have been observed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIn the absence of product safety studies, the minimum interval between treatments is 4 weeks.\u003c\/li\u003e\n\u003cli\u003eMonthly treatment is recommended if there is a high risk of repeated flea infestations, if dogs are allergic to flea bites, and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once every two or three months.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoute of administration:\u003c\/strong\u003e External application to the skin (spot-on use).\u003c\/li\u003e\n\u003cli class=\"last\"\u003e\n\u003cstrong\u003eMethod of administration:\u003c\/strong\u003e Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap upside down and place the other end of the cap on the single-dose pipette. Push and twist the cap to perforate the seal, then remove the cap from the single-dose pipette. Part the animal's hair in the area between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and squeeze the pipette several times to empty the contents directly onto the skin, in one spot.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394239897932,"sku":"MD76","price":59.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/amflee-dog-s-2-10kg_2119.jpg?v=1777298395"},{"product_id":"amflee-dog-268-mg-l-20-40-kgx-10-pipete","title":"AMFLEE DOG 268 MG- L (20-40 KG)X 10 PIPETTES","description":"\u003cp\u003e\u003cstrong\u003eAmflee 268 MG\u003c\/strong\u003e is an antiparasitic pipette for medium-sized dogs, weighing between 20 and 40 kilograms, which prevents and treats flea and tick infestations.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e1 pipette (2.68 ml)\u003c\/strong\u003e contains:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eActive substance: Fipronil 268 mg.\u003c\/li\u003e\n\u003cli\u003eOther substances: Butylhydroxyanisole (E320) 0.54 mg Butylhydroxytoluene (E321) 0.27 mg\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eUsed for:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli class=\"first\"\u003eTreatment and prevention of infestations with fleas (\u003cem\u003eCtenocephalides\u003c\/em\u003e spp), ticks (\u003cem\u003eRhipicephalus\u003c\/em\u003e spp, \u003cem\u003eDermacentor\u003c\/em\u003e spp, \u003cem\u003eIxodes\u003c\/em\u003e spp.), and infestations with biting lice \u003cem\u003eTrichodectes canis\u003c\/em\u003e in dogs.\u003c\/li\u003e\n\u003cli\u003eThe product has a persistent insecticidal efficacy of up to 2 months against fleas and an acaricidal efficacy of up to 4 weeks against ticks.\u003c\/li\u003e\n\u003cli class=\"last\"\u003eThe product can be used as part of a treatment strategy for flea allergy dermatitis (FAD), if it has been previously diagnosed by a veterinarian.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003edo not administer to puppies younger than 8 weeks or weighing less than 2 kg\u003c\/li\u003e\n\u003cli\u003edo not administer to sick animals (systemic diseases, fever) or those in convalescence\u003c\/li\u003e\n\u003cli\u003edo not administer to rabbits due to the risk of serious adverse reactions or even death\u003c\/li\u003e\n\u003cli\u003edo not administer to cats, as it may lead to overdose\u003c\/li\u003e\n\u003cli class=\"last\"\u003edo not administer in cases of hypersensitivity to the active substance or any of the excipients.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePRECAUTIONS:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eTicks on animals must be removed before using the product to reduce the risk of transmissible diseases.\u003c\/li\u003e\n\u003cli\u003eThe product should be applied in a secluded area where the animal cannot lick.\u003c\/li\u003e\n\u003cli\u003eIt is recommended to avoid bathing or immersion in water for 2 days after product application and to avoid bathing more frequently than once a week.\u003c\/li\u003e\n\u003cli\u003eEmollient shampoos can be used before treatment, but when used weekly after product application, they reduce the duration of protection against fleas to approximately 5 weeks.\u003c\/li\u003e\n\u003cli\u003eWeekly bathing with medicated shampoo containing 2% chlorhexidine does not affect the product's efficacy against fleas, as shown in a long-term 6-week study.\u003c\/li\u003e\n\u003cli\u003eTicks may appear sporadically. Thus, complete exclusion of disease infection under unfavorable conditions is impossible. Generally, ticks will die within 24 - 48 hours after infestation without feeding on the animal's blood.\u003c\/li\u003e\n\u003cli\u003eAvoid contact of the product with the animal's eyes.\u003c\/li\u003e\n\u003cli\u003eDogs should not be allowed to swim in running water for 2 days after application.\u003c\/li\u003e\n\u003cli\u003eThe product may cause irritation of the mucous membranes and eyes. Therefore, avoid contact of the product with the mouth and eyes.\u003c\/li\u003e\n\u003cli\u003eIndividuals with known hypersensitivity to insecticides or alcohol should avoid contact with the veterinary medicinal product.\u003c\/li\u003e\n\u003cli\u003eIn case of contact, wash hands with soap and water.\u003c\/li\u003e\n\u003cli\u003eIn case of accidental contact with eyes, wash thoroughly with clean water.\u003c\/li\u003e\n\u003cli\u003eWash hands after use.\u003c\/li\u003e\n\u003cli\u003eDo not touch treated animals and do not let children play with them until the application site has dried. Therefore, it is not recommended to apply the treatment during the day, but in the evening before bedtime, and treated animals should not be allowed to sleep with their owners, especially children.\u003c\/li\u003e\n\u003cli\u003eDo not smoke, drink, or eat while applying the product.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePossible adverse reactions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIf animals lick themselves, short-term hypersalivation may occur, mainly due to the excipients.\u003c\/li\u003e\n\u003cli\u003eExtremely rare adverse reactions: transient skin reactions at the application site (discoloration and hair loss, pruritus and erythema) and generalized pruritus with alopecia.\u003c\/li\u003e\n\u003cli\u003eExceptionally, after use, reversible neurological symptoms (hyperesthesia, depression, nervousness), hypersalivation, or vomiting have been observed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eAdministration:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eIn the absence of product safety studies, the minimum interval between treatments is 4 weeks.\u003c\/li\u003e\n\u003cli\u003eMonthly treatment is recommended if there is an increased risk of repeated flea infestations, if dogs are allergic to flea bites, and in case of necessary tick infestation control, or when frequent bathing with hypoallergenic or emollient shampoos occurs. In areas where there is no high risk of flea and tick infestations, the product can be applied once, at intervals of two or three months.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoute of administration:\u003c\/strong\u003e External application on the skin (spot-on use).\u003c\/li\u003e\n\u003cli class=\"last\"\u003e\n\u003cstrong\u003eMethod of administration:\u003c\/strong\u003e Remove the single-dose pipette from the triplex pouch. Hold the single-dose pipette upright, twist and pull off the cap. Turn the cap over and place the other end of the cap on the single-dose pipette. Push and twist the cap to pierce the seal, then remove the cap from the single-dose pipette. Part the animal's hair in the area between the shoulder blades to make the skin visible. Place the tip of the single-dose pipette on the skin and press the pipette several times to empty the contents directly onto the skin, in a single spot.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003c\/p\u003e","brand":"Anima Land","offers":[{"title":"Default Title","offer_id":57394239996236,"sku":"MD74","price":209.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/files\/res_5f0174d5f5190c9dbe69d48bbf5e224b.jpg?v=1777298397"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1040\/1726\/4972\/collections\/Deparazitare-caini.jpg?v=1777990395","url":"https:\/\/www.animaland.ro\/en\/collections\/antiparazitare-caini.oembed","provider":"Anima Land","version":"1.0","type":"link"}